Paul A Harris

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc ResearchMatch: a national registry to recruit volunteers for clinical research
    Paul A Harris
    Office of Research Informatics, Vanderbilt University, Nashville, Tennessee 37203, USA
    Acad Med 87:66-73. 2012
  2. pmc StarBRITE: the Vanderbilt University Biomedical Research Integration, Translation and Education portal
    Paul A Harris
    Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave, 6th Floor, Nashville, TN 37203, USA
    J Biomed Inform 44:655-62. 2011
  3. pmc Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support
    Paul A Harris
    Department of Biomedical Informatics, Vanderbilt University, 2525 West End Avenue, Suite 674, Nashville, TN 37212, USA
    J Biomed Inform 42:377-81. 2009
  4. pmc Clinical research subject recruitment: the Volunteer for Vanderbilt Research Program www.volunteer.mc.vanderbilt.edu
    Paul A Harris
    General Clinical Research Center, Vanderbilt University, Nashville, TN 37212, USA
    J Am Med Inform Assoc 12:608-13. 2005
  5. ncbi request reprint Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Hypertens 25:763-71. 2007
  6. ncbi request reprint Water ingestion as prophylaxis against syncope
    Chih Cherng Lu
    Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tenn 37232 2195, USA
    Circulation 108:2660-5. 2003
  7. pmc Rate-independent QT shortening during exercise in healthy subjects: terminal repolarization does not shorten with exercise
    Prince J Kannankeril
    Oates Institute for Experimental Therapeutics, Clinical Research Center, Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 9119, USA
    J Cardiovasc Electrophysiol 19:1284-8. 2008
  8. ncbi request reprint Dopamine-beta-hydroxylase in postural tachycardia syndrome
    Emily M Garland
    Autonomic Dysfunction Center, AA3228 Medical Center North, Vanderbilt University, Nashville, TN 37232 2195, USA
    Am J Physiol Heart Circ Physiol 293:H684-90. 2007
  9. ncbi request reprint Sodium paradoxically reduces the gastropressor response in patients with orthostatic hypotension
    Satish R Raj
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Hypertension 48:329-34. 2006
  10. ncbi request reprint Endothelial NO synthase polymorphisms and postural tachycardia syndrome
    Emily M Garland
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Hypertension 46:1103-10. 2005

Collaborators

Detail Information

Publications21

  1. pmc ResearchMatch: a national registry to recruit volunteers for clinical research
    Paul A Harris
    Office of Research Informatics, Vanderbilt University, Nashville, Tennessee 37203, USA
    Acad Med 87:66-73. 2012
    ..ResearchMatch has proven successful in connecting volunteers with researchers, and the authors are currently evaluating regulatory and workflow options to open access to researchers at non-CTSA institutions...
  2. pmc StarBRITE: the Vanderbilt University Biomedical Research Integration, Translation and Education portal
    Paul A Harris
    Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave, 6th Floor, Nashville, TN 37203, USA
    J Biomed Inform 44:655-62. 2011
    ..75-years of operation, and a report of lessons learned during organizing, launching and refining the portal...
  3. pmc Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support
    Paul A Harris
    Department of Biomedical Informatics, Vanderbilt University, 2525 West End Avenue, Suite 674, Nashville, TN 37212, USA
    J Biomed Inform 42:377-81. 2009
    ..REDCap is currently supporting 286 translational research projects in a growing collaborative network including 27 active partner institutions...
  4. pmc Clinical research subject recruitment: the Volunteer for Vanderbilt Research Program www.volunteer.mc.vanderbilt.edu
    Paul A Harris
    General Clinical Research Center, Vanderbilt University, Nashville, TN 37212, USA
    J Am Med Inform Assoc 12:608-13. 2005
    ....
  5. ncbi request reprint Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Hypertens 25:763-71. 2007
    ..We therefore examined the hypothesis that the ADRA2C deletion variant would alter sympathetic activity and contribute to ethnic differences in blood pressure...
  6. ncbi request reprint Water ingestion as prophylaxis against syncope
    Chih Cherng Lu
    Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tenn 37232 2195, USA
    Circulation 108:2660-5. 2003
    ..Water ingestion raises blood pressure substantially in patients with perturbed autonomic control and more modestly in older subjects. It is unclear whether prophylactic water drinking improves orthostatic tolerance in normal healthy adults...
  7. pmc Rate-independent QT shortening during exercise in healthy subjects: terminal repolarization does not shorten with exercise
    Prince J Kannankeril
    Oates Institute for Experimental Therapeutics, Clinical Research Center, Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 9119, USA
    J Cardiovasc Electrophysiol 19:1284-8. 2008
    ..We hypothesized that QT hysteresis is evident within stages of exercise and investigated which component of the QT contributes to hysteresis...
  8. ncbi request reprint Dopamine-beta-hydroxylase in postural tachycardia syndrome
    Emily M Garland
    Autonomic Dysfunction Center, AA3228 Medical Center North, Vanderbilt University, Nashville, TN 37232 2195, USA
    Am J Physiol Heart Circ Physiol 293:H684-90. 2007
    ..Although DBH activity and genotype are unlikely to be primary determinants of susceptibility to POTS, differences in DBH activity in POTS may reflect differences in the level of sympathetic activation...
  9. ncbi request reprint Sodium paradoxically reduces the gastropressor response in patients with orthostatic hypotension
    Satish R Raj
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Hypertension 48:329-34. 2006
    ..These data suggest a potentially important role for gastrointestinal osmolality in the activation of the sympathetic nervous system leading to cardiovascular reflexes responsible for the gastropressor response...
  10. ncbi request reprint Endothelial NO synthase polymorphisms and postural tachycardia syndrome
    Emily M Garland
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Hypertension 46:1103-10. 2005
    ..These results indicate that NO may influence the development of POTS and the severity of POTS symptoms...
  11. ncbi request reprint Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndrome
    Satish R Raj
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, 1161 21st Ave South, Nashville, TN 37232 2195, USA
    Circulation 111:2734-40. 2005
    ..The objective of this study was to test the hypothesis that acetylcholinesterase inhibitors will attenuate the tachycardia and improve symptom burden in patients with POTS...
  12. ncbi request reprint Variations in the alpha2A-adrenergic receptor gene and their functional effects
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232 6606, USA
    Clin Pharmacol Ther 79:173-85. 2006
    ..The objectives of this study were to systematically search for variants in the ADRA2A gene, to define the gene's haplotype structure, and to examine potential functional effects of these variants...
  13. pmc An informatics-based tool to assist researchers in initiating research at an academic medical center: Vanderbilt Customized Action Plan
    Jill M Pulley
    Vanderbilt Institute for Clinical and Translational Research VICTR, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    Acad Med 85:164-8. 2010
    ..The informatics-systems-based approach of the V-CAP is scalable to other academic medical centers and may serve as a useful model to help researchers navigate the complexity of the regulatory approvals process...
  14. pmc Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade
    Daniel Kurnik
    Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenet Genomics 18:895-902. 2008
    ..The purpose of this study was to determine whether ethnic differences in response to beta-blockade can be explained by differing distributions of functional genetic variants in the beta1-AR...
  15. ncbi request reprint Volatility: a new vital sign identified using a novel bedside monitoring strategy
    Eric L Grogan
    VA Quality Scholars Program, Vanderbilt University Department of Surgery, Nashville, Tennessee, USA
    J Trauma 58:7-12; discussion 12-4. 2005
    ..We hypothesized: heart rate (HR) volatility predicts outcome better than measures of central tendency (mean and median)...
  16. pmc Reduced heart rate volatility: an early predictor of death in trauma patients
    Eric L Grogan
    VA Quality Scholars Program, Vanderbilt University, Nashville, TN, USA
    Ann Surg 240:547-54; discussion 554-6. 2004
    ..To determine if using dense data capture to measure heart rate volatility (standard deviation) measured in 5-minute intervals predicts death...
  17. pmc The alpha2C-adrenoceptor deletion322-325 variant and cold-induced vasoconstriction
    Eitan A Friedman
    Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, 542 RRB, Nashville, TN 37232 6602, USA
    Clin Auton Res 19:247-54. 2009
    ..We tested the hypothesis that individuals with the ADRA2C del322-325 variant have attenuated vasoconstriction in response to cold...
  18. pmc Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception
    Utkarsh Kohli
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Eur J Pain 14:154-9. 2010
    ..We hypothesized that common genetic variants in these genes, particularly the ADRA2C 322-325 deletion variant, affect pain perception or cognitive responses...
  19. pmc Sildenafil does not improve nitric oxide-mediated endothelium-dependent vascular responses in smokers
    Victor Dishy
    Division of Clinical Pharmacology, General Clinical Research Center, Department of Biomedical Engineering, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
    Br J Clin Pharmacol 57:209-12. 2004
    ..To examine the hypothesis that sildenafil, a phosphodiesterase type 5 inhibitor that inhibits cGMP breakdown, could enhance nitric oxide-mediated vasodilation and reverse endothelial dysfunction in chronic smokers...
  20. ncbi request reprint Effects of unilateral and bilateral carotid baroreflex stimulation on cardiac and neural sympathetic discharge oscillatory patterns
    Raffaello Furlan
    Unità Sincopi e Disturbi della Postura, Medicina Interna II, Ospedale L Sacco, Universita di Milano, Via G B Grassi 74, 20157 Milano, Italy
    Circulation 108:717-23. 2003
    ..We tested the hypothesis that unilateral carotid baroreceptor perturbation might differentially affect HR, AP, and MSNA variability compared with stimulation of the opposite side...
  21. ncbi request reprint Management of extravasation injuries
    Paul A Harris
    ANZ J Surg 72:684. 2002