David M Miller

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Neuroscience. Synapses here and not everywhere
    David M Miller
    Department of Cell and Developmental Biology, Vanderbilt University, 465 21st Avenue South, Nashville, TN 37232-8240, USA
    Science 317:907-8. 2007
  2. ncbi Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain
    Elizabeth A D Hammock
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neural Dev 5:32. 2010
  3. ncbi The embryonic muscle transcriptome of Caenorhabditis elegans
    Rebecca M Fox
    Department of Cell and Developmental Biology, Vanderbilt University, 465 21st Ave S, Nashville, TN 37232 8240, USA
    Genome Biol 8:R188. 2007
  4. ncbi Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system
    Stephen E Von Stetina
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232 8240, USA
    Genome Biol 8:R135. 2007
  5. ncbi A gene expression fingerprint of C. elegans embryonic motor neurons
    Rebecca M Fox
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232 8240, USA
    BMC Genomics 6:42. 2005
  6. ncbi Complementary RNA amplification methods enhance microarray identification of transcripts expressed in the C. elegans nervous system
    JOSEPH D WATSON
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232 8240, USA
    BMC Genomics 9:84. 2008
  7. ncbi A primary culture system for functional analysis of C. elegans neurons and muscle cells
    Michael Christensen
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neuron 33:503-14. 2002
  8. ncbi Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans
    Cody J Smith
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232 8240, USA
    Dev Biol 345:18-33. 2010
  9. ncbi UNC-4 represses CEH-12/HB9 to specify synaptic inputs to VA motor neurons in C. elegans
    Stephen E Von Stetina
    Department of Cell and Developmental Biology, Program in Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genes Dev 21:332-46. 2007
  10. ncbi Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans
    Richard Nass
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6420, USA
    Proc Natl Acad Sci U S A 99:3264-9. 2002

Research Grants

  1. Identification of Synaptic remodeling Genes in C. elegans
    David Miller; Fiscal Year: 2007
  2. MOLECULAR GENETICS OF NEURAL SPECIFICITY
    David Miller; Fiscal Year: 2006
  3. MOLECULAR GENETICS OF NEURAL SPECIFICITY
    David Miller; Fiscal Year: 2003
  4. MOLECULAR GENETICS OF NEURAL SPECIFICITY
    David Miller; Fiscal Year: 2001
  5. MOLECULAR GENETICS OF NEURAL SPECIFICITY
    David M Miller; Fiscal Year: 2010

Collaborators

Detail Information

Publications16

  1. ncbi Neuroscience. Synapses here and not everywhere
    David M Miller
    Department of Cell and Developmental Biology, Vanderbilt University, 465 21st Avenue South, Nashville, TN 37232-8240, USA
    Science 317:907-8. 2007
  2. ncbi Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain
    Elizabeth A D Hammock
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neural Dev 5:32. 2010
    ..A cell-specific microarray profiling study revealed a set of transcription factors that are highly expressed in embryonic C. elegans GABAergic neurons...
  3. ncbi The embryonic muscle transcriptome of Caenorhabditis elegans
    Rebecca M Fox
    Department of Cell and Developmental Biology, Vanderbilt University, 465 21st Ave S, Nashville, TN 37232 8240, USA
    Genome Biol 8:R188. 2007
    ..To this end, we applied microarray profiling of Caenorhabtidis elegans cells (MAPCeL) to muscle cell populations extracted from developing C. elegans embryos...
  4. ncbi Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system
    Stephen E Von Stetina
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232 8240, USA
    Genome Biol 8:R135. 2007
    ..Here we describe microarray-based methods that monitor gene expression in C. elegans neurons and, thereby, link comprehensive profiles of neuronal transcription to key developmental and functional properties of the nervous system...
  5. ncbi A gene expression fingerprint of C. elegans embryonic motor neurons
    Rebecca M Fox
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232 8240, USA
    BMC Genomics 6:42. 2005
    ..Here we describe a powerful strategy, Micro-Array Profiling of C. elegans cells (MAPCeL), and confirm that this approach provides a comprehensive gene expression profile of unc-4::GFP motor neurons in vivo...
  6. ncbi Complementary RNA amplification methods enhance microarray identification of transcripts expressed in the C. elegans nervous system
    JOSEPH D WATSON
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232 8240, USA
    BMC Genomics 9:84. 2008
    ..Here we compare microarray results obtained with two different methods of RNA amplification to profile gene expression in the C. elegans larval nervous system...
  7. ncbi A primary culture system for functional analysis of C. elegans neurons and muscle cells
    Michael Christensen
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neuron 33:503-14. 2002
    ..Primary nematode cell culture provides a new foundation for a wide variety of experimental opportunities heretofore unavailable in the field...
  8. ncbi Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans
    Cody J Smith
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232 8240, USA
    Dev Biol 345:18-33. 2010
    ....
  9. ncbi UNC-4 represses CEH-12/HB9 to specify synaptic inputs to VA motor neurons in C. elegans
    Stephen E Von Stetina
    Department of Cell and Developmental Biology, Program in Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genes Dev 21:332-46. 2007
    ..The conservation of UNC-4, HB9, and Groucho expression in the vertebrate motor circuit argues that similar mechanisms may regulate synaptic specificity in the spinal cord...
  10. ncbi Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans
    Richard Nass
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6420, USA
    Proc Natl Acad Sci U S A 99:3264-9. 2002
    ..6-OHDA-triggered neural degeneration does not require the CED-3/CED-4 cell death pathway, but is abolished by the genetic disruption of the C. elegans DAT...
  11. ncbi The motor circuit
    Stephen E Von Stetina
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA
    Int Rev Neurobiol 69:125-67. 2006
  12. ncbi Characterization of the effects of methylmercury on Caenorhabditis elegans
    Kirsten J Helmcke
    Pharmacology Department, Vanderbilt University Medical Center, Nashville, TN 37232 0414, USA
    Toxicol Appl Pharmacol 240:265-72. 2009
    ..We propose, therefore, that C. elegans should be a useful model for discovering intrinsic mechanisms that confer resistance to MeHgCl exposure...
  13. ncbi Coenzyme Q protects Caenorhabditis elegans GABA neurons from calcium-dependent degeneration
    Laurie R Earls
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232 8240, USA
    Proc Natl Acad Sci U S A 107:14460-5. 2010
    ..We conclude that the cell selectivity and developmental progression of CoQ deficiency in C. elegans indicate that this model may be useful for delineating the role of mitochondrial dysfunction in neurodegenerative disease...
  14. ncbi acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the Caenorhabditis elegans neuromuscular junction
    Denis Touroutine
    Department of Biology, University of Illinois, Chicago, Illinois 60607, USA
    J Biol Chem 280:27013-21. 2005
    ..elegans NMJ. The determination of subunit composition for all three C. elegans body wall muscle ionotropic receptors provides a critical foundation for future research at this tractable model synapse...
  15. ncbi The C. elegans even-skipped homologue, vab-7, specifies DB motoneurone identity and axon trajectory
    Behrooz Esmaeili
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Development 129:853-62. 2002
    ....
  16. ncbi Computational inference of the molecular logic for synaptic connectivity in C. elegans
    Vinay Varadan
    Center for Computational Biology and Bioinformatics (C2B2, and Department of Electrical Engineering, Columbia University, New York, NY 10027, USA
    Bioinformatics 22:e497-506. 2006
    ..Ultimately, we expect our approach to provide important clues for universal mechanisms of neural interconnectivity...

Research Grants17

  1. Identification of Synaptic remodeling Genes in C. elegans
    David Miller; Fiscal Year: 2007
    ....
  2. MOLECULAR GENETICS OF NEURAL SPECIFICITY
    David Miller; Fiscal Year: 2006
    ..Thus, our work with a simple nematode model system is likely to provide important clues to fundamental processes governing the development and function of the human brain. ..
  3. MOLECULAR GENETICS OF NEURAL SPECIFICITY
    David Miller; Fiscal Year: 2003
    ..Thus, our work with a simple nematode model system is likely to provide important clues to fundamental processes governing the development and function of the human brain. ..
  4. MOLECULAR GENETICS OF NEURAL SPECIFICITY
    David Miller; Fiscal Year: 2001
    ..These unc-4 target genes will be ectopically expressed in the VAs in order to determine if either induces VB-type inputs; 3) to molecularly define bkn-1 and bkn-2, which are suppressors of unc-4 and unc-37, respectively. ..
  5. MOLECULAR GENETICS OF NEURAL SPECIFICITY
    David M Miller; Fiscal Year: 2010
    ..The results of this work should reveal similar human genes with crucial roles in the creation spinal cord circuits and therefore potentially contribute to the development of treatments for spinal cord injury and dysfunction. ..