MARK MCCLAIN

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Control of gene expression in Helicobacter pylori using the Tet repressor
    Mark S McClain
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA Electronic address
    J Microbiol Methods 95:336-41. 2013
  2. pmc Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin
    Susan E Ivie
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Microbiol 10:60. 2010
  3. pmc Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer
    Mark S McClain
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    BMC Genomics 10:3. 2009
  4. pmc Functional analysis of neutralizing antibodies against Clostridium perfringens epsilon-toxin
    Mark S McClain
    Department of Medicine, Division of Infectious Diseases, A2200 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Infect Immun 75:1785-93. 2007
  5. pmc Mapping of a domain required for protein-protein interactions and inhibitory activity of a Helicobacter pylori dominant-negative VacA mutant protein
    Victor J Torres
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Infect Immun 74:2093-101. 2006

Research Grants

Collaborators

  • TIMOTHY COVER
  • Susan E Ivie
  • Victor J Torres
  • Holly M Scott Algood
  • D Borden Lacy

Detail Information

Publications5

  1. pmc Control of gene expression in Helicobacter pylori using the Tet repressor
    Mark S McClain
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA Electronic address
    J Microbiol Methods 95:336-41. 2013
    ..These studies demonstrate the effectiveness of the tetR-tetO system to control gene expression in H. pylori and provide an improved system for studying H. pylori physiology and pathogenesis. ..
  2. pmc Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin
    Susan E Ivie
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Microbiol 10:60. 2010
    ..To test this hypothesis, we introduced eight deletion mutations (each corresponding to a single coil within a beta-helical segment spanning VacA amino acids 433-628) into the H. pylori chromosomal vacA gene...
  3. pmc Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer
    Mark S McClain
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    BMC Genomics 10:3. 2009
    ..In this study, we analyzed the genome sequences of an H. pylori strain (98-10) isolated from a patient with gastric cancer and an H. pylori strain (B128) isolated from a patient with gastric ulcer disease...
  4. pmc Functional analysis of neutralizing antibodies against Clostridium perfringens epsilon-toxin
    Mark S McClain
    Department of Medicine, Division of Infectious Diseases, A2200 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Infect Immun 75:1785-93. 2007
    ..Identifying the epitopes recognized by these neutralizing antibodies constitutes an important first step in the development of therapeutic agents that could be used to counter the effects of the epsilon-toxin...
  5. pmc Mapping of a domain required for protein-protein interactions and inhibitory activity of a Helicobacter pylori dominant-negative VacA mutant protein
    Victor J Torres
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Infect Immun 74:2093-101. 2006
    ....

Research Grants4

  1. Inhibition of Clostridium perfringens epsilon toxin
    Mark S McClain; Fiscal Year: 2010
    ..Currently, there is no countermeasure approved for use in humans and the specific aims of this proposal are designed to develop inhibitors of epsilon toxin activity. ..
  2. Inhibitors to Clostridium perfrigens epsilon toxin
    MARK MCCLAIN; Fiscal Year: 2007
    ....