Ji Rong Long

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Evaluating GWAS-identified SNPs for age at natural menopause among chinese women
    Chong Shen
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 8:e58766. 2013
  2. pmc Steps to ensure accuracy in genotype and SNP calling from Illumina sequencing data
    Qi Liu
    Center for Quantitative Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Genomics 13:S8. 2012
  3. pmc The effect of strand bias in Illumina short-read sequencing data
    Yan Guo
    Vanderbilt Ingram Cancer Center, Nashville, TN, USA
    BMC Genomics 13:666. 2012
  4. pmc Exome sequencing generates high quality data in non-target regions
    Yan Guo
    Center for Quantitative Sciences, Vanderbilt Ingram Cancer Center, Nashville, TN, USA
    BMC Genomics 13:194. 2012
  5. pmc Evaluating genome-wide association study-identified breast cancer risk variants in African-American women
    Jirong Long
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 8:e58350. 2013
  6. pmc A common deletion in the APOBEC3 genes and breast cancer risk
    Jirong Long
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    J Natl Cancer Inst 105:573-9. 2013
  7. pmc Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans
    Jirong Long
    Division of Epidemiology, Departmentof Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee 37203 1738, USA
    Am J Epidemiol 176:995-1001. 2012
  8. pmc Evaluation of breast cancer susceptibility loci in Chinese women
    Jirong Long
    Division of Epidemiology, Department ofMedicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 19:2357-65. 2010
  9. ncbi request reprint Polymorphisms of the CYP1B1 gene may be associated with the onset of natural menopause in Chinese women
    Ji Rong Long
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, 1161 21st Avenue South, S 1108 Medical Center North, Nashville, TN 37232 2587, United States
    Maturitas 55:238-46. 2006
  10. ncbi request reprint CYP19A1 genetic polymorphisms may be associated with obesity-related phenotypes in Chinese women
    J R Long
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232 2587, USA
    Int J Obes (Lond) 31:418-23. 2007

Research Grants

Collaborators

Detail Information

Publications47

  1. pmc Evaluating GWAS-identified SNPs for age at natural menopause among chinese women
    Chong Shen
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 8:e58766. 2013
    ..No study has been conducted to evaluate whether these findings can be generalized to Chinese women...
  2. pmc Steps to ensure accuracy in genotype and SNP calling from Illumina sequencing data
    Qi Liu
    Center for Quantitative Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Genomics 13:S8. 2012
    ..In this study, we made a systematic assessment of the relative contribution of each step to the accuracy of variant calling from Illumina DNA sequencing data...
  3. pmc The effect of strand bias in Illumina short-read sequencing data
    Yan Guo
    Vanderbilt Ingram Cancer Center, Nashville, TN, USA
    BMC Genomics 13:666. 2012
    ..This phenomenon is known as strand bias. In this study, we used Illumina short-read sequencing data to evaluate the effect of strand bias on genotyping quality, and to explore the possible causes of strand bias...
  4. pmc Exome sequencing generates high quality data in non-target regions
    Yan Guo
    Center for Quantitative Sciences, Vanderbilt Ingram Cancer Center, Nashville, TN, USA
    BMC Genomics 13:194. 2012
    ..A significant amount of DNA fragments from the capture process fall outside target regions, and sequence data for positions outside target regions have been mostly ignored after alignment...
  5. pmc Evaluating genome-wide association study-identified breast cancer risk variants in African-American women
    Jirong Long
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 8:e58350. 2013
    ..75 (1.30-2.37), 1.56 (1.15-2.11), 2.02 (1.50-2.74) and 2.63 (1.96-3.52), respectively, (P = 7.8 × 10(-10)). Results from this study highlight the need for large genetic studies in AAs to identify risk variants impacting this population...
  6. pmc A common deletion in the APOBEC3 genes and breast cancer risk
    Jirong Long
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    J Natl Cancer Inst 105:573-9. 2013
    ..However, these loci explain only a small fraction of the heritability. Very few studies have evaluated copy number variation (CNV), another important source of human genetic variation, in relation to breast cancer risk...
  7. pmc Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans
    Jirong Long
    Division of Epidemiology, Departmentof Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee 37203 1738, USA
    Am J Epidemiol 176:995-1001. 2012
    ..These results extend some of the recent GWAS findings to African Americans and may guide future efforts to identify causal variants for T2D...
  8. pmc Evaluation of breast cancer susceptibility loci in Chinese women
    Jirong Long
    Division of Epidemiology, Department ofMedicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 19:2357-65. 2010
    ..Recent genome-wide association studies (GWAS), mostly conducted among women of European ancestry, have identified 16 single-nucleotide polymorphisms (SNP) associated with breast cancer...
  9. ncbi request reprint Polymorphisms of the CYP1B1 gene may be associated with the onset of natural menopause in Chinese women
    Ji Rong Long
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, 1161 21st Avenue South, S 1108 Medical Center North, Nashville, TN 37232 2587, United States
    Maturitas 55:238-46. 2006
    ..6 fewer menstrual cycles than those women without this allele. In conclusion, the results from this study suggested that CYP1B1 genetic polymorphisms may be associated with the natural onset of menopause...
  10. ncbi request reprint CYP19A1 genetic polymorphisms may be associated with obesity-related phenotypes in Chinese women
    J R Long
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232 2587, USA
    Int J Obes (Lond) 31:418-23. 2007
    ..To examine the relationship between genetic polymorphisms of the CYP19A1 gene and obesity-related phenotypes, body mass index (BMI) and waist-to-hip ratio (WHR)...
  11. ncbi request reprint Population-based case-control study of AhR (aryl hydrocarbon receptor) and CYP1A2 polymorphisms and breast cancer risk
    Ji Rong Long
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
    Pharmacogenet Genomics 16:237-43. 2006
    ....
  12. ncbi request reprint Genetic polymorphisms of the CYP19A1 gene and breast cancer survival
    Ji Rong Long
    Department of Medicine, Center for Epidemiologic Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2587, USA
    Cancer Epidemiol Biomarkers Prev 15:2115-22. 2006
    ..2-4.1) for overall survival and 2.1 (95% CI, 1.1-3.9) for disease-free survival, compared with those carrying the Arg (C) allele. These results suggest that polymorphisms in the CYP19A1 gene may have effects on breast cancer prognosis...
  13. pmc Association of a single nucleotide polymorphism at 6q25.1,rs2046210, with endometrial cancer risk among Chinese women
    Guoliang Li
    Division of Epidemiology and Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University School of Medicine and Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232, USA
    Chin J Cancer 30:138-43. 2011
    ..Our study suggests that rs2046210 may play a role in the etiology of endometrial cancer. Additional studies are needed to confirm our findings...
  14. pmc Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women
    Hui Cai
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Pharmacogenet Genomics 18:657-64. 2008
    ..We investigated the associations of genetic polymorphisms in CYP19A1, a critical gene involved in estrogen synthesis, with plasma levels of sex hormones among postmenopausal Chinese women...
  15. pmc Genetic polymorphisms in obesity-related genes and endometrial cancer risk
    Xiaoli Chen
    Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee 37203 1738, USA
    Cancer 118:3356-64. 2012
    ....
  16. ncbi request reprint Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival
    Ji Rong Long
    Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, S 1121 Medical Center North, Nashville, TN 37232, USA
    Pharmacogenet Genomics 17:331-8. 2007
    ..The objective of the study is to investigate associations of breast cancer survival with genetic polymorphisms in several genes involved in estrogen metabolism (CYP1A1, CYP1A2, CYP1B1, COMT, and AhR)...
  17. pmc Matrix metalloproteinase-2 polymorphisms and breast cancer susceptibility
    Alicia Beeghly-Fadiel
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 18:1770-6. 2009
    ..4; 95% CI, 0.9-2.4). Together, these findings support a role for MMP-2 genetic variation in breast cancer susceptibility...
  18. pmc IGF-I and IGF-II genetic variation and breast cancer risk in Chinese women: results from the Shanghai Breast Cancer Study
    Sandra L Deming
    Institute for Medicine and Public Health, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 3720 1738, USA
    Cancer Epidemiol Biomarkers Prev 17:255-7. 2008
  19. pmc Common MMP-7 polymorphisms and breast cancer susceptibility: a multistage study of association and functionality
    Alicia Beeghly-Fadiel
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203 1738, USA
    Cancer Res 68:6453-9. 2008
    ..Results from our study suggest that common MMP-7 genetic polymorphisms may contribute to breast cancer susceptibility...
  20. pmc Interaction of soy and 17beta-HSD1 gene polymorphisms in the risk of endometrial cancer
    Qi Dai
    Department of Medicine and Vanderbilt Ingram Cancer Center, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Pharmacogenet Genomics 17:161-7. 2007
    ..In-vitro studies have found that soy isoflavones can inhibit the activity of 17beta-hydroxysteroid dehydrogenase type I, a key enzyme in catalyzing estrone (E1), to the biologically more active estradiol (E2)...
  21. pmc HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes
    Todd L Edwards
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    Am J Epidemiol 175:11-21. 2012
    ..A SNP in CYP19A1 interacted with dietary energy intake in African Americans, and another SNP in CYP191A had an independent association with BMI in Caucasians...
  22. pmc Evaluating cost efficiency of SNP chips in genome-wide association studies
    Chun Li
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Genet Epidemiol 32:387-95. 2008
    ..We illustrate these approaches using five currently available whole genome SNP chips...
  23. ncbi request reprint Genomic regions identified for BMD in a large sample including epistatic interactions and gender-specific effects
    Peng Xiao
    Department of Biomedical Sciences and Osteoporosis Research Center, School of Medicine, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 21:1536-44. 2006
    ..A genome-wide linkage scan was conducted using a large white sample to identify QTLs for BMD. We found QTLs in the total sample and the gender-specific subgroups, as well as significant epistatic interactions underlying BMD variations...
  24. ncbi request reprint Genomewide linkage scan for quantitative trait loci underlying variation in age at menarche
    Yan Guo
    Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, People s Republic of China
    J Clin Endocrinol Metab 91:1009-14. 2006
    ..Genetic influence has been shown to contribute greatly to AAM, but the specific genetic determinants are largely unknown...
  25. pmc Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes
    Ji Rong Long
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    BMC Genet 5:11. 2004
    ..The adequacy of association studies for complex diseases depends critically on the existence of linkage disequilibrium (LD) between functional alleles and surrounding SNP markers...
  26. ncbi request reprint Genetic determination and correlation of body weight and body mass index (BMI) and cross-sectional geometric parameters of the femoral neck
    Hong Xu
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People s Republic of China
    Osteoporos Int 17:1602-7. 2006
    ....
  27. ncbi request reprint Association between COL1A1 gene polymorphisms and bone size in Caucasians
    Ji Rong Long
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Eur J Hum Genet 12:383-8. 2004
    ..011 and 0.010, respectively. In conclusion, the COL1A1 gene may have some effects on bone size variation at the wrist, but not at the spine or hip in our Caucasian nuclear families...
  28. ncbi request reprint Tests of linkage and/or association of the LEPR gene polymorphisms with obesity phenotypes in Caucasian nuclear families
    Yong Jun Liu
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Physiol Genomics 17:101-6. 2004
    ..Our results suggest that the LEPR gene polymorphisms contribute to variation in obesity phenotypes...
  29. pmc Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis
    Volodymyr Dvornyk
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 601 N, 30th St, Suite 6730, Omaha, NE 68131, USA
    BMC Genet 5:4. 2004
    ..However, their utility for such studies of diseases with ethnic-dependent background has never been evaluated...
  30. ncbi request reprint Tests of linkage and/or association of TGF-beta1 and COL1A1 genes with bone mass
    Ji Rong Long
    Osteoporosis Research Center, Creighton University, 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
    Osteoporos Int 16:86-92. 2005
    ..021) in male offspring families. Further studies with denser markers and larger sample size are required to eventually define the relationship between these two genes with bone mass at the spine and hip...
  31. ncbi request reprint APOE haplotypes influence bone mineral density in Caucasian males but not females
    Ji Rong Long
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Calcif Tissue Int 75:299-304. 2004
    ..008) for the total hip BMD. These data suggested that in our studied Caucasian population, APOE may have effects on BMD variation in males but not females. Further studies with a larger sample size are required to confirm such results...
  32. ncbi request reprint Estrogen receptor alpha and vitamin D receptor gene polymorphisms and bone mineral density: association study of healthy pre- and postmenopausal Chinese women
    Yuan Yuan Zhang
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China
    Biochem Biophys Res Commun 308:777-83. 2003
    ..02), and PX carriers had lower hip BMD than the non-carriers (p=0.04). Our data suggest that the ER-alpha and VDR genes may be associated with the BMD variation in Chinese women...
  33. ncbi request reprint Interaction effects between estrogen receptor alpha and vitamin D receptor genes on age at menarche in Chinese women
    Hong Xu
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hu nan Normal University, Changsha 410081, China
    Acta Pharmacol Sin 26:860-4. 2005
    ..To evaluate whether estrogen receptor alpha (ER-alpha) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women...
  34. ncbi request reprint Estrogen receptor alpha gene relationship with peak bone mass and body mass index in Chinese nuclear families
    Wei xia Jian
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, 410081 Changsha, Hunan, PR China
    J Hum Genet 50:477-82. 2005
    ..Our study does not support an association of the ER-alpha gene with BMD and BMI in the Chinese population...
  35. ncbi request reprint Tests of linkage and association of PTH/PTHrP receptor type 1 gene with bone mineral density and height in Caucasians
    Yuan Yuan Zhang
    Osteoporosis Research Center, Creighton University Medical Center, 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
    J Bone Miner Metab 24:36-41. 2006
    ..05). Our findings suggest that the PTHR1 gene may be important for PBMD, height variation, or both, although the significance is dampened by correction for multiple testing...
  36. ncbi request reprint Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: a test for five candidate genes for bone mass
    Volodymyr Dvornyk
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha 410081, China
    Chin Med J (Engl) 118:1235-44. 2005
    ....
  37. ncbi request reprint Polymorphisms of the vitamin D receptor gene predict the onset of surgical menopause in Caucasian females
    Volodymyr Dvornyk
    Department of Biological Sciences, Kent State University, Kent, OH, USA
    Gynecol Endocrinol 22:552-6. 2006
    ..These results reveal the potential effect of the VDR gene on ovaries and uterus, and suggest that its SNPs can be used as predictors of genetic susceptibility for early surgical menopause and respective causal health problems...
  38. ncbi request reprint High heritability of bone size at the hip and spine in Chinese
    Wei xia Jian
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, 410081 Changsha Hunan, PR China
    J Hum Genet 49:87-91. 2004
    ..The significantly and moderately high h2 values for bone size demonstrated in this study warrant a subsequent genetic study to search for the genes or genomic regions underlying the phenotype in Chinese...
  39. ncbi request reprint Genome-wide scan identified QTLs underlying femoral neck cross-sectional geometry that are novel studied risk factors of osteoporosis
    Dong Hai Xiong
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 21:424-37. 2006
    ..We found significant linkage of FNCS parameters to 20q12 and Xq25, plus significant epistatic interactions and sex-specific QTLs influencing FNCS geometry variation...
  40. ncbi request reprint AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families
    Yan Jun Yang
    Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, PR China
    Eur J Epidemiol 22:527-32. 2007
    ..To investigate the role of alpha2-HS glycoprotein (AHSG) gene on bone mineral density (BMD) variation...
  41. ncbi request reprint Test of linkage and/or association between the estrogen receptor alpha gene with bone mineral density in Caucasian nuclear families
    Lan Juan Zhao
    Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE 68131, USA
    Bone 35:395-402. 2004
    ..015). However, after correction for multiple testing, these associations did not reach statistical significance. Denser markers may be necessary to better define the relationship between the ER-alpha gene and BMD variation in our sample...
  42. ncbi request reprint Genetic dissection of human stature in a large sample of multiplex pedigrees
    Yao Zhong Liu
    Osteoporosis Research Center, Creighton University, 601 N 30th St Suite 6787, Omaha, NE 68131, USA
    Ann Hum Genet 68:472-88. 2004
    ..To date, our study has achieved the largest sample size in the field of genetic linkage studies of human height. Together with the findings of other studies, the current study has further delineated the genetic basis of human stature...
  43. ncbi request reprint Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis
    Julie Decock
    Laboratory for Experimental Oncology, Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Cancer Res 67:10214-21. 2007
    ..The data suggest that MMP8 gene variation may influence breast cancer prognosis and support the notion that MMP8 has an inhibitory effect on cancer metastasis...
  44. ncbi request reprint Genetic determination of variation and covariation of bone mineral density at the hip and spine in a Chinese population
    Wei xia Jian
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    J Bone Miner Metab 23:181-5. 2005
    ..We conclude that genetic factors play a major role in the determination of the variation and covariation of BMD at the spine and hip in our Chinese sample...
  45. ncbi request reprint Mapping quantitative trait loci for cross-sectional geometry at the femoral neck
    Hui Shen
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    J Bone Miner Res 20:1973-82. 2005
    ..Potential quantitative trait loci were detected at several genomic regions, such as 10q26, 20p12-q12, and chromosome X...
  46. ncbi request reprint Predictive factors for age at menopause in Caucasian females
    Volodymyr Dvornyk
    Department of Biological Sciences, Kent State University, Kent, OH 44242 0001, USA
    Maturitas 54:19-26. 2006
    ..The aim of this study was to determine genetic and environmental factors associated with age at natural and surgical menopause...
  47. ncbi request reprint The genetics of osteoporosis
    Ji Rong Long
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA
    Drugs Today (Barc) 41:205-18. 2005
    ....

Research Grants2