BETHANN M MCLAUGHLIN

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. doi request reprint Poised for success: implementation of sound conditioning strategies to promote endogenous protective responses to stroke in patients
    BethAnn McLaughlin
    Department of Neurology and Pharmacology, JB Marshall Laboratory for Neurovascular Therapeutics, Vanderbilt University School of Medicine, Nashville, TN, 37221, USA
    Transl Stroke Res 4:104-13. 2013
  2. pmc Alteration of isocitrate dehydrogenase following acute ischemic injury as a means to improve cellular energetic status in neuroadaptation
    Kimberly N Grelli
    465 21st Avenue South, MRB III Room 8110A, Nashville, TN 37232 8548, USA
    CNS Neurol Disord Drug Targets 12:849-60. 2013
  3. pmc Haploinsufficiency of the E3 ubiquitin ligase C-terminus of heat shock cognate 70 interacting protein (CHIP) produces specific behavioral impairments
    BethAnn McLaughlin
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 7:e36340. 2012
  4. pmc Caspase 3 activation is essential for neuroprotection in preconditioning
    BethAnn McLaughlin
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:715-20. 2003
  5. pmc The kinder side of killer proteases: caspase activation contributes to neuroprotection and CNS remodeling
    B McLaughlin
    Department of Pharmacology, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232 8548, USA
    Apoptosis 9:111-21. 2004
  6. pmc Neuron specific metabolic adaptations following multi-day exposures to oxygen glucose deprivation
    Stephanie L H Zeiger
    Department of Neurology, Vanderbilt University, Nashville, TN 37232, USA
    Biochim Biophys Acta 1802:1095-104. 2010
  7. pmc Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning
    Jacquelynn E Brown
    Department of Neurology, Medicine and Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Neurosci 30:5242-52. 2010
  8. ncbi request reprint In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway
    Shen Du
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 22:7408-16. 2002
  9. pmc Killer proteases and little strokes--how the things that do not kill you make you stronger
    Yvette M Bordelon
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232 8548, USA
    J Cereb Blood Flow Metab 27:655-68. 2007
  10. pmc Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration
    Erik S Musiek
    Department of Pharmacology, Venderbilt University, Nashville, Tennessee 37232, USA
    J Neurochem 97:1301-13. 2006

Research Grants

  1. Cellular Mechanisms of Preconditioning Neuroprotection
    BethAnn McLaughlin; Fiscal Year: 2006
  2. Cellular Mechanisms of Preconditioning Neuroprotection
    BethAnn McLaughlin; Fiscal Year: 2007
  3. Cellular Mechanisms of Preconditioning Neuroprotection
    BethAnn McLaughlin; Fiscal Year: 2009

Collaborators

  • Jeffrey J Legos
  • Elias Aizenman
  • Frank C Barone
  • M Aschner
  • GREGG DAVID STANWOOD
  • Erik S Musiek
  • Stephanie L H Zeiger
  • Jason D Morrow
  • Kimberly N Grelli
  • Jeannette N Stankowski
  • Erin L Albers
  • Jacquelynn E Brown
  • Ginger L Milne
  • Giuseppe Zanoni
  • Yvette M Bordelon
  • Shen Du
  • Britney N Lizama-Manibusan
  • Amy M Palubinsky
  • A Cozette Kale
  • Robert Singer
  • Ginger Milne
  • Joshua D Brooks
  • David E Cliffel
  • David P Bichell
  • Jacob A Martin
  • Jane C Hettinger
  • Benjamin Holt
  • Jennifer R McKenzie
  • Ginger J Milne
  • Giovanni Vidari
  • Rebecca S Breeding
  • Sumon Pal

Detail Information

Publications14

  1. doi request reprint Poised for success: implementation of sound conditioning strategies to promote endogenous protective responses to stroke in patients
    BethAnn McLaughlin
    Department of Neurology and Pharmacology, JB Marshall Laboratory for Neurovascular Therapeutics, Vanderbilt University School of Medicine, Nashville, TN, 37221, USA
    Transl Stroke Res 4:104-13. 2013
    ..The following perspective represents our summary of questions, ideas, concerns, and recommendations expressed by speakers and discussants at the second Biennial Translational Preconditioning Workshop held in Miami in December 2011. ..
  2. pmc Alteration of isocitrate dehydrogenase following acute ischemic injury as a means to improve cellular energetic status in neuroadaptation
    Kimberly N Grelli
    465 21st Avenue South, MRB III Room 8110A, Nashville, TN 37232 8548, USA
    CNS Neurol Disord Drug Targets 12:849-60. 2013
    ..These data also suggest that IDH enzymes respond not only to allosteric modulation, but can also change patterns of expression in response to moderate stress in an effort to maximize ATP production and survival. ..
  3. pmc Haploinsufficiency of the E3 ubiquitin ligase C-terminus of heat shock cognate 70 interacting protein (CHIP) produces specific behavioral impairments
    BethAnn McLaughlin
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 7:e36340. 2012
    ....
  4. pmc Caspase 3 activation is essential for neuroprotection in preconditioning
    BethAnn McLaughlin
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:715-20. 2003
    ..We outline a neuroprotective pathway where events normally associated with apoptotic cell death are critical for cell survival...
  5. pmc The kinder side of killer proteases: caspase activation contributes to neuroprotection and CNS remodeling
    B McLaughlin
    Department of Pharmacology, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232 8548, USA
    Apoptosis 9:111-21. 2004
    ....
  6. pmc Neuron specific metabolic adaptations following multi-day exposures to oxygen glucose deprivation
    Stephanie L H Zeiger
    Department of Neurology, Vanderbilt University, Nashville, TN 37232, USA
    Biochim Biophys Acta 1802:1095-104. 2010
    ..We believe coupling this neuron-enriched multi-day model with microphysiometry will allow us to assess neuronal specific real-time metabolic adaptations necessary for preconditioning...
  7. pmc Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning
    Jacquelynn E Brown
    Department of Neurology, Medicine and Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Neurosci 30:5242-52. 2010
    ....
  8. ncbi request reprint In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway
    Shen Du
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 22:7408-16. 2002
    ..Because of their widespread use, the neurotoxic consequences of both acute and chronic human exposure to these toxins need to be evaluated...
  9. pmc Killer proteases and little strokes--how the things that do not kill you make you stronger
    Yvette M Bordelon
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232 8548, USA
    J Cereb Blood Flow Metab 27:655-68. 2007
    ..These data emphasize the importance of understanding the complex interplay between chaperones, apoptotic proteases including caspases, and the proteolytic degradation machinery in adaptation to neurological injury...
  10. pmc Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration
    Erik S Musiek
    Department of Pharmacology, Venderbilt University, Nashville, Tennessee 37232, USA
    J Neurochem 97:1301-13. 2006
    ..Together these findings suggest that cyclopentenone IsoPs may contribute to neuronal death caused by oxidative insults, and that their activity should perhaps be addressed when designing neuroprotective therapies...
  11. pmc Neurotoxic lipid peroxidation species formed by ischemic stroke increase injury
    Stephanie L H Zeiger
    Department of Neurology, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 47:1422-31. 2009
    ..These data are the first documentation of significant 15-A(2t)-IsoP formation after acute ischemic stroke and suggest that the addition of 15-A(2t)-IsoP to in vitro models of ischemia may help to more fully recapitulate stroke injury...
  12. pmc New approaches to neuroprotection in infant heart surgery
    Erin L Albers
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37323, USA
    Pediatr Res 68:1-9. 2010
    ....
  13. pmc Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia
    Gregg D Stanwood
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37620, USA
    J Neurochem 110:378-89. 2009
    ..These studies suggest that acute manganese exposure induces cytoskeletal dysfunction prior to degeneration and that chronic manganese exposure results in neurochemical dysfunction with overlapping features to PD...
  14. pmc Electrophilic cyclopentenone isoprostanes in neurodegeneration
    Erik S Musiek
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, 526 RRB, 23rd and Pierce Aves, Nashville, TN 37232 6602, USA
    J Mol Neurosci 33:80-6. 2007
    ..These data are reviewed, whereas new data demonstrating the neurotoxicity of J-ring IsoPs and a discussion of the possible role of cyclopentenone IsoPs as contributors to neurodegeneration are presented...

Research Grants4

  1. Cellular Mechanisms of Preconditioning Neuroprotection
    BethAnn McLaughlin; Fiscal Year: 2006
    ..These studies will provide novel insight into endogenous molecular events that can be exploited to enhance neuronal survival. ..
  2. Cellular Mechanisms of Preconditioning Neuroprotection
    BethAnn McLaughlin; Fiscal Year: 2007
    ..These studies will provide novel insight into endogenous molecular events that can be exploited to enhance neuronal survival. ..
  3. Cellular Mechanisms of Preconditioning Neuroprotection
    BethAnn McLaughlin; Fiscal Year: 2009
    ..These studies will provide novel insight into endogenous molecular events that can be exploited to enhance neuronal survival. ..