Dineo Khabele

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc A case of extrauterine endometrial stromal sarcoma in the colon diagnosed three decades after hysterectomy for benign disease
    Andres Ayuso
    Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Case Rep Obstet Gynecol 2013:202458. 2013
  2. pmc Thailandepsins are new small molecule class I HDAC inhibitors with potent cytotoxic activity in ovarian cancer cells: a preclinical study of epigenetic ovarian cancer therapy
    Andrew J Wilson
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Vanderbilt University Medical Center, 21st Avenue South, B 1100 Medical Center North, Nashville, TN 37232, USA
    J Ovarian Res 5:12. 2012
  3. pmc An orthotopic model of platinum-sensitive high grade serous fallopian tube carcinoma
    Dineo Khabele
    Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Int J Clin Exp Pathol 5:37-45. 2012
  4. pmc The clinicopathologic significance of p53 and BAF-250a (ARID1A) expression in clear cell carcinoma of the endometrium
    Oluwole Fadare
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mod Pathol 26:1101-10. 2013
  5. pmc Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma
    Christina E Wells
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS ONE 8:e68915. 2013
  6. pmc TR3 modulates platinum resistance in ovarian cancer
    Andrew J Wilson
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, B1100 Medical Center North, Nashville, TN 37232, USA
    Cancer Res 73:4758-69. 2013
  7. pmc The effects of the histone deacetylase inhibitor romidepsin (FK228) are enhanced by aspirin (ASA) in COX-1 positive ovarian cancer cells through augmentation of p21
    Deok Soo Son
    Department of Obstetrics and Gynecology, Meharry Medical College, Vanderbilt University School of Medicine, Nashville, TN, USA
    Cancer Biol Ther 9:928-35. 2010
  8. pmc The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells
    Andrew J Wilson
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Cancer Biol Ther 12:484-93. 2011
  9. pmc Coordinate patterns of estrogen receptor, progesterone receptor, and Wilms tumor 1 expression in the histopathologic distinction of ovarian from endometrial serous adenocarcinomas
    Oluwole Fadare
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN, USA Electronic address
    Ann Diagn Pathol 17:430-3. 2013
  10. pmc Romidepsin (FK228) combined with cisplatin stimulates DNA damage-induced cell death in ovarian cancer
    Andrew J Wilson
    Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Gynecol Oncol 127:579-86. 2012

Collaborators

Detail Information

Publications22

  1. pmc A case of extrauterine endometrial stromal sarcoma in the colon diagnosed three decades after hysterectomy for benign disease
    Andres Ayuso
    Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Case Rep Obstet Gynecol 2013:202458. 2013
    ..ESS in the colon may be treated successfully with surgical resection and progestin therapy. Indefinite surveillance is recommended to monitor for late recurrences...
  2. pmc Thailandepsins are new small molecule class I HDAC inhibitors with potent cytotoxic activity in ovarian cancer cells: a preclinical study of epigenetic ovarian cancer therapy
    Andrew J Wilson
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Vanderbilt University Medical Center, 21st Avenue South, B 1100 Medical Center North, Nashville, TN 37232, USA
    J Ovarian Res 5:12. 2012
    ..abstract:..
  3. pmc An orthotopic model of platinum-sensitive high grade serous fallopian tube carcinoma
    Dineo Khabele
    Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Int J Clin Exp Pathol 5:37-45. 2012
    ..This orthotopic model of platinum sensitive high grade serous FTCA is a viable platform to study the biology and treatment of FTCA and other STIC-related pelvic serous carcinomas...
  4. pmc The clinicopathologic significance of p53 and BAF-250a (ARID1A) expression in clear cell carcinoma of the endometrium
    Oluwole Fadare
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mod Pathol 26:1101-10. 2013
    ..P53 expression may be a negative prognostic factor in this histotype, and warrants additional studies. Loss of BAF250a expression has no prognostic significance in endometrial clear cell carcinomas...
  5. pmc Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma
    Christina E Wells
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS ONE 8:e68915. 2013
    ..These results suggest that selective inhibition of HDAC3 could be useful in treatment of CTCL by disrupting DNA replication of the rapidly cycling tumor cells, ultimately leading to cell death. ..
  6. pmc TR3 modulates platinum resistance in ovarian cancer
    Andrew J Wilson
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, B1100 Medical Center North, Nashville, TN 37232, USA
    Cancer Res 73:4758-69. 2013
    ..Moreover, we have described a treatment strategy aimed at overcoming platinum resistance by targeting TR3...
  7. pmc The effects of the histone deacetylase inhibitor romidepsin (FK228) are enhanced by aspirin (ASA) in COX-1 positive ovarian cancer cells through augmentation of p21
    Deok Soo Son
    Department of Obstetrics and Gynecology, Meharry Medical College, Vanderbilt University School of Medicine, Nashville, TN, USA
    Cancer Biol Ther 9:928-35. 2010
    ..Our study provides a potential rationale for combining ASA with HDAC inhibitors in a subset of ovarian cancers...
  8. pmc The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells
    Andrew J Wilson
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Cancer Biol Ther 12:484-93. 2011
    ..In addition, these results lend support to the inclusion of ketone-derived HDACi compounds for future development...
  9. pmc Coordinate patterns of estrogen receptor, progesterone receptor, and Wilms tumor 1 expression in the histopathologic distinction of ovarian from endometrial serous adenocarcinomas
    Oluwole Fadare
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN, USA Electronic address
    Ann Diagn Pathol 17:430-3. 2013
    ..The use of single markers for this purpose is not recommended, as each lacks optimal discriminatory power. Coordinate profiles, in general, have a high specificity but low sensitivity in this differential diagnosis. ..
  10. pmc Romidepsin (FK228) combined with cisplatin stimulates DNA damage-induced cell death in ovarian cancer
    Andrew J Wilson
    Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Gynecol Oncol 127:579-86. 2012
    ..We have shown in vitro efficacy of FK228 in ovarian cancer. Here, our goal was to evaluate FK228 combined with cisplatin in ovarian cancer in vitro and in vivo...
  11. ncbi request reprint Keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) chemokines and pro-inflammatory chemokine networks in mouse and human ovarian epithelial cancer cells
    Deok Soo Son
    Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, Tennessee 37208, USA
    Cancer Biol Ther 6:1302-12. 2007
    ..Taken together, the results indicate that KC/GRO chemokines are the principal chemokines induced by LPS and pro-inflammatory cytokines IL-1 and TNF via NFkappaB signaling in ovarian surface epithelial cancer cells...
  12. ncbi request reprint Differential vimentin expression in ovarian and uterine corpus endometrioid adenocarcinomas: diagnostic utility in distinguishing double primaries from metastatic tumors
    Mohamed M Desouki
    Departments of Pathology, Microbiology and Immunology M M D, S J K, O H, O F Obstetrics and Gynecology D K, M A C, O F, Division of Gynecologic Oncology, Vanderbilt University Medical Center, Nashville, Tennessee
    Int J Gynecol Pathol 33:274-81. 2014
    ..If validated in larger and/or different data sets, these findings may have diagnostic value in distinguishing metastatic lesions from double primary tumors involving both sites. ..
  13. pmc Expression of the oncofetal protein IGF2BP3 in endometrial clear cell carcinoma: assessment of frequency and significance
    Oluwole Fadare
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hum Pathol 44:1508-15. 2013
    ..These preliminary findings suggest that IMP3 expression may be involved in the pathogenesis of CCC and is worthy of further exploration...
  14. pmc Salpingo-oophorectomy specimens for endometrial cancer staging: a comparative analysis of representative sampling versus whole tissue processing
    Oluwole Fadare
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hum Pathol 44:643-50. 2013
    ..However, the findings in this study do not provide direct evidentiary support for routine complete processing...
  15. pmc Hdac3 is essential for the maintenance of chromatin structure and genome stability
    Srividya Bhaskara
    Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Cell 18:436-47. 2010
    ..siRNA targeting of NCOR1 and SMRT (NCOR2) increased H4K5ac and caused DNA damage, indicating that the HDAC3/NCOR/SMRT axis is critical for maintaining chromatin structure and genomic stability...
  16. pmc Tracking NF-κB activity in tumor cells during ovarian cancer progression in a syngeneic mouse model
    Andrew J Wilson
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Vanderbilt University Medical Center, B1100 Medical Center North, Nashville, TN 37232, USA
    J Ovarian Res 6:63. 2013
    ..Our objective was to track NF-kappaB signaling during ovarian cancer progression in a syngeneic mouse model using tumor cells stably expressing an NF-kappaB reporter...
  17. ncbi request reprint Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer
    Takiko Daikoku
    Department of Pediatrics, Division of Reproductive and Development Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Cancer Res 67:5285-92. 2007
    ..The ability of aspirin to inhibit EOC growth in vivo is an exciting finding because of its low cost, lack of cardiovascular side effects, and availability...
  18. ncbi request reprint Ovarian volume measurements in mice with high-resolution ultrasonography
    Andrej Lyshchik
    Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, CCC 1118 MCN, 1161 21st Ave, Nashville, TN 37232 2675, USA
    J Ultrasound Med 26:1419-25. 2007
    ..The aim of our study was to evaluate the intraobserver and interobserver variability of ovarian volume measurements in mice with high-resolution 2-dimensional ultrasonography (2DUS) and 3-dimensional ultrasonography (3DUS)...
  19. ncbi request reprint Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy
    Dineo Khabele
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, Tennessee 37208, USA
    Cancer Biol Ther 6:795-801. 2007
    ..Taken together, the present studies offer several novel findings that have direct relevance for the strategic use of inhibitors that target Class I HDACs, particularly HDAC3, in the treatment of ovarian cancer...
  20. doi request reprint Pleomorphic liposarcoma of the uterine corpus with focal smooth muscle differentiation
    Oluwole Fadare
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Int J Gynecol Pathol 30:282-7. 2011
    ..This may have adjuvant management implications for patients with these rare tumors...
  21. ncbi request reprint Evaluation of low-dose intraperitoneal interferon-alpha for palliation of ascites in patients with non-ovarian gynecologic malignancies
    Dineo Khabele
    Department of Obstetrics and Gynecology and Women s Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
    Gynecol Oncol 89:420-3. 2003
    ..Our goal was to evaluate the use of low-dose IP-IFNalpha for the palliative control of ascites in non-ovarian gynecologic malignancies, including primary peritoneal and uterine papillary serous carcinomas...