Paul A Harris
Affiliation: Vanderbilt University
- ResearchMatch: a national registry to recruit volunteers for clinical researchPaul A Harris
Office of Research Informatics, Vanderbilt University, Nashville, Tennessee 37203, USA
Acad Med 87:66-73. 2012..ResearchMatch has proven successful in connecting volunteers with researchers, and the authors are currently evaluating regulatory and workflow options to open access to researchers at non-CTSA institutions...
- StarBRITE: the Vanderbilt University Biomedical Research Integration, Translation and Education portalPaul A Harris
Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave, 6th Floor, Nashville, TN 37203, USA
J Biomed Inform 44:655-62. 2011..75-years of operation, and a report of lessons learned during organizing, launching and refining the portal...
- Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics supportPaul A Harris
Department of Biomedical Informatics, Vanderbilt University, 2525 West End Avenue, Suite 674, Nashville, TN 37212, USA
J Biomed Inform 42:377-81. 2009..REDCap is currently supporting 286 translational research projects in a growing collaborative network including 27 active partner institutions...
- Clinical research subject recruitment: the Volunteer for Vanderbilt Research Program www.volunteer.mc.vanderbilt.eduPaul A Harris
General Clinical Research Center, Vanderbilt University, Nashville, TN 37212, USA
J Am Med Inform Assoc 12:608-13. 2005....
- Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjectsDaniel Kurnik
Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
J Hypertens 25:763-71. 2007..We therefore examined the hypothesis that the ADRA2C deletion variant would alter sympathetic activity and contribute to ethnic differences in blood pressure...
- Water ingestion as prophylaxis against syncopeChih-Cherng Lu
Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tenn 37232-2195, USA
Circulation 108:2660-5. 2003..The effect of water is mediated by increased peripheral vascular resistance. Water ingestion may constitute a simple and effective prophylaxis against vasovagal reactions in healthy subjects, such as those associated with blood donation...
- Rate-independent QT shortening during exercise in healthy subjects: terminal repolarization does not shorten with exercisePrince J Kannankeril
Oates Institute for Experimental Therapeutics, Clinical Research Center, Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 9119, USA
J Cardiovasc Electrophysiol 19:1284-8. 2008..We hypothesized that QT hysteresis is evident within stages of exercise and investigated which component of the QT contributes to hysteresis...
- Dopamine-beta-hydroxylase in postural tachycardia syndromeEmily M Garland
Autonomic Dysfunction Center, AA3228 Medical Center North, Vanderbilt University, Nashville, TN 37232 2195, USA
Am J Physiol Heart Circ Physiol 293:H684-90. 2007..Although DBH activity and genotype are unlikely to be primary determinants of susceptibility to POTS, differences in DBH activity in POTS may reflect differences in the level of sympathetic activation...
- Sodium paradoxically reduces the gastropressor response in patients with orthostatic hypotensionSatish R Raj
Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN, USA
Hypertension 48:329-34. 2006..These data suggest a potentially important role for gastrointestinal osmolality in the activation of the sympathetic nervous system leading to cardiovascular reflexes responsible for the gastropressor response...
- Endothelial NO synthase polymorphisms and postural tachycardia syndromeEmily M Garland
Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
Hypertension 46:1103-10. 2005..These results indicate that NO may influence the development of POTS and the severity of POTS symptoms...
- Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndromeSatish R Raj
Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, 1161 21st Ave South, Nashville, TN 37232 2195, USA
Circulation 111:2734-40. 2005..The objective of this study was to test the hypothesis that acetylcholinesterase inhibitors will attenuate the tachycardia and improve symptom burden in patients with POTS...
- Variations in the alpha2A-adrenergic receptor gene and their functional effectsDaniel Kurnik
Department of Medicine, Division of Clinical Pharmacology, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232 6606, USA
Clin Pharmacol Ther 79:173-85. 2006..The objectives of this study were to systematically search for variants in the ADRA2A gene, to define the gene's haplotype structure, and to examine potential functional effects of these variants...
- An informatics-based tool to assist researchers in initiating research at an academic medical center: Vanderbilt Customized Action PlanJill M Pulley
Vanderbilt Institute for Clinical and Translational Research VICTR, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
Acad Med 85:164-8. 2010..The informatics-systems-based approach of the V-CAP is scalable to other academic medical centers and may serve as a useful model to help researchers navigate the complexity of the regulatory approvals process...
- Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockadeDaniel Kurnik
Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
Pharmacogenet Genomics 18:895-902. 2008..The purpose of this study was to determine whether ethnic differences in response to beta-blockade can be explained by differing distributions of functional genetic variants in the beta1-AR...
- Volatility: a new vital sign identified using a novel bedside monitoring strategyEric L Grogan
VA Quality Scholars Program, Vanderbilt University Department of Surgery, Nashville, Tennessee, USA
J Trauma 58:7-12; discussion 12-4. 2005..3) Densely sampled aggregated physiologic data may identify sub-groups of patients requiring new treatment strategies...
- Reduced heart rate volatility: an early predictor of death in trauma patientsEric L Grogan
VA Quality Scholars Program, Vanderbilt University, Nashville, TN, USA
Ann Surg 240:547-54; discussion 554-6. 2004..CONCLUSIONS: CVRD identifies a subgroup of patients with a high probability of dying. Death is predicted within first 24 hours of stay. We hypothesize CVRD is a surrogate for autonomic nervous system dysfunction...
- The alpha2C-adrenoceptor deletion322-325 variant and cold-induced vasoconstrictionEitan A Friedman
Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, 542 RRB, Nashville, TN 37232 6602, USA
Clin Auton Res 19:247-54. 2009..We tested the hypothesis that individuals with the ADRA2C del322-325 variant have attenuated vasoconstriction in response to cold...
- Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perceptionUtkarsh Kohli
Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Eur J Pain 14:154-9. 2010..We hypothesized that common genetic variants in these genes, particularly the ADRA2C 322-325 deletion variant, affect pain perception or cognitive responses...
- Sildenafil does not improve nitric oxide-mediated endothelium-dependent vascular responses in smokersVictor Dishy
Division of Clinical Pharmacology, General Clinical Research Center, Department of Biomedical Engineering, Vanderbilt University Medical Center, Nashville, TN 37232-6602, USA
Br J Clin Pharmacol 57:209-12. 2004..39 and 0.7, respectively). Resting heart rate and blood pressure were unaffected by sildenafil. CONCLUSIONS: Acute sildenafil administration did not improve endothelial function in chronic smoking men...
- Effects of unilateral and bilateral carotid baroreflex stimulation on cardiac and neural sympathetic discharge oscillatory patternsRaffaello Furlan
Unità Sincopi e Disturbi della Postura, Medicina Interna II, Ospedale L Sacco, Universita di Milano, Via G B Grassi 74, 20157 Milano, Italy
Circulation 108:717-23. 2003..We tested the hypothesis that unilateral carotid baroreceptor perturbation might differentially affect HR, AP, and MSNA variability compared with stimulation of the opposite side...
- Management of extravasation injuriesPaul A Harris
ANZ J Surg 72:684. 2002