Chee Chew Lim

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms
    Chee Chew Lim
    Department of Cardiovascular Medicine, Vanderbilt University School of Medicine, 2220 Pierce Ave, PRB 340, Nashville, TN 37232, USA
    Am J Physiol Heart Circ Physiol 297:H2144-53. 2009
  2. ncbi A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility
    Chee Chew Lim
    Department of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biophys J 94:3577-89. 2008
  3. ncbi Neuregulin-1β regulation of embryonic endothelial progenitor cell survival
    Radwan N Safa
    Department of Molecular Medicine, Boston University, Massachusetts, USA
    Am J Physiol Heart Circ Physiol 300:H1311-9. 2011
  4. ncbi 26S proteasome regulation of Ankrd1/CARP in adult rat ventricular myocytes and human microvascular endothelial cells
    Susan E Samaras
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2561, USA
    Biochem Biophys Res Commun 425:830-5. 2012
  5. ncbi Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection?
    Douglas B Sawyer
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Prog Cardiovasc Dis 53:105-13. 2010
  6. ncbi Titin determines the Frank-Starling relation in early diastole
    Michiel Helmes
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Gen Physiol 121:97-110. 2003
  7. ncbi Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes
    Mohit Jain
    Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    Circ Res 93:e9-16. 2003
  8. ncbi Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein
    Ming Zhu
    Division of Cardiology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Am J Physiol Heart Circ Physiol 294:H1335-47. 2008
  9. ncbi Molecular and cellular mechanisms of anthracycline cardiotoxicity
    Billy Chen
    Department of Molecular Medicine, Boston University, Boston, TN, USA
    Cardiovasc Toxicol 7:114-21. 2007
  10. ncbi Simultaneous orientation and cellular force measurements in adult cardiac myocytes using three-dimensional polymeric microstructures
    Yi Zhao
    Laboratory for Biomedical Microsystems, Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio 43210, USA
    Cell Motil Cytoskeleton 64:718-25. 2007

Research Grants

  1. Regulation and Maintenance of Cardiac Muscle Sarcomere Integrity
    Chee Chew Lim; Fiscal Year: 2010
  2. Role of titin in age-associated diastolic dysfunction
    Chee Chew Lim; Fiscal Year: 2007

Collaborators

  • Douglas Sawyer
  • RONGLIH contact LIAO
  • Nathan S Bryan
  • Diane E Handy
  • Martin Feelisch
  • Joseph Loscalzo
  • ROGER JOSEPH HAJJAR
  • Billy Chen
  • Yukio Kuramochi
  • Susan E Samaras
  • Radwan N Safa
  • Laura Pentassuglia
  • Ming Zhu
  • Mo Yang
  • Xin Zhang
  • Yi Zhao
  • Xinxin Guo
  • Lei Cui
  • Mohit Jain
  • Michiel Helmes
  • Marc A Forgione
  • Jeffrey M Davidson
  • Stephen R Koch
  • Xu Yang Peng
  • Mathias Lamparter
  • Jeremy Walker
  • Antonis K Hatzopoulos
  • Carrie Geisberg
  • Cheri Silverstein
  • GongXin Liu
  • Kurt Chuprun
  • Julie X Zhang
  • Lan Mao
  • Xiaomei Xu
  • Burns C Blaxall
  • Gideon Koren
  • Agnieszka A Gach
  • Walter J Koch
  • Ulrike Mende
  • Xuyang Peng
  • Wilson S Colucci
  • Stanley Koh
  • Carl S Apstein
  • Jane A Leopold
  • Bo Wang
  • Ajit Bharti
  • David R Pimentel
  • Daniel A Brenner
  • Pascal J Goldschmidt-Clermont
  • Nicanor I Moldovan
  • Robert T Eberhardt
  • Andre Cap
  • John Jones

Detail Information

Publications15

  1. ncbi Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms
    Chee Chew Lim
    Department of Cardiovascular Medicine, Vanderbilt University School of Medicine, 2220 Pierce Ave, PRB 340, Nashville, TN 37232, USA
    Am J Physiol Heart Circ Physiol 297:H2144-53. 2009
    ....
  2. ncbi A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility
    Chee Chew Lim
    Department of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biophys J 94:3577-89. 2008
    ..This in turn may trigger pathways leading to aberrant ventricular remodeling and ultimately a dilated cardiomyopathy phenotype...
  3. ncbi Neuregulin-1β regulation of embryonic endothelial progenitor cell survival
    Radwan N Safa
    Department of Molecular Medicine, Boston University, Massachusetts, USA
    Am J Physiol Heart Circ Physiol 300:H1311-9. 2011
    ..NRG does not induce eEPC proliferation or migration but does protect eEPCs against serum deprivation-induced apoptosis. These results suggest a role for tissue-derived NRG in the regulation of EPC survival...
  4. ncbi 26S proteasome regulation of Ankrd1/CARP in adult rat ventricular myocytes and human microvascular endothelial cells
    Susan E Samaras
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2561, USA
    Biochem Biophys Res Commun 425:830-5. 2012
    ....
  5. ncbi Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection?
    Douglas B Sawyer
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Prog Cardiovasc Dis 53:105-13. 2010
    ..Moreover, assessing an individual's risk for anthracycline injury may be improved by having some measure of endogenous activity of this and other myocardial protective signals...
  6. ncbi Titin determines the Frank-Starling relation in early diastole
    Michiel Helmes
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Gen Physiol 121:97-110. 2003
    ..This study demonstrates for the first time the importance of titin-based restoring force in length-dependent deactivation during the early phase of diastole...
  7. ncbi Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes
    Mohit Jain
    Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    Circ Res 93:e9-16. 2003
    ..The full text of this article is available online at http://www.circresaha.org...
  8. ncbi Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein
    Ming Zhu
    Division of Cardiology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Am J Physiol Heart Circ Physiol 294:H1335-47. 2008
    ..Alterations in protein phosphatase 1 activity rather than PKA-mediated phosphorylation might be involved in hyperphosphorylation of key Ca2+ handling proteins in hearts with constitutive G alpha o activation...
  9. ncbi Molecular and cellular mechanisms of anthracycline cardiotoxicity
    Billy Chen
    Department of Molecular Medicine, Boston University, Boston, TN, USA
    Cardiovasc Toxicol 7:114-21. 2007
    ....
  10. ncbi Simultaneous orientation and cellular force measurements in adult cardiac myocytes using three-dimensional polymeric microstructures
    Yi Zhao
    Laboratory for Biomedical Microsystems, Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio 43210, USA
    Cell Motil Cytoskeleton 64:718-25. 2007
    ....
  11. ncbi A novel microfluidic impedance assay for monitoring endothelin-induced cardiomyocyte hypertrophy
    Mo Yang
    Laboratory for Microsystems Technology, Department of Manufacturing Engineering, 15 Saint Mary s Street, Boston University, Boston, MA 02215, USA
    Biosens Bioelectron 22:1688-93. 2007
    ..An equivalent circuit model is introduced to fit the impedance spectrum to fully understand the impedance sensing system...
  12. ncbi Rapid electrical stimulation induces early activation of kinase signal transduction pathways and apoptosis in adult rat ventricular myocytes
    Yukio Kuramochi
    Molecular Stress Response Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Exp Physiol 91:773-80. 2006
    ..The rapid pacing methodology described in this report will be particularly useful in determination of cell signalling pathways associated with tachycardia-induced cardiomyopathy...
  13. ncbi Modulation of cardiac function: titin springs into action
    Chee Chew Lim
    Whitaker Cardiovascular Institute and Center for the Molecular Stress Response, Boston University School of Medicine, Boston, MA 02118, USA
    J Gen Physiol 125:249-52. 2005
  14. ncbi Myocyte contractile activity modulates norepinephrine cytotoxicity and survival effects of neuregulin-1beta
    Yukio Kuramochi
    Whitaker Cardiovascular Institute and Cardiovascular Divisions, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Am J Physiol Cell Physiol 286:C222-9. 2004
    ..These results demonstrate the feasibility and importance of using electrically paced cardiomyocytes in primary culture when examining the signaling pathways of cell survival...
  15. ncbi Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure
    Marc A Forgione
    Evans Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    Circulation 106:1154-8. 2002
    ..Cellular GPx (GPx-1) is the principal intracellular isoform of GPx. We hypothesized that GPx-1 deficiency per se induces endothelial dysfunction and structural vascular abnormalities through increased oxidant stress...

Research Grants4

  1. Regulation and Maintenance of Cardiac Muscle Sarcomere Integrity
    Chee Chew Lim; Fiscal Year: 2010
    ..Understanding the molecular mechanisms of titin protein turnover will provide insight into the regulatory processes of sarcomere maintenance, and may ultimately lead to novel therapeutic approaches for heart failure cardiomyopathies. ..
  2. Role of titin in age-associated diastolic dysfunction
    Chee Chew Lim; Fiscal Year: 2007
    ..The fourth aim will test if mechanisms involved in proteolytic processing of titin are impaired with aging. ..