J H Moore

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Optimization of neural network architecture using genetic programming improves detection and modeling of gene-gene interactions in studies of human diseases
    Marylyn D Ritchie
    Program in Human Genetics and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN, 37232 0700, USA
    BMC Bioinformatics 4:28. 2003
  2. ncbi Detection of linear and nonlinear dependencies in time series using the method of surrogate data in S-PLUS
    J H Moore
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, 519 Light Hall, Nashville, TN 37232 0700, USA
    Comput Methods Programs Biomed 63:117-21. 2000
  3. ncbi A comparison of combinatorial partitioning and linear regression for the detection of epistatic effects of the ACE I/D and PAI-1 4G/5G polymorphisms on plasma PAI-1 levels
    J H Moore
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, 519 Light Hall, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Clin Genet 62:74-9. 2002
  4. ncbi The relationship between plasma t-PA and PAI-1 levels is dependent on epistatic effects of the ACE I/D and PAI-1 4G/5G polymorphisms
    J H Moore
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, 519 Light Hall, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Clin Genet 62:53-9. 2002
  5. ncbi Symbolic discriminant analysis of microarray data in autoimmune disease
    Jason H Moore
    Program in Human Genetics, Vanderbilt University Medical School, Nashville, Tennessee 37232 0700, USA
    Genet Epidemiol 23:57-69. 2002
  6. ncbi New strategies for identifying gene-gene interactions in hypertension
    Jason H Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Ann Med 34:88-95. 2002
  7. ncbi Improved power of sib-pair linkage analysis using measures of complex trait dynamics
    J H Moore
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tenn 37232 0700, USA
    Hum Hered 52:113-5. 2001
  8. ncbi The ubiquitous nature of epistasis in determining susceptibility to common human diseases
    Jason H Moore
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Hum Hered 56:73-82. 2003
  9. pmc Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population
    J A Schoenhard
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Hum Genet 124:479-88. 2008
  10. pmc Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer
    M D Ritchie
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Am J Hum Genet 69:138-47. 2001

Collaborators

Detail Information

Publications67

  1. pmc Optimization of neural network architecture using genetic programming improves detection and modeling of gene-gene interactions in studies of human diseases
    Marylyn D Ritchie
    Program in Human Genetics and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN, 37232 0700, USA
    BMC Bioinformatics 4:28. 2003
    ....
  2. ncbi Detection of linear and nonlinear dependencies in time series using the method of surrogate data in S-PLUS
    J H Moore
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, 519 Light Hall, Nashville, TN 37232 0700, USA
    Comput Methods Programs Biomed 63:117-21. 2000
    ..We expect these S functions will be useful for the application of the method of surrogate data to the analysis of biomedical time series using the S-PLUS statistical software package...
  3. ncbi A comparison of combinatorial partitioning and linear regression for the detection of epistatic effects of the ACE I/D and PAI-1 4G/5G polymorphisms on plasma PAI-1 levels
    J H Moore
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, 519 Light Hall, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Clin Genet 62:74-9. 2002
    ....
  4. ncbi The relationship between plasma t-PA and PAI-1 levels is dependent on epistatic effects of the ACE I/D and PAI-1 4G/5G polymorphisms
    J H Moore
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, 519 Light Hall, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Clin Genet 62:53-9. 2002
    ..This study supports the idea that interactions between the fibrinolytic and renin-angiotensin systems play an important role in the genetic architecture of plasma t-PA and PAI-1...
  5. ncbi Symbolic discriminant analysis of microarray data in autoimmune disease
    Jason H Moore
    Program in Human Genetics, Vanderbilt University Medical School, Nashville, Tennessee 37232 0700, USA
    Genet Epidemiol 23:57-69. 2002
    ..In the present study, we demonstrate that SDA is capable of identifying combinations of gene expression variables that are able to classify and predict autoimmune diseases...
  6. ncbi New strategies for identifying gene-gene interactions in hypertension
    Jason H Moore
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Ann Med 34:88-95. 2002
    ..Here, we review the general problem of identifying gene-gene interactions and describe several traditional and several newer methods that are being used to assess complex genetic interactions in essential hypertension...
  7. ncbi Improved power of sib-pair linkage analysis using measures of complex trait dynamics
    J H Moore
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tenn 37232 0700, USA
    Hum Hered 52:113-5. 2001
    ..Using this simple genetic architecture, we demonstrate that the power of sib-pair linkage analysis can be greatly improved if measures of complex trait dynamics are considered...
  8. ncbi The ubiquitous nature of epistasis in determining susceptibility to common human diseases
    Jason H Moore
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Hum Hered 56:73-82. 2003
    ..If this working hypothesis is true, it suggests that we need a research strategy for identifying common disease susceptibility genes that embraces, rather than ignores, the complexity of the genotype to phenotype relationship...
  9. pmc Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population
    J A Schoenhard
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Hum Genet 124:479-88. 2008
    ....
  10. pmc Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer
    M D Ritchie
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Am J Hum Genet 69:138-47. 2001
    ..To our knowledge, this is the first report of a four-locus interaction associated with a common complex multifactorial disease...
  11. ncbi Hybrid grammar-based approach to nonlinear dynamical system identification from biological time series
    B A McKinney
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 73:021912. 2006
    ..From the observed data, we infer a cytokine protein interaction network for an individual's response to the smallpox vaccine...
  12. pmc Exploiting the proteome to improve the genome-wide genetic analysis of epistasis in common human diseases
    Kristine A Pattin
    Computational Genetics Laboratory, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH, USA
    Hum Genet 124:19-29. 2008
    ..We explore some of the fundamentals of protein interactions and the databases that are publicly available...
  13. ncbi A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction
    Digna R Velez
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee
    Genet Epidemiol 31:306-15. 2007
    ..These results suggest that balanced accuracy should be used instead of accuracy for the MDR analysis of epistasis in imbalanced datasets...
  14. ncbi ABCB1 and GST polymorphisms associated with TP53 status in breast cancer
    Silje H Nordgard
    Department of Genetics, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Pharmacogenet Genomics 17:127-36. 2007
    ..The goal of this study was to characterize the genetic variation in the ABCB1, GSTM1, GSTT1 and GSTP1 genes, as well as the haplotype structure in the ABCB1 gene...
  15. ncbi Symbolic modeling of epistasis
    Jason H Moore
    Computational Genetics Laboratory, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Hered 63:120-33. 2007
    ..We illustrate this five step SDA modeling process with a real case-control dataset...
  16. pmc Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Genomics 89:362-9. 2007
    ..These results support the idea that the interplay between the renin-angiotensin, bradykinin, and fibrinolytic systems might play an important role in t-PA and PAI-1 biology...
  17. ncbi Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels
    Ana M Coutinho
    Instituto Gulbenkian de Ciencia, R Quinta Grande 6, Ap 14, 2781 901 Oeiras, Portugal
    Hum Genet 121:243-56. 2007
    ....
  18. ncbi Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction
    Chia Ti Tsai
    Division of Cardiology, Department of Internal Medicine, National Taiwan, University Hospital, Taipei, Taiwan
    Atherosclerosis 195:172-80. 2007
    ..These results are compatible with the concept of multilocus and multi-gene effects in complex diseases that would be missed with conventional approaches...
  19. ncbi Elevated male European and female African contributions to the genomes of African American individuals
    Joanne M Lind
    Laboratory of Genomic Diversity, NCI Frederick, Frederick, MD, USA
    Hum Genet 120:713-22. 2007
    ..mtDNA) to the genomes of African American individuals meaning that admixture-based gene discovery will have the most power for the autosomes and will be more limited for X chromosome analysis...
  20. ncbi The gender-specific role of polymorphisms from the fibrinolytic, renin-angiotensin, and bradykinin systems in determining plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Thromb Haemost 96:471-7. 2006
    ..In addition, the results support the idea that the biology of t-PA and PAI-1 is different between females and males...
  21. pmc Machine learning for detecting gene-gene interactions: a review
    Brett A McKinney
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University Medical School, Nashville, Tennessee, USA
    Appl Bioinformatics 5:77-88. 2006
    ..We conclude with some ideas about how these methods and others can be integrated into a comprehensive and flexible framework for data mining and knowledge discovery in human genetics...
  22. pmc A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    BMC Med Genet 7:39. 2006
    ..We aimed to investigate the association between several environmental factors and loci of candidate genes, which might be related to the presence of AF...
  23. pmc Dissecting trait heterogeneity: a comparison of three clustering methods applied to genotypic data
    Tricia A Thornton-Wells
    Neuroscience Graduate Program, Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA
    BMC Bioinformatics 7:204. 2006
    ..To determine the efficacy of applying the Bayesian Classification method to real data, the reliability of its internal clustering metrics at finding good clusterings was evaluated using permutation testing...
  24. ncbi Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation
    Merce Garcia-Barcelo
    Division of Paediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    J Pediatr Surg 42:666-71. 2007
    ..We conducted a pilot study to investigate whether genes encoding neurotransmitters (TAC1, TAC3, VIP, NOS1) and receptors (TACR1, TACR2, TACR3, KIT) could be responsible for STC...
  25. doi Genetic interactions model among Eotaxin gene polymorphisms in asthma
    June Hyuk Lee
    Department of Internal Medicine, Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, Gyeonggi Do, 420 021, South Korea
    J Hum Genet 53:867-75. 2008
    ..Although the models are limited to determining statistical interactions within a population, they may be useful for identifying groups at high risk of developing asthma...
  26. ncbi Detecting pathway-based gene-gene and gene-environment interactions in pancreatic cancer
    Eric J Duell
    International Agency for Research Cancer, 150 cours Albert Thomas, 69008 Lyon, France
    Cancer Epidemiol Biomarkers Prev 17:1470-9. 2008
    ....
  27. pmc Genetic basis for adverse events after smallpox vaccination
    David M Reif
    Computational Genetics Laboratory, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Infect Dis 198:16-22. 2008
    ....
  28. doi Analysis of gene-gene interactions
    Jason H Moore
    Vanderbilt University Medical School, Nashville, Tennessee, USA
    Curr Protoc Hum Genet . 2004
    ..The focus of this unit is genetic association studies of discrete and quantitative traits since most of the methods for detecting gene-gene interactions have been developed specifically for these study designs...
  29. doi Interleukin-1 gene complex single nucleotide polymorphisms in systemic sclerosis: a further step ahead
    Lorenzo Beretta
    Referral Center for Systemic Autoimmune Diseases, IRCCS Fondazione Policlinico Mangiagalli Regina Elena and University of Milan, Milan, Italy
    Hum Immunol 69:187-92. 2008
    ..Epistatic interactions among IL-1 gene complex SNPs and clinical or environmental factors are more important than the singe attributes in the development of severe ventilatory restriction in SSc patients...
  30. ncbi Genomics and proteomics of lung disease: conference summary
    J Usha Raj
    Division of Neonatology, Harbor UCLA Medical Center, Geffen School of Medicine at University of California, and Los Angeles Biomedical Research Institute, Los Angeles, California, USA
    Am J Physiol Lung Cell Mol Physiol 293:L45-51. 2007
  31. pmc Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis
    Tricia A Thornton-Wells
    Biobehavioral Intervention Training Program, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University Institute for Imaging Science, Vanderbilt University, Nashville, Tennessee 37203, USA
    Genet Epidemiol 32:187-203. 2008
    ..Further studies are needed to replicate these statistical findings and to elucidate possible biological interaction mechanisms between LRRTM3 and these genes...
  32. doi Ability of epistatic interactions of cytokine single-nucleotide polymorphisms to predict susceptibility to disease subsets in systemic sclerosis patients
    Lorenzo Beretta
    Referral Center for Systemic Autoimmune Diseases, IRCCS Fondazione Policlinico Mangiagalli Regina Elena and University of Milan, Milan, Italy
    Arthritis Rheum 59:974-83. 2008
    ..Epistasis is difficult to model by traditional parametric approaches; therefore, nonparametric computational algorithms, such as multifactor dimensionality reduction (MDR), have been developed...
  33. pmc Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells
    Kelly C Heim
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, USA
    Mol Cancer 6:57. 2007
    ..This implies that RIP140 represses key genes required for RA-mediated tumor cell differentiation. Identification of these genes would be of considerable interest...
  34. pmc Specific polymorphic variation in the mitochondrial genome and increased in-hospital mortality after severe trauma
    Jeffrey A Canter
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    Ann Surg 246:406-11; discussion 411-4. 2007
    ..To determine whether specific genetic variations in the mtDNA that impact energy production and free-radical generation are potential new risk factors for in-hospital mortality after severe trauma...
  35. ncbi Problems with genome-wide association studies
    Scott M Williams
    Science 316:1840-2. 2007
  36. ncbi The effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels are dependent on environmental context
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Hum Genet 122:275-81. 2007
    ..The present study emphasizes the importance of including environmental factors in genetic analyses to fully comprehend the genetic architecture of a specific trait...
  37. ncbi A population-based study in Ghana to investigate inter-individual variation in plasma t-PA and PAI-1
    Scott M Williams
    Center for Human Genetics Research, 519 Light Hall, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Ethn Dis 17:492-7. 2007
    ..We have initiated a large-scale population-based study to characterize the genetic architecture of plasma t-PA and PAI-1 in Blacks from Sunyani, Ghana...
  38. ncbi Visual analysis of statistical results from microarray studies of human breast cancer
    David M Reif
    Computational Genetics Laboratory, Norris Cotton Cancer Center, Department of Genetics, Dartmouth Medical School, One MedicalCenter Drive, Lebanon, NH 03756, USA
    Oncol Rep 15:1043-7. 2006
    ..Thus, we anticipate EVA will prove a useful addition to the repertoire of computational methods for microarray data analysis. The EVA software is freely available to academic users...
  39. pmc A high-density admixture map for disease gene discovery in african americans
    Michael W Smith
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA
    Am J Hum Genet 74:1001-13. 2004
    ..The map is especially appropriate for those diseases that differ in incidence between the parental African and European populations...
  40. ncbi STUDENTJAMA. The challenges of whole-genome approaches to common diseases
    Jason H Moore
    Vanderbilt University Medical School, Nashville, Tenn, USA
    JAMA 291:1642-3. 2004
  41. ncbi Profiles of gene expression in human autoimmune disease
    Thomas M Aune
    Division of Rheumatology, Department of Medicine, Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cell Biochem Biophys 40:81-96. 2004
    ..These data argue that that there is a constant pattern of gene expression in autoimmunity that is independent of the specific autoimmune disease and clinical parameters associated with any individual autoimmune disease...
  42. ncbi Renin-angiotensin system gene polymorphisms and atrial fibrillation
    Chia Ti Tsai
    Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Circulation 109:1640-6. 2004
    ..We hypothesized that RAS genes might be among the susceptibility genes of nonfamilial structural AF and conducted a genetic case-control study to demonstrate this...
  43. ncbi Association of homozygous wild-type glutathione S-transferase M1 genotype with increased breast cancer risk
    Nady Roodi
    Department of Pathology, Program in Human Genetics and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cancer Res 64:1233-6. 2004
    ..2%) of 203 patients. Compared with women with the -/- genotype, the relative risk of breast cancer for the +/+ genotype was 2.83 (95% confidence interval, 1.45-5.59; P = 0.002), suggesting a protective effect of the GSTM1 deletion...
  44. ncbi The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings?
    Scott M Williams
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Bioessays 26:170-9. 2004
    ..This article contains supplementary material, which may be viewed at the BioEssays website at http://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html...
  45. ncbi Reporting of model validation procedures in human studies of genetic interactions
    Christopher S Coffey
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nutrition 20:69-73. 2004
  46. ncbi Petri net modeling of high-order genetic systems using grammatical evolution
    Jason H Moore
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, 519 Light Hall, Nashville, TN 37232 0700, USA
    Biosystems 72:177-86. 2003
    ..The results indicate that our model-building approach is capable of routinely identifying good, but not perfect, Petri net models. Ideas for improving the algorithm for this high-dimensional problem are presented...
  47. ncbi MnSOD polymorphism and breast cancer in a population-based case-control study
    Kathleen M Egan
    Department of Medicine, Vanderbilt University Medical Center, Suite 6000 Medical Center East, Nashville, TN 37232 8300, USA
    Cancer Lett 199:27-33. 2003
    ..91-1.77) or two (RR: 1.18; 95% CI: 0.81-1.73) Ala alleles compared to those homozygous for the wild-type Val genotype. Results do not support any overall association of the Ala-9Val MnSOD polymorphism to the development of breast cancer...
  48. ncbi Gene expression profiles in human autoimmune disease
    Thomas M Aune
    Division of Rheumatology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Pharm Des 9:1905-17. 2003
    ....
  49. ncbi Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions
    Lance W Hahn
    Program in Human Genetics and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Bioinformatics 19:376-82. 2003
    ..In this paper, we describe the MDR approach and an MDR software package...
  50. ncbi Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity
    Marylyn D Ritchie
    Program in Human Genetics and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Genet Epidemiol 24:150-7. 2003
    ..Extending MDR to address genetic heterogeneity should be a priority for the continued methodological development of this new approach...
  51. ncbi Ideal discrimination of discrete clinical endpoints using multilocus genotypes
    Lance W Hahn
    Center for Human Genetics Research, 519 Light Hall, Vanderbilt University, Nashville, TN 37232 0700, USA
    In Silico Biol 4:183-94. 2004
    ..This study provides a theoretical foundation for the continued development, evaluation, and application of the MDR as a data mining tool in the domain of statistical genetics and genetic epidemiology...
  52. pmc An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation
    Christopher S Coffey
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    BMC Bioinformatics 5:49. 2004
    ..One advantage of the MDR method is that it provides an internal prediction error for validation. We summarize our use of this internal prediction error for model validation...
  53. ncbi Multilocus analysis of hypertension: a hierarchical approach
    Scott M Williams
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Hered 57:28-38. 2004
    ..5% of the time. Thus, our data indicate epistatic interactions play a major role in hypertension susceptibility. Our data also support a model where multiple pathways need to be affected in order to predispose to hypertension...
  54. ncbi A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility
    Jason H Moore
    Computational Genetics Laboratory, Department of Genetics, Dartmouth Hitchcock Medical Center, One Medical Center Dr, 706 Rubin Bldg, HB7937, Lebanon, NH 03756, USA
    J Theor Biol 241:252-61. 2006
    ..We then apply this strategy to detecting, characterizing, and interpreting epistatic models in a genetic study (n = 500) of atrial fibrillation and show that both classification and model interpretation are significantly improved...
  55. ncbi Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension
    Hironobu Sanada
    Third Department of Internal Medicine, Fukushima Medical University, School of Medicine, Fukushima City, Japan
    Clin Chem 52:352-60. 2006
    ..Salt-sensitive (SS) hypertension affects >30 million Americans and is often associated with low plasma renin activity. We tested the diagnostic validity of several candidate genes for SS and low-renin hypertension...
  56. ncbi Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Carcinogenesis 27:1030-7. 2006
    ..These results support the hypothesis that common polymorphisms in DNA repair genes modify bladder cancer risk and emphasize the need for a multifaceted statistical approach to identify gene-gene and gene-environment interactions...
  57. ncbi The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 14:2563-8. 2005
    ....
  58. ncbi Integrated analysis of genetic, genomic and proteomic data
    David M Reif
    Center for Human Genetics Research, Vanderbilt University Medical School, 519 Light Hall, Nashville, TN 37232 0700, USA
    Expert Rev Proteomics 1:67-75. 2004
    ..The idea that the integrated analysis of multiple data types will improve the identification of biomarkers of clinical endpoints, such as disease susceptibility, is presented as a working hypothesis...
  59. pmc A gene expression fingerprint of C. elegans embryonic motor neurons
    Rebecca M Fox
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232 8240, USA
    BMC Genomics 6:42. 2005
    ..Here we describe a powerful strategy, Micro-Array Profiling of C. elegans cells (MAPCeL), and confirm that this approach provides a comprehensive gene expression profile of unc-4::GFP motor neurons in vivo...
  60. ncbi Computational analysis of gene-gene interactions using multifactor dimensionality reduction
    Jason H Moore
    Dartmouth Medical School, Computational Genetics Laboratory, 706 Rubin Building, HB7937, One Medical Center Drive, Lebanon, NH 03756, USA
    Expert Rev Mol Diagn 4:795-803. 2004
    ..Several case studies that demonstrate the detection of gene-gene interactions in common diseases such as atrial fibrillation, Type II diabetes and essential hypertension are also discussed...
  61. ncbi Genetics, statistics and human disease: analytical retooling for complexity
    Tricia A Thornton-Wells
    Neuroscience Graduate Program, Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN 37240, USA
    Trends Genet 20:640-7. 2004
    ..Finally, we propose a comprehensive two-step approach to analysis that systemically addresses the different genetic factors that are likely to underlie complex diseases...
  62. ncbi Linear dynamic features of ambulatory blood pressure in a population-based study
    Sharon L R Kardia
    Department of Epidemiology, University of Michigan, 611 Church Street 246, Ann Arbor, MI 48109 2029, USA
    Blood Press Monit 9:259-67. 2004
    ....
  63. ncbi Co-localization of differentially expressed genes and shared susceptibility loci in human autoimmunity
    Thomas M Aune
    Division of Rheumatology, Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    Genet Epidemiol 27:162-72. 2004
    ..To our knowledge, this is the first study showing concordance between gene expression and genetic linkage results in common complex multifactorial human diseases...
  64. pmc Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells
    Nancy J Olsen
    Division of Rheumatology, T 3219 Medical Center North, Vanderbilt University, Nashville, Tennessee, USA
    Arthritis Res Ther 6:120-8. 2004
    ..Furthermore, the genes that are identified provide clues to possible pathogenetic mechanisms and are likely to be useful in developing tests to establish diagnostic categories and predict therapeutic responses...
  65. pmc DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategy
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Hered 65:105-18. 2008
    ..These include: APE1-Asn148Gln, XRCC1-Arg399Gln and XRCC1-Arg194Trp in the BER pathway, XPD-Gln751Lys in the NER pathway and XRCC3-Thr241Met in the DSB repair pathway...
  66. ncbi Diabetic nephropathy is associated with gene expression levels of oxidative phosphorylation and related pathways
    Chunmei Huang
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Diabetes 55:1826-31. 2006
    ..Whether these findings reflect inherent genetic cellular characteristics, "cell memory," or both requires further study...
  67. pmc Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition
    Eric Arehart
    Department of Pharmacology and Toxicology, Dartmouth Hitchcock Medical Center, Hanover, NH 03755, USA
    Circ Res 102:986-93. 2008
    ..Combining both biochemical and clinical approaches, we conclude that diminished prostacyclin receptor signaling may contribute, in part, to the underlying adverse cardiovascular outcomes observed with cyclooxygenase-2 inhibition...