Research Topics
Genomes and Genes
| Ji Rong LongSummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
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Detail Information
Publications
A Common Deletion in the APOBEC3 Genes and Breast Cancer RiskJirong Long
Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, 2525W End Ave, 8th Fl, Nashville, TN 37203 1738
J Natl Cancer Inst 105:573-9. 2013..0×10(-24)). Conclusions We provide convincing evidence for a novel breast cancer locus at the APOBEC3 genes. This CNV is one of the strongest common genetic risk variants identified so far for breast cancer...- Evaluation of genome-wide association study-identified type 2 diabetes loci in African AmericansJirong Long
Division of Epidemiology, Departmentof Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee 37203 1738, USA
Am J Epidemiol 176:995-1001. 2012..These results extend some of the recent GWAS findings to African Americans and may guide future efforts to identify causal variants for T2D... 
CYP19A1 genetic polymorphisms may be associated with obesity-related phenotypes in Chinese womenJ R Long
Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232 2587, USA
Int J Obes (Lond) 31:418-23. 2007..To examine the relationship between genetic polymorphisms of the CYP19A1 gene and obesity-related phenotypes, body mass index (BMI) and waist-to-hip ratio (WHR)...- Polymorphisms of the CYP1B1 gene may be associated with the onset of natural menopause in Chinese womenJi Rong Long
Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, 1161 21st Avenue South, S 1108 Medical Center North, Nashville, TN 37232 2587, United States
Maturitas 55:238-46. 2006..6 fewer menstrual cycles than those women without this allele. In conclusion, the results from this study suggested that CYP1B1 genetic polymorphisms may be associated with the natural onset of menopause... - Evaluation of breast cancer susceptibility loci in Chinese womenJirong Long
Division of Epidemiology, Department ofMedicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
Cancer Epidemiol Biomarkers Prev 19:2357-65. 2010..Recent genome-wide association studies (GWAS), mostly conducted among women of European ancestry, have identified 16 single-nucleotide polymorphisms (SNP) associated with breast cancer... - Population-based case-control study of AhR (aryl hydrocarbon receptor) and CYP1A2 polymorphisms and breast cancer riskJi Rong Long
Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
Pharmacogenet Genomics 16:237-43. 2006.... - Genetic polymorphisms of the CYP19A1 gene and breast cancer survivalJi Rong Long
Department of Medicine, Center for Epidemiologic Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2587, USA
Cancer Epidemiol Biomarkers Prev 15:2115-22. 2006..2-4.1) for overall survival and 2.1 (95% CI, 1.1-3.9) for disease-free survival, compared with those carrying the Arg (C) allele. These results suggest that polymorphisms in the CYP19A1 gene may have effects on breast cancer prognosis... - Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese womenHui Cai
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
Pharmacogenet Genomics 18:657-64. 2008..We investigated the associations of genetic polymorphisms in CYP19A1, a critical gene involved in estrogen synthesis, with plasma levels of sex hormones among postmenopausal Chinese women... - Association of a single nucleotide polymorphism at 6q25.1,rs2046210, with endometrial cancer risk among Chinese womenGuoliang Li
Division of Epidemiology and Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University School of Medicine and Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232, USA
Chin J Cancer 30:138-43. 2011..Our study suggests that rs2046210 may play a role in the etiology of endometrial cancer. Additional studies are needed to confirm our findings... - Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survivalJi Rong Long
Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, S 1121 Medical Center North, Nashville, TN 37232, USA
Pharmacogenet Genomics 17:331-8. 2007..The objective of the study is to investigate associations of breast cancer survival with genetic polymorphisms in several genes involved in estrogen metabolism (CYP1A1, CYP1A2, CYP1B1, COMT, and AhR)... - Matrix metalloproteinase-2 polymorphisms and breast cancer susceptibilityAlicia Beeghly-Fadiel
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203 1738, USA
Cancer Epidemiol Biomarkers Prev 18:1770-6. 2009..4; 95% CI, 0.9-2.4). Together, these findings support a role for MMP-2 genetic variation in breast cancer susceptibility... - Common MMP-7 polymorphisms and breast cancer susceptibility: a multistage study of association and functionalityAlicia Beeghly-Fadiel
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203 1738, USA
Cancer Res 68:6453-9. 2008..Results from our study suggest that common MMP-7 genetic polymorphisms may contribute to breast cancer susceptibility... - Genetic polymorphisms in obesity-related genes and endometrial cancer riskXiaoli Chen
Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee 37203 1738, USA
Cancer 118:3356-64. 2012.... - HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genesTodd L Edwards
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
Am J Epidemiol 175:11-21. 2012..A SNP in CYP19A1 interacted with dietary energy intake in African Americans, and another SNP in CYP191A had an independent association with BMI in Caucasians... - Interaction of soy and 17beta-HSD1 gene polymorphisms in the risk of endometrial cancerQi Dai
Department of Medicine and Vanderbilt Ingram Cancer Center, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA
Pharmacogenet Genomics 17:161-7. 2007..In-vitro studies have found that soy isoflavones can inhibit the activity of 17beta-hydroxysteroid dehydrogenase type I, a key enzyme in catalyzing estrone (E1), to the biologically more active estradiol (E2)... - Evaluating cost efficiency of SNP chips in genome-wide association studiesChun Li
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Genet Epidemiol 32:387-95. 2008..We illustrate these approaches using five currently available whole genome SNP chips... - IGF-I and IGF-II genetic variation and breast cancer risk in Chinese women: results from the Shanghai Breast Cancer StudySandra L Deming
Institute for Medicine and Public Health, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 3720-1738, USA
Cancer Epidemiol Biomarkers Prev 17:255-7. 2008 - Genetic determination and correlation of body weight and body mass index (BMI) and cross-sectional geometric parameters of the femoral neckHong Xu
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People's Republic of China
Osteoporos Int 17:1602-7. 2006..The strong genetic correlations suggested that the genetic factors of bone geometry may be overlapped with those of body weight and BMI... - Patterns of linkage disequilibrium and haplotype distribution in disease candidate genesJi Rong Long
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
BMC Genet 5:11. 2004..The adequacy of association studies for complex diseases depends critically on the existence of linkage disequilibrium (LD) between functional alleles and surrounding SNP markers... - Estrogen receptor alpha and vitamin D receptor gene polymorphisms and bone mineral density: association study of healthy pre- and postmenopausal Chinese womenYuan Yuan Zhang
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China
Biochem Biophys Res Commun 308:777-83. 2003..02), and PX carriers had lower hip BMD than the non-carriers (p=0.04). Our data suggest that the ER-alpha and VDR genes may be associated with the BMD variation in Chinese women... - Tests of linkage and/or association of TGF-beta1 and COL1A1 genes with bone massJi-Rong Long
Osteoporosis Research Center, Creighton University, 601 N. 30th Street, Suite 6787, Omaha, NE 68131, USA
Osteoporos Int 16:86-92. 2005..021) in male offspring families. Further studies with denser markers and larger sample size are required to eventually define the relationship between these two genes with bone mass at the spine and hip... - Interaction effects between estrogen receptor alpha and vitamin D receptor genes on age at menarche in Chinese womenHong Xu
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hu nan Normal University, Changsha 410081, China
Acta Pharmacol Sin 26:860-4. 2005..To evaluate whether estrogen receptor alpha (ER-alpha) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women... - Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosisVolodymyr Dvornyk
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 601 N, 30th St, Suite 6730, Omaha, NE 68131, USA
BMC Genet 5:4. 2004..However, their utility for such studies of diseases with ethnic-dependent background has never been evaluated... - Tests of linkage and/or association of the LEPR gene polymorphisms with obesity phenotypes in Caucasian nuclear familiesYong Jun Liu
Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
Physiol Genomics 17:101-6. 2004..Our results suggest that the LEPR gene polymorphisms contribute to variation in obesity phenotypes... - Estrogen receptor alpha gene relationship with peak bone mass and body mass index in Chinese nuclear familiesWei xia Jian
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, 410081 Changsha, Hunan, PR China
J Hum Genet 50:477-82. 2005..Our study does not support an association of the ER-alpha gene with BMD and BMI in the Chinese population... - Association between COL1A1 gene polymorphisms and bone size in CaucasiansJi Rong Long
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
Eur J Hum Genet 12:383-8. 2004..011 and 0.010, respectively. In conclusion, the COL1A1 gene may have some effects on bone size variation at the wrist, but not at the spine or hip in our Caucasian nuclear families... - Tests of linkage and association of PTH/PTHrP receptor type 1 gene with bone mineral density and height in CaucasiansYuan Yuan Zhang
Osteoporosis Research Center, Creighton University Medical Center, 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
J Bone Miner Metab 24:36-41. 2006..05). Our findings suggest that the PTHR1 gene may be important for PBMD, height variation, or both, although the significance is dampened by correction for multiple testing... - Genomewide linkage scan for quantitative trait loci underlying variation in age at menarcheYan Guo
Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China
J Clin Endocrinol Metab 91:1009-14. 2006.... - APOE haplotypes influence bone mineral density in Caucasian males but not femalesJi Rong Long
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
Calcif Tissue Int 75:299-304. 2004..008) for the total hip BMD. These data suggested that in our studied Caucasian population, APOE may have effects on BMD variation in males but not females. Further studies with a larger sample size are required to confirm such results... - High heritability of bone size at the hip and spine in ChineseWei-Xia Jian
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, 410081 Changsha Hunan, PR China
J Hum Genet 49:87-91. 2004..The significantly and moderately high h2 values for bone size demonstrated in this study warrant a subsequent genetic study to search for the genes or genomic regions underlying the phenotype in Chinese... - Mapping quantitative trait loci for cross-sectional geometry at the femoral neckHui Shen
Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
J Bone Miner Res 20:1973-82. 2005..The identification of the genes responsible for bone geometric variation will improve our knowledge of bone strength and aid in development of diagnostic approaches and interventions for osteoporotic fractures... - Test of linkage and/or association between the estrogen receptor alpha gene with bone mineral density in Caucasian nuclear familiesLan-Juan Zhao
Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE 68131, USA
Bone 35:395-402. 2004..015). However, after correction for multiple testing, these associations did not reach statistical significance. Denser markers may be necessary to better define the relationship between the ER-alpha gene and BMD variation in our sample... - Genetic dissection of human stature in a large sample of multiplex pedigreesYao-Zhong Liu
Osteoporosis Research Center, Creighton University, 601 N. 30th St. Suite 6787, Omaha, NE 68131, USA
Ann Hum Genet 68:472-88. 2004..To date, our study has achieved the largest sample size in the field of genetic linkage studies of human height. Together with the findings of other studies, the current study has further delineated the genetic basis of human stature... - Genetic determination of variation and covariation of bone mineral density at the hip and spine in a Chinese populationWei-Xia Jian
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
J Bone Miner Metab 23:181-5. 2005..We conclude that genetic factors play a major role in the determination of the variation and covariation of BMD at the spine and hip in our Chinese sample... - Association of matrix metalloproteinase-8 gene variation with breast cancer prognosisJulie Decock
Laboratory for Experimental Oncology, Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
Cancer Res 67:10214-21. 2007..The data suggest that MMP8 gene variation may influence breast cancer prognosis and support the notion that MMP8 has an inhibitory effect on cancer metastasis... - AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear familiesYan Jun Yang
Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, PR China
Eur J Epidemiol 22:527-32. 2007..To investigate the role of alpha2-HS glycoprotein (AHSG) gene on bone mineral density (BMD) variation... - The genetics of osteoporosisJi-Rong Long
Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA
Drugs Today (Barc) 41:205-18. 2005.... - Polymorphisms of the vitamin D receptor gene predict the onset of surgical menopause in Caucasian femalesVolodymyr Dvornyk
Department of Biological Sciences, Kent State University, Kent, OH, USA
Gynecol Endocrinol 22:552-6. 2006..These results reveal the potential effect of the VDR gene on ovaries and uterus, and suggest that its SNPs can be used as predictors of genetic susceptibility for early surgical menopause and respective causal health problems... - Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: a test for five candidate genes for bone massVolodymyr Dvornyk
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha 410081, China
Chin Med J (Engl) 118:1235-44. 2005.... - Genomic regions identified for BMD in a large sample including epistatic interactions and gender-specific effectsPeng Xiao
Department of Biomedical Sciences and Osteoporosis Research Center, School of Medicine, Creighton University, Omaha, Nebraska, USA
J Bone Miner Res 21:1536-44. 2006..The results of this study provide a foundation for the future fine mapping and gene identification in our population... - Predictive factors for age at menopause in Caucasian femalesVolodymyr Dvornyk
Department of Biological Sciences, Kent State University, Kent, OH 44242-0001, USA
Maturitas 54:19-26. 2006..Given the important role of the ER-alpha in estrogen signaling, which directly influences the menopausal process, further studies are required to better define the relationship between this gene and age at menopause... - Genome-wide scan identified QTLs underlying femoral neck cross-sectional geometry that are novel studied risk factors of osteoporosisDong-Hai Xiong
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
J Bone Miner Res 21:424-37. 2006....
Research Grants
- Genome-wide Copy Number Variation and Breast Cancer RiskJirong Long; Fiscal Year: 2009....
- Genome-wide Copy Number Variation and Breast Cancer RiskJirong Long; Fiscal Year: 2010....