Jing Qiong Kang

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. doi request reprint A common susceptibility factor of both autism and epilepsy: functional deficiency of GABA A receptors
    Jing Qiong Kang
    Department of Neurology, Vanderbilt University Medical Center, 465 21st Ave, Nashville, TN 37232 8552, USA
    J Autism Dev Disord 43:68-79. 2013
  2. pmc The GABRG2 mutation, Q351X, associated with generalized epilepsy with febrile seizures plus, has both loss of function and dominant-negative suppression
    Jing Qiong Kang
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neurosci 29:2845-56. 2009
  3. pmc Slow degradation and aggregation in vitro of mutant GABAA receptor gamma2(Q351X) subunits associated with epilepsy
    Jing Qiong Kang
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212 8552, USA
    J Neurosci 30:13895-905. 2010
  4. pmc Making sense of nonsense GABA(A) receptor mutations associated with genetic epilepsies
    Jing Qiong Kang
    Department of Neurology, Vanderbilt University, Nashville, TN 37232 8552, USA
    Trends Mol Med 15:430-8. 2009
  5. pmc Two molecular pathways (NMD and ERAD) contribute to a genetic epilepsy associated with the GABA(A) receptor GABRA1 PTC mutation, 975delC, S326fs328X
    Jing Qiong Kang
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37212, USA
    J Neurosci 29:2833-44. 2009
  6. ncbi request reprint Why does fever trigger febrile seizures? GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies
    Jing Qiong Kang
    Departments of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neurosci 26:2590-7. 2006
  7. pmc Trafficking-deficient mutant GABRG2 subunit amount may modify epilepsy phenotype
    Jing Qiong Kang
    Departments of Neurology, Vanderbilt University Medical Center, Nashville, TN
    Ann Neurol 74:547-59. 2013
  8. ncbi request reprint Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation
    Jing Qiong Kang
    Department of Neurology, 8C 1 UHC, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Mol Pharmacol 64:557-69. 2003
  9. ncbi request reprint Delta subunit susceptibility variants E177A and R220H associated with complex epilepsy alter channel gating and surface expression of alpha4beta2delta GABAA receptors
    Hua Jun Feng
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neurosci 26:1499-506. 2006
  10. pmc Mutations in GABAA receptor subunits associated with genetic epilepsies
    Robert L Macdonald
    Department of Neurology, Vanderbilt University, 6140 Medical Research Building III, 465 21st Avenue, Nashville, TN 37232 8552, USA
    J Physiol 588:1861-9. 2010

Detail Information

Publications13

  1. doi request reprint A common susceptibility factor of both autism and epilepsy: functional deficiency of GABA A receptors
    Jing Qiong Kang
    Department of Neurology, Vanderbilt University Medical Center, 465 21st Ave, Nashville, TN 37232 8552, USA
    J Autism Dev Disord 43:68-79. 2013
    ..In this paper, we address the hypothesis that functional deficiency of GABAergic signaling is a potential common molecular mechanism underpinning the co-morbidity of autism and epilepsy...
  2. pmc The GABRG2 mutation, Q351X, associated with generalized epilepsy with febrile seizures plus, has both loss of function and dominant-negative suppression
    Jing Qiong Kang
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neurosci 29:2845-56. 2009
    ..Thus, we hypothesize that a likely explanation for the GEFS+ phenotype is a dominant-negative suppression of wild-type receptors by the mutant gamma2S subunit in combination with loss of mutant gamma2S subunit protein function...
  3. pmc Slow degradation and aggregation in vitro of mutant GABAA receptor gamma2(Q351X) subunits associated with epilepsy
    Jing Qiong Kang
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212 8552, USA
    J Neurosci 30:13895-905. 2010
    ....
  4. pmc Making sense of nonsense GABA(A) receptor mutations associated with genetic epilepsies
    Jing Qiong Kang
    Department of Neurology, Vanderbilt University, Nashville, TN 37232 8552, USA
    Trends Mol Med 15:430-8. 2009
    ....
  5. pmc Two molecular pathways (NMD and ERAD) contribute to a genetic epilepsy associated with the GABA(A) receptor GABRA1 PTC mutation, 975delC, S326fs328X
    Jing Qiong Kang
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37212, USA
    J Neurosci 29:2833-44. 2009
    ..The molecular mechanisms outlined here delineate a model for the pathogenesis of many PTC-generating mutations...
  6. ncbi request reprint Why does fever trigger febrile seizures? GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies
    Jing Qiong Kang
    Departments of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neurosci 26:2590-7. 2006
    ....
  7. pmc Trafficking-deficient mutant GABRG2 subunit amount may modify epilepsy phenotype
    Jing Qiong Kang
    Departments of Neurology, Vanderbilt University Medical Center, Nashville, TN
    Ann Neurol 74:547-59. 2013
    ....
  8. ncbi request reprint Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation
    Jing Qiong Kang
    Department of Neurology, 8C 1 UHC, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Mol Pharmacol 64:557-69. 2003
    ..Our work elucidates a novel capacity for Akt1 to maintain cellular integrity through a series of cysteine protease pathways and to uniquely regulate microglial activation through the modulation of membrane PS residue externalization...
  9. ncbi request reprint Delta subunit susceptibility variants E177A and R220H associated with complex epilepsy alter channel gating and surface expression of alpha4beta2delta GABAA receptors
    Hua Jun Feng
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neurosci 26:1499-506. 2006
    ....
  10. pmc Mutations in GABAA receptor subunits associated with genetic epilepsies
    Robert L Macdonald
    Department of Neurology, Vanderbilt University, 6140 Medical Research Building III, 465 21st Avenue, Nashville, TN 37232 8552, USA
    J Physiol 588:1861-9. 2010
    ....
  11. pmc mRNA surveillance and endoplasmic reticulum quality control processes alter biogenesis of mutant GABAA receptor subunits associated with genetic epilepsies
    Robert L Macdonald
    Department of Neurology Molecular Physiology and Biophysics Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 8552, USA
    Epilepsia 53:59-70. 2012
    ....
  12. ncbi request reprint The GABAA receptor gamma2 subunit R43Q mutation linked to childhood absence epilepsy and febrile seizures causes retention of alpha1beta2gamma2S receptors in the endoplasmic reticulum
    Jing Qiong Kang
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37212, USA
    J Neurosci 24:8672-7. 2004
    ..These results provide evidence that the gamma2S(R43Q) mutation impaired GABA(A) receptor function by compromising receptor trafficking and reducing surface expression...
  13. ncbi request reprint Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    Circulation 106:2973-9. 2002
    ..Erythropoietin (EPO) is a critical regulator for the proliferation of immature erythroid precursors, but its role as a potential cytoprotectant in the cerebrovasculature system has not been defined...