Research Topics
Genomes and Genes
| Peter J MohlerSummaryAffiliation: Vanderbilt University Country: USA Publications
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Detail Information
Publications
Dysfunction in ankyrin-based cellular pathways and human cardiac arrhythmiaPeter J Mohler
Vanderbilt University Medical Center, Department of Pathology, Nashville, TN 37232, USA
Future Cardiol 1:363-71. 2005..This review will present an overview of the ankyrin family with special emphasis on the recently identified roles of ankyrin polypeptides in ion channel and transporter targeting in the heart...
Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomainPeter J Mohler
Department of Pathology, Vanderbilt University, Nashville, Tennessee, USA
PLoS Biol 3:e423. 2005..Ankyrin-B also is not abundantly expressed in smooth muscle. We propose that the ankyrin-B-based complex is a specialized adaptation of cardiomyocytes with a role for cytosolic Ca2+ modulation...- Defects in ankyrin-based cellular pathways in metazoan physiologyPeter J Mohler
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Front Biosci 10:2832-40. 2005..This review will provide an overview of the ankyrin family and highlight seminal findings in the field which have linked dysfunction in ankyrin-based pathways with defects in metazoan physiology and human disease... - Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targetingPeter J Mohler
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Curr Opin Cardiol 20:189-93. 2005..The focus is on ankyrins, a family of proteins that localize diverse membrane ion channels and transporters, and recent evidence that mutations affecting functions of ankyrins result in cardiac arrhythmia... 
Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytesPeter J Mohler
Howard Hughes Medical Institute and Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 101:17533-8. 2004..Together with previous work in neurons, these results in cardiomyocytes suggest that ankyrin-G participates in a common pathway for localization of voltage-gated Na(v) channels at sites of function in multiple excitable cell types...- Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-BPeter J Mohler
Howard Hughes Medical Institute and Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
J Biol Chem 279:12980-7. 2004..These new results provide the first physiological evidence of a molecular partner required for early post-translational stability of InsP(3)R... - A cardiac arrhythmia syndrome caused by loss of ankyrin-B functionPeter J Mohler
Howard Hughes Medical Institute and Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 101:9137-42. 2004.... - Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytesPeter J Mohler
Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 279:40185-93. 2004..This work also establishes a functional hierarchy in which ankyrin-B determines the localization of beta(2)-spectrin and operates independently of beta(2)-spectrin in its role in organizing membrane-spanning proteins... - Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cellsKrishnakumar Kizhatil
Howard Hughes Medical Institute and Departments of Cell Biology, Biochemistry, and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 282:2029-37. 2007..These results demonstrate that ankyrin-G and beta(2)-spectrin are functional partners in biogenesis of the lateral membrane of epithelial cells... - Isoform specificity of ankyrin-B: a site in the divergent C-terminal domain is required for intramolecular associationKhadar M Abdi
Howard Hughes Medical Institute, and Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
J Biol Chem 281:5741-9. 2006..Taken together these results suggest a model of an extended and unstructured C-terminal domain folding back to bind and potentially regulate the membrane-binding domain of ankyrin-B... - Isoform specificity among ankyrins. An amphipathic alpha-helix in the divergent regulatory domain of ankyrin-b interacts with the molecular co-chaperone Hdj1/Hsp40Peter J Mohler
Howard Hughes Medical Institute and Departments of Cell Biology, Biochemistry, and Neurosciences, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 279:25798-804. 2004.... - Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac deathPeter J Mohler
Howard Hughes Medical Institute and Departments of Cell Biology, Biochemistry, and Neuroscience, Duke University Medical Center, Durham, North Carolina 27710, USA
Nature 421:634-9. 2003..Thus, we identify a new mechanism for cardiac arrhythmia due to abnormal coordination of multiple functionally related ion channels and transporters... - Proarrhythmic defects in Timothy syndrome require calmodulin kinase IIWilliam H Thiel
Vanderbilt University, Nashville, TN, USA
Circulation 118:2225-34. 2008..2 current (I(Ca)). During cellular Ca(2+) overload, the calmodulin-dependent protein kinase II (CaMKII) causes arrhythmias. We hypothesized that CaMKII is a part of the proarrhythmic mechanism in TS... - Weighing in on molecular anchors: the role of ankyrin polypeptides in human arrhythmiaCrystal F Kline
Vanderbilt University School of Medicine, Graduate Program in Pathology, Nashville, TN 37232, USA
Expert Rev Cardiovasc Ther 4:477-85. 2006.... - The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytesPeter J Mohler
Howard Hughes Medical Institute and Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 277:10599-607. 2002..C-terminal domains are the most divergent between ankyrin isoforms and are candidates to encode the signal(s) that enable ankyrins to selectively target proteins to diverse cellular sites... - Cardiac ankyrins: Essential components for development and maintenance of excitable membrane domains in heartShane R Cunha
Department of Pathology, Vanderbilt University Medical School, Nashville, TN 37232, USA
Cardiovasc Res 71:22-9. 2006.... - L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKIIChad E Grueter
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Mol Cell 23:641-50. 2006..These findings reveal a molecular mechanism for targeting CaMKII to LTCCs and facilitating I(Ca) that may modulate Ca(2+) entry in diverse cell types coexpressing CaMKII and the beta(2a) subunit... - AnkyrinsPeter J Mohler
Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, NC 27513, USA
J Cell Sci 115:1565-6. 2002 - Microsomal triglyceride transfer protein expression in adipocytes: a new component in fat metabolismLarry L Swift
Department of Pathology, C 3321 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232 2561, USA
FEBS Lett 579:3183-9. 2005..Our results provide unequivocal evidence for the presence of MTP in adipocytes and present new possibilities for defining the mechanisms by which triglyceride is stored and/or hydrolyzed and mobilized... - Identification of a novel isoform of microsomal triglyceride transfer proteinPeter J Mohler
Department of Internal Medicine, University of Iowa School of Medicine, Iowa City, IA 52242, USA
J Biol Chem 282:26981-8. 2007..However, in nonlipoprotein-secreting cells, such as the adipocyte, MTP-B may have different localization properties, perhaps reflecting a distinct role in lipid storage and mobilization... - Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathwayJohn S Lowe
Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
J Cell Biol 180:173-86. 2008..These data are the first report of a cellular pathway required for Na(v) channel trafficking in the heart and suggest that ankyrin-G is critical for cardiac depolarization and Na(v) channel organization in multiple excitable tissues... - Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescencePeter J Mohler
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
PLoS ONE 2:e1051. 2007..Together these findings suggest a constellation of traits that we term "ankyrin-B syndrome", which may contribute to both aging-related disorders and enhanced cardiac function... - Cardiac cytoskeleton and arrhythmia: an unexpected role for protein 4.1R in cardiac excitabilityShane R Cunha
Circ Res 103:779-81. 2008 - Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytesNaina Bhasin
Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, 285 Newton Road, Iowa City, IA 52242, USA
Am J Physiol Heart Circ Physiol 293:H109-19. 2007..These new data implicate ankyrin-B as a critical targeting component for PP2A in heart and identify a new class of signaling proteins targeted by ankyrin polypeptides... - Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytesPeter J Mohler
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA
Circulation 115:432-41. 2007..More importantly, there is no cellular explanation for the range of severity of cardiac phenotypes associated with specific ANK2 variants... - Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-BShane R Cunha
Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
J Biol Chem 282:4875-83. 2007..These results raise exciting new questions regarding potentially dynamic roles for ankyrin proteins in the biogenesis and maintenance of specialized membrane domains in excitable cells... - FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac deathXander H T Wehrens
Department of Physiology and Cellular Biophysics, Center for Molecular Cardiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Cell 113:829-40. 2003..6 for RyR2 and increased single-channel activity under conditions that simulate exercise. These data suggest that "leaky" RyR2 channels can trigger fatal cardiac arrhythmias, providing a possible explanation for CPVT... - Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptorCrystal F Kline
Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
J Cell Biochem 104:1244-53. 2008..In summary, our findings demonstrate that the ankyrin-binding site is located on the cytoplasmic face of the InsP(3) receptor, thus validating the feasibility of in vivo ankyrin-InsP(3) receptor interactions... - Biochemical assays for studying indirect interactions between CFTR and the cytoskeletonPeter J Mohler
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC, USA
Methods Mol Med 70:383-94. 2002 - The cardiac IP3 receptor: uncovering the role of "the other" calcium-release channelThomas J Hund
J Mol Cell Cardiol 45:159-61. 2008 - A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidationJeffrey R Erickson
Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1109, USA
Cell 133:462-74. 2008..Our data demonstrate a dynamic mechanism for CaMKII activation by oxidation and highlight the critical importance of oxidation-dependent CaMKII activation to AngII and ischemic myocardial apoptosis... - Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactionsPeter J Mohler
Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Physiology (Bethesda) 22:342-50. 2007..The association of genetic defects in regulatory and targeting proteins to inherited arrhythmia syndromes has led to a better understanding of the critical role these proteins play in ion channel modulation... - Polarized apical sorting of guanylyl cyclase C is specified by a cytosolic signalCaleb A Hodson
Graduate Program in Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Traffic 7:456-64. 2006.... - MicroRNA may have macro effect on sudden deathMark E Anderson
Nat Med 13:410-1. 2007 - Ankyrins and human disease: what the electrophysiologist should knowPeter J Mohler
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J Cardiovasc Electrophysiol 17:1153-9. 2006..Moreover, these data define an exciting new field of cardiac "channelopathies" due to defects in proper channel targeting/localization...