BETHANN M MCLAUGHLIN

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Haploinsufficiency of the E3 ubiquitin ligase C-terminus of heat shock cognate 70 interacting protein (CHIP) produces specific behavioral impairments
    BethAnn McLaughlin
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 7:e36340. 2012
  2. ncbi Caspase 3 activation is essential for neuroprotection in preconditioning
    BethAnn McLaughlin
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:715-20. 2003
  3. ncbi The kinder side of killer proteases: caspase activation contributes to neuroprotection and CNS remodeling
    B McLaughlin
    Department of Pharmacology, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232 8548, USA
    Apoptosis 9:111-21. 2004
  4. ncbi Neuron specific metabolic adaptations following multi-day exposures to oxygen glucose deprivation
    Stephanie L H Zeiger
    Department of Neurology, Vanderbilt University, Nashville, TN 37232, USA
    Biochim Biophys Acta 1802:1095-104. 2010
  5. ncbi Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning
    Jacquelynn E Brown
    Department of Neurology, Medicine and Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Neurosci 30:5242-52. 2010
  6. ncbi In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway
    Shen Du
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 22:7408-16. 2002
  7. ncbi Neurotoxic lipid peroxidation species formed by ischemic stroke increase injury
    Stephanie L H Zeiger
    Department of Neurology, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 47:1422-31. 2009
  8. ncbi Killer proteases and little strokes--how the things that do not kill you make you stronger
    Yvette M Bordelon
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232 8548, USA
    J Cereb Blood Flow Metab 27:655-68. 2007
  9. ncbi Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration
    Erik S Musiek
    Department of Pharmacology, Venderbilt University, Nashville, Tennessee 37232, USA
    J Neurochem 97:1301-13. 2006
  10. ncbi Electrophilic cyclopentenone isoprostanes in neurodegeneration
    Erik S Musiek
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, 526 RRB, 23rd and Pierce Aves, Nashville, TN 37232 6602, USA
    J Mol Neurosci 33:80-6. 2007

Research Grants

  1. Cellular Mechanisms of Preconditioning Neuroprotection
    BethAnn McLaughlin; Fiscal Year: 2009

Collaborators

  • Jeffrey J Legos
  • Elias Aizenman
  • Frank C Barone
  • M Aschner
  • GREGG DAVID STANWOOD
  • Erik S Musiek
  • Stephanie L H Zeiger
  • Jason D Morrow
  • Jacquelynn E Brown
  • Erin L Albers
  • Giuseppe Zanoni
  • Yvette M Bordelon
  • Shen Du
  • Jane C Hettinger
  • Benjamin Holt
  • David E Cliffel
  • David P Bichell
  • Ginger Milne
  • Jeannette N Stankowski
  • Jacob A Martin
  • Jennifer R McKenzie
  • Joshua D Brooks
  • Giovanni Vidari
  • Ginger J Milne
  • Ginger L Milne
  • Rebecca S Breeding
  • Sumon Pal

Detail Information

Publications12

  1. ncbi Haploinsufficiency of the E3 ubiquitin ligase C-terminus of heat shock cognate 70 interacting protein (CHIP) produces specific behavioral impairments
    BethAnn McLaughlin
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 7:e36340. 2012
    ....
  2. ncbi Caspase 3 activation is essential for neuroprotection in preconditioning
    BethAnn McLaughlin
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:715-20. 2003
    ..We outline a neuroprotective pathway where events normally associated with apoptotic cell death are critical for cell survival...
  3. ncbi The kinder side of killer proteases: caspase activation contributes to neuroprotection and CNS remodeling
    B McLaughlin
    Department of Pharmacology, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232 8548, USA
    Apoptosis 9:111-21. 2004
    ....
  4. ncbi Neuron specific metabolic adaptations following multi-day exposures to oxygen glucose deprivation
    Stephanie L H Zeiger
    Department of Neurology, Vanderbilt University, Nashville, TN 37232, USA
    Biochim Biophys Acta 1802:1095-104. 2010
    ..We believe coupling this neuron-enriched multi-day model with microphysiometry will allow us to assess neuronal specific real-time metabolic adaptations necessary for preconditioning...
  5. ncbi Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning
    Jacquelynn E Brown
    Department of Neurology, Medicine and Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Neurosci 30:5242-52. 2010
    ....
  6. ncbi In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway
    Shen Du
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 22:7408-16. 2002
    ..Because of their widespread use, the neurotoxic consequences of both acute and chronic human exposure to these toxins need to be evaluated...
  7. ncbi Neurotoxic lipid peroxidation species formed by ischemic stroke increase injury
    Stephanie L H Zeiger
    Department of Neurology, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 47:1422-31. 2009
    ..These data are the first documentation of significant 15-A(2t)-IsoP formation after acute ischemic stroke and suggest that the addition of 15-A(2t)-IsoP to in vitro models of ischemia may help to more fully recapitulate stroke injury...
  8. ncbi Killer proteases and little strokes--how the things that do not kill you make you stronger
    Yvette M Bordelon
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232 8548, USA
    J Cereb Blood Flow Metab 27:655-68. 2007
    ..These data emphasize the importance of understanding the complex interplay between chaperones, apoptotic proteases including caspases, and the proteolytic degradation machinery in adaptation to neurological injury...
  9. ncbi Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration
    Erik S Musiek
    Department of Pharmacology, Venderbilt University, Nashville, Tennessee 37232, USA
    J Neurochem 97:1301-13. 2006
    ..Together these findings suggest that cyclopentenone IsoPs may contribute to neuronal death caused by oxidative insults, and that their activity should perhaps be addressed when designing neuroprotective therapies...
  10. ncbi Electrophilic cyclopentenone isoprostanes in neurodegeneration
    Erik S Musiek
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, 526 RRB, 23rd and Pierce Aves, Nashville, TN 37232 6602, USA
    J Mol Neurosci 33:80-6. 2007
    ..These data are reviewed, whereas new data demonstrating the neurotoxicity of J-ring IsoPs and a discussion of the possible role of cyclopentenone IsoPs as contributors to neurodegeneration are presented...
  11. ncbi New approaches to neuroprotection in infant heart surgery
    Erin L Albers
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37323, USA
    Pediatr Res 68:1-9. 2010
    ....
  12. ncbi Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia
    Gregg D Stanwood
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37620, USA
    J Neurochem 110:378-89. 2009
    ..These studies suggest that acute manganese exposure induces cytoskeletal dysfunction prior to degeneration and that chronic manganese exposure results in neurochemical dysfunction with overlapping features to PD...

Research Grants4

  1. Cellular Mechanisms of Preconditioning Neuroprotection
    BethAnn McLaughlin; Fiscal Year: 2009
    ..These studies will provide novel insight into endogenous molecular events that can be exploited to enhance neuronal survival. ..