PAT R LEVITT

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Neuroscience. Sealing cortical cell fate
    Pat Levitt
    Vanderbilt Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University, Nashville, TN 37203, USA
    Science 303:48-9. 2004
  2. ncbi request reprint Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4)
    Pat Levitt
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA
    Biol Psychiatry 60:534-7. 2006
  3. ncbi request reprint Disruption of interneuron development
    Pat Levitt
    Vanderbilt University, Vanderbilt Kennedy Center for Research on Human Development, Nashville, Tennessee 37203, USA
    Epilepsia 46:22-8. 2005
  4. ncbi request reprint Developmental neurobiology and clinical disorders: lost in translation?
    Pat Levitt
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA
    Neuron 46:407-12. 2005
  5. ncbi request reprint Regulation of neocortical interneuron development and the implications for neurodevelopmental disorders
    Pat Levitt
    Vanderbilt Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University, Nashville, TN 37203, USA
    Trends Neurosci 27:400-6. 2004
  6. pmc Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain
    Matthew C Judson
    Graduate Program in Neuroscience, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    J Comp Neurol 513:511-31. 2009
  7. pmc A genetic variant that disrupts MET transcription is associated with autism
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37203, USA
    Proc Natl Acad Sci U S A 103:16834-9. 2006
  8. ncbi request reprint Disruption of cerebral cortex MET signaling in autism spectrum disorder
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37203, USA
    Ann Neurol 62:243-50. 2007
  9. doi request reprint Association of MET with social and communication phenotypes in individuals with autism spectrum disorder
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
    Am J Med Genet B Neuropsychiatr Genet 153:438-46. 2010
  10. pmc Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity, and spatial memory deficit
    Shenfeng Qiu
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 8548, USA
    Biol Psychiatry 68:197-204. 2010

Detail Information

Publications34

  1. ncbi request reprint Neuroscience. Sealing cortical cell fate
    Pat Levitt
    Vanderbilt Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University, Nashville, TN 37203, USA
    Science 303:48-9. 2004
  2. ncbi request reprint Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4)
    Pat Levitt
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA
    Biol Psychiatry 60:534-7. 2006
    ..RGS4 is an example of a molecule that may underlie increased vulnerability through either genetic or non-genetic mechanisms, which we suggest may be typical of other genes in a complex, polygenic disorder such as schizophrenia...
  3. ncbi request reprint Disruption of interneuron development
    Pat Levitt
    Vanderbilt University, Vanderbilt Kennedy Center for Research on Human Development, Nashville, Tennessee 37203, USA
    Epilepsia 46:22-8. 2005
    ..It is suggested that disruption of GABAergic interneuron development may represent a common point of convergence underlying the etiologies of many of these developmental disorders...
  4. ncbi request reprint Developmental neurobiology and clinical disorders: lost in translation?
    Pat Levitt
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA
    Neuron 46:407-12. 2005
    ..This can occur through an improved delineation of pathophysiological characteristics unique to specific complex disorders and the application of this information to the refinement of the most relevant model systems...
  5. ncbi request reprint Regulation of neocortical interneuron development and the implications for neurodevelopmental disorders
    Pat Levitt
    Vanderbilt Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University, Nashville, TN 37203, USA
    Trends Neurosci 27:400-6. 2004
    ....
  6. pmc Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain
    Matthew C Judson
    Graduate Program in Neuroscience, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    J Comp Neurol 513:511-31. 2009
    ..Collectively, these data suggest that Met signaling may be necessary for the appropriate wiring of forebrain circuits, with particular relevance to the social and emotional dimensions of behavior...
  7. pmc A genetic variant that disrupts MET transcription is associated with autism
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37203, USA
    Proc Natl Acad Sci U S A 103:16834-9. 2006
    ..These data implicate reduced MET gene expression in autism susceptibility, providing evidence of a previously undescribed pathophysiological basis for this behaviorally and medically complex disorder...
  8. ncbi request reprint Disruption of cerebral cortex MET signaling in autism spectrum disorder
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37203, USA
    Ann Neurol 62:243-50. 2007
    ..Here we examined expression levels of MET and members of the MET signaling pathway in postmortem cerebral cortex from ASD cases and healthy control subjects...
  9. doi request reprint Association of MET with social and communication phenotypes in individuals with autism spectrum disorder
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
    Am J Med Genet B Neuropsychiatr Genet 153:438-46. 2010
    ..These data indicate that the MET C allele influences at least two of the three domains of the autism triad...
  10. pmc Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity, and spatial memory deficit
    Shenfeng Qiu
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 8548, USA
    Biol Psychiatry 68:197-204. 2010
    ..Here, we demonstrate a critical role of LAMP in hippocampal-dependent synaptic physiology and behavior...
  11. ncbi request reprint Prenatal cocaine exposure specifically alters spontaneous alternation behavior
    Barbara L Thompson
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 8548, USA
    Behav Brain Res 164:107-16. 2005
    ....
  12. pmc The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders
    Pat Levitt
    Vanderbilt Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 119:747-54. 2009
    ....
  13. ncbi request reprint Waved-1 mutant mice are hypersensitive to the locomotor actions of cocaine
    Gregg D Stanwood
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Synapse 61:259-62. 2007
    ..These data indicate that adult Wa-1 mice are hypersensitive to the locomotor effects of cocaine and provide a new potential link between neurodevelopmental processes and adult psychostimulant responsiveness...
  14. pmc Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biol Psychiatry 63:32-41. 2008
    ..The central role of RGS4 in regulating signaling via Gi/o coupled neurotransmitter receptors led us to hypothesize that there may be RGS4 genotypes predictive of specific disease phenotypes and antipsychotic treatment responses...
  15. ncbi request reprint Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions
    Daniel B Campbell
    Vanderbilt University, 8114 MRB3, 465 21st Ave South, Nashville, TN 37232, USA
    Pediatrics 123:1018-24. 2009
    ....
  16. pmc Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments
    Elizabeth Haldeman Catania
    Neuroscience Graduate Program, Vanderbilt University, Nashville, TN 37232, USA
    Behav Brain Res 188:380-90. 2008
    ..Genetic deletion of Lsamp may thus cause circumscribed changes in the fine connectivity of specific circuits that underlie these behaviors...
  17. pmc Association of RGS2 and RGS5 variants with schizophrenia symptom severity
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Schizophr Res 101:67-75. 2008
    ..3-1q31. Due to overlapping cellular functions and chromosomal proximity, we hypothesized that multiple RGS genes may contribute to schizophrenia severity and treatment responsiveness...
  18. pmc Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Autism Res 1:159-68. 2008
    ..These data further support our hypothesis that genetic susceptibility impacting multiple components of the MET signaling pathway contributes to ASD risk...
  19. ncbi request reprint Structural and functional maturation of the developing primate brain
    Pat Levitt
    John F Kennedy Center for Research on Human Development, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37203, USA
    J Pediatr 143:S35-45. 2003
    ....
  20. ncbi request reprint Prenatal exposure to cocaine produces unique developmental and long-term adaptive changes in dopamine D1 receptor activity and subcellular distribution
    Gregg D Stanwood
    Vanderbilt Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Neurosci 27:152-7. 2007
    ....
  21. ncbi request reprint Genetic or pharmacological inactivation of the dopamine D1 receptor differentially alters the expression of regulator of G-protein signalling (Rgs) transcripts
    Gregg D Stanwood
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville TN 37203, USA
    Eur J Neurosci 24:806-18. 2006
    ..These data suggest that an absolute absence of D1R signalling (Drd1a-KO) and hypomorphic D1R signalling (prenatal cocaine) produce common alterations in neuronal morphology, but distinct outcomes in molecular neuroadaptations...
  22. ncbi request reprint Distinct domains of the limbic system-associated membrane protein (LAMP) mediate discrete effects on neurite outgrowth
    Kathie L Eagleson
    John F Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Mol Cell Neurosci 24:725-40. 2003
    ..The data suggest that LAMP may serve as a bifunctional guidance molecule, with distinct structural domains contributing to the promotion and inhibition of neurite outgrowth...
  23. ncbi request reprint Drug exposure early in life: functional repercussions of changing neuropharmacology during sensitive periods of brain development
    Gregg D Stanwood
    Vanderbilt Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University, 8110A Medical Research Building III, Nashville, TN 37232 8548, USA
    Curr Opin Pharmacol 4:65-71. 2004
    ..As a result, children exposed to drugs pre- or postnatally might respond abnormally to therapeutics used to treat the very disorders that they later exhibit as a result of their previous drug exposure...
  24. ncbi request reprint Characterization of the genomic structure of the mouse limbic system-associated membrane protein (Lsamp) gene
    Aurea F Pimenta
    John F Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Genomics 83:790-801. 2004
    ....
  25. ncbi request reprint Autism and 15q11-q13 disorders: behavioral, genetic, and pathophysiological issues
    Elisabeth M Dykens
    Department of Psychology and Human Development, Vanderbilt Kennedy Center for Research on Human Development, 230 Appleton Place, Peabody Box 40, Nashville, TN 37203, USA
    Ment Retard Dev Disabil Res Rev 10:284-91. 2004
    ....
  26. ncbi request reprint Anatomical abnormalities in dopaminoceptive regions of the cerebral cortex of dopamine D1 receptor mutant mice
    Gregg D Stanwood
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA
    J Comp Neurol 487:270-82. 2005
    ....
  27. ncbi request reprint Region- and age-specific deficits in gamma-aminobutyric acidergic neuron development in the telencephalon of the uPAR(-/-) mouse
    Kathie L Eagleson
    Vanderbilt Kennedy Center for Research on Human Development Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Comp Neurol 489:449-66. 2005
    ..Thus, an interplay between complex genetic factors and the environment may influence the phenotypic impact of the uPAR mutation both pre- and postnatally...
  28. ncbi request reprint Regional expression of brain derived neurotrophic factor (BDNF) is correlated with dynamic patterns of promoter methylation in the developing mouse forebrain
    Kathleen E Dennis
    Vanderbilt Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University School of Medicine, 465 21st Avenue S MRBIII, Rm 8114, Nashville, TN 37232, USA
    Brain Res Mol Brain Res 140:1-9. 2005
    ..These studies demonstrate that DNA methylation of this regulatory region may be an important mechanism controlling differential expression of BDNF during forebrain development...
  29. ncbi request reprint Dissociation of corticothalamic and thalamocortical axon targeting by an EphA7-mediated mechanism
    Masaaki Torii
    Vanderbilt Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37203, USA
    Neuron 48:563-75. 2005
    ..Our results support a model in which EphA/ephrin-A signaling controls independently the precision with which CT and TC projections develop, yet is essential for establishing their topographic reciprocity...
  30. pmc Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain
    Elizabeth A D Hammock
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neural Dev 5:32. 2010
    ..A cell-specific microarray profiling study revealed a set of transcription factors that are highly expressed in embryonic C. elegans GABAergic neurons...
  31. ncbi request reprint Applications of gene targeting technology to mental retardation and developmental disability research
    Aurea F Pimenta
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA
    Ment Retard Dev Disabil Res Rev 11:295-302. 2005
    ..In this article, we reviewed gene targeting methodologies with emphasis on applications to CNS development and neurodevelopmental disorders...
  32. ncbi request reprint Serotonin modulates the response of embryonic thalamocortical axons to netrin-1
    Alexandre Bonnin
    Department of Pharmacology, Vanderbilt University, 465 21st Ave South, Nashville, Tennessee 37232, USA
    Nat Neurosci 10:588-97. 2007
    ..These data demonstrate that serotonergic signaling has a previously unrecognized role in the modulation of axonal responsiveness to a classic guidance cue...
  33. ncbi request reprint Regionally restricted expression of the transcription factor c-myc intron 1 binding protein during brain development
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Comp Neurol 467:581-92. 2003
    ..5 to E14.5; N-myc was absent from the telencephalon by E15.5. The specificity and timing of mibp1 expression in the cerebral cortex suggests a role in maintaining a state of neuronal differentiation in the dorsal telencephalon...
  34. pmc Prenatal exposure to drugs: effects on brain development and implications for policy and education
    Barbara L Thompson
    Department of Pharmacology, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232, USA
    Nat Rev Neurosci 10:303-12. 2009
    ..It is important to close the gap between what science tells us about the impact of prenatal drug exposure on the fetus and the mother and what we do programmatically with regard to at-risk populations...

Research Grants10

  1. FETAL COCAINE AND GENE EXPRESSION DEFECTS IN FOREBRAIN
    Pat Levitt; Fiscal Year: 2002
    ..abstract_text> ..
  2. Development of Reciprocal Neural Circuitry
    Pat Levitt; Fiscal Year: 2007
    ....
  3. John F. Kennedy Center for Mental Retardation
    Pat Levitt; Fiscal Year: 2007
    ..Dr. Harrell serves as Director of Core C, with five statistical and one database and methodology consultants to support the efforts of 84 VKC Investigators. ..
  4. Neurodevelopmental Mechanisms of Social Behavior
    Pat Levitt; Fiscal Year: 2007
    ....
  5. Biobehavioral Intervention in Developmental Disabilities(RMI)
    Pat Levitt; Fiscal Year: 2007
    ..The program will facilitate ongoing, interdisciplinary application of interventions, either behavioral (e.g. cognitive training) or biological (e.g. pharmacological), in the community. ..
  6. 16th Biennial Meeting of the International Society for Developmental Neurobiology
    Pat Levitt; Fiscal Year: 2006
    ..Such interactions are essential if we are to attack these problems in a cohesive, rational fashion. ..