Junji Ichikawa

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Valproic acid potentiates both typical and atypical antipsychotic-induced prefrontal cortical dopamine release
    Junji Ichikawa
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, 1601 23rd Avenue South, The First Floor Laboratory Rm 1117, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 1052:56-62. 2005
  2. ncbi request reprint Lithium differs from anticonvulsant mood stabilizers in prefrontal cortical and accumbal dopamine release: role of 5-HT(1A) receptor agonism
    Junji Ichikawa
    Department of Psychiatry, Vanderbilt University School of Medicine, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 1049:182-90. 2005
  3. ncbi request reprint ACP-103, a 5-HT2A/2C inverse agonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens
    Zhu Li
    Psychiatry Department, Psychopharmacology Division, Vanderbilt University School of Medicine, Suite 306, 1601 23rd Ave S, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 183:144-53. 2005
  4. ncbi request reprint Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism
    Junji Ichikawa
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Brain Res 956:349-57. 2002
  5. ncbi request reprint SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens
    Stefania Bonaccorso
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Neuropsychopharmacology 27:430-41. 2002
  6. ncbi request reprint Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain
    Zhu Li
    Division of Psychopharmacology, Departments of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, USA
    Eur J Pharmacol 493:75-83. 2004
  7. ncbi request reprint Effects of divalproex and atypical antipsychotic drugs on dopamine and acetylcholine efflux in rat hippocampus and prefrontal cortex
    Mei Huang
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 1099:44-55. 2006
  8. ncbi request reprint A comparison of the effects of loxapine with ziprasidone and thioridazine on the release of dopamine and acetylcholine in the prefrontal cortex and nucleus accumbens
    Zhu Li
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 167:315-23. 2003
  9. ncbi request reprint Cholinergic modulation of basal and amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens
    Junji Ichikawa
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Brain Res 958:176-84. 2002
  10. ncbi request reprint 5-HT(2A) receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner
    Jean François Liégeois
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Brain Res 947:157-65. 2002

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Valproic acid potentiates both typical and atypical antipsychotic-induced prefrontal cortical dopamine release
    Junji Ichikawa
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, 1601 23rd Avenue South, The First Floor Laboratory Rm 1117, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 1052:56-62. 2005
    ..Furthermore, they provide a strong rationale for testing for possible clinical synergism of an APD and anticonvulsant mood-stabilizer in improving the cognitive deficits present in patients with schizophrenia and bipolar disorder...
  2. ncbi request reprint Lithium differs from anticonvulsant mood stabilizers in prefrontal cortical and accumbal dopamine release: role of 5-HT(1A) receptor agonism
    Junji Ichikawa
    Department of Psychiatry, Vanderbilt University School of Medicine, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 1049:182-90. 2005
    ..However, the combination of lithium and 5-HT(1A) blockade may result in excessive 5-HT(2A) receptor stimulation, relative to 5-HT(1A) receptor stimulation, both of which can increase prefrontal cortical DA release...
  3. ncbi request reprint ACP-103, a 5-HT2A/2C inverse agonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens
    Zhu Li
    Psychiatry Department, Psychopharmacology Division, Vanderbilt University School of Medicine, Suite 306, 1601 23rd Ave S, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 183:144-53. 2005
    ..However, pretreatment with the 5-HT(2A/2C) receptor antagonist SR46349-B with haloperidol increased both mPFC and NAC DA release, suggesting that both 5-HT(2A) and 5-HT(2C) properties may be important for atypical APD effects...
  4. ncbi request reprint Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism
    Junji Ichikawa
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Brain Res 956:349-57. 2002
    ..However, 5-HT(1A) agonism may be important only for quetiapine-induced ACh release...
  5. ncbi request reprint SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens
    Stefania Bonaccorso
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Neuropsychopharmacology 27:430-41. 2002
    ..These results suggest that 5-HT(2A/2C) antagonism may be more advantageous than selective 5-HT(2A) antagonism as an adjunct to D(2) antagonists to improve cognition and negative symptoms in schizophrenia...
  6. ncbi request reprint Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain
    Zhu Li
    Division of Psychopharmacology, Departments of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, USA
    Eur J Pharmacol 493:75-83. 2004
    ..It also suggests that the function of both the medial prefrontal cortex and hippocampus may contribute to the ability of aripiprazole to improve negative symptom and cognition...
  7. ncbi request reprint Effects of divalproex and atypical antipsychotic drugs on dopamine and acetylcholine efflux in rat hippocampus and prefrontal cortex
    Mei Huang
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 1099:44-55. 2006
    ..The clinical significance of this potentiation for the beneficial clinical effects of this combination of agents and the differences between AMS in this regard warrants further study...
  8. ncbi request reprint A comparison of the effects of loxapine with ziprasidone and thioridazine on the release of dopamine and acetylcholine in the prefrontal cortex and nucleus accumbens
    Zhu Li
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 167:315-23. 2003
    ..Moreover, loxapine, like its congener clozapine, has higher affinity for serotonin (5-HT)(2A) than dopamine D(2) receptors, in vitro, suggesting the possibility it could be an atypical APD with clozapine-like potential...
  9. ncbi request reprint Cholinergic modulation of basal and amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens
    Junji Ichikawa
    Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Brain Res 958:176-84. 2002
    ....
  10. ncbi request reprint 5-HT(2A) receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner
    Jean François Liégeois
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Brain Res 947:157-65. 2002
    ....
  11. ncbi request reprint N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors
    Zhu Li
    Psychiatry Department, Psychopharmacology Division, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Neuropsychopharmacology 30:1986-95. 2005
    ....
  12. ncbi request reprint Clozapine increases both acetylcholine and dopamine release in rat ventral hippocampus: role of 5-HT1A receptor agonism
    Young Chul Chung
    Division of Psychopharmacology, Departments of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, 1601 23rd Avenue South, The First Floor Laboratory Rm 1117, The Psychiatric Hospital at Vanderbilt, Nashville, TN 37212, USA
    Brain Res 1023:54-63. 2004
    ..The role of hippocampus in the cognitive effects of atypical APDs warrants more intensive study...
  13. ncbi request reprint Serotonin receptors: their key role in drugs to treat schizophrenia
    Herbert Y Meltzer
    Department of Psychiatry, Division of Psychopharmacology, Vanderbilt University School of Medicine, Suite 306, 1601 23rd Avenue, Nashville, TN 37212, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:1159-72. 2003
    ..g., the D3 or D4 receptor, and drugs that are selective for them...
  14. ncbi request reprint 5-HT(1A) and 5-HT(2A) receptors minimally contribute to clozapine-induced acetylcholine release in rat medial prefrontal cortex
    Junji Ichikawa
    Division of Psychopharmacology, Departments of Psychiatry and Pharmacology, Ther Psychiatric Hospital at Vanderbilt, Vanderbilt University School of Medicine, 1601 23rd Avenue South, Nashville, TN 37212, USA
    Brain Res 939:34-42. 2002
    ..These results suggest that 5-HT(1A) agonism and 5-HT(2A) antagonism, as well as DA release, contribute minimally to the ability of clozapine, and perhaps other atypical APDs, to increase ACh release in the mPFC...
  15. ncbi request reprint Atypical, but not typical, antipsychotic drugs increase cortical acetylcholine release without an effect in the nucleus accumbens or striatum
    Junji Ichikawa
    Departments of Psychiatry and Pharmacology, The Psychiatric Hospital at Vanderbilt, Vanderbilt University School of Medicine, 1601 23rd Avenue South, Nashville, TN 37212, USA
    Neuropsychopharmacology 26:325-39. 2002
    ..g., early Alzheimer's disease, by enhancing cortical cholinergic transmission...
  16. ncbi request reprint Effect of repeated administration of phencyclidine on spatial performance in an eight-arm radial maze with delay in rats and mice
    Zhu Li
    Division of Psychopharmacology, Departments of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Pharmacol Biochem Behav 75:335-40. 2003
    ..Thus, the present study failed to demonstrate that repeated administration of PCP to rats or mice produces enduring memory impairment. Factors potentially contributing to the discrepancies between various studies are discussed...
  17. ncbi request reprint 5-HT 2A receptor stimulation by DOI, a 5-HT 2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens
    Toshihide Kuroki
    Department of Neuropsychiatry, Kyushu University Graduate School of Medical Science, Maidashi 3 1 1, Higashiku, Fukuoka 812 8582, Japan
    Brain Res 972:216-21. 2003
    ..Thus, 5-HT(2A) receptor agonism potentiates AMPH-induced DA release in the mPFC and NAC...