H Y Meltzer

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial
    Richard S E Keefe
    Department of Psychiatry, John Umstead Hospital, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 64:633-47. 2007
  2. ncbi Interpreting the efficacy findings in the CATIE study: what clinicians should know
    Herbert Y Meltzer
    Psychopharmacology Division, Vanderbilt University Medical Center, Nashville, TX 37215, USA
    CNS Spectr 11:14-24. 2006
  3. doi Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    Am J Psychiatry 168:957-67. 2011
  4. doi The role of serotonin receptors in the action of atypical antipsychotic drugs
    H Y Meltzer
    Vanderbilt University School of Medicine, Department of Psychiatry, 1601 23rd Avenue South, Suite 306, Nashville, TN 37212, USA
    Curr Opin Pharmacol 11:59-67. 2011
  5. doi The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 213:289-305. 2011
  6. pmc Pimavanserin, a serotonin(2A) receptor inverse agonist, for the treatment of parkinson's disease psychosis
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Neuropsychopharmacology 35:881-92. 2010
  7. doi Asenapine
    Herbert Y Meltzer
    Herbert Y Meltzer is at Vanderbilt University School of Medicine, Nashville, Tennessee 32712, USA
    Nat Rev Drug Discov 8:843-4. 2009
  8. ncbi Serotonin receptors: their key role in drugs to treat schizophrenia
    Herbert Y Meltzer
    Department of Psychiatry, Division of Psychopharmacology, Vanderbilt University School of Medicine, Suite 306, 1601 23rd Avenue, Nashville, TN 37212, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:1159-72. 2003
  9. doi Association of Sult4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, United States
    Schizophr Res 106:258-64. 2008
  10. ncbi What's atypical about atypical antipsychotic drugs?
    Herbert Y Meltzer
    Psychiatric Hospital at Vanderbilt, 1601 23rd Avenue South, Nashville, TN 37212, USA
    Curr Opin Pharmacol 4:53-7. 2004

Detail Information

Publications122 found, 100 shown here

  1. ncbi Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial
    Richard S E Keefe
    Department of Psychiatry, John Umstead Hospital, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 64:633-47. 2007
    ..The relative effect of the second-generation (atypical) antipsychotic drugs and older agents on neurocognition has not been comprehensively determined...
  2. ncbi Interpreting the efficacy findings in the CATIE study: what clinicians should know
    Herbert Y Meltzer
    Psychopharmacology Division, Vanderbilt University Medical Center, Nashville, TX 37215, USA
    CNS Spectr 11:14-24. 2006
    ..In particular, the use of a higher-than-usual peak dose of olanzapine may have led to the superior results achieved with it. Practical suggestions are given for choice of antipsychotic medication in patients with chronic schizophrenia...
  3. doi Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    Am J Psychiatry 168:957-67. 2011
    ..The study was designed to evaluate the short-term efficacy and safety of lurasidone in the treatment of acute schizophrenia...
  4. doi The role of serotonin receptors in the action of atypical antipsychotic drugs
    H Y Meltzer
    Vanderbilt University School of Medicine, Department of Psychiatry, 1601 23rd Avenue South, Suite 306, Nashville, TN 37212, USA
    Curr Opin Pharmacol 11:59-67. 2011
    ..5-HT(2C) receptor antagonism appears to contribute to the weight gain produced by some atypical APDs and may also affect cognition and psychosis via its influence on cortical and limbic dopaminergic activity...
  5. doi The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 213:289-305. 2011
    ..g., phencyclidine (PCP), dizocilpine (MK-801), and ketamine, to stimulate locomotor activity (LA), and to impair novel object recognition (NOR)...
  6. pmc Pimavanserin, a serotonin(2A) receptor inverse agonist, for the treatment of parkinson's disease psychosis
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Neuropsychopharmacology 35:881-92. 2010
    ..Furthermore, these results support the hypothesis that attenuation of psychosis secondary to DA receptor stimulation in PDP may be achieved through selective 5-HT(2A) receptor antagonism...
  7. doi Asenapine
    Herbert Y Meltzer
    Herbert Y Meltzer is at Vanderbilt University School of Medicine, Nashville, Tennessee 32712, USA
    Nat Rev Drug Discov 8:843-4. 2009
    ..In August 2009, asenapine (Saphris; Schering-Plough) was approved by the US FDA for the acute treatment of schizophrenia and manic or mixed episodes associated with bipolar I disorder in adults...
  8. ncbi Serotonin receptors: their key role in drugs to treat schizophrenia
    Herbert Y Meltzer
    Department of Psychiatry, Division of Psychopharmacology, Vanderbilt University School of Medicine, Suite 306, 1601 23rd Avenue, Nashville, TN 37212, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:1159-72. 2003
    ..g., the D3 or D4 receptor, and drugs that are selective for them...
  9. doi Association of Sult4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, United States
    Schizophr Res 106:258-64. 2008
    ....
  10. ncbi What's atypical about atypical antipsychotic drugs?
    Herbert Y Meltzer
    Psychiatric Hospital at Vanderbilt, 1601 23rd Avenue South, Nashville, TN 37212, USA
    Curr Opin Pharmacol 4:53-7. 2004
    ..Effects on neuronal survival and plasticity, together with decreased neurotoxicity, might also contribute to their clinical advantage over typical neuroleptic drugs...
  11. ncbi Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder
    Herbert Y Meltzer
    Psychiatric Hospital at Vanderbilt University, Nashville, TN, USA
    Am J Psychiatry 161:975-84. 2004
    ....
  12. doi In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Prog Brain Res 172:177-97. 2008
    ..Other serotonergic actions, e.g. 5-HT(2C), 5-HT(6) and possibly 5-HT(7) antagonism, may also contribute to their efficacy or, in the case of 5-HT(2C) antagonism, side effects such as weight gain...
  13. doi Does stimulation of 5-HT(1A) receptors improve cognition in schizophrenia?
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Vanderbilt Psychiatric Hospital, 1601 23rd Avenue South, Nashville, TN 37212, USA
    Behav Brain Res 195:98-102. 2008
    ..Further study is needed to determine the role of the 5-HT(1A) receptor to improve cognitive function in schizophrenia...
  14. ncbi Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 6-week, placebo-controlled studies
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt Medical Center, Nashville, TN, USA
    J Clin Psychiatry 69:817-29. 2008
    ..To evaluate the efficacy and safety of an extended-release (ER) formulation of paliperidone in patients with an acute episode of schizophrenia, in the dosage range of 3 to 15 mg daily...
  15. ncbi Cognitive factors in schizophrenia: causes, impact, and treatment
    Herbert Y Meltzer
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212 8645, USA
    CNS Spectr 9:15-24. 2004
    ..Verbal learning and executive function, in particular, have been found to be valid predictors of employment success independent of the degree of severity of positive symptoms...
  16. ncbi A randomized, double-blind comparison of clozapine and high-dose olanzapine in treatment-resistant patients with schizophrenia
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    J Clin Psychiatry 69:274-85. 2008
    ..There are conflicting data concerning the potential utility of olanzapine in treatment-resistant schizophrenia at doses beyond the 10- to 20-mg/day range that has proven to be effective for most nonrefractory patients with schizophrenia...
  17. ncbi Focus on the metabolic consequences of long-term treatment with olanzapine, quetiapine and risperidone: are there differences?
    Herbert Y Meltzer
    Vanderbilt University School of Medicine, USA
    Int J Neuropsychopharmacol 8:153-6. 2005
  18. doi A 12-month randomized, open-label study of the metabolic effects of olanzapine and risperidone in psychotic patients: influence of valproic acid augmentation
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Psychiatry 72:1602-10. 2011
    ..Longitudinal data comparing the metabolic effects of olanzapine and risperidone with or without valproic acid supplementation in schizophrenic and bipolar patients are lacking...
  19. ncbi Suicide in schizophrenia, clozapine, and adoption of evidence-based medicine
    Herbert Y Meltzer
    Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    J Clin Psychiatry 66:530-3. 2005
  20. ncbi The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens
    J Ichikawa
    The First Floor Laboratory, Psychopharmacology Division, Department of Psychiatry, Vanderbilt University School of Medicine, 1601 23rd Avenue South, Suite 306, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 858:252-63. 2000
    ..The significance of these results for EPS and antipsychotic action is discussed...
  21. doi Asenapine increases dopamine, norepinephrine, and acetylcholine efflux in the rat medial prefrontal cortex and hippocampus
    Mei Huang
    Department of Psychiatry, Division of Psychopharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Neuropsychopharmacology 33:2934-45. 2008
    ....
  22. ncbi Atypical, but not typical, antipsychotic drugs increase cortical acetylcholine release without an effect in the nucleus accumbens or striatum
    Junji Ichikawa
    Departments of Psychiatry and Pharmacology, The Psychiatric Hospital at Vanderbilt, Vanderbilt University School of Medicine, 1601 23rd Avenue South, Nashville, TN 37212, USA
    Neuropsychopharmacology 26:325-39. 2002
    ..g., early Alzheimer's disease, by enhancing cortical cholinergic transmission...
  23. ncbi Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens
    J Ichikawa
    Department of Psychiatry, Vanderbilt University School of Medicine, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Eur J Pharmacol 351:163-71. 1998
    ....
  24. ncbi DOI, a 5-HT2A/2C receptor agonist, attenuates clozapine-induced cortical dopamine release
    J Ichikawa
    Division of Psychopharmacology, Departments of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Brain Res 907:151-5. 2001
    ..These results suggest that 5-HT2A receptor stimulation increases basal cortical dopamine release via 5-HT1A receptor stimulation, and inhibits clozapine-induced cortical dopamine release by diminishing 5-HT2A receptor blockade...
  25. ncbi 5-HT(2A) receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner
    Jean François Liégeois
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Brain Res 947:157-65. 2002
    ....
  26. ncbi SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens
    Stefania Bonaccorso
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Neuropsychopharmacology 27:430-41. 2002
    ..These results suggest that 5-HT(2A/2C) antagonism may be more advantageous than selective 5-HT(2A) antagonism as an adjunct to D(2) antagonists to improve cognition and negative symptoms in schizophrenia...
  27. ncbi The blunted plasma cortisol response to apomorphine and its relationship to treatment response in patients with schizophrenia
    H Y Meltzer
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Neuropsychopharmacology 24:278-90. 2001
    ..These results provide further evidence of dopaminergic dysfunction in SCH. Furthermore, the APO-stimulated cortisol response may be predictive of subsequent clinical response to antipsychotic drug treatment...
  28. doi The InterSePT suicide scale for prediction of imminent suicidal behaviors
    David W Ayer
    Research Department at Centerstone, 1101 6th Avenue North, Nashville, TN 37208, United States
    Psychiatry Res 161:87-96. 2008
    ..These results indicate that the ISST and CDS may provide some additional information that can assist clinical decision making regarding suicidal risk in patients with schizophrenia or schizoaffective disorder...
  29. doi The role of 5-HT1A receptors in phencyclidine (PCP)-induced novel object recognition (NOR) deficit in rats
    M Horiguchi
    Division of Psychopharmacology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 221:205-15. 2012
    ..Atypical antipsychotic drugs (APDs), many of which are direct or indirect serotonin (5-HT)(1A) agonists, and tandospirone, a 5-HT(1A) partial agonist, have been reported to improve cognition in schizophrenia...
  30. ncbi R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum
    J Ichikawa
    Department of Psychiatry, Psychopharmacology Division, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Pharmacol Exp Ther 291:1227-32. 1999
    ..05 mg/kg s.c.), which alone had no effect on DA release. These results suggest that 5-HT(1A) receptor agonism facilitates DA release in mPFC and NAC but not STR in combination with D(2) receptor antagonism...
  31. ncbi Lower plasma CC16, a natural anti-inflammatory protein, and increased plasma interleukin-1 receptor antagonist in schizophrenia: effects of antipsychotic drugs
    M Maes
    Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
    Schizophr Res 21:39-50. 1996
    ..e. CC16, and that the latter may constitute a trait market of schizophrenia; and that (ii) chronic treatment with atypical antipsychotic agents, i.e., risperidone, may normalize lower plasma CC16 and increase plasma sIL-2R...
  32. ncbi Changes in cognitive functioning with risperidone and olanzapine treatment: a large-scale, double-blind, randomized study
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, Box 1229, New York, NY 10029, USA
    Psychopharmacology (Berl) 169:404-11. 2003
    ..The effects of risperidone and olanzapine on cognitive functioning in patients with schizophrenia were compared in a randomized, double-blind trial...
  33. ncbi Augmentation by citalopram of risperidone-induced monoamine release in rat prefrontal cortex
    Mei Huang
    Division of Psychopharmacology, Departments of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Psychopharmacology (Berl) 185:274-81. 2006
    ..A typical antipsychotics (APDs), e.g. olanzapine and risperidone, have been reported to be effective adjunctive treatment for depression if selective serotonin (5-HT) reuptake inhibitors (SSRIs) alone are ineffective...
  34. ncbi Serotonin receptors as targets for drugs useful to treat psychosis and cognitive impairment in schizophrenia
    H Y Meltzer
    Department of Psychiatry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Pharm Biotechnol 13:1572-86. 2012
    ....
  35. ncbi Serotonin 5-HT2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens
    D L Willins
    Department of Psychiatry, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    Brain Res 781:291-9. 1998
    ..These results suggest that the activation of 5-HT2C receptors selectively inhibits morphine-induced DA release in the NAc in a manner which is independent of the inhibition of 5-HT neurons...
  36. ncbi 5-HT(1A) receptor dysfunction in female patients with schizophrenia
    M A Lee
    Department of Psychiatry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37212, USA
    Biol Psychiatry 50:758-66. 2001
    ....
  37. ncbi The effect of ipsapirone and S(-)-pindolol on dopamine release in rat striatum and nucleus accumbens
    J Ichikawa
    Department of Psychiatry, Psychopharmacology Division, Vanderbilt University School of Medicine, Nashville, USA
    Brain Res 842:445-51. 1999
    ..The mechanism and clinical significance of these results for developing antipsychotic drugs is discussed...
  38. ncbi RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy
    C M Niswender
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Neuropsychopharmacology 24:478-91. 2001
    ..These findings suggest that alterations in RNA editing may contribute to or complicate therapy in certain psychiatric disorders...
  39. ncbi Age at onset and gender of schizophrenic patients in relation to neuroleptic resistance
    H Y Meltzer
    Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, USA
    Am J Psychiatry 154:475-82. 1997
    ..The authors compared age at onset in neuroleptic-resistant and -responsive schizophrenic patients to determine whether the gender difference in age at onset is related to response to neuroleptic treatment...
  40. ncbi Effects of divalproex and atypical antipsychotic drugs on dopamine and acetylcholine efflux in rat hippocampus and prefrontal cortex
    Mei Huang
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 1099:44-55. 2006
    ..The clinical significance of this potentiation for the beneficial clinical effects of this combination of agents and the differences between AMS in this regard warrants further study...
  41. ncbi Hopelessness, neurocognitive function, and insight in schizophrenia: relationship to suicidal behavior
    Chan Hyung Kim
    Department of Psychiatry, Psychiatric Hospital at Vanderbilt, Vanderbilt University School of Medicine, 1601 23rd Avenue South, Suite 306, Nashville, TN 37212, USA
    Schizophr Res 60:71-80. 2003
    ....
  42. ncbi A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia
    Neil D Woodward
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Int J Neuropsychopharmacol 8:457-72. 2005
    ..Atypical antipsychotics produce a mild remediation of cognitive deficits in schizophrenia, and specific atypicals have differential effects within certain cognitive domains...
  43. ncbi Reducing the risk for suicide in schizophrenia and affective disorders
    Herbert Y Meltzer
    Division of Psychopharmacology, Psychiatric Hospital, Vanderbilt University Medical Center, Nashville, Tenn, USA
    J Clin Psychiatry 64:1122-9. 2003
  44. ncbi Reduced levels of norepinephrine transporters in the locus coeruleus in major depression
    V Klimek
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    J Neurosci 17:8451-8. 1997
    ....
  45. ncbi Relationship between dopaminergic and serotonergic neuronal activity in the frontal cortex and the action of typical and atypical antipsychotic drugs
    J Ichikawa
    Department of Psychiatry, Vanderbilt University School of Medicine, Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Eur Arch Psychiatry Clin Neurosci 249:90-8. 1999
    ..The mechanism of action of these drugs is a matter of keen interest. We review here the evidence that some, or all, of these advantages are related to their actions at serotonin and dopamine receptors...
  46. doi Attenuation of phencyclidine-induced object recognition deficits by the combination of atypical antipsychotic drugs and pimavanserin (ACP 103), a 5-hydroxytryptamine(2A) receptor inverse agonist
    S Snigdha
    Division of Psychopharmacology, Vanderbilt Psychiatric Hospital, Nashville TN 37212, USA
    J Pharmacol Exp Ther 332:622-31. 2010
    ....
  47. doi The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats
    M Horiguchi
    Division of Psychopharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Pharmacol Exp Ther 338:605-14. 2011
    ..These results suggest 5-HT(7) antagonism may contribute to the efficacy of some atypical APDs in the treatment of cognitive impairment in schizophrenia and may itself have some benefit in this regard...
  48. ncbi Beyond control of acute exacerbation: enhancing affective and cognitive outcomes
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    CNS Spectr 8:16-8, 22. 2003
    ..Finally, pharmacologic strategies to augment affect and cognitive improvements due to the new antipsychotic drug therapies will be discussed...
  49. ncbi The effect of melperone, an atypical antipsychotic drug, on cognitive function in schizophrenia
    Tomiki Sumiyoshi
    Department of Psychiatry, Division of Psychopharmacology, Psychiatric Hospital at Vanderbilt, Vanderbilt University School of Medicine, 1601 23rd Avenue South, Suite 306, Nashville, TN 37212, USA
    Schizophr Res 59:7-16. 2003
    ..These results suggest the usefulness of melperone for facilitating work and social function in patients with schizophrenia. The differences in the cognition-enhancing abilities between melperone and clozapine are discussed...
  50. ncbi A comparison of two doses of melperone, an atypical antipsychotic drug, in the treatment of schizophrenia
    Tomiki Sumiyoshi
    Department of Psychiatry, Vanderbilt University School of Medicine, Psychiatric Hospital at Vanderbilt, 1601 23rd Avenue South, Suite 306, Nashville, TN 37212, USA
    Schizophr Res 62:65-72. 2003
    ..The lack of significant side effects such as exacerbation of EPS, pPRL elevation, and weight gain indicates melperone is well tolerated...
  51. ncbi Prediction of the ability of clozapine to treat negative symptoms from plasma glycine and serine levels in schizophrenia
    Tomiki Sumiyoshi
    Department of Psychiatry, Division of Psychopharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Int J Neuropsychopharmacol 8:451-5. 2005
    ..These results indicate the association of these amino acid measures with response to clozapine in terms of negative symptoms in patients with schizophrenia...
  52. ncbi 5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release
    J Ichikawa
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Neurochem 76:1521-31. 2001
    ....
  53. ncbi Quantitative distribution of monoamine oxidase A in brainstem monoamine nuclei is normal in major depression
    G A Ordway
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, MS, USA
    Brain Res 847:71-9. 1999
    ..These findings demonstrate that the pathophysiology of major depression is not likely to involve abnormalities in MAO-A...
  54. ncbi A novel augmentation strategy for treating resistant major depression
    R C Shelton
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Am J Psychiatry 158:131-4. 2001
    ..The authors hypothesized that fluoxetine could be augmented with olanzapine to successfully treat resistant depression...
  55. pmc Illuminating the molecular basis for some antipsychotic drug-induced metabolic burden
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Proc Natl Acad Sci U S A 104:3019-20. 2007
  56. ncbi Clozapine increases both acetylcholine and dopamine release in rat ventral hippocampus: role of 5-HT1A receptor agonism
    Young Chul Chung
    Division of Psychopharmacology, Departments of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, 1601 23rd Avenue South, The First Floor Laboratory Rm 1117, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 1023:54-63. 2004
    ..The role of hippocampus in the cognitive effects of atypical APDs warrants more intensive study...
  57. ncbi Putting metabolic side effects into perspective: risks versus benefits of atypical antipsychotics
    H Y Meltzer
    Department of Psychiatry and Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn 37212, USA
    J Clin Psychiatry 62:35-9; discussion 40-1. 2001
    ....
  58. ncbi Low-dose loxapine in the treatment of schizophrenia: is it more effective and more "atypical" than standard-dose loxapine?
    H Y Meltzer
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tenn 37212, USA
    J Clin Psychiatry 60:47-51. 1999
    ..Further study of the dose-response curve for loxapine and its usefulness in treating neuroleptic-resistant schizophrenia is indicated...
  59. ncbi Enhancement of cognitive performance in schizophrenia by addition of tandospirone to neuroleptic treatment
    T Sumiyoshi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University School of Medicine, Japan
    Am J Psychiatry 158:1722-5. 2001
    ....
  60. pmc Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 38:428-37. 2010
    ..To demonstrate the feasibility of a placebo-controlled trial of antipsychotics for delirium in the intensive care unit and to test the hypothesis that antipsychotics would improve days alive without delirium or coma...
  61. doi Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection
    Jeffrey A Lieberman
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, 1051 Riverside Dr, Unit 4, New York, NY 10032, USA
    Pharmacol Rev 60:358-403. 2008
    ....
  62. ncbi A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects
    Neil D Woodward
    Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Ave S, Nashville, TN 37203, USA
    Schizophr Res 89:211-24. 2007
    ....
  63. ncbi COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia
    Neil D Woodward
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Schizophr Res 90:86-96. 2007
    ..The results are discussed in relation to previous cross-sectional studies and prospective investigations of the associations between COMT genotype, cognition, and cognitive improvement with atypical APDs in schizophrenia...
  64. ncbi 5-HT6 receptor antagonist SB-399885 potentiates haloperidol and risperidone-induced dopamine efflux in the medial prefrontal cortex or hippocampus
    Zhu Li
    Psychopharmacology Division, Psychiatry Department, Vanderbilt University School of Medicine, 1601 23rd Ave South, Suite 306, Nashville, TN 37212, USA
    Brain Res 1134:70-8. 2007
    ..The present data provides additional evidence in support of a possible therapeutic role for 5-HT6 receptor antagonism, as an addition on therapy, to enhance cognitive function in schizophrenia...
  65. pmc Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects
    Robert M Kessler
    Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biol Psychiatry 65:1024-31. 2009
    ..Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments...
  66. doi Differential effects of M1 and 5-hydroxytryptamine1A receptors on atypical antipsychotic drug-induced dopamine efflux in the medial prefrontal cortex
    Zhu Li
    Psychiatry Department, Vanderbilt University School of Medicine, 1601 23rd Ave South, 3035, Nashville, TN 37212, USA
    J Pharmacol Exp Ther 330:948-55. 2009
    ..These results suggest that the AC260584-, NDMC-, and clozapine-induced DA efflux in the mPFC is mediated directly by mPFC M(1) receptors...
  67. doi Effect of muscarinic receptor agonists xanomeline and sabcomeline on acetylcholine and dopamine efflux in the rat brain; comparison with effects of 4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one (AC260584) and N-desmethylclozapine
    Zhu Li
    Psychiatry Department, Vanderbilt University School of Medicine, 1601 23rd Ave South, 3035, Nashville, TN 37212, USA
    Eur J Pharmacol 596:89-97. 2008
    ....
  68. doi Decreased plasma tryptophan and tryptophan/large neutral amino acid ratio in patients with neuroleptic-resistant schizophrenia: relationship to plasma cortisol concentration
    Myung Lee
    Department of Psychiatry, School of Medicine, Vanderbilt University, Nashville, TN 37212, USA
    Psychiatry Res 185:328-33. 2011
    ..These results suggest the tryptophan-kynurenine pathway may be particularly relevant to TR-SCH and that this may be influenced by the activity of the hypothalamic-pituitary-adrenal axis...
  69. ncbi AC260584 (4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one), a selective muscarinic M1 receptor agonist, increases acetylcholine and dopamine release in rat medial prefrontal cortex and hippocampus
    Zhu Li
    Psychiatry Department, Vanderbilt University School of Medicine, Nashville, TN USA
    Eur J Pharmacol 572:129-37. 2007
    ..Therefore, AC260584, as well as other muscarinic M1 receptor agonists, may be a valuable target for the development of drugs which can improve the cognitive deficits in schizophrenia and perhaps other neuropsychiatric disorders, as well...
  70. doi Changes in weight and body mass index during treatment with melperone, clozapine and typical neuroleptics
    William V Bobo
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Psychiatry Res 176:114-9. 2010
    ..Because of the relationship between BMI and cardiovascular risk, melperone deserves further study as both a first line treatment and as an alternative to clozapine in refractory schizophrenia...
  71. doi A randomized trial comparing clozapine and typical neuroleptic drugs in non-treatment-resistant schizophrenia
    Herbert Y Meltzer
    Department of Psychiatry, School of Medicine, Vanderbilt University, Nashville, TN, USA
    Psychiatry Res 177:286-93. 2010
    ..These considerations should be taken into account in decisions of how best to utilize clozapine in the treatment of schizophrenia...
  72. ncbi The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions?
    Marilyn A Davies
    Department of Psychiatry, Case Western Reserve University Medical School, Cleveland, OH 44106, USA
    Psychopharmacology (Berl) 178:451-60. 2005
    ..Recent studies have suggested that the salutary actions of clozapine in schizophrenia may be due to selective activation of M(1) muscarinic receptors by clozapine and/or its major active metabolite N-desmethylclozapine...
  73. ncbi Lithium differs from anticonvulsant mood stabilizers in prefrontal cortical and accumbal dopamine release: role of 5-HT(1A) receptor agonism
    Junji Ichikawa
    Department of Psychiatry, Vanderbilt University School of Medicine, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 1049:182-90. 2005
    ..However, the combination of lithium and 5-HT(1A) blockade may result in excessive 5-HT(2A) receptor stimulation, relative to 5-HT(1A) receptor stimulation, both of which can increase prefrontal cortical DA release...
  74. ncbi A comparison of the effects of loxapine with ziprasidone and thioridazine on the release of dopamine and acetylcholine in the prefrontal cortex and nucleus accumbens
    Zhu Li
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 167:315-23. 2003
    ..Moreover, loxapine, like its congener clozapine, has higher affinity for serotonin (5-HT)(2A) than dopamine D(2) receptors, in vitro, suggesting the possibility it could be an atypical APD with clozapine-like potential...
  75. ncbi N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors
    Zhu Li
    Psychiatry Department, Psychopharmacology Division, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Neuropsychopharmacology 30:1986-95. 2005
    ....
  76. ncbi Commentary on "clinical studies on the mechanism of action of clozapine; the dopamine-serotonin hypothesis of schizophrenia." Psychopharmacology (1989) 99:S18-S27
    Herbert Y Meltzer
    Vanderbilt University School of Medicine, 1601 23rd Avenue South, Suite 306, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 163:1-3. 2002
  77. ncbi Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT)
    Herbert Y Meltzer
    Psychiatric Hospital at Vanderbilt, 1601 23rd Ave S, Suite 306, Nashville, TN 37212, USA
    Arch Gen Psychiatry 60:82-91. 2003
    ..Approximately 50% of patients with schizophrenia or schizoaffective disorder attempt suicide, and approximately 10% die of suicide. Study results suggest that clozapine therapy significantly reduces suicidal behavior in these patients...
  78. ncbi Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism
    Junji Ichikawa
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Brain Res 956:349-57. 2002
    ..However, 5-HT(1A) agonism may be important only for quetiapine-induced ACh release...
  79. doi Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics
    William V Bobo
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee 37211, USA
    Hum Psychopharmacol 24:415-22. 2009
    ..To evaluate the effect of melperone, a butyrophenone with atypical antipsychotic properties, on plasma prolactin (PRL) concentrations compared with clozapine and typical neuroleptics...
  80. ncbi Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: relation to negative symptoms
    Tomiki Sumiyoshi
    Department of Psychiatry, Division of Psychopharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Int J Neuropsychopharmacol 7:1-8. 2004
    ....
  81. ncbi Assessing cardiovascular risks versus clinical benefits of atypical antipsychotic drug treatment
    Herbert Y Meltzer
    Department of Psychiatry and Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn 37212, USA
    J Clin Psychiatry 63:25-9. 2002
    ..This article discusses both risks and benefits of antipsychotic treatment and presents a treatment algorithm to aid the clinician in choosing medications for the psychotic patient...
  82. ncbi Valproic acid potentiates both typical and atypical antipsychotic-induced prefrontal cortical dopamine release
    Junji Ichikawa
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, 1601 23rd Avenue South, The First Floor Laboratory Rm 1117, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 1052:56-62. 2005
    ..Furthermore, they provide a strong rationale for testing for possible clinical synergism of an APD and anticonvulsant mood-stabilizer in improving the cognitive deficits present in patients with schizophrenia and bipolar disorder...
  83. ncbi Clozapine-induced weight gain predicts improvement in psychopathology
    Herbert Y Meltzer
    Department of Psychiatry, Psychiatric Hospital at Vanderbilt, Vanderbilt University School of Medicine, 1601 23rd Avenue South 306, Nashville, TN 37215, USA
    Schizophr Res 59:19-27. 2003
    ..The purpose of this study was to test the hypothesis that clozapine-induced weight gain is related to antipsychotic efficacy at 6 weeks and 6 months after adjusting for initial body weight and severity of illness...
  84. ncbi Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain
    Zhu Li
    Division of Psychopharmacology, Departments of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, USA
    Eur J Pharmacol 493:75-83. 2004
    ..It also suggests that the function of both the medial prefrontal cortex and hippocampus may contribute to the ability of aripiprazole to improve negative symptom and cognition...
  85. ncbi 5-HT(1A) and 5-HT(2A) receptors minimally contribute to clozapine-induced acetylcholine release in rat medial prefrontal cortex
    Junji Ichikawa
    Division of Psychopharmacology, Departments of Psychiatry and Pharmacology, Ther Psychiatric Hospital at Vanderbilt, Vanderbilt University School of Medicine, 1601 23rd Avenue South, Nashville, TN 37212, USA
    Brain Res 939:34-42. 2002
    ..These results suggest that 5-HT(1A) agonism and 5-HT(2A) antagonism, as well as DA release, contribute minimally to the ability of clozapine, and perhaps other atypical APDs, to increase ACh release in the mPFC...
  86. ncbi Suicidality in schizophrenia: a review of the evidence for risk factors and treatment options
    Herbert Y Meltzer
    Psychiatric Hospital of Vanderbilt, 1601 23rd Avenue South, Nashville, TN 37212, USA
    Curr Psychiatry Rep 4:279-83. 2002
    ..The results support the superiority of clozapine over olanzapine to reduce the risk of suicidality and suggest its use should be considered for all patients with schizophrenia with high risk for suicide...
  87. ncbi ACP-103, a 5-HT2A/2C inverse agonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens
    Zhu Li
    Psychiatry Department, Psychopharmacology Division, Vanderbilt University School of Medicine, Suite 306, 1601 23rd Ave S, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 183:144-53. 2005
    ..However, pretreatment with the 5-HT(2A/2C) receptor antagonist SR46349-B with haloperidol increased both mPFC and NAC DA release, suggesting that both 5-HT(2A) and 5-HT(2C) properties may be important for atypical APD effects...
  88. ncbi Occupancy of striatal and extrastriatal dopamine D2/D3 receptors by olanzapine and haloperidol
    Robert M Kessler
    Department of Radiology, Vanderbilt University School of Medicine, University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA
    Neuropsychopharmacology 30:2283-9. 2005
    ..Sparing of substantia nigra/VTA dopamine D(2)/D(3) receptor occupancy may contribute to the low incidence of extrapyramidal side effects in olanzapine-treated patients...
  89. ncbi Cholinergic modulation of basal and amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens
    Junji Ichikawa
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Brain Res 958:176-84. 2002
    ....
  90. ncbi Occupancy of striatal and extrastriatal dopamine D2 receptors by clozapine and quetiapine
    Robert M Kessler
    Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neuropsychopharmacology 31:1991-2001. 2006
    ..Preferential occupancy of cortical DA D2r, sparing occupancy of substantia nigra receptors, and non-DA D2r-mediated actions may contribute to the antipsychotic actions of these and other atypical APDs...
  91. ncbi Effect of repeated administration of phencyclidine on spatial performance in an eight-arm radial maze with delay in rats and mice
    Zhu Li
    Division of Psychopharmacology, Departments of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Pharmacol Biochem Behav 75:335-40. 2003
    ..Thus, the present study failed to demonstrate that repeated administration of PCP to rats or mice produces enduring memory impairment. Factors potentially contributing to the discrepancies between various studies are discussed...
  92. ncbi Prediction of changes in memory performance by plasma homovanillic acid levels in clozapine-treated patients with schizophrenia
    Tomiki Sumiyoshi
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    Psychopharmacology (Berl) 177:79-83. 2004
    ..Cognitive dysfunction in schizophrenia has been demonstrated to be dependent, in part, on dopaminergic activity. Clozapine has been found to improve some domains of cognition, including verbal memory, in patients with schizophrenia...
  93. ncbi Treatment of suicidality in schizophrenia
    H Y Meltzer
    Division of Psychopharmacology, Vanderbilt University School of Medicine, Psychiatric Hospital at Vanderbilt, 1601 23rd Ave South, Suite 306, Nashville, TN 37212, USA
    Ann N Y Acad Sci 932:44-58; discussion 58-60. 2001
    ..Some information about suicidality in the patient sample is reported here...
  94. ncbi Melperone in the treatment of neuroleptic-resistant schizophrenia
    H Y Meltzer
    Department of Psychiatry, Psychopharmacology Division, Vanderbilt University School of Medicine, Psychiatric Hospital at Vanderbilt, 1601 23rd Avenue South, Suite 306, Nashville, TN 37212, USA
    Psychiatry Res 105:201-9. 2001
    ..The results suggest that a proportion of neuroleptic-resistant patients with schizophrenia respond to melperone, which requires further controlled study...
  95. doi Blonanserin reverses the phencyclidine (PCP)-induced impairment in novel object recognition (NOR) in rats: Role of indirect 5-HT1A partial agonism
    M Horiguchi
    Division of Psychiatry and Behavioural Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA Division of Psychopharmacology, Vanderbilt University Medical Center, Nashville, TN 37212, USA Dainippon Sumitomo Pharma Co, Ltd, Osaka 564 0053, Japan
    Behav Brain Res 247:158-64. 2013
    ....
  96. ncbi 759C/T genetic variation of 5HT(2C) receptor and clozapine-induced weight gain
    Vincenzo S Basile
    Lancet 360:1790-1. 2002
  97. ncbi Regional selectivity in clozapine treatment?
    Robert M Kessler
    Am J Psychiatry 159:1064-5. 2002
  98. ncbi 5-HT 2A receptor stimulation by DOI, a 5-HT 2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens
    Toshihide Kuroki
    Department of Neuropsychiatry, Kyushu University Graduate School of Medical Science, Maidashi 3 1 1, Higashiku, Fukuoka 812 8582, Japan
    Brain Res 972:216-21. 2003
    ..Thus, 5-HT(2A) receptor agonism potentiates AMPH-induced DA release in the mPFC and NAC...
  99. ncbi Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms
    Adam J Prus
    Department of Psychology, Virginia Commonwealth University, 808 W Franklin, Box 842018, Richmond, VA 23284 2018, USA
    Pharmacol Biochem Behav 77:199-208. 2004
    ..25 mg/kg CLZ cue, but only partial substitution for the 5.0 mg/kg CLZ cue. These results provide evidence that antagonism at the muscarinic M(1) receptor is sufficient to provide 1.25 mg/kg CLZ-like discriminative stimulus effects...
  100. ncbi Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment
    Rudi Hwang
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Eur Neuropsychopharmacol 16:248-59. 2006
    ....
  101. ncbi Atypical antipsychotic drugs improve cognition in schizophrenia
    Herbert Y Meltzer
    Biol Psychiatry 53:265-7; author reply 267-8. 2003