Fiona E Harrison

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Ascorbic acid and the brain: rationale for the use against cognitive decline
    Fiona E Harrison
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Nutrients 6:1752-81. 2014
  2. pmc Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung
    Fiona Edith Harrison
    Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 7:e35623. 2012
  3. pmc A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease
    Fiona E Harrison
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    J Alzheimers Dis 29:711-26. 2012
  4. pmc Low ascorbic acid and increased oxidative stress in gulo(-/-) mice during development
    Fiona E Harrison
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Brain Res 1349:143-52. 2010
  5. pmc Spatial and nonspatial escape strategies in the Barnes maze
    Fiona E Harrison
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 0325, USA
    Learn Mem 13:809-19. 2006
  6. pmc Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2
    F E Harrison
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 49:821-9. 2010
  7. pmc Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice
    F E Harrison
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Pharmacol Biochem Behav 94:543-52. 2010
  8. pmc Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice
    F E Harrison
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 0475, USA
    Nutr Neurosci 12:203-18. 2009
  9. pmc Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze
    F E Harrison
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Behav Brain Res 205:550-8. 2009
  10. pmc Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid
    Fiona E Harrison
    Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University, 7465 MRB IV, 2213 Garland Avenue, Nashville, TN 37232 0475, USA
    J Neurochem 106:1198-208. 2008

Collaborators

Detail Information

Publications20

  1. pmc Ascorbic acid and the brain: rationale for the use against cognitive decline
    Fiona E Harrison
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Nutrients 6:1752-81. 2014
    ..Vascular risk factors and comorbidity relationships with cognitive decline and AA are discussed to facilitate strategies for advancing AA research in the area of brain health and neurodegeneration. ..
  2. pmc Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung
    Fiona Edith Harrison
    Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 7:e35623. 2012
    ..SVCT2-Tg mice showed a clear attenuation of Paraquat-induced oxidative stress in lung, as measured by F(2)-isoprostanes. Paraquat also decreased SVCT2 mRNA signal in liver, lung and kidney in SVCT2-Tg mice...
  3. pmc A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease
    Fiona E Harrison
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    J Alzheimers Dis 29:711-26. 2012
    ....
  4. pmc Low ascorbic acid and increased oxidative stress in gulo(-/-) mice during development
    Fiona E Harrison
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Brain Res 1349:143-52. 2010
    ..They reinforce the critical role of ascorbic acid in preventing oxidative stress in the developing brain in animals that, like humans, cannot synthesize their own AA...
  5. pmc Spatial and nonspatial escape strategies in the Barnes maze
    Fiona E Harrison
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 0325, USA
    Learn Mem 13:809-19. 2006
    ..Importantly, these data show that the cued-target control version of the Barnes maze as typically conducted does not dissociate spatial from nonspatial abilities...
  6. pmc Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2
    F E Harrison
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 49:821-9. 2010
    ....
  7. pmc Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice
    F E Harrison
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Pharmacol Biochem Behav 94:543-52. 2010
    ..These data indicate an interaction between the cholinergic system and vitamin C that could be important given the cholinergic degeneration associated with Alzheimer's disease...
  8. pmc Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice
    F E Harrison
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 0475, USA
    Nutr Neurosci 12:203-18. 2009
    ..Amyloid deposition was not reduced by antioxidant supplementation in either experiment...
  9. pmc Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze
    F E Harrison
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Behav Brain Res 205:550-8. 2009
    ..However, further investigation is necessary to isolate the cognition-enhancing effects of ascorbate...
  10. pmc Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid
    Fiona E Harrison
    Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University, 7465 MRB IV, 2213 Garland Avenue, Nashville, TN 37232 0475, USA
    J Neurochem 106:1198-208. 2008
    ....
  11. pmc Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks
    F E Harrison
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Behav Brain Res 198:247-51. 2009
    ..These findings are important when considering the appropriate cognitive tasks for any experiment in which stress responses may differ systematically across groups...
  12. pmc Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice
    F E Harrison
    Department of Medicine, Vanderbilt University, Nashville, TN 37232 0475, USA
    Pharmacol Biochem Behav 93:443-50. 2009
    ..These data suggest that ascorbate may have noötropic functions when administered parenterally in high doses and that the mode of action is via an acute, pharmacological-like mechanism that likely modulates neurotransmitter function...
  13. pmc Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion
    M Elizabeth Meredith
    Department of Molecular Physiology and Biophysics, Vanderbilt University, 2213 Garland Ave, 7465 MRBIV, Nashville, TN 37232 0465, USA
    Biochem Biophys Res Commun 414:737-42. 2011
    ..The results suggest that expression of the SVCT2 is differentially regulated during embryonic development and in adulthood...
  14. doi request reprint Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice
    Alexandra Bernardo
    Department of Pharmacology, Vanderbilt University, Nashville, TN, United States
    Neurobiol Aging 30:1777-91. 2009
    ..These results suggest that GD3 synthase may be a novel therapeutic target to combat the cognitive deficits, amyloid plaque formation, and neurodegeneration that afflict Alzheimer's patients...
  15. pmc Vitamin C distribution and retention in the mouse brain
    Fiona E Harrison
    Department of Medicine, Vanderbilt University, Nashville, TN, 37232, USA
    Brain Res 1348:181-6. 2010
    ..These results suggest enhanced susceptibility of the cortex to oxidative stress induced by low VC compared to other brain regions...
  16. pmc Combined vitamin C and E deficiency induces motor defects in gulo(-/-)/SVCT2(+/-) mice
    Marquicia R Pierce
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232 0465, USA
    Nutr Neurosci 16:160-73. 2013
    ..To obtain an additional cellular deficiency of vitamin C, the second model also lacked one allele for the cellular vitamin C transporter gene (Gulo(-/-)/SVCT2(+/-))...
  17. pmc Treatment with a γ-ketoaldehyde scavenger prevents working memory deficits in hApoE4 mice
    Sean S Davies
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232 6602, USA
    J Alzheimers Dis 27:49-59. 2011
    ..These data provide a rational basis for future studies exploring whether γ-ketoaldehyde scavengers may mitigate the development of cognitive dysfunction in patients with AD...
  18. pmc Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2
    Fiona E Harrison
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6303, USA
    Free Radic Biol Med 46:719-30. 2009
    ....
  19. pmc Role of vitamin C in the function of the vascular endothelium
    James M May
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
    Antioxid Redox Signal 19:2068-83. 2013
    ..Although ascorbate may not be able to reverse inflammatory vascular diseases such as atherosclerosis, it may well play a role in preventing the endothelial dysfunction that is the earliest sign of many such diseases...
  20. pmc Behavioral and monoamine changes following severe vitamin C deficiency
    Margaret S Ward
    Department of Neuroscience, Vanderbilt University, Nashville, TN, USA
    J Neurochem 124:363-75. 2013
    ..Given the reasonably high proportions of the population that do not consume sufficient AA in the diet, these data have important implications for physical and psychological function in the general population...