Chuan Ming Hao

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptor
    Jian Chen
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 295:F818-25. 2008
  2. pmc Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection
    Jinsong Sheng
    Veterans Affairs Tennessee Valley Healthcare System, Department of Medicine, Division of Infectious Diseases, Vanderbilt University, Nashville, TN, USA
    BMC Cell Biol 5:32. 2004
  3. ncbi request reprint Roles of lipid mediators in kidney injury
    Chuan Ming Hao
    Division of Nephrology, Department of Medicine, Vanderbilt University, and Veterans Affairs Medical Center, Nashville, TN 37232, USA
    Semin Nephrol 27:338-51. 2007
  4. ncbi request reprint Physiologic and pathophysiologic roles of lipid mediators in the kidney
    C M Hao
    Division of Nephrology, Department of Medicine, Vanderbilt University, Veterans Administration Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 71:1105-15. 2007
  5. ncbi request reprint Physiological regulation of prostaglandins in the kidney
    Chuan Ming Hao
    Division of Nephrology, Department of Medicine, Vanderbilt University, and Veterans Affair Medical Center, Nashville, TN 37232, USA
    Annu Rev Physiol 70:357-77. 2008
  6. ncbi request reprint Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria
    Reena Rao
    Div of Nephrology, Vanderbilt Univ Medical Ctr, S3223, MCN, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 288:F642-9. 2005
  7. pmc Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II
    Zhonghua Qi
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    J Clin Invest 110:61-9. 2002
  8. ncbi request reprint Hypertonic stress activates glycogen synthase kinase 3beta-mediated apoptosis of renal medullary interstitial cells, suppressing an NFkappaB-driven cyclooxygenase-2-dependent survival pathway
    Reena Rao
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 279:3949-55. 2004
  9. ncbi request reprint Peroxisome proliferator-activated receptor delta activation promotes cell survival following hypertonic stress
    Chuan Ming Hao
    Division of Nephrology and Department of Pharmacology, Vanderbilt University and Department of Veterans Affairs Hospital, Nashville, Tennessee 37232, USA
    J Biol Chem 277:21341-5. 2002
  10. ncbi request reprint COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress
    Gilbert W Moeckel
    Renal Pathology Division, Department of Pathology, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 278:19352-7. 2003

Collaborators

Detail Information

Publications24

  1. pmc Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptor
    Jian Chen
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 295:F818-25. 2008
    ..Renal medullary PGE(2) promotes renal sodium excretion via the EP2 receptor, thereby maintaining normotension in the setting of high salt intake...
  2. pmc Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection
    Jinsong Sheng
    Veterans Affairs Tennessee Valley Healthcare System, Department of Medicine, Division of Infectious Diseases, Vanderbilt University, Nashville, TN, USA
    BMC Cell Biol 5:32. 2004
    ..The characterization of cellular genes required for virus infection and/or cell killing will be essential for understanding viral life cycles, and may provide cellular targets for new antiviral therapies...
  3. ncbi request reprint Roles of lipid mediators in kidney injury
    Chuan Ming Hao
    Division of Nephrology, Department of Medicine, Vanderbilt University, and Veterans Affairs Medical Center, Nashville, TN 37232, USA
    Semin Nephrol 27:338-51. 2007
    ..Those pathways should provide fruitful targets for intervention in the pharmacologic treatment of renal disease...
  4. ncbi request reprint Physiologic and pathophysiologic roles of lipid mediators in the kidney
    C M Hao
    Division of Nephrology, Department of Medicine, Vanderbilt University, Veterans Administration Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 71:1105-15. 2007
    ..Those pathways should provide fruitful targets for intervention in the pharmacologic treatment of renal disease...
  5. ncbi request reprint Physiological regulation of prostaglandins in the kidney
    Chuan Ming Hao
    Division of Nephrology, Department of Medicine, Vanderbilt University, and Veterans Affair Medical Center, Nashville, TN 37232, USA
    Annu Rev Physiol 70:357-77. 2008
    ..COXs, prostanoid synthases, and prostanoid receptors should provide fruitful targets for intervention in the pharmacological treatment of renal disease...
  6. ncbi request reprint Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria
    Reena Rao
    Div of Nephrology, Vanderbilt Univ Medical Ctr, S3223, MCN, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 288:F642-9. 2005
    ..In conclusion, these findings temporally link decreased GSK-3 activity to enhanced renal COX2 expression and COX2-derived urine PGE(2) excretion. Suppression of COX2-derived PGE(2) blunts lithium-associated polyuria...
  7. pmc Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II
    Zhonghua Qi
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    J Clin Invest 110:61-9. 2002
    ..In contrast, the pressor effect of Ang II is blunted by COX1 inhibition. These results suggest that, rather than having similar cardiovascular effects, the activities of COX1 and COX2 are functionally antagonistic...
  8. ncbi request reprint Hypertonic stress activates glycogen synthase kinase 3beta-mediated apoptosis of renal medullary interstitial cells, suppressing an NFkappaB-driven cyclooxygenase-2-dependent survival pathway
    Reena Rao
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 279:3949-55. 2004
    ..These findings suggest that GSK 3beta negatively regulates COX 2 expression and that GSK 3beta inhibitors protect RMICs from hypertonic stress via induction of NFkappaB-COX 2-dependent pathway...
  9. ncbi request reprint Peroxisome proliferator-activated receptor delta activation promotes cell survival following hypertonic stress
    Chuan Ming Hao
    Division of Nephrology and Department of Pharmacology, Vanderbilt University and Department of Veterans Affairs Hospital, Nashville, Tennessee 37232, USA
    J Biol Chem 277:21341-5. 2002
    ..Inhibition of PPARdelta activity may contribute to the renal papillary necrosis associated with analgesic and/or NSAID use...
  10. ncbi request reprint COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress
    Gilbert W Moeckel
    Renal Pathology Division, Department of Pathology, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 278:19352-7. 2003
    ..These findings may have implications for the pathogenesis of analgesic nephropathy...
  11. ncbi request reprint Mineralocorticoid regulation of cyclooxygenase-2 expression in rat renal medulla
    Ming Zhi Zhang
    George O Brien Center for Kidney and Urologic Diseases, Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 283:F509-16. 2002
    ..Together, these results suggest that mineralocorticoids lead to upregulation of COX-2 in rat renal medulla by indirect pathways, probably involving induced electrolyte hypertonicity in the interstitial fluid...
  12. ncbi request reprint C/EBP{beta} and its binding element are required for NF{kappa}B-induced COX2 expression following hypertonic stress
    Jing Chen
    Division of Nephrology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 280:16354-9. 2005
    ..These studies indicate C/EBPbeta is required for the transcriptional activation of COX2 by NFkappaB, suggesting a dominant role for the C/EBPbeta pathway in regulating induction of RMIC COX2 by hypertonicity...
  13. ncbi request reprint Overexpression of cyclooxygenase-2 predisposes to podocyte injury
    Huifang Cheng
    Division of Nephrology, C3115 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Am Soc Nephrol 18:551-9. 2007
    ..SC58236 also reduced Adriamycin-induced foot process effacement in both the COX-2 transgenic mice and Balb/C mice. Therefore, overexpression of COX-2 may predispose podocytes to further injury...
  14. ncbi request reprint Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes
    Jing Chen
    Vanderbilt University Medical Center, S3223 MCN, Nashville, TN 37232, USA
    J Am Soc Nephrol 17:1283-91. 2006
    ..In the adult kidney, nestin expression is restricted to differentiated podocytes, suggesting that nestin could play an important role in maintaining the structural integrity of the podocytes...
  15. pmc Sirt1 activation protects the mouse renal medulla from oxidative injury
    Wenjuan He
    Nephrology Division, Vanderbilt University Medical Center School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 120:1056-68. 2010
    ..We therefore suggest that Sirt1 provides a potential therapeutic target to minimize renal medullary cell damage following oxidative stress...
  16. pmc Increased dietary sodium induces COX2 expression by activating NFκB in renal medullary interstitial cells
    Wenjuan He
    Division of Nephrology, Department of Medicine and Cancer Biology, Veteran Affair Medical Center, Vanderbilt University, Nashville, TN, USA
    Pflugers Arch 466:357-67. 2014
    ..These data therefore suggest that renal medullary interstitial cell NFκB plays an important role in mediating renal medullary COX2 expression and promoting renal PGE2 synthesis in response to increased dietary sodium. ..
  17. pmc Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c
    Byoung Geun Han
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Am J Physiol Endocrinol Metab 295:E981-6. 2008
    ..These results show that 6-h fasting glucose provides a superior index of glycemic control and correlates more closely with Hb A(1c) than overnight-fasted blood glucose in these strains of mice...
  18. pmc Assessment of renal function in mice with unilateral ureteral obstruction using 99mTc-MAG3 dynamic scintigraphy
    Mohammed N Tantawy
    Radiology and Vanderbilt University Institute of Imaging Science, Nashville, TN, USA
    BMC Nephrol 13:168. 2012
    ..Here, we have applied 99mTc-MAG3 renal scintigraphy to a mouse model of unilateral ureteral obstruction (UUO) and evaluated its utility in studying obstructive renal disease...
  19. pmc Sirtuins and their relevance to the kidney
    Chuan Ming Hao
    Division of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Am Soc Nephrol 21:1620-7. 2010
    ..Here, we review sirtuin biology and discuss how CR-triggered sirtuin-dependent pathways affect renal physiology and the pathogenesis of kidney diseases and related disorders...
  20. ncbi request reprint Plasminogen activator inhibitor-1 modulates adipocyte differentiation
    Xiubin Liang
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232 2561, USA
    Am J Physiol Endocrinol Metab 290:E103-E113. 2006
    ..We postulate that these PAI-1 effects on adipocytes may, at least in part, be mediated via modulation of plasmin activity and extracellular matrix components...
  21. pmc Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells
    Surekha Neelisetty
    Division of Nephrology, Department of Medicine, Vanderbilt Medical Center, Nashville, Tennessee, USA
    Kidney Int 88:503-14. 2015
    ..Thus, abrogating TGF-β signaling in matrix-producing interstitial cells is not sufficient to reduce fibrosis after renal injury. ..
  22. ncbi request reprint Hypertension and cyclooxygenase-2 inhibitors: target: the renal medulla
    Chuan Ming Hao
    Hypertension 44:396-7. 2004
  23. ncbi request reprint Aldosterone upregulates vascular endothelial growth factor expression in mouse cortical collecting duct epithelial cells through classic mineralocorticoid receptor
    Lingyun Lai
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, PR China
    Life Sci 81:570-6. 2007
    ..This finding provides experimental evidence for the local non-hemodynamic action of aldosterone...
  24. ncbi request reprint Expression of nestin in the podocytes of normal and diseased human kidneys
    Wei Su
    Division of Nephrology, Huashan Hospital, Institute of Nephrology, Fudan University, Shanghai, PR Chiina
    Am J Physiol Regul Integr Comp Physiol 292:R1761-7. 2007
    ..These studies suggest that nestin may play an important role in maintaining normal podocyte function in the human kidney...

Research Grants3

  1. Interstitial Cell COXs in Renal Development and Disease
    Chuan Ming Hao; Fiscal Year: 2004
    ....
  2. Role of Cyclooxygenase stimulated Neovascularization in Diabetic Nephropathy
    Chuan Ming Hao; Fiscal Year: 2008
    ..Pozzi's expertise in angiogenesis and Dr. Breyer's expertise in mouse models of diabetic nephropathy, and draws on their common interest in the prostanoid pathway in cell differentiation and survival. ..
  3. Renal Medullary COX2 in Blood Pressure Regulation
    Chuan Ming Hao; Fiscal Year: 2009
    ..Specific Aim III: To define the down-stream target of activated renal medullary COX2 expression. ..