Li Kang

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice
    Li Kang
    Department of Molecular Physiology and Biophysics, Vanderbilt University, 2215 Garland Ave, Nashville, TN, 37232, USA
    Diabetologia 57:603-13. 2014
  2. pmc Hyaluronan accumulates with high-fat feeding and contributes to insulin resistance
    Li Kang
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes 62:1888-96. 2013
  3. pmc Mitochondrial antioxidative capacity regulates muscle glucose uptake in the conscious mouse: effect of exercise and diet
    Li Kang
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA
    J Appl Physiol (1985) 113:1173-83. 2012
  4. pmc Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice
    Li Kang
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes 60:416-26. 2011
  5. pmc Endothelial nitric oxide synthase is central to skeletal muscle metabolic regulation and enzymatic signaling during exercise in vivo
    Robert S Lee-Young
    Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, 2200 Pierce Ave, Nashville, TN 37232, U S A
    Am J Physiol Regul Integr Comp Physiol 298:R1399-408. 2010
  6. pmc Relaxin treatment reverses insulin resistance in mice fed a high-fat diet
    Jeffrey S Bonner
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 62:3251-60. 2013
  7. pmc Heterozygous SOD2 deletion impairs glucose-stimulated insulin secretion, but not insulin action, in high-fat-fed mice
    Li Kang
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, TN Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, U K
    Diabetes 63:3699-710. 2014
  8. pmc The physiological regulation of glucose flux into muscle in vivo
    David H Wasserman
    Department of Molecular Physiology and Biophysics and the Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Exp Biol 214:254-62. 2011
  9. pmc Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo
    Eric D Berglund
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Physiol Endocrinol Metab 299:E607-14. 2010

Detail Information

Publications9

  1. pmc Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice
    Li Kang
    Department of Molecular Physiology and Biophysics, Vanderbilt University, 2215 Garland Ave, Nashville, TN, 37232, USA
    Diabetologia 57:603-13. 2014
    ..We tested the hypotheses that genetic deletion of MMP9 in mice increases muscle ColIV, induces insulin resistance in lean mice and worsens diet-induced muscle insulin resistance...
  2. pmc Hyaluronan accumulates with high-fat feeding and contributes to insulin resistance
    Li Kang
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes 62:1888-96. 2013
    ..01 mg/kg. PEGPH20 at doses of 0.1 and 1 mg/kg reduced muscle HA to levels seen in chow-fed mice, decreased fat mass, and increased muscle glucose uptake. These findings suggest that ECM HA is a target for treatment of insulin resistance...
  3. pmc Mitochondrial antioxidative capacity regulates muscle glucose uptake in the conscious mouse: effect of exercise and diet
    Li Kang
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA
    J Appl Physiol (1985) 113:1173-83. 2012
    ..Exercise Kg was also augmented in HF-fed sod2(Tg) and mcat(Tg) mice but unchanged in HF-fed mtAO mice. In conclusion, mtROS scavenging is a key regulator of exercise-mediated MGU and this regulation depends on nutritional state...
  4. pmc Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice
    Li Kang
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes 60:416-26. 2011
    ....
  5. pmc Endothelial nitric oxide synthase is central to skeletal muscle metabolic regulation and enzymatic signaling during exercise in vivo
    Robert S Lee-Young
    Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, 2200 Pierce Ave, Nashville, TN 37232, U S A
    Am J Physiol Regul Integr Comp Physiol 298:R1399-408. 2010
    ....
  6. pmc Relaxin treatment reverses insulin resistance in mice fed a high-fat diet
    Jeffrey S Bonner
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 62:3251-60. 2013
    ..Relaxin provides a novel therapeutic approach targeting the extramyocellular barriers to insulin action, which are critical to the pathogenesis of insulin resistance. ..
  7. pmc Heterozygous SOD2 deletion impairs glucose-stimulated insulin secretion, but not insulin action, in high-fat-fed mice
    Li Kang
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, TN Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, U K
    Diabetes 63:3699-710. 2014
    ..We conclude that heterozygous SOD2 deletion in mice, a model that mimics SOD2 changes observed in diabetic humans, impairs GSIS in HF-fed mice without affecting insulin action. ..
  8. pmc The physiological regulation of glucose flux into muscle in vivo
    David H Wasserman
    Department of Molecular Physiology and Biophysics and the Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Exp Biol 214:254-62. 2011
    ..More recent research definitively shows that the distributed control paradigm more accurately defines the regulation of muscle glucose uptake as each of the three steps that define this process are important sites of flux control...
  9. pmc Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo
    Eric D Berglund
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Physiol Endocrinol Metab 299:E607-14. 2010
    ....