Brigid L Hogan

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure
    B Chang
    The Howard Hughes Medical Institute, USA
    BMC Genet 2:18. 2001
  2. ncbi Morphogenesis
    B L Hogan
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Cell 96:225-33. 1999
  3. ncbi Epithelial/mesenchymal interactions and branching morphogenesis of the lung
    B L Hogan
    Howard Hughes Medical Institute, Vanderbilt Medical Center, Nashville, Tennessee 37232 2175, USA
    Curr Opin Genet Dev 8:481-6. 1998
  4. ncbi Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
    S Bellusci
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 124:53-63. 1997
  5. ncbi Evidence for the involvement of the Gli gene family in embryonic mouse lung development
    J C Grindley
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee, 37232 2175, USA
    Dev Biol 188:337-48. 1997
  6. ncbi Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
    S Bellusci
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 124:4867-78. 1997
  7. ncbi Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis
    M Weaver
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt Medical Center, Nashville, TN, USA
    Development 127:2695-704. 2000
  8. ncbi Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis
    S Bellusci
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2175, USA
    Development 122:1693-702. 1996
  9. ncbi Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4
    N R Dunn
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee, 37232 2175, USA
    Dev Biol 188:235-47. 1997
  10. ncbi Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development
    M Weaver
    Howard Hughes Medical Institute, Department of Cell Biology, Nashville, TN, USA
    Development 126:4005-15. 1999

Collaborators

  • Guang Quan Zhao
  • Robert Schneider
  • Hidefumi Sasaki
  • A K Ryan
  • S J Conway
  • A Catharine Ross
  • J C Smith
  • M Fukagawa
  • Lilianna Solnica-Krezel
  • T Kume
  • G E Winnier
  • S Bellusci
  • Y Furuta
  • N R Dunn
  • P A Labosky
  • M Weaver
  • J M Topczewska
  • Paula Sommer
  • K Deng
  • J C Grindley
  • L Hargett
  • G Winnier
  • B Chang
  • T Fujiwara
  • L C Post
  • Y Miyazaki
  • H Kulessa
  • M A Walter
  • Y Maruoka
  • L Liaw
  • S C Wu
  • C M Jones
  • Susan H Kidson
  • Hugh R Napier
  • A Fogo
  • C V Wright
  • J Grindley
  • N Itoh
  • I Ichikawa
  • L K Hargett
  • T L Jetton
  • R Henderson
  • A B Fogo
  • M F Offield
  • N Suzuki
  • S W John
  • J E Martin
  • J Topczewski
  • M L Davisson
  • N L Hawes
  • A Zabaleta
  • M Blessing
  • S Nusinowitz
  • O V Savinova
  • R S Smith
  • C L Cepko
  • M Peters
  • H Jiang
  • K Oshima
  • M Ternet
  • J Kakuchi
  • G Turk
  • J Bundy
  • J M Yingling
  • C Raines
  • R Rogers
  • D E Birk
  • M Hoshikawa
  • J S Whitsitt
  • K Y Deng
  • C B Ballas
  • V Winfrey
  • N Ohbayashi
  • J D Barnes
  • J M Davidson
  • D B Gould
  • M G Rosenfeld
  • H Emoto
  • D W Piston
  • A F Parlow
  • D Perkins
  • J J Schrick
  • M G Rush
  • R E Hill
  • D S Greenspan
  • T Oikawa
  • R Dunn
  • D M Peters
  • K Takahara
  • R W Stein

Detail Information

Publications46

  1. pmc Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure
    B Chang
    The Howard Hughes Medical Institute, USA
    BMC Genet 2:18. 2001
    ..Bone morphogenetic proteins (BMPs) participate in various developmental processes. We tested the importance of Bmp4 gene dosage for ocular development and developmental glaucoma...
  2. ncbi Morphogenesis
    B L Hogan
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Cell 96:225-33. 1999
  3. ncbi Epithelial/mesenchymal interactions and branching morphogenesis of the lung
    B L Hogan
    Howard Hughes Medical Institute, Vanderbilt Medical Center, Nashville, Tennessee 37232 2175, USA
    Curr Opin Genet Dev 8:481-6. 1998
    ..Although there are obvious differences in the complexity of these branched organs, many of the underlying mechanisms and genes regulating their development appear to have been evolutionarily conserved...
  4. ncbi Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
    S Bellusci
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 124:53-63. 1997
    ..By contrast, Ptc is clearly upregulated in the transgenic lung. These results thus establish a role for SHH in lung morphogenesis, and suggest that SHH normally regulates lung mesenchymal cell proliferation in vivo...
  5. ncbi Evidence for the involvement of the Gli gene family in embryonic mouse lung development
    J C Grindley
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee, 37232 2175, USA
    Dev Biol 188:337-48. 1997
    ..Thus, our data indicate that one of the Gli genes, Gli3, is essential for normal lung development, and that another, Gli, can be placed downstream of Shh signaling in the lung...
  6. ncbi Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
    S Bellusci
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 124:4867-78. 1997
    ..We conclude that, during early lung development, localized sources of FGF10 in the mesoderm regulate endoderm proliferation and bud outgrowth...
  7. ncbi Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis
    M Weaver
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt Medical Center, Nashville, TN, USA
    Development 127:2695-704. 2000
    ..By contrast, the Bmp-binding protein Noggin enhances Fgf-induced morphogenesis. Based on these and other results, we propose a model for the combinatorial roles of Fgf10 and Bmp4 in branching morphogenesis of the lung...
  8. ncbi Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis
    S Bellusci
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2175, USA
    Development 122:1693-702. 1996
    ..A model is proposed for the role of BMP4 and other signalling molecules in embryonic lung morphogenesis...
  9. ncbi Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4
    N R Dunn
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee, 37232 2175, USA
    Dev Biol 188:235-47. 1997
    ..These genetic interactions suggest a model for the multigenic control of anterior digit patterning during vertebrate limb development...
  10. ncbi Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development
    M Weaver
    Howard Hughes Medical Institute, Department of Cell Biology, Nashville, TN, USA
    Development 126:4005-15. 1999
    ..Endodermal cells at the periphery of the lung, which are exposed to high levels of Bmp4, maintain or adopt a distal character, while cells receiving little or no Bmp4 signal initiate a proximal differentiation program...
  11. ncbi Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo
    Y Maruoka
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt Medical Center, Nashville, TN 37232, USA
    Mech Dev 74:175-7. 1998
    ..In the developing tail bud, each Fgf gene shows a different pattern of transcription. Distinct and overlapping expression patterns are also described in the developing brain and limbs...
  12. ncbi Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon
    J C Grindley
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2175, USA
    Mech Dev 64:111-26. 1997
    ..Thus, PAX6 is essential for the normal development and regionalization of the diencephalon...
  13. ncbi Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis
    S C Wu
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Mech Dev 70:3-13. 1998
    ..These results suggest that Mf2, like other murine forkhead genes, has multiple roles in embryogenesis, possibly mediating the response of cells to signaling molecules such as SHH...
  14. pmc BMP4 is essential for lens induction in the mouse embryo
    Y Furuta
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175 USA
    Genes Dev 12:3764-75. 1998
    ..Based on these results we propose that BMP4 is required for the optic vesicle to manifest its lens-inducing activity, by regulating downstream genes and/or serving as one component of multiple inductive signals...
  15. ncbi Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse
    C M Jones
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175
    Development 111:531-42. 1991
    ..Together, the data support the hypothesis that polypeptide growth factors of the TGF-beta superfamily play key roles in the initial stages of neurogenesis and organogenesis during murine development...
  16. ncbi Bone morphogenetic proteins in development
    B L Hogan
    Howard Hughes Medical Institute Research Laboratories, Vanderbilt University School of Medicine, C 2310 Medical Center North, Nashville, Tennessee 37232 2174, USA
    Curr Opin Genet Dev 6:432-8. 1996
    ..Extracellular modifiers of BMP activity may constitute an opposing morphogenetic system...
  17. ncbi Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    G Winnier
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, Tennessee 37232 2175, USA
    Genes Dev 9:2105-16. 1995
    ..Moreover, in the presumed absence of zygotic ligand, it appears that homozygous mutants can be rescued partially by related proteins or by maternal BMP-4...
  18. ncbi Developmental signalling. Sorting out the signals
    B L Hogan
    Howard Hughes Medical Institute, Vanderbilt University Medical Centre, Nashville, Tennessee 37027, USA
    Curr Biol 4:1122-4. 1994
    ..New insights into the developmental roles played by the TGF-beta family of signalling molecules come from the identification in Drosophila of two transmembrane receptors encoded by the thick veins and saxophone genes...
  19. ncbi The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo
    G E Winnier
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232 2175, USA
    Genes Dev 11:926-40. 1997
    ..A model is proposed for the role of mfh1 in regulating the proliferation and differentiation of cell lineages giving rise to the axial skeleton and skull...
  20. ncbi Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract
    T Kume
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 127:1387-95. 2000
    ..Here, we show that most compound heterozygotes have hypoplastic kidneys and a single hydroureter, while all heterozygotes are normal. This provides evidence that the two genes interact in kidney as well as heart development...
  21. pmc Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse
    T Fujiwara
    Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232 2175, USA
    Proc Natl Acad Sci U S A 98:13739-44. 2001
    ..These findings suggest that Bmp4 expressed in epiblast-derived tissues plays vital roles in reproduction by regulating both the development of the germ line and the vascular connection between the embryo and the placenta...
  22. ncbi Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors
    J M Topczewska
    Department of Cell Biology and Howard Hughes Medical Institute, Vanderbilt Medical Center, Nashville, TN 37232 2175, USA
    Mech Dev 100:343-7. 2001
    ..Early expression of foxc1a in the paraxial mesoderm is modified in chordino, swirl, somitabun, and spadetail mutants...
  23. ncbi Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation
    C M Jones
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, TN 37232 2175, USA
    Development 121:3651-62. 1995
    ....
  24. ncbi Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
    Y Furuta
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 124:2203-12. 1997
    ..These results provide evidence that BMPs function during regional morphogenesis of the dorsal telencephalon by regulating specific gene expression, cell proliferation and local cell death...
  25. ncbi Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles
    G E Winnier
    Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee, 37232 2175, USA
    Dev Biol 213:418-31. 1999
    ..Implications for the development of human congenital heart defects are discussed...
  26. ncbi Notch/Delta expression in the developing mouse lung
    L C Post
    Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mech Dev 98:95-8. 2000
    ..Here, we report the localization of transcripts of several genes encoding members of the Notch/Delta pathway in the early mouse lung. Most genes are expressed in specific populations and so may contribute to cell diversification...
  27. pmc Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2
    T Kume
    Howard Hughes Medical Institute, Nashville, Tennessee 37232 2175, USA
    Mol Cell Biol 20:1419-25. 2000
    ..These data suggest that Mf2 can play a unique role in kidney development, but there is functional redundancy in this organ and other tissues with other forkhead/winged helix genes...
  28. pmc Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle
    H Kulessa
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    EMBO J 19:6664-74. 2000
    ..These results identify Bmps as key regulators of the genetic program controlling hair shaft differentiation in postnatal hair follicles...
  29. pmc The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis
    T Kume
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genes Dev 15:2470-82. 2001
    ..We propose that the two genes interact with the Notch signaling pathway and are required for the prepatterning of anterior and posterior domains in the presumptive somites through a putative Notch/Delta/Mesp regulatory loop...
  30. pmc Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter
    Y Miyazaki
    Department of Pediatrics, Department of Pathology, Department of Cell Biology, and Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 105:863-73. 2000
    ..The other is to promote the elongation of the branching ureter within the metanephros, thereby promoting kidney morphogenesis...
  31. ncbi The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus
    T Kume
    Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Cell 93:985-96. 1998
    ....
  32. ncbi Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A)
    K M Lyons
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232 2175
    Development 109:833-44. 1990
    ..These results suggest that BMP-2A plays multiple roles in morphogenesis and pattern formation in the vertebrate embryo...
  33. ncbi Developmental expression of renal angiotensin II receptor genes in the mouse
    J Kakuchi
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Kidney Int 47:140-7. 1995
    ..Thus, contrary to current belief, the activation of AT1 and AT2 genes takes place in different cell types of the kidney during embryonic development, and thereby conceivably contributes to the ontogeny of those specific renal cells...
  34. ncbi Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase
    M Fukagawa
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, Tennessee 37232
    Dev Biol 163:175-83. 1994
    ..5 days p.c. in the floorplate region of the developing neural tube. Potential therefore exists for the interaction of BMP-1 protein with products of TGF-beta-related genes expressed during embryogenesis...
  35. ncbi HNF-3 beta as a regulator of floor plate development
    H Sasaki
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175
    Cell 76:103-15. 1994
    ..Ectopic dorsal neuronal differentiation and abnormal dorsal axonal projections are also seen. These results suggest that HNF-3 beta is an important regulator of floor plate development in vivo...
  36. ncbi PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
    M F Offield
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 122:983-95. 1996
    ..These results offer additional insight into the role of pdx-1 in the determination and differentiation of the posterior foregut, particularly regarding the proliferation and differentiation of the pancreatic progenitors...
  37. ncbi The chromosomal mapping of four genes encoding winged helix proteins expressed early in mouse development
    P A Labosky
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, Tennessee, 37232 2175, USA
    Genomics 34:241-5. 1996
    ..Since Mf3 is located in a region of Chromosome 9 containing many well-characterized mouse mutations such as short ear (se), ashen (ash), and dilute (d), we have analyzed deletion mutants to determine the location of Mf3 more precisely...
  38. ncbi The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse
    G Q Zhao
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, Tennessee 37232 2175, USA
    Genes Dev 10:1657-69. 1996
    ....
  39. ncbi Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development
    G Q Zhao
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, TN 37232 2175, USA
    Mech Dev 57:159-68. 1996
    ..These results suggest that Bmp8a and 8b are not required for development of the embryo proper but regulate aspects of cell proliferation, survival and/or differentiation during spermatogenesis and placentation...
  40. ncbi Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid
    N Suzuki
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, TN 37232 2175, USA
    Development 122:3587-95. 1996
    ..Metabolical labelling and immunofluorescence studies also reveal abnormal processing and deposition of procollagen by homozygous mutant fibroblasts in culture...
  41. ncbi Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse
    G Q Zhao
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, TN 37232 2175, USA
    Mech Dev 61:63-73. 1997
    ..These data suggest that MADR1 serves as a downstream component of the BMP8 signaling pathway during the differentiation of meiotic male germ cells...
  42. ncbi The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex
    P A Labosky
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    Development 124:1263-74. 1997
    ..These results provide evidence that Mf3 is required for normal hypothalamus development and suggest that Mf3 may play a role in postnatal growth and lactation...
  43. ncbi Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis
    J D Barnes
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Dev Biol 161:168-78. 1994
    ..These data suggest that in the mouse embryo Lim-1 plays a role in early mesoderm formation and later specification of a differentiated phenotype in subsets of cells of the mesonephros and sensory neurons of the CNS...
  44. ncbi Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis
    G Q Zhao
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical School, Nashville, TN 37232 2175, USA
    Development 125:1103-12. 1998
    ..A small proportion of the mating homozygous Bmp8atm1 males also show degeneration of the epididymal epithelium, indicating a novel role for BMPs in the control of epididymal function...
  45. pmc Altered wound healing in mice lacking a functional osteopontin gene (spp1)
    L Liaw
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 101:1468-78. 1998
    ..These data indicate a role for OPN in tissue remodeling in vivo, and suggest physiological functions during matrix reorganization after injury...
  46. ncbi Identification of Tgf beta1i4 as a downstream target of Foxc1
    Paula Sommer
    Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, South Africa
    Dev Growth Differ 48:297-308. 2006
    ..Since Foxc1 expression is essential for normal craniofacial development, it is possible that its downstream targets play a role in the development of the phenotypes associated with null mutations in Foxc1...