Research Topics
Genomes and Genes
| Lawrence J MarnettSummaryAffiliation: Vanderbilt University Country: USA Publications
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Detail Information
Publications
Cyclooxygenase 2 inhibitors: discovery, selectivity and the futureL J Marnett
Departments of Biochemistry and Chemistry, Center in Molecular Toxicology and Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Trends Pharmacol Sci 20:465-9. 1999..In this review, some key points and unresolved issues related to the discovery of COX-2 inhibitors, the kinetic and structural basis for their selectivity, and possible complications in their development and use will be discussed...- COX-2: a target for colon cancer preventionLawrence J Marnett
A B Hancock Jr Memorial Laboratory for Cancer Research, Center in Molecular Toxicology, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Annu Rev Pharmacol Toxicol 42:55-80. 2002..It is hoped that, as the genome sequence is understood more clearly, other targets will emerge that will provide even more effective drugs for future cancer prevention... - Endogenous DNA damage and mutationL J Marnett
A B Hancock Jr Memorial Laboratory for Cancer Research, Vanderbilt Ingram Cancer Center, Center in Molecular Toxicology, Dept of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Trends Genet 17:214-21. 2001..This article highlights recent discoveries and emerging opportunities in the study of endogenous DNA damage and mutation... - Recent developments in cyclooxygenase inhibitionLawrence J Marnett
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37215, USA
Prostaglandins Other Lipid Mediat 68:153-64. 2002..New strategies for the development of COX-2-selective inhibitors are highlighted... - Oxy radicals, lipid peroxidation and DNA damageLawrence J Marnett
A B Hancock Jr Memorial Laboratory for Cancer Research, Center in Molecular Toxicology and The Vanderbilt Cancer Center, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Toxicology 181:219-22. 2002..Lipid peroxidation appears to be a major source of endogenous DNA damage in humans that may contribute significantly to cancer and other genetic diseases linked to lifestyle and dietary factors... - Cyclooxygenase mechanismsL J Marnett
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Curr Opin Chem Biol 4:545-52. 2000.... - Regulation of prostaglandin biosynthesis by nitric oxide is revealed by targeted deletion of inducible nitric-oxide synthaseL J Marnett
Department of Biochemistry and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 275:13427-30. 2000..These studies support the hypothesis that NO and/or NO-derived species modulate cyclooxygenase activity and eicosanoid production in vivo... 
Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and proteinLawrence J Marnett
Department of Biochemistry, Vanderbilt University School of Medicine, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Nashville, Tennessee, USA
J Clin Invest 111:583-93. 2003- Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agentsL J Marnett
AB Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Curr Opin Chem Biol 2:482-90. 1998..Preclinical and clinical studies suggest cyclooxygenase-2 inhibitors are highly promising new agents for the treatment of pain and inflammation, and for the prevention of cancer... - Lipid peroxidation-DNA damage by malondialdehydeL J Marnett
A B Hancock Jr Memorial Laboratory for Cancer Research Center in Molecular Toxicology, Vanderbilt Cancer Center, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville TN 37232, USA
Mutat Res 424:83-95. 1999..High throughput methods for its detection and quantitation will be extremely useful for screening large populations... - Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adductRobert L Eoff
Department of Chemistry, A B Hancock Jr Memorial Laboratory for Cancer Research, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
Biochemistry 48:7079-88. 2009..The results are consistent with the reported mutagenicity of M1dG and illustrate how the lesion may affect replication events... - Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamideKevin R Kozak
Department of Biochemistry, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biochemistry 42:9041-9. 2003..Coupled with earlier observations with the endocannabinoid 2-arachidonylglycerol, these results indicate that one possible function of the highly conserved COX-2 active site side pocket is to promote endocannabinoid oxygenation... - A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385Scott W Rowlinson
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
J Biol Chem 278:45763-9. 2003..Mutagenesis experiments suggest Ser-530 is also important in time-dependent inhibition by nimesulide and piroxicam... - Genetic loss of Faah compromises male fertility in miceXiaofei Sun
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Biol Reprod 80:235-42. 2009..Collectively, the results show that aberrant endocannabinoid signaling via CNR1 impairs normal sperm function. Besides unveiling a new regulatory mechanism of sperm function, this study has clinical significance in male fertility... - Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-oneJennifer B Stafford
Department of Chemistry, A B Hancock, Jr, Memorial Laboratory for Cancer Research, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biochemistry 48:471-80. 2009..Human DNA polymerase eta bypass may lead to M(1)dG to dT and frameshift but likely not M(1)dG to dA mutations during DNA replication... - Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null miceMichael E Burleigh
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6300, USA
Biochem Pharmacol 70:334-42. 2005.... - Oxidation and glycolytic cleavage of etheno and propano DNA base adductsCharles G Knutson
A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
Biochemistry 48:800-9. 2009..These multiple pathways of biotransformation produce an array of products. Thus, the biotransformation of exocyclic adducts may lead to an additional class of biomarkers suitable for use in animal and human studies... - Prostaglandin H Synthase-2-catalyzed Oxygenation of 2-Arachidonoylglycerol Is More Sensitive to Peroxide Tone than Oxygenation of Arachidonic AcidJoel Musee
From the A B Hancock Jr Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146
J Biol Chem 287:37383-94. 2012..GPx4 silencing led to 2-4-fold increases in PG-G formation but no change in PG formation. Thus, cellular peroxide tone may be an important determinant of the extent of endocannabinoid oxygenation by PGHS-2... - The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomeraseZheyong Yu
Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 100:9162-7. 2003..Our results provide strong biochemical evidence for a functional linkage of 12R-LOX and eLOX3 and clues into skin biochemistry and the etiology of ichthyosiform diseases in humans... - Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometryBrian O Bachmann
Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 77842 3012, USA
Org Lett 12:2944-7. 2010..The isolation, characterization, and cytotoxicity against H292 cells of apoptolidin G are reported. Apoptolidin G is shown to be derived by a light-induced isomerization of the C2-C3 carbon-carbon double bond of apoptolidin A... - Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acidJeffery J Prusakiewicz
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
Biochemistry 48:7353-5. 2009..In contrast, ibuprofen and mefenamate must bind in both subunits to inhibit AA binding... - Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamidesKevin R Kozak
Department of Biochemistry, Vanderbilt-Ingram Cancer Center, and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA
J Biol Chem 277:44877-85. 2002..These results define the in vitro diversity of endocannabinoid-derived prostanoids and will permit focused investigations into their production and potential biological actions in vivo... - Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adductLaurie A VanderVeen
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA
Biochemistry 44:5024-33. 2005..Comparison of the solution structures of DNA adducts and the crystal structure of EcoRI complexed to substrate suggest a model to explain the functional differences... - Kinetic and thermodynamic analysis of the hydrolytic ring-opening of the malondialdehyde-deoxyguanosine adduct, 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)- pyrimido[1,2-alpha]purin-10(3H)-oneJames N Riggins
A. B. Hancock Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry and Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA
J Am Chem Soc 126:8237-43. 2004..A mechanism is proposed for ring-opening of M1dG under basic conditions and a role is proposed for duplex DNA in accelerating the rate of ring-opening of M1dG at neutral pH... - Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantationHaibin Wang
Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Prostaglandins Other Lipid Mediat 83:62-74. 2007..The results suggest that aberrant functioning of these pathways impacting uterine anandamide and/or 2-AG levels would compromise pregnancy outcome... - Structure of the 1,N(2)-propanodeoxyguanosine adduct in a three-base DNA hairpin loop derived from a palindrome in the Salmonella typhimurium hisD3052 geneJason P Weisenseel
Department of Chemistry, Center in Molecular Toxicology, A.B. Hancock, Jr, Memorial Laboratory for Cancer Research, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, USA
Chem Res Toxicol 15:140-52. 2002..The geometry of this three-base loop is similar to that of other DNA hairpins containing three-base loops, and suggests a common motif for the folding of these loops... - Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurineMELISSA V TURMAN
A B Hancock, Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
Biochemistry 47:3917-25. 2008..Over prolonged incubations, RPMs also generated small amounts of diHETE-T. Oxidative metabolism of polyunsaturated N-acyltaurines may represent a pathway for the generation or termination of novel signaling molecules... - (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2Kelsey C Duggan
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Nat Chem Biol 7:803-9. 2011.... - In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1Leena Maddukuri
A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
Biochemistry 49:8415-24. 2010..The results indicate that DNA hPol κ or the combined action of hPol ι or Rev1 and hPol κ bypass M(1)dG residues in DNA and generate products that are consistent with some of the mutations induced by M(1)dG in mammalian cells... - Fatty acid amide hydrolase deficiency limits early pregnancy eventsHaibin Wang
Department of Pediatrics, Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Clin Invest 116:2122-31. 2006..This study uncovers what we believe to be a novel regulation of preimplantation processes, which could be clinically relevant for fertility regulation in women... - Kinetics and mechanism of the general-acid-catalyzed ring-closure of the malondialdehyde-DNA adduct, N2-(3-oxo-1-propenyl)deoxyguanosine (N2OPdG-), to 3-(2'-Deoxy-beta-D-erythro-pentofuranosyl)pyrimido[1,2-alpha]purin- 10(3H)-one (M1dG)James N Riggins
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Am Chem Soc 126:10571-81. 2004..This work details the complexity of ring-closure in the nucleoside and oligonucleotides and provides new insight into the role of duplex DNA in catalyzing ring-opening and ring-closing of M1dG and N2OPdG... - In vitro bypass of malondialdehyde-deoxyguanosine adducts: differential base selection during extension by the Klenow fragment of DNA polymerase I is the critical determinant of replication outcomeMuhammed F Hashim
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA
Biochemistry 43:11828-35. 2004..They also provide a detailed picture of in vitro replication in which the outcome is determined primarily by the selectivity of template-primer extension beyond rather than insertion opposite the adducts... - Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2Carol A Rouzer
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
Biochem J 399:91-9. 2006..They also indicate that the 2-AG and AA used for PG-G and PG synthesis respectively are derived from independent pathways... - Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxenKelsey C Duggan
AB Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute for Chemical Biology, the Center in Molecular Toxicology, Nashville, Tennessee 37232 0146
J Biol Chem 285:34950-9. 2010..7 and 2.3 Å resolution, respectively. The combination of mutagenesis, structure analysis, and x-ray crystallography provided comprehensive information on the unique interactions responsible for naproxen binding to COX-2... - In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dGMichael B Otteneder
Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA
Proc Natl Acad Sci U S A 103:6665-9. 2006..6-Oxo-M1dG may be a useful biomarker of endogenous DNA damage associated with inflammation, oxidative stress, and certain types of cancer chemotherapy... - Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agentsMd Jashim Uddin
AB Hancock, Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
Cancer Res 70:3618-27. 2010.... - Metabolism in vitro and in vivo of the DNA base adduct, M1GCharles G Knutson
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
Chem Res Toxicol 20:550-7. 2007..Alternative repair pathways or biological processing of M1dG makes the fate of M1G of interest as a potential marker of oxidative damage in vivo... - Bulge migration of the malondialdehyde OPdG DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 geneYazhen Wang
Departments of Chemistry and Biochemistry, Institute of Chemical Biology, Center in Molecular Toxicology, A B Hancock Jr Memorial Laboratory for Cancer Research, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37235, USA
Chem Res Toxicol 20:1200-10. 2007..Both samples attained equilibrium in approximately 140 days at pH 7 and 25 degrees C... - Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffoldAndy J Liedtke
A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Med Chem 55:2287-300. 2012..E-DMSS analogues may be useful probes of COX-1 biology in vivo and promising leads for COX-1-targeted therapeutic agents... - The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivativesMatthew J Walters
A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Bioorg Med Chem Lett 19:3271-4. 2009..Thus, although the 2'-methyl group is a major determinant of time-dependent cyclooxygenase inhibition, the geometry of the benzylidene double bond plays a role as well... - Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2Jeffery J Prusakiewicz
Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Biochem Biophys Res Commun 296:612-7. 2002..These results suggest a possible role for COX-2 in the regulation of NAGly levels and the formation of a novel class of eicosanoids from NAGly metabolism... - Lipid profiling reveals glycerophospholipid remodeling in zymosan-stimulated macrophagesCarol A Rouzer
Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
Biochemistry 46:6026-42. 2007..These results suggest that GPCho is the major ultimate source of 20:4 that is mobilized in zymosan-stimulated RPMs but that 20:4 mobilization may involve the intermediate turnover of alkyl acyl GPEtn species... - Fluorinated COX-2 inhibitors as agents in PET imaging of inflammation and cancerMd Jashim Uddin
A B Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Molecular Toxicology, TN, USA
Cancer Prev Res (Phila) 4:1536-45. 2011..The in vitro and in vivo properties of compound 7 suggest it will be a useful probe for early detection of cancer and for evaluation of the COX-2 status of premalignant and malignant tumors... - Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cellsRenier Velez-Cruz
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
Biochemistry 44:3972-81. 2005..This finding suggests that type II topoisomerases interact with exocyclic DNA lesions in physiological systems... - Glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulusCarol A Rouzer
Department of Biochemistry, the Vanderbilt Institute of Chemical Biology, the Center in Molecular Toxicology, Nashville, TN 37232-0146, USA
J Biol Chem 280:26690-700. 2005..In conclusion, lipopolysaccharide-pretreated macrophages produce PG-Gs from endogenous 2-AG during zymosan phagocytosis, but PG-G formation is limited by substrate hydrolysis and inactivation of COX-2... - Molecular basis of the time-dependent inhibition of cyclooxygenases by indomethacinJeffery J Prusakiewicz
A. B. Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute for Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biochemistry 43:15439-45. 2004..These results highlight binding of the 2'-methyl of INDO in the hydrophobic pocket as an important determinant of its time-dependent inhibition of COX enzymes... - Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthasesOlivier Boutaud
Department of Medicine, Vanderbilt University, Nashville, TN 37232 6602, USA
Proc Natl Acad Sci U S A 99:7130-5. 2002..Together these findings support the hypothesis that the clinical action of acetaminophen is mediated by inhibition of PGHS activity, and that hydroperoxide concentration contributes to its cellular selectivity... - Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophagesCarol A Rouzer
Departments of Biochemistry and Chemistry, Vanderbilt Institute for Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 0146
J Biol Chem 279:34256-68. 2004..These results demonstrate autocrine regulation of TNF-alpha secretion by endogenous PGs synthesized primarily by COX-1 in RPM and suggest that COX-1 may play a significant role in the regulation of the early response to endotoxemia... - Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidationJames D West
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University, Nashville, Tennessee 37232-0146, USA
Chem Res Toxicol 17:453-62. 2004..The results presented herein suggest that these molecules commonly activate certain signaling pathways that control cell death irrespective of their reactive properties... 
Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin AR Nathan Daniels
Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
J Org Chem 74:8852-5. 2009..2% overall yield. The key epi-nonproteogenic 3-methyl-4-ethylideneproline was synthesized via a titanium-mediated cycloisomerization reaction...- Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolitesRory P Remmel
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Drug Metab Dispos 32:113-22. 2004..The glucuronides of 2'hydroxy-LM-4108 and O-desmethyl-2'-hydroxy-LM-4108 were also identified in rat bile... - Semisynthesis of 6-chloropurine-2'-deoxyriboside 5'-dimethoxytrityl 3'-(2-cyanoethyl-N,N-diisopropylamino)phosphoramidite and its use in the synthesis of fluorescently labeled oligonucleotidesMd Jashim Uddin
A B Hancock Jr Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
Nucleosides Nucleotides Nucleic Acids 29:831-40. 2010.... - Functional analysis of the molecular determinants of cyclooxygenase-2 acetylation by 2-acetoxyphenylhept-2-ynyl sulfideG Phillip Hochgesang
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Nashville, TN 37232-0146, USA
Arch Biochem Biophys 409:127-33. 2003..Arg-120 is proposed to fix the conformation of the active site to one that favors acetylation... - Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxibAnna L Blobaum
A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute for Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 282:16379-90. 2007..Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition... - RAW264.7 cells lack prostaglandin-dependent autoregulation of tumor necrosis factor-alpha secretionCarol A Rouzer
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
J Lipid Res 46:1027-37. 2005.... - Indolyl esters and amides related to indomethacin are selective COX-2 inhibitorsAmit S Kalgutkar
A.B. Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry and Chemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA
Bioorg Med Chem 13:6810-22. 2005..7. Overall, this strategy broadens the scope of our previous methodology of neutralizing the carboxylic acid group in NSAIDs as a means of generating COX-2-selective inhibitors and is potentially applicable to other NSAIDs... - Insertion of dNTPs opposite the 1,N2-propanodeoxyguanosine adduct by Sulfolobus solfataricus P2 DNA polymerase IVYazhen Wang
Department of Chemistry, Center in Molecular Toxicology, Vanderbilt University, Nashville, Tennessee 37235, USA
Biochemistry 47:7322-34. 2008..These results provide insight into how -1 frameshift mutations might be generated for the PdG adduct, a structural model for the exocylic M 1dG adduct formed by malondialdehyde... - Chemical properties of oxopropenyl adducts of purine and pyrimidine nucleosides and their reactivity toward amino acid cross-link formationJoseph Szekely
Department of Chemistry, Center in Molecular Toxicology, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235 1822, USA
J Am Chem Soc 130:2195-201. 2008..The results define the acidity of oxopropenyl deoxynucleosides and highlight its importance to their reactivity toward nucleophiles. This study also identifies the structures of a potential novel class of DNA-protein cross-links... - Metabolism and elimination of the endogenous DNA adduct, 3-(2-deoxy-beta-D-erythropentofuranosyl)-pyrimido[1,2-alpha]purine-10(3H)-one, in the ratCharles G Knutson
A B Hancock, Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
J Biol Chem 282:36257-64. 2007..Additionally, both M1dG and 6-oxo-M1dG exhibited a long residence time following administration (>48 h), and the major species observed in urine at late collections was 6-oxo-M1dG... - HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteinsAaron T Jacobs
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
J Biol Chem 284:9176-83. 2009..Overall, our data reveal that BAG3 is HSF1-inducible and has a unique role facilitating cancer cell survival during pro-apoptotic stress by stabilizing the level of Bcl-2 family proteins... - Identification of the protein targets of the reactive metabolite of teucrin A in vivo in the ratAlexandra Druckova
Department of Biochemistry, A B Hancock Jr Memorial Laboratory for Cancer Research, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
Chem Res Toxicol 20:1393-408. 2007.... - Site-specific synthesis of oligonucleotides containing malondialdehyde adducts of deoxyguanosine and deoxyadenosine via a postsynthetic modification strategyHao Wang
Department of Chemistry and Biochemistry, Center in Molecular Toxicology and Vanderbilt Institute of Chemical Biology, Vanderbilt University, VU Station B 351822, Nashville, Tennessee 37235-1822, USA
Chem Res Toxicol 19:1467-74. 2006..The stability of the modified oligonucleotides was examined by UV thermal melting studies (Tm). In contrast to the M1dG adduct, OPdA caused very little change in the Tm... - N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantationYong Guo
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Biol Chem 280:23429-32. 2005..The expression is well correlated with its activity and anandamide levels. This study is clinically relevant, since elevated anandamide levels in peripheral circulation are associated with spontaneous pregnancy failure in women... - Modulation of DNA fragmentation factor 40 nuclease activity by poly(ADP-ribose) polymerase-1James D West
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology and the Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
J Biol Chem 280:15141-7. 2005..Our results suggest that PARP-1 poly(ADP-ribosyl)ation is a terminal event in the apoptotic response that occurs in response to DNA fragmentation and directly influences DFF40 activity... - Combined chemical and biosynthetic route to access a new apoptolidin congenerVictor P Ghidu
Department of Chemistry, Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
Org Lett 11:3032-4. 2009.... - Characterization of an AM404 analogue, N-(3-hydroxyphenyl)arachidonoylamide, as a substrate and inactivator of prostaglandin endoperoxide synthaseMELISSA V TURMAN
A B Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biochemistry 48:12233-41. 2009..These studies provide additional insight into the structural requirements for substrate metabolism and inactivation of PGHS and report the first metabolism-dependent, selective inactivator of PGHS-2... - Heat shock factor 1 attenuates 4-Hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XLAaron T Jacobs
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
J Biol Chem 282:33412-20. 2007..Overall, activation of HSF1 and stabilization of Bcl-X(L) mediate a protective response that may contribute significantly to the cellular biology of lipid peroxidation... - Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient miceMichael E Burleigh
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn, USA
Circulation 105:1816-23. 2002.... - Lipid profiling reveals arachidonate deficiency in RAW264.7 cells: Structural and functional implicationsCarol A Rouzer
Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA
Biochemistry 45:14795-808. 2006.... - Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitorsAmit S Kalgutkar
A B Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Bioorg Med Chem Lett 12:521-4. 2002..This paper describes SAR studies involved in the transformation of the NSAID meclofenamic acid into potent and selective cyclooxygenase-2 (COX-2) inhibitors via neutralization of the carboxylate moiety in this nonselective COX inhibitor... - Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerolK R Kozak
Departments of Biochemistry and Chemistry, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 276:30072-7. 2001..Finally, the differences in substrate binding do not alter the stereospecificity of the cyclooxygenase reaction; 2-AG-derived and arachidonic acid-derived products share identical stereochemistry... - Substitution of tyrosine for the proximal histidine ligand to the heme of prostaglandin endoperoxide synthase 2: implications for the mechanism of cyclooxygenase activation and catalysisD C Goodwin
Departments of Biochemistry and Chemistry, Center in Molecular Toxicology, and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
Biochemistry 39:5422-32. 2000..In addition, our findings are strongly supportive of a branched-chain mechanism of cyclooxygenase catalysis in which one activation event leads to many cyclooxygenase turnovers... - The COXIB experience: a look in the rearview mirrorLawrence J Marnett
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
Annu Rev Pharmacol Toxicol 49:265-90. 2009..This review provides an overview of the discovery, development, and difficulties of the COXIBs, a perspective on what has been learned, and speculation on the way forward... - Induction and function of lipocalin prostaglandin D synthase in host immunityMyungsoo Joo
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Immunol 179:2565-75. 2007..Our study suggests a potential therapeutic usage of L-PGDS or PGD(2) against Pseudomonas pneumonia... - Chemical stability of 2-arachidonylglycerol under biological conditionsCarol A Rouzer
Department of Biochemistry, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
Chem Phys Lipids 119:69-82. 2002.... - Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdalaSachin Patel
Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
Neuropsychopharmacology 34:2699-709. 2009..We suggest stress-induced enhancement of eCB-mediated suppression of inhibitory transmission in the BLA could contribute to affective dysregulation associated with chronic stress... - Oxidative metabolism of endocannabinoids by COX-2Kevin R Kozak
Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Curr Pharm Des 10:659-67. 2004..The available biochemical evidence supporting a role for COX-2 in endocannabinoid metabolism will be presented. Finally, the potential biological consequences of COX-2-mediated endocannabinoid oxygenation will be discussed... - Relating protein adduction to gene expression changes: a systems approachBing Zhang
Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Mol Biosyst 7:2118-27. 2011..Although developed for analyzing protein adduction data, the framework can be easily adapted for phosphoproteomics and other types of protein modification data... - Kinetics of the interaction of nonsteroidal antiinflammatory drugs with prostaglandin endoperoxide synthase-1 studied by limited proteolysisA S Kalgutkar
A B Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biochemistry 35:9076-82. 1996..The results suggest that induction of trypsin resistance is a reflection of the initial association of reversible as well as irreversible inhibitors with the apoprotein... - Nitric oxide trapping of tyrosyl radicals generated during prostaglandin endoperoxide synthase turnover. Detection of the radical derivative of tyrosine 385D C Goodwin
Department of Biochemistry, A B Hancock, Jr Memorial Laboratory for Cancer Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
J Biol Chem 273:8903-9. 1998..Peptide sequencing indicated that the modified residue was tyrosine 385, the source of the putative catalytically active tyrosyl radical... - Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesisT O Daniel
Department of Medicine, The Vanderbilt Center for Vascular Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
Cancer Res 59:4574-7. 1999..A TXA2 agonist, U46619, reconstitutes both migration and angiogenesis responses under COX-2-inhibited conditions. These findings identify TXA2 as a COX-2 product that functions as a critical intermediary of angiogenesis... - Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acidO Boutaud
Department of Pharmacology, Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
Biochemistry 40:6948-55. 2001..The reactivity of the PGH-synthase adducts themselves is demonstrated by the formation of intermolecular cross-links... - Analysis of endocannabinoids, their congeners and COX-2 metabolitesPhilip J Kingsley
A B Hancock, Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States
J Chromatogr B Analyt Technol Biomed Life Sci 877:2746-54. 2009..This review will summarize quantitative analytical methodology as reported in the literature from 1992 to present for the analysis of endocannabinoids and related compounds... - Non-redundant functions of cyclooxygenases: oxygenation of endocannabinoidsCarol A Rouzer
A B Hancock Jr Memorial Laboratory for Cancer Research, The Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
J Biol Chem 283:8065-9. 2008..These compounds are produced in intact cells stimulated with physiological agonists and have been isolated from in vivo sources. Important concepts relevant to the hypothesis of a COX-2-selective signaling pathway are presented... - Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349Claus Schneider
Department of Pharmacology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 277:478-85. 2002..The findings may also explain the absolute conservation of Ser-530, the target of aspirin, throughout the families of cyclooxygenase enzymes... - 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonistKevin R Kozak
Department of Biochemistry, Vanderbilt Ingram Cancer Center and Center in Molecular Toxicology, Nashville, Tennessee, USA
J Biol Chem 277:23278-86. 2002..The results demonstrate that 15-LOXs are capable of acting on 2-AG to provide 15-HETE-G and elucidate a potential role for endocannabinoid oxygenation in the generation of peroxisome proliferator-activated receptor alpha agonists... - Prostaglandin E2 inhibits tumor necrosis factor-alpha RNA through PKA type IJennifer B Stafford
Department of Biochemistry, Vanderbilt University School of Medicine, 23rd Avenue South at Pierce, Nashville, TN 37232 0146, USA
Biochem Biophys Res Commun 366:104-9. 2008..The mechanisms by which prostaglandins limit TNF-alpha mRNA levels may underlie endogenous regulatory mechanisms that limit inflammation, and may have important implications for understanding chronic inflammatory disease pathogenesis... - Structural and functional differences between cyclooxygenases: fatty acid oxygenases with a critical role in cell signalingCarol A Rouzer
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA
Biochem Biophys Res Commun 338:34-44. 2005..These findings suggest that PG-Gs comprise a new class of lipid mediators, and that oxygenation of neutral derivatives of AA is a distinct function for the COX-2 isoform... - Formation of DNA-protein cross-links between gamma-hydroxypropanodeoxyguanosine and EcoRILaurie A VanderVeen
A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Chem Res Toxicol 21:1733-8. 2008..This work indicates that the gamma-HOPdG-EcoRI cross-link is in equilibrium with free oligonucleotide and enzyme. Reversal of cross-link formation allows EcoRI to effect enzymatic cleavage of competitor oligonucleotides... - Synthesis and evaluation of the cytotoxicity of apoptolidinones A and DVictor P Ghidu
Department of Chemistry, Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235 1822, USA
J Org Chem 73:4949-55. 2008..In contrast to apoptolidin A, the aglycones apoptolidinone A and D were shown to be noncytotoxic when evaluated against human lung cancer cells (H292)... - Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cellsLaura J Niedernhofer
Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 278:31426-33. 2003..These experiments provide biological and biochemical evidence for the existence of MDA-induced DNA interstrand cross-links that could result from endogenous oxidative stress and likely have potent biological effects... - Development of a method for determination of the malondialdehyde-deoxyguanosine adduct in urine using liquid chromatography-tandem mass spectrometryMichael Otteneder
Department of Biochemistry, Center in Molecular Toxicology, and Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University, Nashville, TN 37232, USA
Anal Biochem 315:147-51. 2003..This method is easily adaptable to the analysis of M(1)GdR in DNA samples or biological fluids... - Kinetics of inhibition of leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acidJohn S Moody
Department of Biochemistry, Vanderbilt-Ingram Comprehensive Cancer Center and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biochemistry 41:10297-303. 2002.... - Effects of DNA structure on oxopropenylation by the endogenous mutagens malondialdehyde and base propenalJohn P Plastaras
A. B. Hancock Jr. Memorial Laboratory for Cancer Research, Department of Biochemistry, Center in Molecular Toxicology and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biochemistry 41:5033-42. 2002..These data suggest that steric access to the target nucleophile located in the minor groove of DNA is critical for adduct formation by the endogenous mutagens MDA and base propenals... - Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenasesCarol A Rouzer
A. B. Hancock Jr. Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA
Chem Rev 103:2239-304. 2003 - Evaluation of the mutagenic potential of the principal DNA adduct of acroleinL A VanderVeen
Department of Biochemistry, A. B. Hancock Jr. Memorial Laboratory for Cancer Research, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 276:9066-70. 2001..The combination of these studies showed that HOPdG is not miscoding in vivo at the level of sensitivity of these site-specific mutagenesis assays... - Abasic sites stimulate double-stranded DNA cleavage mediated by topoisomerase II. DNA lesions as endogenous topoisomerase II poisonsP S Kingma
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
J Biol Chem 270:21441-4. 1995..These findings suggest that abasic sites represent endogenous topoisomerase II poisons and imply that anticancer drugs mimic the cleavage-enhancing actions of naturally occurring DNA lesions... - Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehydeJ P Plastaras
A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Center in Molecular Toxicology and the Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 275:11784-90. 2000..These results suggest that co-expression of cyclooxygenase-2 and P450s in developing cancers may contribute to genomic instability due to production of the endogenous mutagen, MDA... - The relative contribution of adduct blockage and DNA repair on template utilization during replication of 1,N2-propanodeoxyguanosine and pyrimidoS P Fink
A.B. Hancock, Jr, Memorial Laboratory for Cancer Research, The Vanderbilt-Ingram Cancer Center, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA
Mutat Res 485:209-18. 2001..The increased strand bias indicates the importance of nucleotide excision repair in the removal of PdG and M1G... - The exocyclic 1,N2-deoxyguanosine pyrimidopurinone M1G is a chemically stable DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 geneN C Schnetz-Boutaud
Department of Chemistry, Center in Molecular Toxicology, A.B. Hancock, Jr. Memorial Laboratory for Cancer Research, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, USA
Biochemistry 40:15638-49. 2001..P., Moe, J. G., Reddy, G. R., Marnett, L. J., and Stone, M. P. (1995) Biochemistry 34, 50-64]. The fixed position of the bulged bases in both instances suggests that these exocyclic adducts do not facilitate transient bulge migration... - Inhibitors of cytochrome P-450-dependent arachidonic acid metabolismJ Capdevila
Division of Nephrology, Vanderbilt Medical School, Nashville, Tennessee 37232
Arch Biochem Biophys 261:257-63. 1988..In decreasing order of potency, they were NDGA, ETYA, and indomethacin (IC50, 15, 40, and 70 microM, respectively)...