MARK MCCLAIN

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin
    Susan E Ivie
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Microbiol 10:60. 2010
  2. ncbi Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer
    Mark S McClain
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    BMC Genomics 10:3. 2009
  3. ncbi Functional analysis of neutralizing antibodies against Clostridium perfringens epsilon-toxin
    Mark S McClain
    Department of Medicine, Division of Infectious Diseases, A2200 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Infect Immun 75:1785-93. 2007
  4. ncbi Mapping of a domain required for protein-protein interactions and inhibitory activity of a Helicobacter pylori dominant-negative VacA mutant protein
    Victor J Torres
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Infect Immun 74:2093-101. 2006

Research Grants

  1. Inhibitors to Clostridium perfrigens epsilon toxin
    MARK MCCLAIN; Fiscal Year: 2007
  2. Inhibition of Clostridium perfringens epsilon toxin
    Mark S McClain; Fiscal Year: 2010

Collaborators

  • TIMOTHY COVER
  • Susan E Ivie
  • Victor J Torres
  • Holly M Scott Algood
  • D Borden Lacy

Detail Information

Publications4

  1. ncbi Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin
    Susan E Ivie
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Microbiol 10:60. 2010
    ..To test this hypothesis, we introduced eight deletion mutations (each corresponding to a single coil within a beta-helical segment spanning VacA amino acids 433-628) into the H. pylori chromosomal vacA gene...
  2. ncbi Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer
    Mark S McClain
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    BMC Genomics 10:3. 2009
    ..In this study, we analyzed the genome sequences of an H. pylori strain (98-10) isolated from a patient with gastric cancer and an H. pylori strain (B128) isolated from a patient with gastric ulcer disease...
  3. ncbi Functional analysis of neutralizing antibodies against Clostridium perfringens epsilon-toxin
    Mark S McClain
    Department of Medicine, Division of Infectious Diseases, A2200 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Infect Immun 75:1785-93. 2007
    ..Identifying the epitopes recognized by these neutralizing antibodies constitutes an important first step in the development of therapeutic agents that could be used to counter the effects of the epsilon-toxin...
  4. ncbi Mapping of a domain required for protein-protein interactions and inhibitory activity of a Helicobacter pylori dominant-negative VacA mutant protein
    Victor J Torres
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Infect Immun 74:2093-101. 2006
    ....

Research Grants4

  1. Inhibitors to Clostridium perfrigens epsilon toxin
    MARK MCCLAIN; Fiscal Year: 2007
    ....
  2. Inhibition of Clostridium perfringens epsilon toxin
    Mark S McClain; Fiscal Year: 2010
    ..Currently, there is no countermeasure approved for use in humans and the specific aims of this proposal are designed to develop inhibitors of epsilon toxin activity. ..