Patricia Labosky

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Loss of Foxd3 results in decreased β-cell proliferation and glucose intolerance during pregnancy
    Jennifer L Plank
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0494, USA
    Endocrinology 152:4589-600. 2011
  2. ncbi Regulation of embryonic stem cell self-renewal and pluripotency by Foxd3
    Ying Liu
    Department of Cell and Developmental Biology, Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0494, USA
    Stem Cells 26:2475-84. 2008
  3. ncbi Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation
    Jennifer L Plank
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 349:321-30. 2011
  4. ncbi Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo
    Lynn A Hanna
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6058, USA
    Genes Dev 16:2650-61. 2002
  5. ncbi Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas
    Hemashi K Perera
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104 6058, USA
    Gene Expr Patterns 6:971-7. 2006
  6. ncbi Requirement for Foxd3 in the maintenance of neural crest progenitors
    Lu Teng
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Development 135:1615-24. 2008
  7. ncbi Neural crest stem cells
    Lu Teng
    Department of Cell and Developmental Biology, 1109 BRBII/III, 421 Curie Blvd, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6058, USA
    Adv Exp Med Biol 589:206-12. 2006
  8. ncbi Foxd3 is required in the trophoblast progenitor cell lineage of the mouse embryo
    Dennie M Tompers
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104 6058, USA
    Dev Biol 285:126-37. 2005
  9. ncbi FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development
    Aaron B Steiner
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 133:4827-38. 2006
  10. ncbi Endocardial cells are a distinct endothelial lineage derived from Flk1+ multipotent cardiovascular progenitors
    Andrew M Misfeldt
    Department of Pediatrics, Division of Cardiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Dev Biol 333:78-89. 2009

Research Grants

  1. ANALYSIS OF WINGED HELIX GENES IN DEVELOPMENT OF THE CNS
    Patricia Labosky; Fiscal Year: 2003
  2. Neural crest formation and maintenance of multipotency
    Patricia Labosky; Fiscal Year: 2009

Collaborators

  • Ying Liu
  • Jennifer L Plank
  • Victoria Bautch
  • Thomas L Jetton
  • Lu Teng
  • Andrew M Misfeldt
  • Qiaohong Wang
  • Aaron B Steiner
  • Hemashi K Perera
  • Dennie M Tompers
  • Daniel S Kessler
  • Ruth K Foreman
  • Lynn A Hanna
  • H Scott Baldwin
  • Scott C Boyle
  • Kevin L Tompkins
  • Audrey Y Frist
  • Nathan A Mundell
  • James W Walters
  • Meredith E Caldwell
  • Sergey Yaklichkin
  • Julie L Lefebvre
  • Qun Lu
  • Liliam Pineda-Salgado
  • Eileen C Piwarzyk
  • Mina Peshavaria
  • Mark J Engleka
  • Daniel Hayes-Patterson
  • Monika Kumanova
  • Illya A Tarasenko

Detail Information

Publications10

  1. ncbi Loss of Foxd3 results in decreased β-cell proliferation and glucose intolerance during pregnancy
    Jennifer L Plank
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0494, USA
    Endocrinology 152:4589-600. 2011
    ..Together, these data place Foxd3 upstream of several pathways critical for β-cell mass expansion in vivo...
  2. ncbi Regulation of embryonic stem cell self-renewal and pluripotency by Foxd3
    Ying Liu
    Department of Cell and Developmental Biology, Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0494, USA
    Stem Cells 26:2475-84. 2008
    ..We present a model for the role of Foxd3 in repressing differentiation, promoting self-renewal, and maintaining survival of mouse ESCs. Disclosure of potential conflicts of interest is found at the end of this article...
  3. ncbi Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation
    Jennifer L Plank
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 349:321-30. 2011
    ..Together, these data demonstrate that the neural crest is a critical regulator of beta cell development on two levels: by negatively regulating beta cell proliferation and by promoting beta cell maturation...
  4. ncbi Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo
    Lynn A Hanna
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6058, USA
    Genes Dev 16:2650-61. 2002
    ..These results establish Foxd3 as a factor required for the maintenance of progenitor cells in the mammalian embryo...
  5. ncbi Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas
    Hemashi K Perera
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104 6058, USA
    Gene Expr Patterns 6:971-7. 2006
    ..Foxd3 is differentially localized in a rat model of diabetes: it is nuclear in ZDF rats but cytoplasmic in their lean counterparts. Foxd3 is nuclear in Lep(Ob/Ob) mice...
  6. ncbi Requirement for Foxd3 in the maintenance of neural crest progenitors
    Lu Teng
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Development 135:1615-24. 2008
    ....
  7. ncbi Neural crest stem cells
    Lu Teng
    Department of Cell and Developmental Biology, 1109 BRBII/III, 421 Curie Blvd, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6058, USA
    Adv Exp Med Biol 589:206-12. 2006
    ....
  8. ncbi Foxd3 is required in the trophoblast progenitor cell lineage of the mouse embryo
    Dennie M Tompers
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104 6058, USA
    Dev Biol 285:126-37. 2005
    ..Moreover, this provides support for the hypothesis that there are conserved molecular mechanisms for maintaining the self-renewing properties of diverse progenitor cell types...
  9. ncbi FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development
    Aaron B Steiner
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 133:4827-38. 2006
    ..Therefore, FoxD3 is required for Nodal expression in the Spemann organizer and this function is essential for dorsal mesoderm formation...
  10. ncbi Endocardial cells are a distinct endothelial lineage derived from Flk1+ multipotent cardiovascular progenitors
    Andrew M Misfeldt
    Department of Pediatrics, Division of Cardiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Dev Biol 333:78-89. 2009
    ..Taken together, these studies emphasize that the endocardium is a unique cardiac lineage and provides further evidence that endocardium and myocardium are derived from a common precursor...

Research Grants12

  1. ANALYSIS OF WINGED HELIX GENES IN DEVELOPMENT OF THE CNS
    Patricia Labosky; Fiscal Year: 2003
    ..This model provides an important experimental paradigm to study general mechanisms of developmental regulation. ..
  2. Neural crest formation and maintenance of multipotency
    Patricia Labosky; Fiscal Year: 2009
    ....