Nipun B Merchant

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Survival Benefit of Adjuvant Radiation Therapy for Gastric Cancer following Gastrectomy and Extended Lymphadenectomy
    R A Snyder
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Int J Surg Oncol 2012:307670. 2012
  2. pmc 53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19-9 in pancreatic adenocarcinoma
    Natalie L Ausborn
    Department of Radiation Oncology, The Ohio State University College of Medicine, Starling Loving, 300 W 10th Avenue, Columbus, OH, 43210, USA
    BMC Cancer 13:155. 2013
  3. ncbi request reprint Evidence for enhanced telomerase activity in Barrett's esophagus with dysplasia and adenocarcinoma
    Nipun B Merchant
    Surgery and Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Asian Pac J Cancer Prev 14:679-83. 2013
  4. ncbi request reprint Should all distal pancreatectomies be performed laparoscopically?
    Nipun B Merchant
    Division of Surgical Oncology, Department of Surgery, Vanderbilt University Medical Center, 597 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232 6860, USA
    Adv Surg 43:283-300. 2009
  5. ncbi request reprint Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells
    Nipun B Merchant
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 8680, USA
    Surgery 138:415-21. 2005
  6. pmc Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer
    J Joshua Smith
    Department of Surgery, Vanderbilt Medical Center, Nashville, TN, USA
    Gastroenterology 138:958-68. 2010
  7. pmc Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth
    Nagathihalli S Nagaraj
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Cancer Res 17:483-93. 2011
  8. doi request reprint Analysis of 6,747 pancreatic neuroendocrine tumors for a proposed staging system
    Robert C G Martin
    Department of Surgery, University of Louisville Hospital, Louisville, KY, USA
    J Gastrointest Surg 15:175-83. 2011
  9. pmc Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma
    Nicole T Al-Greene
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 8:e69660. 2013
  10. ncbi request reprint Factors influencing readmission after pancreaticoduodenectomy: a multi-institutional study of 1302 patients
    Syed A Ahmad
    Central Pancreas Consortium, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Ann Surg 256:529-37. 2012

Detail Information

Publications31

  1. pmc Survival Benefit of Adjuvant Radiation Therapy for Gastric Cancer following Gastrectomy and Extended Lymphadenectomy
    R A Snyder
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Int J Surg Oncol 2012:307670. 2012
    ..Furthermore, removal of >25 LNs results in improved OS and DSS compared with patients who have fewer LNs resected...
  2. pmc 53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19-9 in pancreatic adenocarcinoma
    Natalie L Ausborn
    Department of Radiation Oncology, The Ohio State University College of Medicine, Starling Loving, 300 W 10th Avenue, Columbus, OH, 43210, USA
    BMC Cancer 13:155. 2013
    ..The role of 53BP1 in pancreatic ductal adenocarcinoma (PDAC) has yet to be determined. We aimed to investigate whether 53BP1 levels interact with established prognostic factors in PDAC...
  3. ncbi request reprint Evidence for enhanced telomerase activity in Barrett's esophagus with dysplasia and adenocarcinoma
    Nipun B Merchant
    Surgery and Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Asian Pac J Cancer Prev 14:679-83. 2013
    ..The aim of the current study was to correlate increased telomerase activity (TA) with dysplasia and adenocarcinoma occurring in the setting of BE...
  4. ncbi request reprint Should all distal pancreatectomies be performed laparoscopically?
    Nipun B Merchant
    Division of Surgical Oncology, Department of Surgery, Vanderbilt University Medical Center, 597 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232 6860, USA
    Adv Surg 43:283-300. 2009
    ..This technology must clear several hurdles before it is cancer ready; however, technology is moving at a rapid pace...
  5. ncbi request reprint Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells
    Nipun B Merchant
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 8680, USA
    Surgery 138:415-21. 2005
    ..The purpose of this study was to determine the mechanism by which DCA activates EGFR in human polarizing CRC cell lines HCA-7 and HCT-8...
  6. pmc Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer
    J Joshua Smith
    Department of Surgery, Vanderbilt Medical Center, Nashville, TN, USA
    Gastroenterology 138:958-68. 2010
    ..We used a gene expression profile derived from invasive, murine colon cancer cells that were highly metastatic in an immunocompetent mouse model to identify patients with colon cancer at risk of recurrence...
  7. pmc Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth
    Nagathihalli S Nagaraj
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Cancer Res 17:483-93. 2011
    ..The purpose of this study was to translate the current understanding of complementary activated tyrosine kinase signaling pathways by targeting Src kinase and epidermal growth factor receptor (EGFR)...
  8. doi request reprint Analysis of 6,747 pancreatic neuroendocrine tumors for a proposed staging system
    Robert C G Martin
    Department of Surgery, University of Louisville Hospital, Louisville, KY, USA
    J Gastrointest Surg 15:175-83. 2011
    ..The aim of this study was to devise a staging system of relevant prognostic factors to better predict overall survival in PNET...
  9. pmc Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma
    Nicole T Al-Greene
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 8:e69660. 2013
    ..Taken together our results support the conclusion that FJX1 is a novel regulator of tumor progression, due in part, to its effect on tumor vascularization. ..
  10. ncbi request reprint Factors influencing readmission after pancreaticoduodenectomy: a multi-institutional study of 1302 patients
    Syed A Ahmad
    Central Pancreas Consortium, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Ann Surg 256:529-37. 2012
    ..Despite this progress, early readmission rates after PD have been reported as high as 50%. Few reports have delineated factors associated with readmission after PD...
  11. doi request reprint Vein involvement during pancreaticoduodenectomy: is there a need for redefinition of "borderline resectable disease"?
    Kaitlyn J Kelly
    Department of Surgery, University of Wisconsin, Madison, WI, USA
    J Gastrointest Surg 17:1209-17; discussion 1217. 2013
    ..This study compares the outcome of patients who underwent pancreaticoduodenectomy with or without vein resection without neoadjuvant therapy...
  12. doi request reprint A multicenter analysis of distal pancreatectomy for adenocarcinoma: is laparoscopic resection appropriate?
    David A Kooby
    Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Am Coll Surg 210:779-85, 786-7. 2010
    ..As compared with open distal pancreatectomy (ODP), laparoscopic distal pancreatectomy (LDP) affords improved perioperative outcomes. The role of LDP for patients with pancreatic ductal adenocarcinoma (PDAC) is not defined...
  13. pmc TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer
    Nipun B Merchant
    Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8355, USA
    Clin Cancer Res 14:1182-91. 2008
    ..TACE/ADAM-17 (tumor necrosis factor-alpha converting enzyme/a disintegrin and metalloprotease) has been implicated in ectodomain cleavage of TGF-alpha and amphiregulin...
  14. pmc Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis
    Nagathihalli S Nagaraj
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA
    Mol Cancer Ther 9:2322-32. 2010
    ..These results establish a mechanistic rationale for Src inhibition with dasatinib as a therapeutic target in the treatment of pancreatic cancer and identify potential biomarkers of resistance to Src inhibition...
  15. pmc Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels
    Kaidi Mikhitarian
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA
    Mod Pathol 27:665-74. 2014
    ..Mutational analysis of the EGFR pathway genes may provide important insights into personalized treatment for patients with ampullary carcinoma. ..
  16. ncbi request reprint Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy
    Nagathihalli S Nagaraj
    Department of Surgery, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Expert Rev Proteomics 7:613-23. 2010
    ..The possibility of targeting the targets to repair or degrade protein misfolding in cancer therapy is discussed...
  17. doi request reprint Administration of oxaliplatin to a pregnant woman with rectal cancer
    Michael Gensheimer
    Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Cancer Chemother Pharmacol 63:371-3. 2009
    ..The platinum agent oxaliplatin could be useful in treatment of cancer in pregnant women, but it is fetotoxic in rats and its effect on the human fetus is unknown...
  18. doi request reprint Genomics and proteomics in predicting cancer outcomes
    Alexander A Parikh
    Vanderbilt University School of Medicine, 597 PRB, 2220 Pierce Avenue, Nashville, TN 37232, USA
    Surg Oncol Clin N Am 17:257-77, vii. 2008
    ..This article provides a summary of technologies, potential clinical applications, and challenges...
  19. ncbi request reprint Endoscopic ultrasound and computed tomography predictors of pancreatic cancer resectability
    Philip Q Bao
    Department of Surgery, Vanderbilt University Medical Center, D 4314 MCN, 1161 21st Ave, Nashville, TN 37232, USA
    J Gastrointest Surg 12:10-6; discussion 16. 2008
    ..This study investigates the ability of endoscopic ultrasound (EUS) and computed tomography (CT) to predict a margin negative (R0) resection and the need for venous resection in patients undergoing pancreaticoduodenectomy (PD)...
  20. pmc Loss of HNF6 expression correlates with human pancreatic cancer progression
    Kelly R Pekala
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Lab Invest 94:517-27. 2014
    ..Insight on the role of HNF6 in pancreatic cancer development could lead to its use as a biomarker for early detection and prognosis. ..
  21. pmc Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer
    H Charles Manning
    Vanderbilt Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
    Clin Cancer Res 14:7413-22. 2008
    ..The correlation between molecular imaging and immunohistochemical analysis to quantify epidermal growth factor (EGF) binding, apoptosis, and proliferation was evaluated in treated and untreated tumor-bearing cohorts...
  22. ncbi request reprint Gastric schwannoma
    Rebecca A Snyder
    Division of Surgical Oncology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6860, USA
    Am Surg 74:753-6. 2008
  23. doi request reprint Improvement of survival with response to neoadjuvant radiation therapy for rectal cancer
    Eric T Castaldo
    Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Vanderbilt University Medical Center, 2220 Pierce Ave, Nashville, TN 37232, USA
    Arch Surg 144:129-34; discussion 134-5. 2009
    ....
  24. doi request reprint Adjuvant chemoradiation therapy for pancreatic adenocarcinoma: who really benefits?
    Nipun B Merchant
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 6860, USA
    J Am Coll Surg 208:829-38; discussion 838-41. 2009
    ..The primary aim of this study was to determine if CRT improved survival in patients with resected pancreatic cancer in a large, multiinstitutional cohort of patients...
  25. ncbi request reprint Src-mediated regulation of E-cadherin and EMT in pancreatic cancer
    Nagaraj S Nagathihalli
    Division of Surgical Oncology, Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232 6860, USA
    Front Biosci (Landmark Ed) 17:2059-69. 2012
    ..Here we highlight recent work that advances our understanding of Src signaling as it relates to E-cadherin associated regulation and EMT in PDAC...
  26. ncbi request reprint Trends in the use of evidence-based therapy for resectable gastric cancer
    Rebecca A Snyder
    Department of Surgery, Vanderbilt Medical Center, Nashville, Tennessee
    J Surg Oncol 110:285-90. 2014
    ..The purpose of this study was to determine utilization rates of these treatment regimens in the United States and to identify factors associated with receipt of evidence-based care...
  27. pmc Multi-institutional analysis of pancreatic adenocarcinoma demonstrating the effect of diabetes status on survival after resection
    Robert M Cannon
    Surgery, University of Louisville, Louisville, KY 40202, USA
    HPB (Oxford) 14:228-35. 2012
    ..The effect of diabetes on survival after resection pancreatic ductal carcinoma (PDAC) is unclear. The present study was undertaken to determine whether pre-operative diabetes has any predictive value for survival...
  28. pmc Organic anion transporting polypeptide 1B3 (OATP1B3) is overexpressed in colorectal tumors and is a predictor of clinical outcome
    Albert Craig Lockhart
    Vanderbilt University Medical Center, Nashville, TN, USA
    Clin Exp Gastroenterol 1:1-7. 2008
    ..OATP1B3 is an organic anion transporting polypeptide (OATP) that functions as a multispecific transporter in the normal liver. We examined the expression and clinical significance of OATP1B3 in colon cancers in tissue microarrays...
  29. ncbi request reprint Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia
    J Chad Johnson
    Department of Surgery, Vanderbilt University, Nashville, Tennessee, USA
    Clin Gastroenterol Hepatol 4:1358-65. 2006
    ..The purpose of this pre-validation study was to determine if urinary PGE-M levels can be used as a biomarker to discriminate between healthy patients and those with colorectal disease...
  30. ncbi request reprint Proteome analysis of human colon cancer by two-dimensional difference gel electrophoresis and mass spectrometry
    David B Friedman
    Mass Spectrometry Research Center, Department of Biochemistry, Vanderbilt University, Nashville, TN 37232 8575, USA
    Proteomics 4:793-811. 2004
    ..Without the benefit of the Cy2-labeled 12 sample mixture internal standard, 42 of these proteins would have been overlooked due to the large degree of variation inherent between normal and tumor samples...
  31. doi request reprint Full-dose gemcitabine with concurrent radiation therapy in patients with nonmetastatic pancreatic cancer: a multicenter phase II trial
    William Small
    Robert H Lurie Comprehensive Cancer Center of Northwestern University, 251 East Huron St, LC 178, Chicago, IL 60611, USA
    J Clin Oncol 26:942-7. 2008
    ..This study assessed safety and efficacy of full-dose gemcitabine administered before and during concurrent three-dimensional conformal radiation (3D-CRT) in patients with nonmetastatic pancreatic cancer...