Lynne A Lapierre

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Rab11b resides in a vesicular compartment distinct from Rab11a in parietal cells and other epithelial cells
    Lynne A Lapierre
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Exp Cell Res 290:322-31. 2003
  2. pmc Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial cells
    Lynne A Lapierre
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232 0443, USA
    Exp Cell Res 318:103-13. 2012
  3. pmc Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells
    Lynne A Lapierre
    Section of Surgical Sciences and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mol Biol Cell 23:2302-18. 2012
  4. ncbi request reprint Rab11-FIP2 regulates differentiable steps in transcytosis
    Nicole A Ducharme
    Vanderbilt Univ School of Medicine, Dept of Surgery, Epithelial Biology Program, 4160A MRB III, 465 21st St S, Nashville, TN 37232 2733, USA
    Am J Physiol Cell Physiol 293:C1059-72. 2007
  5. pmc MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells
    Nicole A Ducharme
    Department of Surgery and Cell and Developmental Biology, Vanderbilt University School of Medicine, Vanderbilt Ingram Cancer Center, and the Nashville VA Medical Center, Nashville, TN 37232, USA
    Mol Biol Cell 17:3625-37. 2006
  6. pmc Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex
    Melissa A Farrow
    Department of Pathology, Microbiology, and Immunology, Chemical and Physical Biology Program, Department of Surgery, Epithelial Biology Center, Department of Medicine, and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232
    Proc Natl Acad Sci U S A 110:18674-9. 2013
  7. pmc RhoB plays an essential role in CXCR2 sorting decisions
    Nicole F Neel
    Department of Veterans Affairs, Nashville, TN 37212 2637, USA
    J Cell Sci 120:1559-71. 2007
  8. pmc Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis
    Zheng Cao
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Mol Cell Proteomics 7:1651-67. 2008
  9. ncbi request reprint Dynamics of the apical plasma membrane recycling system during cell division
    Karen C Hobdy-Henderson
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Traffic 4:681-93. 2003
  10. pmc Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis
    Guo Huang Fan
    Department of Veterans Affairs, Nashville, Tennessee 37212 2637, USA
    Mol Biol Cell 15:2456-69. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Rab11b resides in a vesicular compartment distinct from Rab11a in parietal cells and other epithelial cells
    Lynne A Lapierre
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Exp Cell Res 290:322-31. 2003
    ..Thus, while Rab11a and Rab11b share high sequence homology, they appear to reside within distinct vesicle compartments...
  2. pmc Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial cells
    Lynne A Lapierre
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232 0443, USA
    Exp Cell Res 318:103-13. 2012
    ..These findings indicate that caveolin-1 is coordinately regulated with Rab11a within the apical recycling system of polarized epithelial cells, suggesting that the two proteins are components of the same pathway...
  3. pmc Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells
    Lynne A Lapierre
    Section of Surgical Sciences and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mol Biol Cell 23:2302-18. 2012
    ..These results indicate that Ser-227 phosphorylation of Rab11-FIP2 regulates the composition of both adherens and tight junctions and is intimately involved in the regulation of polarity in epithelial cells...
  4. ncbi request reprint Rab11-FIP2 regulates differentiable steps in transcytosis
    Nicole A Ducharme
    Vanderbilt Univ School of Medicine, Dept of Surgery, Epithelial Biology Program, 4160A MRB III, 465 21st St S, Nashville, TN 37232 2733, USA
    Am J Physiol Cell Physiol 293:C1059-72. 2007
    ..The results indicate that Rab11-FIP2 regulates trafficking at multiple points within the apical recycling system of polarized cells...
  5. pmc MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells
    Nicole A Ducharme
    Department of Surgery and Cell and Developmental Biology, Vanderbilt University School of Medicine, Vanderbilt Ingram Cancer Center, and the Nashville VA Medical Center, Nashville, TN 37232, USA
    Mol Biol Cell 17:3625-37. 2006
    ..These results indicate that phosphorylation of Rab11-FIP2 on serine 227 by MARK2 regulates an alternative pathway modulating the establishment of epithelial polarity...
  6. pmc Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex
    Melissa A Farrow
    Department of Pathology, Microbiology, and Immunology, Chemical and Physical Biology Program, Department of Surgery, Epithelial Biology Center, Department of Medicine, and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232
    Proc Natl Acad Sci U S A 110:18674-9. 2013
    ..The efficacy of DPI and NAC provides proof of concept that chemical attenuation of ROS could serve as a viable strategy for protecting the colonic mucosa of patients with CDI. ..
  7. pmc RhoB plays an essential role in CXCR2 sorting decisions
    Nicole F Neel
    Department of Veterans Affairs, Nashville, TN 37212 2637, USA
    J Cell Sci 120:1559-71. 2007
    ..We conclude that oscillation of RhoB GTPase activity is essential for appropriate sorting decisions, and for directing CXCR2 degradation and recycling--events that are required for optimal chemotaxis...
  8. pmc Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis
    Zheng Cao
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Mol Cell Proteomics 7:1651-67. 2008
    ....
  9. ncbi request reprint Dynamics of the apical plasma membrane recycling system during cell division
    Karen C Hobdy-Henderson
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Traffic 4:681-93. 2003
    ..These results indicate that critical components of the apical recycling system remain associated on vesicles throughout the cell cycle and may provide a means for rapid re-establishment of plasma membrane components after mitosis...
  10. pmc Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis
    Guo Huang Fan
    Department of Veterans Affairs, Nashville, Tennessee 37212 2637, USA
    Mol Biol Cell 15:2456-69. 2004
    ....
  11. pmc Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking
    Heinrich J G Matthies
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Neurosci 30:7863-77. 2010
    ..Our data demonstrate that AMPH leads to an increase of NET in endosomes of single boutons and varicosities in a Rab11-dependent manner...
  12. ncbi request reprint Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling
    Lynne A Lapierre
    Dept of Surgery, Vanderbilt Univ School of Medicine, 4160A MRB III, 465 21st St S, Nashville, TN 37232 2733, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1249-62. 2007
    ..This study, which represents the first proteomic analysis of an immunoisolated vesicle population from native human tissue, demonstrates the diversity of putative regulators of the apical recycling system...
  13. pmc Rab25 regulates integrin expression in polarized colonic epithelial cells
    Moorthy Krishnan
    Section of Surgical Sciences and the Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mol Biol Cell 24:818-31. 2013
    ..The results suggest that Rab25 controls intestinal cell polarity through the regulation of gene expression...
  14. ncbi request reprint Differential regulation of CXCR2 trafficking by Rab GTPases
    Guo Huang Fan
    Department of Veterans Affairs, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Blood 101:2115-24. 2003
    ..Our data suggest that the intracellular trafficking of CXCR2 is differentially regulated by Rab proteins...
  15. ncbi request reprint The pericentriolar recycling endosome plays a key role in Vpu-mediated enhancement of HIV-1 particle release
    Vasundhara Varthakavi
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232 2581, USA
    Traffic 7:298-307. 2006
    ..These studies indicate that Vpu and HIV-2 envelope glycoprotein enhance particle release via a common mechanism that requires the activity of the pericentriolar recycling endosome...
  16. pmc Alternative splicing in class V myosins determines association with Rab10
    Joseph T Roland
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232 2733, USA
    J Biol Chem 284:1213-23. 2009
    ..These results indicate that Rab GTPases regulate diverse endocytic trafficking pathways through recruitment of multiple myosin V isoforms...
  17. pmc Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent
    Lynne A Lapierre
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cytoskeleton (Hoboken) 68:97-111. 2011
    ..Thus, depolymerization of microtubules may be a potent therapeutic target for cancer therapy through the reversal of the invasive phenotype of certain cancer cells...
  18. pmc Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism
    Nicole M Chumbler
    Chemical and Physical Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS Pathog 8:e1003072. 2012
    ..difficile - associated disease...
  19. ncbi request reprint Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation
    Michael R Lang
    Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Nat Genet 38:1198-203. 2006
    ..As SEC23A lesions cause the cranio-lenticulo-sutural dysplasia syndrome, crusher provides the first vertebrate model system that links the biology of endoplasmic reticulum to Golgi trafficking with a clinically relevant dysmorphology...
  20. pmc Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas
    Ki Taek Nam
    Nashville Department of Veterans Affairs Medical Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2733, USA
    J Clin Invest 120:840-9. 2010
    ..Taken together, these results suggest that Rab25 may function as a tumor suppressor in intestinal epithelial cells through regulation of protein trafficking to the cell surface...
  21. doi request reprint Rab11-FIP2 Interaction with MYO5B Regulates Movement of Rab11a-Containing Recycling Vesicles
    Jenny C Schafer
    Section of Surgical Sciences and the Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Traffic 15:292-308. 2014
    ..These results support a critical role for the interaction of MYO5B with Rab11-FIP2 in stabilizing the functional complex with Rab11a, which regulates dynamic movements of membrane recycling vesicles. ..
  22. pmc Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation
    Lydia E Wroblewski
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2279, USA
    Gastroenterology 136:236-46. 2009
    ..We determined whether MLCK was activated by H pylori and defined the mechanisms through which such activation dysregulates gastric epithelial barrier function...
  23. ncbi request reprint Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus
    Brent T Steadman
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia and the Augusta Veterans Affairs Medical Center, Augusta, Georgia 30912, USA
    J Biol Chem 277:30165-76. 2002
    ..We propose that AKAP350 is responsible for sequestration of TACC4 to the centrosome in interphase, whereas a separate TACC4 domain results in functional localization of TACC4 to the spindle apparatus in mitotic cells...
  24. ncbi request reprint Interactions of myosin vb with rab11 family members and cargoes traversing the plasma membrane recycling system
    Lynne A Lapierre
    Methods Enzymol 403:715-23. 2005
    ..Expression of myosin Vb tail represents a powerful provocative test for the trafficking of cargoes through Rab11-containing plasma membrane recycling systems...
  25. ncbi request reprint Assessment of Rab11-FIP2 interacting proteins in vitro
    Nicole A Ducharme
    Methods Enzymol 403:706-15. 2005
    ..We then broaden this application to assess binding of Rab11-FIP2 with myosin Vb and homodimerization of Rab11-FIP2...