TODD M HULGAN

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc T cell activation markers and African mitochondrial DNA haplogroups among non-Hispanic black participants in AIDS clinical trials group study 384
    Todd Hulgan
    Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS ONE 7:e43803. 2012
  2. pmc European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142
    Todd Hulgan
    Vanderbilt University, Nashville, Tennessee, USA
    AIDS 25:37-47. 2011
  3. pmc African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy
    Jeffrey A Canter
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 345 24th Ave North, Nashville, TN 37203, USA
    J Infect Dis 201:1703-7. 2010
  4. pmc Oral cyclosporin A inhibits CD4 T cell P-glycoprotein activity in HIV-infected adults initiating treatment with nucleoside reverse transcriptase inhibitors
    Todd Hulgan
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Eur J Clin Pharmacol 65:1081-8. 2009
  5. doi request reprint Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapy
    Todd Hulgan
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    J Infect Dis 197:858-66. 2008
  6. ncbi request reprint Absolute count and percentage of CD4+ lymphocytes are independent predictors of disease progression in HIV-infected persons initiating highly active antiretroviral therapy
    Todd Hulgan
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Infect Dis 195:425-31. 2007
  7. ncbi request reprint Oxidant stress and peripheral neuropathy during antiretroviral therapy: an AIDS clinical trials group study
    Todd Hulgan
    Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Acquir Immune Defic Syndr 42:450-4. 2006
  8. ncbi request reprint CD4 lymphocyte percentage predicts disease progression in HIV-infected patients initiating highly active antiretroviral therapy with CD4 lymphocyte counts >350 lymphocytes/mm3
    Todd Hulgan
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    J Infect Dis 192:950-7. 2005
  9. ncbi request reprint Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study
    Todd Hulgan
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    AIDS 19:1341-9. 2005
  10. ncbi request reprint Oral quinolones in hospitalized patients: an evaluation of a computerized decision support intervention
    T Hulgan
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, 345 24th Avenue N, Suite 105, Nashville, TN 37203, USA
    J Intern Med 256:349-57. 2004

Detail Information

Publications27

  1. pmc T cell activation markers and African mitochondrial DNA haplogroups among non-Hispanic black participants in AIDS clinical trials group study 384
    Todd Hulgan
    Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS ONE 7:e43803. 2012
    ..We explored whether additional T cell parameters in this cohort differed by mtDNA haplogroup...
  2. pmc European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142
    Todd Hulgan
    Vanderbilt University, Nashville, Tennessee, USA
    AIDS 25:37-47. 2011
    ..Mitochondrial DNA (mtDNA) influences metabolic diseases and perhaps antiretroviral therapy (ART) complications. We explored associations between European mtDNA haplogroups and metabolic changes among A5142 participants...
  3. pmc African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy
    Jeffrey A Canter
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 345 24th Ave North, Nashville, TN 37203, USA
    J Infect Dis 201:1703-7. 2010
    ..7 [95% confidence interval, 1.1-12.0]). An African mtDNA subhaplogroup is for the first time implicated in susceptibility to nucleoside reverse-transcriptase inhibitor-associated toxicity...
  4. pmc Oral cyclosporin A inhibits CD4 T cell P-glycoprotein activity in HIV-infected adults initiating treatment with nucleoside reverse transcriptase inhibitors
    Todd Hulgan
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Eur J Clin Pharmacol 65:1081-8. 2009
    ..The aim of our study was to characterize the effects of the P-glycoprotein substrate cyclosporin A on T cell P-glycoprotein activity in human immunodeficiency virus-infected participants in the AIDS Clinical Trials Group study A5138...
  5. doi request reprint Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapy
    Todd Hulgan
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    J Infect Dis 197:858-66. 2008
    ..Mitochondrial haplogroups and hemochromatosis gene (HFE) polymorphisms have been associated with ART-induced neuropathy. We assessed relationships between these variants and lipoatrophy...
  6. ncbi request reprint Absolute count and percentage of CD4+ lymphocytes are independent predictors of disease progression in HIV-infected persons initiating highly active antiretroviral therapy
    Todd Hulgan
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Infect Dis 195:425-31. 2007
    ....
  7. ncbi request reprint Oxidant stress and peripheral neuropathy during antiretroviral therapy: an AIDS clinical trials group study
    Todd Hulgan
    Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Acquir Immune Defic Syndr 42:450-4. 2006
    ..Mitochondria play a central role in regulating oxidant stress. We explored the relationships between oxidant stress and NRTI-induced peripheral neuropathy...
  8. ncbi request reprint CD4 lymphocyte percentage predicts disease progression in HIV-infected patients initiating highly active antiretroviral therapy with CD4 lymphocyte counts >350 lymphocytes/mm3
    Todd Hulgan
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    J Infect Dis 192:950-7. 2005
    ..CD4 lymphocyte percentage could add prognostic information...
  9. ncbi request reprint Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study
    Todd Hulgan
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    AIDS 19:1341-9. 2005
    ..The objective of this study was to determine if NRTI-associated peripheral neuropathy is associated with European mitochondrial haplogroups...
  10. ncbi request reprint Oral quinolones in hospitalized patients: an evaluation of a computerized decision support intervention
    T Hulgan
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, 345 24th Avenue N, Suite 105, Nashville, TN 37203, USA
    J Intern Med 256:349-57. 2004
    ..To determine whether a computerized decision support system could increase the proportion of oral quinolone antibiotic orders placed for hospitalized patients...
  11. ncbi request reprint Prescribing of contraindicated protease inhibitor and statin combinations among HIV-infected persons
    Todd Hulgan
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Acquir Immune Defic Syndr 38:277-82. 2005
    ..0% of combinations to 20.8% during the same periods (P < 0.001). Use of PIs and statins has increased in the adult TennCare population. Contraindicated combinations have decreased but remain unacceptably high...
  12. pmc Clinical factors associated with plasma F2-isoprostane levels in HIV-infected adults
    Leigh Anne Redhage
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    HIV Clin Trials 10:181-92. 2009
    ..Plasma F2-isoprostanes (F2-IsoP) reflect lipid peroxidation and oxidant stress and have been described in ART-associated toxicities. We explored factors associated with F2-IsoP in HIV-infected adults...
  13. doi request reprint Race and sex differences in antiretroviral therapy use and mortality among HIV-infected persons in care
    Diana C Lemly
    School of Medicine, Department of Biostatistics, Vanderbilt University, Nashville, TN 37203, USA
    J Infect Dis 199:991-8. 2009
    ..There are conflicting data regarding race, sex, and mortality among persons infected with human immunodeficiency virus (HIV). We studied all-cause mortality among persons in care during the highly-active antiretroviral therapy (HAART) era...
  14. ncbi request reprint Implications of T-cell P-glycoprotein activity during HIV-1 infection and its therapy
    Todd Hulgan
    Department of Medicine, Vanderbilt Medical School, Nashville, TN 37203, USA
    J Acquir Immune Defic Syndr 34:119-26. 2003
    ..To explore which of these mechanisms predominate in vivo, this study characterized relationships between T-cell P-gp activity and clinical parameters in HIV-infected adults...
  15. pmc A randomized trial of Raltegravir replacement for protease inhibitor or non-nucleoside reverse transcriptase inhibitor in HIV-infected women with lipohypertrophy
    Jordan E Lake
    Department of Medicine, University of California, Los Angeles, Los Angeles, California 90035, USA
    AIDS Patient Care STDS 26:532-40. 2012
    ..Additional insights into AT and metabolic changes in women on RAL will be provided by 48-week follow-up of the immediate-switch arm...
  16. pmc Estimating the optimal CD4 count for HIV-infected persons to start antiretroviral therapy
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Epidemiology 21:698-705. 2010
    ..We sought to expand this understanding using a novel statistical approach proposed by Robins et al...
  17. ncbi request reprint Oxidant stress is increased during treatment of human immunodeficiency virus infection
    Todd Hulgan
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    Clin Infect Dis 37:1711-7. 2003
    ..Oxidant stress associated with therapeutic control of viral replication may have important implications for long-term complications of antiretroviral therapy...
  18. pmc Highly sensitive C-reactive protein, body mass index, and serum lipids in HIV-infected persons receiving antiretroviral therapy: a longitudinal study
    Michael S Boger
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Acquir Immune Defic Syndr 52:480-7. 2009
    ..Little is known about its utility in chronic inflammatory conditions such as HIV infection. We assessed relationships between hsCRP and metabolic parameters over time in HIV-infected patients on ART...
  19. pmc Postpartum discontinuation of antiretroviral therapy and risk of maternal AIDS-defining events, non-AIDS-defining events, and mortality among a cohort of HIV-1-infected women in the United States
    Vlada V Melekhin
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    AIDS Patient Care STDS 24:279-86. 2010
    ..Larger studies with longer follow-up are indicated to assess this association...
  20. pmc Pharmacogenetics of nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy
    Asha R Kallianpur
    Department of Medicine, Vanderbilt University, 2525 West End Avenue, Suite 600, Nashville, TN 37203 31738, USA
    Pharmacogenomics 10:623-37. 2009
    ..Such investigations may facilitate the development of more effective strategies to predict, prevent and ameliorate this debilitating treatment toxicity in diverse clinical settings...
  21. pmc Cross-cohort heterogeneity encountered while validating a model for HIV disease progression among antiretroviral initiators
    Bryan E Shepherd
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
    J Clin Epidemiol 62:729-37. 2009
    ..To evaluate a model for predicting time to AIDS or death among HIV-infected persons initiating highly active antiretroviral therapy (HAART)...
  22. ncbi request reprint Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study
    David W Haas
    Program for Human Genetics, Vanderbilt University School of Medicine, 345 24th Avenue North, Nashville, TN 37203, USA
    AIDS 18:2391-400. 2004
    ..Efavirenz is metabolized by cytochrome P4502B6 (CYP2B6). We investigated whether polymorphisms in CYP2B6, CYP3A4, CYP3A5, and MDR1 were associated with efavirenz central nervous system side effects and pharmacokinetics...
  23. ncbi request reprint Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy
    Asha R Kallianpur
    Department of Medicine, Divisions of General Internal Medicine and Public Health, Nashville, TN, USA
    AIDS 20:1503-13. 2006
    ..Since iron deficiency is associated with some types of PN, and iron is essential for mitochondrial function, we tested the hypothesis that hemochromatosis (HFE) gene mutations influence susceptibility to NRTI-induced PN...
  24. pmc Sociodemographic factors predict early discontinuation of HIV non-nucleoside reverse transcriptase inhibitors and protease inhibitors
    Shaheena Asad
    Department of Internal Medicine, Divisions of Hematology Oncology, University School of Medicine, Nashville, TN, USA
    J Natl Med Assoc 100:1417-24. 2008
    ..We performed an observational cohort study to determine the influence of race, sex and other sociodemographic factors on early ART discontinuations among HIV-infected persons...
  25. ncbi request reprint Effects of nelfinavir and its M8 metabolite on lymphocyte P-glycoprotein activity during antiretroviral therapy
    John P Donahue
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville Veterans Affairs Medical Center, TN 37203, USA
    Clin Pharmacol Ther 73:78-86. 2003
    ....
  26. pmc Identification of a CCR5-expressing T cell subset that is resistant to R5-tropic HIV infection
    Kyra Oswald-Richter
    Department of Microbiology and Immunology, Vanderbilt University Medical School, Nashville, Tennessee, United States of America
    PLoS Pathog 3:e58. 2007
    ..Determining the host factors within TEMRA cells that restrict R5-tropic viruses and endow HIV-1-specific CD4(+) T cells with this ability may result in novel therapeutic strategies against HIV-1 infection...
  27. ncbi request reprint Human genomic association studies: a primer for the infectious diseases specialist
    Alison A Motsinger
    School of Medicine, Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    J Infect Dis 195:1737-44. 2007
    ..Our goal is to provide the infectious diseases specialist with information that will aid in the critical evaluation of publications that include human genomic analyses...

Research Grants3

  1. Mitochondrial Genomics and Peripheral Neuropathy during HIV Therapy
    Todd Hulgan; Fiscal Year: 2007
    ..Results from this study will also advance the field of "mitochondrial medicine", having broad application across other scientific disciplines and for other human diseases. ..
  2. Oxidant Stress and Antioxidants during HIV Therapy
    Todd Hulgan; Fiscal Year: 2007
    ..The candidate's long-term goal is to develop into an independent clinical investigator in this field of study. ..