M C Moore

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Nonhepatic response to portal glucose delivery in conscious dogs
    M C Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Am J Physiol Endocrinol Metab 279:E1271-7. 2000
  2. ncbi request reprint Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults
    M C Moore
    Departments of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Clin Endocrinol Metab 85:4515-9. 2000
  3. ncbi request reprint Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes
    M C Moore
    Department of Molecular Physiology, Diabetes Research and Training Center, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Diabetes Care 24:1882-7. 2001
  4. ncbi request reprint Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs
    Mary Courtney Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Endocrinol Metab 282:E286-96. 2002
  5. ncbi request reprint Effects of cyclosporine A and prednisone treatment on mixed meal disposition in dogs with hepatic denervation
    Mary Courtney Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    JPEN J Parenter Enteral Nutr 26:42-50. 2002
  6. ncbi request reprint Nonesterified fatty acids and hepatic glucose metabolism in the conscious dog
    Mary Courtney Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Diabetes 53:32-40. 2004
  7. ncbi request reprint Portal serotonin infusion and glucose disposal in conscious dogs
    Mary Courtney Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Diabetes 53:14-20. 2004
  8. ncbi request reprint Rapid reversal of the effects of the portal signal under hyperinsulinemic conditions in the conscious dog
    P S Hsieh
    Department of Molecular Physiology and Biophysics and Diabetes Research and Training Center, Vanderbilt University, Nashville, Tennessee 37232 0615, USA Po Shiuan
    Am J Physiol 276:E930-7. 1999
  9. ncbi request reprint Insulin-independent effects of GLP-1 on canine liver glucose metabolism: duration of infusion and involvement of hepatoportal region
    D Dardevet
    Vanderbilt Univ School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 287:E75-81. 2004
  10. pmc Comparison of insulins detemir and glargine: effects on glucose disposal, hepatic glucose release and the central nervous system
    M C Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Diabetes Obes Metab 13:832-40. 2011

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Nonhepatic response to portal glucose delivery in conscious dogs
    M C Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Am J Physiol Endocrinol Metab 279:E1271-7. 2000
    ..Even in the absence of somatostatin and fixed hormone concentrations, the portal signal acts to alter partitioning of a glucose load among the tissues, stimulating NHGU and reducing peripheral glucose uptake...
  2. ncbi request reprint Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults
    M C Moore
    Departments of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Clin Endocrinol Metab 85:4515-9. 2000
    ..Fructose appears most effective in those normal individuals who have the poorest glucose tolerance...
  3. ncbi request reprint Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes
    M C Moore
    Department of Molecular Physiology, Diabetes Research and Training Center, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Diabetes Care 24:1882-7. 2001
    ..We hypothesized that an acute catalytic dose of fructose would also improve glucose tolerance in individuals with type 2 diabetes...
  4. ncbi request reprint Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs
    Mary Courtney Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Endocrinol Metab 282:E286-96. 2002
    ..05 vs. Sham-Sal), 9.8 +/- 0.9 (P < 0.05 vs. Sham-Sal), and 13.6 +/- 1.8 mg. kg(-1) x min(-1), respectively. DN caused peripheral insulin resistance, and intraportal but not peripheral acetylcholine restored insulin sensitivity...
  5. ncbi request reprint Effects of cyclosporine A and prednisone treatment on mixed meal disposition in dogs with hepatic denervation
    Mary Courtney Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    JPEN J Parenter Enteral Nutr 26:42-50. 2002
    ..Therefore, we hypothesized that the combination of immunosuppressive therapy and hepatic denervation would create additional alterations in the disposition of glucose from a mixed meal...
  6. ncbi request reprint Nonesterified fatty acids and hepatic glucose metabolism in the conscious dog
    Mary Courtney Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Diabetes 53:32-40. 2004
    ..In the presence of hyperglycemia and relative insulin deficiency, elevated NEFAs reduce NHGU by stimulating hepatic glucose release and suppressing hepatic glucose uptake...
  7. ncbi request reprint Portal serotonin infusion and glucose disposal in conscious dogs
    Mary Courtney Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Diabetes 53:14-20. 2004
    ..SAL), and 34.7 +/- 7.7 (P < 0.05 vs. SAL). Intraportal 5-HT enhances NHGU but blunts nonhepatic glucose uptake, raising the possibility that hepatic-targeted 5-HT or 5-HT receptor agonists might reduce postprandial hyperglycemia...
  8. ncbi request reprint Rapid reversal of the effects of the portal signal under hyperinsulinemic conditions in the conscious dog
    P S Hsieh
    Department of Molecular Physiology and Biophysics and Diabetes Research and Training Center, Vanderbilt University, Nashville, Tennessee 37232 0615, USA Po Shiuan
    Am J Physiol 276:E930-7. 1999
    ..These results indicate that even under hyperinsulinemic conditions the effects of the portal signal on hepatic and peripheral glucose uptake are rapidly reversible...
  9. ncbi request reprint Insulin-independent effects of GLP-1 on canine liver glucose metabolism: duration of infusion and involvement of hepatoportal region
    D Dardevet
    Vanderbilt Univ School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 287:E75-81. 2004
    ..kg(-1).min(-1), respectively). In conclusion: GLP-1 increased glucose disposal in the liver independently of insulin secretion; its full action required long-term infusion. The route of infusion did not modify the hepatic response...
  10. pmc Comparison of insulins detemir and glargine: effects on glucose disposal, hepatic glucose release and the central nervous system
    M C Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Diabetes Obes Metab 13:832-40. 2011
    ..The effects of insulins detemir (Det) and glargine (Glar) on endogenous glucose production (EGP) and net hepatic glucose output (NHGO) were compared...
  11. ncbi request reprint The role of neural signalling and hypoglycaemia per se in the counterregulatory response
    A D Cherrington
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Diabetes Nutr Metab 15:303-7; discussion 307-8. 2002
  12. ncbi request reprint Insulin action on the liver in vivo
    A D Cherrington
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 704 Robinson Research Bldg, Nashville, TN 37232 0615, U S A
    Biochem Soc Trans 35:1171-4. 2007
    ..The primary effect of insulin on the liver is its direct action...
  13. pmc Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs
    Mary Courtney Moore
    702 Light Hall, Dept of Molecular Physiology and Biophysics, Vanderbilt Univ School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 289:E225-31. 2005
    ..Intraportal 5-HTP enhances NHGU without significantly altering nonhepatic glucose uptake or causing gastrointestinal side effects, raising the possibility that a related agent might have a role in reducing postprandial hyperglycemia...
  14. pmc Chronic estradiol and progesterone treatment in conscious dogs: effects on insulin sensitivity and response to hypoglycemia
    Marcia R Batista
    702 Light Hall, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1064-73. 2005
    ..Chronic progesterone and estradiol exposure caused whole body (primarily skeletal muscle) insulin resistance and enhanced the liver's response to hypoglycemia without altering counterregulatory hormone concentrations...
  15. pmc Insulin secretion-independent effects of GLP-1 on canine liver glucose metabolism do not involve portal vein GLP-1 receptors
    Dominique Dardevet
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Am J Physiol Gastrointest Liver Physiol 289:G806-14. 2005
    ..7 +/- 1.0 and 5.4 +/- 0.8 micromol.kg(-1).min(-1), respectively, P < 0.05). In conclusion, physiological GLP-1 levels increase glucose disposal in the liver, and this effect does not involve GLP-1 receptors located in the portal vein...
  16. pmc Glucagon secretion and autonomic signaling during hypoglycemia in late pregnancy
    Kathryn M Canniff
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Regul Integr Comp Physiol 291:R788-95. 2006
    ....
  17. pmc Hepatic and muscle insulin action during late pregnancy in the dog
    Cynthia C Connolly
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Regul Integr Comp Physiol 292:R447-52. 2007
    ..Differing insulin concentrations in pregnant and nonpregnant women and excessive insulin infusion rates may explain previous findings of hepatic insulin resistance in healthy pregnant women...
  18. ncbi request reprint Drug evaluation: tagatose in the treatment of type 2 diabetes and obesity
    Mary Courtney Moore
    Vanderbilt University School of Medicine, Department of Molecular Physiology and Biophysics, 702 Light Hall, Nashville, TN 37232, USA
    Curr Opin Investig Drugs 7:924-35. 2006
    ..The compound is also under investigation for the potential treatment of anemia, hemophilia and medical problems related to infertility, birth weight and excessive maternal food intake. Phase I and II clinical trials have been completed...
  19. doi request reprint Hepatic portal venous delivery of a nitric oxide synthase inhibitor enhances net hepatic glucose uptake
    Mary Courtney Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 294:E768-77. 2008
    ..023, and 0.122 +/- 0.021 during P1, P2, and P3, respectively (P < 0.05 vs. control during P2 and P3), with no significant difference in glucose infusion rates. Thus, NOS inhibition enhanced NHFE, an effect partially reversed by SIN-1...
  20. doi request reprint Intraportal administration of neuropeptide Y and hepatic glucose metabolism
    Makoto Nishizawa
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1197-204. 2008
    ..05). There were no significant differences between groups in the total glucose infusion rate. Thus, intraportal NPY stimulates net hepatic glucose uptake without significantly altering whole body glucose disposal in dogs...
  21. pmc Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs
    Dominique Dardevet
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
    Am J Clin Nutr 88:986-96. 2008
    ..Hepatic glucose uptake is enhanced by the portal delivery of glucose, which creates a negative arterioportal substrate gradient. Hepatic amino acid (AA) utilization may be regulated by the same phenomenon, but this has not been proven...
  22. ncbi request reprint Simulated first-phase insulin release using Humulin or insulin analog HIM2 is associated with prolonged improvement in postprandial glycemia
    Catherine A DiCostanzo
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
    Am J Physiol Endocrinol Metab 289:E46-52. 2005
    ..HIM2 was more effective than Humulin, perhaps because its lowered clearance caused higher levels at the liver and periphery and its biological activity was not reduced proportionally to its decreased clearance...
  23. ncbi request reprint Interaction of a selective serotonin reuptake inhibitor with insulin in the control of hepatic glucose uptake in conscious dogs
    Mary Courtney Moore
    Dept of Molecular Physiology and Biophysics, Vanderbilt Univ School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 288:E556-63. 2005
    ..05). Intraportal fluvoxamine enhanced NHGU and net hepatic carbon retention in the presence of hyperinsulinemia but not euinsulinemia, suggesting that hepatocyte-targeted SSRIs may reduce postprandial hyperglycemia...
  24. ncbi request reprint Chronic hepatic artery ligation does not prevent liver from differentiating portal vs. peripheral glucose delivery
    Mary Courtney Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 702 Light Hall, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 285:E845-53. 2003
    ....
  25. ncbi request reprint Regulation of hepatic and peripheral glucose disposal
    Mary Courtney Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 702 Light Hall, Nashville, TN 37232 0615, USA
    Best Pract Res Clin Endocrinol Metab 17:343-64. 2003
    ..Exercise stimulates insulin-dependent and -independent muscle glucose uptake, as well as the liver's ability to take up glucose...
  26. ncbi request reprint Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion
    Mary Courtney Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Am J Physiol Endocrinol Metab 286:E226-33. 2004
    ..As a result, both groups maintained near-euglycemia. The dog glucoregulates more rigorously than the mouse in response to both portal and peripheral glucose delivery...
  27. ncbi request reprint Portal glucose infusion exerts an incretin effect associated with changes in pancreatic neural activity in conscious dogs
    Beth E Dunning
    Pharmacology Unit of Metabolic and Cardiovascular Diseases Research, Novartis Pharmaceuticals, East Hanover, NJ, USA
    Metabolism 51:1324-30. 2002
    ..Thus, activation of the Po glucose signal appears to inhibit the shift toward sympathetic dominance that would otherwise result, thereby causing an incretin effect...
  28. ncbi request reprint Direct and indirect effects of insulin on glucose uptake and storage by the liver
    Shosuke Satake
    Department of Molecular Physiology and Biophysics, and Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 51:1663-71. 2002
    ..05 vs. BI) in BI, PoI, and PeI, respectively. Both direct and indirect insulin actions increase NHGU, but the rise in hepatic sinusoidal insulin appears critical for efficient storage of glucose as hepatic glycogen...
  29. ncbi request reprint Insulin action during late pregnancy in the conscious dog
    Cynthia C Connolly
    Department of Molecular Physiology and Biophysics, Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 286:E909-15. 2004
    ..Peripheral insulin action is markedly impaired in this canine model of pregnancy, whereas hepatic glucose production is completely suppressed by high circulating insulin levels...
  30. ncbi request reprint Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog
    Masakazu Shiota
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Diabetes 51:469-78. 2002
    ..As a result, postprandial hyperglycemia and insulin release by the pancreatic beta-cell were reduced. In conclusion, catalytic amounts of fructose have the ability to improve glucose tolerance...
  31. ncbi request reprint Pregnancy impairs the counterregulatory response to insulin-induced hypoglycemia in the dog
    Cynthia C Connolly
    Department of Molecular Physiology and Biophysics, and Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Endocrinol Metab 287:E480-8. 2004
    ..The glucagon and norepinephrine responses to insulin-induced hypoglycemia are blunted in late pregnancy in the dog, impacting on the magnitude of the metabolic responses to the fall in glucose...
  32. ncbi request reprint Vagal cooling and concomitant portal norepinephrine infusion do not reduce net hepatic glucose uptake in conscious dogs
    Sylvain Cardin
    Dept of Molecular Physiology and Biophysics, Vanderbilt Univ School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Regul Integr Comp Physiol 287:R742-8. 2004
    ....
  33. ncbi request reprint Portal infusion of a selective serotonin reuptake inhibitor enhances hepatic glucose disposal in conscious dogs
    Mary Courtney Moore
    Dept of Molecular Physiology and Biophysics, 702 Light Hall, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 287:E1057-63. 2004
    ....
  34. ncbi request reprint Effect of intraportal glucagon-like peptide-1 on glucose metabolism in conscious dogs
    Makoto Nishizawa
    Department of Molecular Physiology and Biophysics, Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Am J Physiol Endocrinol Metab 284:E1027-36. 2003
    ..1) to increase during GLP-1 infusion at 20 pmol. kg(-1). min(-1) (24% greater than control). Intraportal infusion of GLP-1 at high physiological and pharmacological rates increased glucose disposal primarily in nonhepatic tissues...