Zeljka Korade

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. doi request reprint Programmed to be human?
    Zeljka Korade
    Department of Psychiatry and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232, USA Electronic address
    Neuron 81:224-6. 2014
  2. pmc Wnt signaling as a potential therapeutic target for frontotemporal dementia
    Zeljka Korade
    Department of Psychiatry and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232, USA
    Neuron 71:955-7. 2011
  3. ncbi request reprint Molecular consequences of altered neuronal cholesterol biosynthesis
    Zeljka Korade
    Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Neurosci Res 87:866-75. 2009
  4. pmc NRIF is a regulator of neuronal cholesterol biosynthesis genes
    Zeljka Korade
    Department of Biochemistry, Vanderbilt University School of Medicine, 8124A MRB III, Nashville, TN 37232, USA
    J Mol Neurosci 38:152-8. 2009
  5. pmc DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model
    Libin Xu
    Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA
    Neurobiol Dis 45:923-9. 2012
  6. pmc Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells
    Libin Xu
    Department of Chemistry and Vanderbilt Institute of Chemical Biology and, Vanderbilt University, Nashville, TN 37235, USA
    J Lipid Res 54:1135-43. 2013
  7. pmc Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome
    Zeljka Korade
    Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA
    J Lipid Res 51:3259-69. 2010
  8. pmc Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome
    Zeljka Korade
    Department of Psychiatry and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37235, USA
    J Inherit Metab Dis 36:113-22. 2013
  9. pmc p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17
    Rajappa S Kenchappa
    Department of Biochemistry and Center for Molecular Neuroscience, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Biol Chem 285:20358-68. 2010
  10. pmc Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome
    Katherine Windsor
    Departments of Chemistry, Vanderbilt University, Nashville, TN and
    J Lipid Res 54:2842-50. 2013

Collaborators

Detail Information

Publications17

  1. doi request reprint Programmed to be human?
    Zeljka Korade
    Department of Psychiatry and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232, USA Electronic address
    Neuron 81:224-6. 2014
    ..Similar changes are not observed in the nonhuman primate-is this what makes us human?..
  2. pmc Wnt signaling as a potential therapeutic target for frontotemporal dementia
    Zeljka Korade
    Department of Psychiatry and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232, USA
    Neuron 71:955-7. 2011
    ..New data by Geschwind and colleagues in this issue of Neuron uncovered that the Wnt/FZD2 signaling pathway is an early and critical contributor to disease pathology...
  3. ncbi request reprint Molecular consequences of altered neuronal cholesterol biosynthesis
    Zeljka Korade
    Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Neurosci Res 87:866-75. 2009
    ....
  4. pmc NRIF is a regulator of neuronal cholesterol biosynthesis genes
    Zeljka Korade
    Department of Biochemistry, Vanderbilt University School of Medicine, 8124A MRB III, Nashville, TN 37232, USA
    J Mol Neurosci 38:152-8. 2009
    ..Our combined in vitro and in vivo studies suggest that hippocampal neuronal cholesterol biosynthesis is regulated through the p75NTR interacting factor NRIF...
  5. pmc DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model
    Libin Xu
    Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA
    Neurobiol Dis 45:923-9. 2012
    ..The future studies will test if antioxidant supplementation will ameliorate some of the clinical symptoms associated with this devastating disease...
  6. pmc Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells
    Libin Xu
    Department of Chemistry and Vanderbilt Institute of Chemical Biology and, Vanderbilt University, Nashville, TN 37235, USA
    J Lipid Res 54:1135-43. 2013
    ....
  7. pmc Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome
    Zeljka Korade
    Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA
    J Lipid Res 51:3259-69. 2010
    ....
  8. pmc Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome
    Zeljka Korade
    Department of Psychiatry and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37235, USA
    J Inherit Metab Dis 36:113-22. 2013
    ....
  9. pmc p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17
    Rajappa S Kenchappa
    Department of Biochemistry and Center for Molecular Neuroscience, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Biol Chem 285:20358-68. 2010
    ....
  10. pmc Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome
    Katherine Windsor
    Departments of Chemistry, Vanderbilt University, Nashville, TN and
    J Lipid Res 54:2842-50. 2013
    ..More broadly, the alkynyl lipid library would facilitate exploration of lipid peroxidation's role in specific biological processes in numerous diseases. ..
  11. doi request reprint Antioxidant supplementation ameliorates molecular deficits in Smith-Lemli-Opitz syndrome
    Zeljka Korade
    Department of Psychiatry, Vanderbilt University, Nashville, Tennessee Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee
    Biol Psychiatry 75:215-22. 2014
    ..7-Dehydrocholesterol is highly reactive, giving rise to biologically active oxysterols...
  12. doi request reprint A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome
    Wei Liu
    Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235
    J Lipid Res 55:329-37. 2014
    ..The method reported here may provide a highly sensitive and high throughput way to identify at-risk populations having errors in cholesterol biosynthesis...
  13. pmc An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome
    Libin Xu
    Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA
    J Lipid Res 52:1222-33. 2011
    ..In a preliminary test, a pyrimidinol antioxidant was found to effectively suppress the formation of DHCEO in SLOS fibroblasts...
  14. pmc Lipid rafts, cholesterol, and the brain
    Zeljka Korade
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neuropharmacology 55:1265-73. 2008
    ....
  15. pmc Oxysterols from free radical chain oxidation of 7-dehydrocholesterol: product and mechanistic studies
    Libin Xu
    Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
    J Am Chem Soc 132:2222-32. 2010
    ....
  16. pmc Oxidative stress and glutathione response in tissue cultures from persons with major depression
    Sara A Gibson
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
    J Psychiatr Res 46:1326-32. 2012
    ..These studies support the role of oxidative stress in the pathophysiology of MDD. Further confirmation of these findings could lead to the development of novel antioxidant approaches for the treatment of depression...
  17. doi request reprint Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype
    Choya Yoon
    Department of Biochemistry, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Neurosci 28:3738-46. 2008
    ....