W N Khan

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase
    W N Khan
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 5632, USA
    Immunol Res 23:147-56. 2001
  2. ncbi Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes
    J B Petro
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 276:1715-9. 2001
  3. ncbi Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement
    J B Petro
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Exp Med 191:1745-54. 2000
  4. ncbi B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB) via a mechanism that involves diacylglycerol
    P Antony
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA
    Biochem Soc Trans 32:113-5. 2004

Collaborators

  • D W Ballard
  • J B Petro
  • P Antony
  • N P Shinners
  • J Lowe
  • G Carlesso
  • S M Rahman

Detail Information

Publications4

  1. ncbi Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase
    W N Khan
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 5632, USA
    Immunol Res 23:147-56. 2001
    ..Elucidation of these regulatory mechanisms is expected to reveal new therapeutic targets for B cell pathologies involving defects in BTK, including X-linked agammaglobulinemia (XLA)...
  2. ncbi Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes
    J B Petro
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 276:1715-9. 2001
    ..Interference with this NF-kappaB cascade may account for some of the B cell defects reported for plc-gamma2(-/-) mice, which develop an X-linked immunodeficiency-like phenotype...
  3. ncbi Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement
    J B Petro
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Exp Med 191:1745-54. 2000
    ..Taken together, these findings indicate that BTK couples IKK and NF-kappaB to the BCR. Interference with this coupling mechanism may contribute to the B cell deficiencies observed in XLA and xid...
  4. ncbi B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB) via a mechanism that involves diacylglycerol
    P Antony
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA
    Biochem Soc Trans 32:113-5. 2004
    ..Therefore the functional integrity of the BTK/PLC-gamma2/diacylglycerol signalling axis is crucial for BCR-directed activation of both transcription factors NFAT and NF-kappaB...