R C Harris

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Physiological regulation of cyclooxygenase-2 in the kidney
    R C Harris
    George M O Brien Kidney and Urologic Diseases Center and Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, and Veterans Affairs Medical Center, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 281:F1-11. 2001
  2. ncbi Cyclooxygenase-2 and the kidney: functional and pathophysiological implications
    Raymond C Harris
    George M O Brien Kidney and Urologic Diseases Center and Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Department of Veterans Affairs, Nashville, Tennessee 37232, USA
    J Hypertens Suppl 20:S3-9. 2002
  3. ncbi Cyclooxygenase-2 inhibition and renal physiology
    Raymond C Harris
    Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Am J Cardiol 89:10D-17D. 2002
  4. ncbi Potential mechanisms and physiologic actions of intracellular angiotensin II
    R C Harris
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Am J Med Sci 318:374-9. 1999
  5. ncbi Prostaglandins in macula densa function
    R C Harris
    George M O Brien Kidney and Urologic Diseases Center and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Kidney Int Suppl 67:S49-52. 1998
  6. ncbi Angiotensin II attenuates renal cortical cyclooxygenase-2 expression
    H F Cheng
    Vanderbilt George M O Brien Kidney and Urologic Diseases Center, Nashville, TN 37232, USA
    J Clin Invest 103:953-61. 1999
  7. ncbi Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibition
    H F Cheng
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 280:F449-56. 2001
  8. ncbi Renal localization and regulation of 15-hydroxyprostaglandin dehydrogenase
    Bing Yao
    Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 294:F433-9. 2008
  9. ncbi Interactions between COX-2 and the renin-angiotensin system in the kidney
    R C Harris
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Acta Physiol Scand 177:423-7. 2003
  10. ncbi Nitric oxide regulates renal cortical cyclooxygenase-2 expression
    H F Cheng
    George M O Brien Kidney and Urologic Diseases Center and Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennesee 37232, USA
    Am J Physiol Renal Physiol 279:F122-9. 2000

Detail Information

Publications86

  1. ncbi Physiological regulation of cyclooxygenase-2 in the kidney
    R C Harris
    George M O Brien Kidney and Urologic Diseases Center and Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, and Veterans Affairs Medical Center, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 281:F1-11. 2001
    ..In addition, COX-2 metabolites appear to be important mediators of medullary blood flow and renal salt handling. Therefore, there is increasing evidence that COX-2 is an important physiological mediator of kidney function...
  2. ncbi Cyclooxygenase-2 and the kidney: functional and pathophysiological implications
    Raymond C Harris
    George M O Brien Kidney and Urologic Diseases Center and Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Department of Veterans Affairs, Nashville, Tennessee 37232, USA
    J Hypertens Suppl 20:S3-9. 2002
    ..In addition, COX-2 metabolites appear to be important mediators of medullary blood flow and renal salt handling. Therefore, there is increasing evidence that COX-2 is an important physiological mediator of kidney function...
  3. ncbi Cyclooxygenase-2 inhibition and renal physiology
    Raymond C Harris
    Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Am J Cardiol 89:10D-17D. 2002
    ..Studies comparing the 2 COX-2 inhibitors conflict in their interpretation. Overall, the data suggest similar effects on renal function among all NSAIDs when used at comparable doses...
  4. ncbi Potential mechanisms and physiologic actions of intracellular angiotensin II
    R C Harris
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Am J Med Sci 318:374-9. 1999
    ..These studies suggest that internalization of peptide and receptor may be a necessary step for the transmission of the full range of cellular responses produced by angiotensin II...
  5. ncbi Prostaglandins in macula densa function
    R C Harris
    George M O Brien Kidney and Urologic Diseases Center and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Kidney Int Suppl 67:S49-52. 1998
    ..As selective inhibitors of COX-2 become available, it will be important to assess their effects on the renin-angiotensin system and glomerular hemodynamics...
  6. ncbi Angiotensin II attenuates renal cortical cyclooxygenase-2 expression
    H F Cheng
    Vanderbilt George M O Brien Kidney and Urologic Diseases Center, Nashville, TN 37232, USA
    J Clin Invest 103:953-61. 1999
    ....
  7. ncbi Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibition
    H F Cheng
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 280:F449-56. 2001
    ..In summary, these results indicate that ACEI-mediated increases in renal renin production were defective in COX-2 knockout (K/O) mice and provide further indication that MD COX-2 is an important mediator of the renin-angiotensin system...
  8. ncbi Renal localization and regulation of 15-hydroxyprostaglandin dehydrogenase
    Bing Yao
    Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 294:F433-9. 2008
    ....
  9. ncbi Interactions between COX-2 and the renin-angiotensin system in the kidney
    R C Harris
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Acta Physiol Scand 177:423-7. 2003
    ....
  10. ncbi Nitric oxide regulates renal cortical cyclooxygenase-2 expression
    H F Cheng
    George M O Brien Kidney and Urologic Diseases Center and Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennesee 37232, USA
    Am J Physiol Renal Physiol 279:F122-9. 2000
    ....
  11. ncbi Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite
    Jianchun Chen
    C 3121 Medical Center North, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Cell Biol 27:3023-34. 2007
    ....
  12. ncbi Juxtacrine activation of epidermal growth factor (EGF) receptor by membrane-anchored heparin-binding EGF-like growth factor protects epithelial cells from anoikis while maintaining an epithelial phenotype
    Amar B Singh
    Department of Medicine, Vanderbilt University, C 3121 Medical Center North, Nashville, TN 37232, USA
    J Biol Chem 282:32890-901. 2007
    ..Taken together, we propose a novel role for membrane-anchored HB-EGF in the cytoprotection of epithelial cells...
  13. ncbi Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1
    Hui Fang Cheng
    George M O Brien Kidney Disease Center, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Regul Integr Comp Physiol 283:R638-46. 2002
    ..The persistent response in EP(2) nulls suggests involvement of prostaglandin E(2) receptor subtype 4 and/or prostacyclin receptor (IP)...
  14. ncbi Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells
    Amar B Singh
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232-4794, USA
    J Biol Chem 279:3543-52. 2004
    ....
  15. ncbi Regulation of cyclooxygenase expression by vasopressin in rat renal medulla
    Ming Zhi Zhang
    George O Bien Center for Kidney and Urologic Diseases, and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Endocrinology 145:1402-9. 2004
    ..These data demonstrate that vasopressin stimulates medullary COX-2 expression through activation of both V1 and V2 receptors, and this stimulation is indirect and probably involves increased medullary electrolyte tonicity...
  16. ncbi Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes
    Yukiko Kanetsuna
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 291:F1315-22. 2006
    ..Thus the HNF6 mouse exhibits diabetic renal changes that parallel the early phase of human DN. The model should facilitate studies of genetic and environmental factors that may affect DN in hypoinsulinemic diabetes...
  17. ncbi Mineralocorticoid regulation of cyclooxygenase-2 expression in rat renal medulla
    Ming Zhi Zhang
    George O Brien Center for Kidney and Urologic Diseases, Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 283:F509-16. 2002
    ..Together, these results suggest that mineralocorticoids lead to upregulation of COX-2 in rat renal medulla by indirect pathways, probably involving induced electrolyte hypertonicity in the interstitial fluid...
  18. ncbi Cyclooxygenase 2 and the kidney
    M D Breyer
    Department of Medicine, Veterans Administration Medical Center and Vanderbilt University, Nashville, Tennessee, USA
    Curr Opin Nephrol Hypertens 10:89-98. 2001
    ....
  19. ncbi Cyclooxygenase-2 and the renal renin-angiotensin system
    R C Harris
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Acta Physiol Scand 181:543-7. 2004
    ..These interactions of COX-2 derived prostaglandins and the renin-angiotensin system may underlie physiological and pathophysiological regulation of renal function...
  20. ncbi ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis
    Fenghua Zeng
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Mol Biol Cell 18:4446-56. 2007
    ....
  21. ncbi Nitric oxide stimulates cyclooxygenase-2 in cultured cTAL cells through a p38-dependent pathway
    Hui-Fang Cheng
    George M. O'Brien Kidney and Urologic Diseases Center and Division of Nephrology, Vanderbilt Univ. School of Medicine, and Nashville Veterans Affairs Hospital, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 290:F1391-7. 2006
    ..In summary, these studies indicate that, in cTAL, NO can increase COX-2 expression in cTAL and macula densa through p38-dependent signaling pathways via activation of NF-kappaB...
  22. ncbi Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice
    Yukiko Kanetsuna
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Pathol 170:1473-84. 2007
    ..The findings indicate a vital role for eNOS-derived NO in the pathogenesis of diabetic nephropathy...
  23. ncbi Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation
    Xiwu Chen
    Department of Medicine, Division of Nephrology, Vanderbilt University, Nashville, TN 37232, USA
    Mol Cell Biol 27:3313-26. 2007
    ....
  24. ncbi Role of EGF receptor activation in angiotensin II-induced renal epithelial cell hypertrophy
    Jianchun Chen
    Department of Medicine, Vanderbilt University School of Medicine, and Department of Veterans Affairs, Nashville, TN 37232, USA
    J Am Soc Nephrol 17:1615-23. 2006
    ..In summary, this is the first demonstration that HB-EGF shedding-dependent EGFR transactivation, along with activation of TGF-beta signaling pathways, mediates Ang II-induced renal tubular epithelial cell hypertrophy...
  25. ncbi Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice
    Hui John Zhao
    Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, C 3121 MCN, Nashville, TN 37232, USA
    J Am Soc Nephrol 17:2664-9. 2006
    ..In summary, eNOS(-/-) db/db mice provide the most robust model of type II DN that has been described to date and support a role for deficient eNOS-derived NO production in the pathogenesis of DN...
  26. ncbi Interactions between 11beta-hydroxysteroid dehydrogenase and COX-2 in kidney
    Bing Yao
    George O Brien Center for Kidney and Urologic Diseases and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 4794, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1767-73. 2005
    ....
  27. ncbi Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension
    Hui-Fang Cheng
    George M. O'Brien Kidney Disease Center and Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2372, USA
    Kidney Int 62:929-39. 2002
    ....
  28. ncbi Renal effects of non-steroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors
    H F Cheng
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Pharm Des 11:1795-804. 2005
    ..Recently, agents with combined lipooxygenase/COX inhibition and agents that combine NSAIDs with a nitric oxide (NO) donor have been reported to reduce adverse renal effects...
  29. ncbi Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity
    Ambra Pozzi
    Department of Medicine, Veterans Affairs Hospital, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 316:288-301. 2008
    ..Thus, expression of beta1 containing integrins by the podocyte is critical for maintaining the structural integrity of the glomerulus...
  30. ncbi Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway
    Bing Yao
    Nashville Veterans Administration Hospital and Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hypertension 54:1077-83. 2009
    ....
  31. ncbi Effects of epidermal growth factor on collagen expression by rat kidney mesangial cells in culture
    M A Haralson
    Department of Pathology, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA
    Matrix Biol 19:47-59. 2000
    ..Rather, these findings suggest the possibility that EGF or EGF-like growth factors may ameliorate the effects of other soluble factors that cause enhanced matrix production and deposition in renal diseases...
  32. ncbi Overexpression of cyclooxygenase-2 predisposes to podocyte injury
    Huifang Cheng
    Division of Nephrology, C3115 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Am Soc Nephrol 18:551-9. 2007
    ..SC58236 also reduced Adriamycin-induced foot process effacement in both the COX-2 transgenic mice and Balb/C mice. Therefore, overexpression of COX-2 may predispose podocytes to further injury...
  33. ncbi Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors
    Ming Zhi Zhang
    George M O Brien Center for Research in Kidney and Urologic Diseases and Departments of Medicine and Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 103:16045-50. 2006
    ....
  34. ncbi Assessing the application of tissue microarray technology to kidney research
    Ming Zhi Zhang
    Vanderbilt O Brien Center, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Histochem Cytochem 58:413-20. 2010
    ..These studies show that kidney TMA technique is a promising and useful tool for investigating the expression profiles of proteins of interest in rodent kidneys under different physiological and pathophysiological conditions...
  35. ncbi Potential side effects of renin inhibitors--mechanisms based on comparison with other renin-angiotensin blockers
    Huifang Cheng
    George M O Brien Kidney and Urologic Diseases Center and Division of Nephrology, Vanderbilt University School of Medicineand Nashville Veterans Affairs Hospital, Nashville, TN 37232, USA
    Expert Opin Drug Saf 5:631-41. 2006
    ..In this review, the authors summarise current knowledge about these renin inhibitors...
  36. ncbi Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression
    Xiwu Chen
    Department of Medicine, Division of Nephrology, Medical Center North B3109, Vanderbilt University, Nashville, TN 37232, USA
    Mol Cell Biol 30:3048-58. 2010
    ....
  37. ncbi The glomerulus--a view from the outside--the podocyte
    Huifang Cheng
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    Int J Biochem Cell Biol 42:1380-7. 2010
    ..However, recent research in rodents has provided suggestive evidence for podocyte regeneration resulting from differentiation of progenitor cells within Bowman's capsule...
  38. ncbi Transmembrane and soluble isoforms of heparin-binding epidermal growth factor-like growth factor regulate distinct processes in the pancreas
    Kevin C Ray
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Gastroenterology 137:1785-94. 2009
    ..HB-EGF, often overexpressed in damaged or diseased epithelium, is normally expressed in pancreatic islets, but its function is not understood...
  39. ncbi Distinct roles for basal and induced COX-2 in podocyte injury
    Huifang Cheng
    Division of Nephrology, Vanderbilt University School of Medicine and Nashville Veterans Affairs Hospital, Nashville, TN 37232, USA
    J Am Soc Nephrol 20:1953-62. 2009
    ..These results suggest that basal COX-2 may be important for podocyte survival, but overexpression of podocyte COX-2 increases susceptibility to podocyte injury, which is mediated, in part, by activation of the thromboxane receptor...
  40. ncbi An update on cyclooxygenase-2 expression and metabolites in the kidney
    Raymond C Harris
    Department of Medicine, Vanderbilt University, Nashville, and Nashville Veterans Affairs Hospital, Tennessee 37232, USA
    Curr Opin Nephrol Hypertens 17:64-9. 2008
    ..This review highlights recent studies examining the expression and function of cyclooxygenase-2 and its metabolites in the kidney...
  41. ncbi Apoptosis of the thick ascending limb results in acute kidney injury
    Manakan B Srichai
    Veterans Administration Hospital, Department of Medicine Division of Nephrology, Vanderbilt University, Nashville, TN 37232, USA
    J Am Soc Nephrol 19:1538-46. 2008
    ..These findings suggest that acute injury targeted only to the TAL is sufficient to cause severe acute kidney injury in mice with features similar to those observed in humans...
  42. ncbi Single amino acid substitution in aquaporin 11 causes renal failure
    Elena E Tchekneva
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Am Soc Nephrol 19:1955-64. 2008
    ..These results demonstrate that the identified mutation causes renal failure in Aqp11 sjds/sjds mutant mice, providing a model for better understanding of the structure and function of aquaporin 11 in renal physiology...
  43. ncbi Puromycin induces reversible proteinuric injury in transgenic mice expressing cyclooxygenase-2 in podocytes
    Young Il Jo
    Division of Nephrology, George M O Brien Kidney and Urologic Diseases Center, Vanderbilt University School of Medicine and Nashville Veterans Affairs Hospital, Nashville, Tenn 37232, USA
    Nephron Exp Nephrol 107:e87-94. 2007
    ..In summary, in transgenic mice with podocyte COX-2 overexpression, PAN increased albuminuria and induced foot process fusion. Thus, increased COX-2 expression increased podocyte susceptibility to further injury...
  44. ncbi Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance
    Amar B Singh
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232 4794, USA
    Am J Physiol Cell Physiol 293:C1660-8. 2007
    ..Therefore, we hypothesize that juxtacrine activation of EGFR by membrane-anchored HB-EGF may play an important role in the regulation of tight junction proteins and TER...
  45. ncbi Intrarenal dopaminergic system regulates renin expression
    Ming Zhi Zhang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 53:564-70. 2009
    ....
  46. ncbi Soluble HB-EGF induces epithelial-to-mesenchymal transition in inner medullary collecting duct cells by upregulating Snail-2
    James P Smith
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Am J Physiol Renal Physiol 296:F957-65. 2009
    ..In summary, sustained exposure to sHB-EGF induces epithelial-to-mesenchymal transition of IMCD cells, in part by upregulating the E-cadherin transcriptional repressor Snail-2...
  47. ncbi Characterization of a putative intrarenal serotonergic system
    Jie Xu
    Division of Nephrology, Vanderbilt Univ School of Medicine, MCN C3121, 1161 21st St S, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 293:F1468-75. 2007
    ..Therefore, these results indicate the presence of an integrated intrarenal serotonergic system and suggest a possible role for 5-HT as a mediator of renal fibrosis in the kidney...
  48. ncbi Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans
    Ming Zhi Zhang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 119:876-85. 2009
    ..Therefore, 11betaHSD2 inhibition represents what we believe to be a novel approach for CRC chemoprevention and therapy by increasing tumor glucocorticoid activity, which in turn selectively blocks local COX-2 activity...
  49. ncbi Update on cyclooxygenase-2 inhibitors
    Raymond C Harris
    Division of Nephrology, S3322 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Clin J Am Soc Nephrol 1:236-45. 2006
    ..This review summarizes the current state of knowledge about both renal and cardiovascular side effects that are attributed to COX-2 selective inhibitors...
  50. ncbi Toward a unified theory of renal progression
    Raymond C Harris
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Annu Rev Med 57:365-80. 2006
    ..New knowledge about the cell biology of progression also suggests that other adjunctive therapies may be possible. We describe the progress and highlight those spheres where new-targeted interventions may arise...
  51. ncbi Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia
    Anna L Means
    Department of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Gastroenterology 124:1020-36. 2003
    ..This report examines the effects of HB-EGF overexpression in mouse pancreas...
  52. ncbi Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance
    Zhonghua Qi
    Department of Medicine, Vanderbilt University, Nashville, TN 37212, USA
    Am J Physiol Renal Physiol 286:F590-6. 2004
    ..11 +/- 26.56 and 157.36 +/- 20.02 microl/min in male and female mice, respectively. These studies demonstrate the feasibility of repeated nonisotopic measurement of inulin clearance in conscious mice...
  53. ncbi Cyclooxygenase-2 expression in cultured cortical thick ascending limb of Henle increases in response to decreased extracellular ionic content by both transcriptional and post-transcriptional mechanisms. Role of p38-mediated pathways
    Hui Fang Cheng
    George M O Brien Kidney and Urologic Diseases Center and Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:45638-43. 2002
    ..05). Therefore, these studies indicate that p38 stimulates COX-2 expression in cTALH and macula densa by transcriptional regulation predominantly via a NF-kappaB-dependent pathway and by post-transcriptional increases in mRNA stability...
  54. ncbi Cyclooxygenases, the kidney, and hypertension
    Hui-Fang Cheng
    Division of Nephrology, S 3322 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232-2372, USA
    Hypertension 43:525-30. 2004
    ....
  55. ncbi Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells
    Jian Kang Chen
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 99:6029-34. 2002
    ..This mechanism involves EET-dependent activation of metalloproteinases and release of the potent mitogenic EGFR ligand, HB-EGF...
  56. ncbi Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells
    Amar B Singh
    Department of Medicine, Vanderbilt University, Nashville, TN 37232-4794, USA
    J Cell Sci 117:1365-79. 2004
    ....
  57. ncbi COX-2 and the kidney
    Raymond C Harris
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cardiovasc Pharmacol 47:S37-42. 2006
    ..Occasional acute renal failure has also been reported. Caution should be taken when COX-2 inhibitors are prescribed, especially in high-risk patients (including elderly patients and patients with volume depletion)...
  58. ncbi Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice
    Michael E Burleigh
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Circulation 105:1816-23. 2002
    ....
  59. ncbi Does cyclooxygenase-2 affect blood pressure?
    Hui Fang Cheng
    Division of Nephrology, S 3223 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    Curr Hypertens Rep 5:87-92. 2003
    ..COX-2 inhibitors may also exacerbate pre-existing hypertension or interfere with other antihypertensive drugs. Special caution should be taken in patients with volume depletion or decreased organ perfusion...
  60. ncbi Mouse models of diabetic nephropathy
    Matthew D Breyer
    Division of Nephrology and Department of Medicine, Vanderbilt University Medical School, S3223 MCN, Nashville, TN 37232, USA
    J Am Soc Nephrol 16:27-45. 2005
    ..Establishment of an authentic mouse model of DN will undoubtedly facilitate testing of translational diagnostic and therapeutic interventions in mice before testing in humans...
  61. ncbi Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy
    Jian Kang Chen
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, S 3223 Medical Center North, Nashville, Tennessee 37232, USA
    J Am Soc Nephrol 16:1384-91. 2005
    ..These studies demonstrate that activation of the mTOR signaling pathway in the remaining kidney after UNX plays an essential role in modulating RNA and protein synthesis during development of compensatory renal hypertrophy...
  62. ncbi Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria
    Reena Rao
    Div of Nephrology, Vanderbilt Univ Medical Ctr, S3223, MCN, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 288:F642-9. 2005
    ..In conclusion, these findings temporally link decreased GSK-3 activity to enhanced renal COX2 expression and COX2-derived urine PGE(2) excretion. Suppression of COX2-derived PGE(2) blunts lithium-associated polyuria...
  63. ncbi Expression of mediators of renal injury in the remnant kidney of ROP mice is attenuated by cyclooxygenase-2 inhibition
    Huifang Cheng
    Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tenn 37232 2372, USA
    Nephron Exp Nephrol 101:e75-85. 2005
    ..Therefore, these results indicate that in a mouse model of subtotal renal ablation, COX-2 inhibition blocks expression of mediators of renal tubulointerstitial injury...
  64. ncbi Diabetic nephropathy: of mice and men
    Matthew D Breyer
    Vanderbilt University and VA Medical Center, Nashville, TN 37232, USA
    Adv Chronic Kidney Dis 12:128-45. 2005
    ..Identification of a mouse model that faithfully mirrors the pathogenesis of DN in humans will undoubtedly facilitate the development of new diagnostic and therapeutic interventions...
  65. ncbi Angiotensin induces the urinary peristaltic machinery during the perinatal period
    Y Miyazaki
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 102:1489-97. 1998
    ..These results reveal a new role for angiotensin in the unique cellular adaptations of the mammalian kidney to the physiological stresses of postnatal life...
  66. ncbi Autocrine, paracrine and juxtacrine signaling by EGFR ligands
    Amar B Singh
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232 4794, USA
    Cell Signal 17:1183-93. 2005
    ..In this review, we discuss the different ways that EGFR ligands can activate the receptor and the possible biological implications...
  67. ncbi Role of renal cortical cyclooxygenase-2 expression in hyperfiltration in rats with high-protein intake
    Bing Yao
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
    Am J Physiol Renal Physiol 291:F368-74. 2006
    ....
  68. ncbi Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury
    Xiwu Chen
    Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University, Medical Center North, B3109, 1161 21st Ave, Nashville, TN 37212, USA
    Am J Pathol 165:617-30. 2004
    ..Because integrin alpha1beta1 is expressed in many cell types this may represent a generalized mechanism of controlling matrix accumulation, which has implications for numerous diseases characterized by fibrosis...
  69. ncbi Cross talk between the intrarenal dopaminergic and cyclooxygenase-2 systems
    Ming Zhi Zhang
    C 3121 Medical Center North, Dept of Medicine, Vanderbilt Univ, Nashville, TN 37232 4794, USA
    Am J Physiol Renal Physiol 288:F840-5. 2005
    ..In contrast, treatment with distally acting diuretics led to elevation of cortical COX-2. These results indicate that dopamine modulates renal cortical COX-2 expression by modifying PT reabsorption...
  70. ncbi Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c
    Byoung Geun Han
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Am J Physiol Endocrinol Metab 295:E981-6. 2008
    ..These results show that 6-h fasting glucose provides a superior index of glycemic control and correlates more closely with Hb A(1c) than overnight-fasted blood glucose in these strains of mice...
  71. ncbi Regulation of renal cortical cyclooxygenase-2 in young rats
    Ming Zhi Zhang
    George O Brien Center for Kidney and Urological Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 285:F881-8. 2003
    ..These results suggest that relative volume depletion and reduced GC levels are involved in elevated cortical COX-2 expression in the immature rodent kidney...
  72. ncbi Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells
    Fenghua Zeng
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    FASEB J 23:1935-45. 2009
    ..These studies indicate that Nedd4 mediates ErbB4 CYT-1 ICD ubiquitination and degradation, and the prevention of both WW binding and PI3 kinase activity are required for ErbB4 nuclear translocation...
  73. ncbi Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis
    Dong Chen
    Division of Nephrology, Department of Medicine, Vanderbilt Medical Center, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 287:F602-11. 2004
    ..This suggests that temporal and spatial changes in integrin expression could help organize the pattern of branching morphogenesis of the developing collecting system in vivo...
  74. ncbi Genetics of diabetic nephropathy: lessons from mice
    Matthew D Breyer
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Semin Nephrol 27:237-47. 2007
    ..In this article we review studies that have started to identify genetic risk factors for diabetic nephropathy in mice and the multiple approaches that may be used to elucidate the genetic pathogenesis of this disorder...
  75. ncbi Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium
    K D Burns
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
    Am J Physiol 264:F645-54. 1993
    ..The clone isolated in the present study should provide a useful tool with which to study the regulation of the PT renin-angiotensin system...
  76. ncbi Leukotriene D4 binding and signal transduction in rat glomerular mesangial cells
    K F Badr
    Department of Medicine, Vanderbilt University, Nashville, Tennesee 37232
    Am J Physiol 257:F280-7. 1989
    ..These studies provide insight into the cellular basis for LTD4-mesangial cell interactions, which are of potential pathophysiological relevance during acute glomerular inflammatory injury...
  77. ncbi Role of membrane-bound heparin-binding epidermal growth factor-like growth factor (HB-EGF) in renal epithelial cell branching
    Tsukasa Takemura
    Department of Pediatrics, Kinki University School of Medicine, Osaka-Sayama, Japan
    Kidney Int 61:1968-79. 2002
    ..Localization of proHB-EGF to the site of cell-cell contact and development of tubule-like structures in collagen gels suggests that proHB-EGF may be an important morphogen for renal epithelial cells...
  78. ncbi Are all COX-2 inhibitors created equal?
    Ingrid J Chang
    Hypertension 45:178-80. 2005
  79. ncbi Insight into the genetics of diabetic nephropathy through the study of mice
    Matthew D Breyer
    Biotherapeutics Discovery Research Eli Lilly and Company, Indianapolis, Indiana 46225, USA
    Curr Opin Nephrol Hypertens 17:82-6. 2008
    ..To discuss mouse models of diabetic nephropathy and their use in discovering genetic risk factors predisposing to diabetic nephropathy...
  80. ncbi EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor
    Bangalore R Shivakumar
    Department of Medicine, Vanderbilt University and Veterans Affairs Medical Center Nashville, TN 37232, USA
    Cell Biochem Funct 23:195-204. 2005
    ..15 associates with AT1 and B2 receptors both at the plasma membrane and after receptor internalization and suggests a possible mechanism for endosomal disposition of ligand that may facilitate receptor recycling...
  81. ncbi A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy
    Maxwell E Fisher
    Division of Nephrology, Vanderbilt Medical Center, Nashville, TN 37232, USA
    Am J Kidney Dis 44:567-73. 2004
  82. ncbi PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells
    Ming Zhi Zhang
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 101:2311-6. 2004
    ..Reduced PKHD1 levels in pck rat kidneys and its colocalization with polycystins may underlie the pathogenic basis for cystogenesis in polycystic kidney diseases...
  83. ncbi Examining diabetic nephropathy through the lens of mouse genetics
    Matthew D Breyer
    Biotherapeutics Discovery Research, Lilly Research Labs, Eli Lilly and Company, 355 E Merrill Street, Indianapolis, IN 46225, USA
    Curr Diab Rep 7:459-66. 2007
    ..This article reviews new studies to identify genetic risk factors for diabetic nephropathy and the unique approaches that may be used to elucidate the genetic pathogenesis of this disorder in mice...
  84. ncbi Angiotensin II activates nuclear transcription factor-kappaB through AT1 and AT2 receptors
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Hamburg, Germany
    Kidney Int 61:1986-95. 2002
    ..We focused particularly on the Ang II subtype 2 (AT2) receptor because we previously observed that Ang II-induction of the chemokine RANTES in vitro and in vivo is mediated through AT2 receptors...
  85. ncbi EGF receptor ligands
    Raymond C Harris
    Department of Medicine, Vanderbilt University, and Nashville Veterans Association, Nashville, TN 37232, USA
    Exp Cell Res 284:2-13. 2003
  86. ncbi Importance of functional EGF receptors in recovery from acute nephrotoxic injury
    Zoufei Wang
    Departments of Medicine and Pathology, Vanderbilt University, Nashville, Tennessee 37232-4794, USA
    J Am Soc Nephrol 14:3147-54. 2003
    ..These studies indicate that functional EGFR activity is an essential component of the kidney's ability to recover from acute injury and that EGFR may regulate genes involved in growth, repair, and cell survival in the kidney...