Steven Hanks

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility
    Steven K Hanks
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Front Biosci 8:d982-96. 2003
  2. ncbi Genomic analysis of the eukaryotic protein kinase superfamily: a perspective
    Steven K Hanks
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Genome Biol 4:111. 2003
  3. ncbi Dynamics and mechanism of p130Cas localization to focal adhesions
    Dominique M Donato
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Biol Chem 285:20769-79. 2010
  4. ncbi Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells
    Jan Brabek
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Mol Cancer Res 3:307-15. 2005
  5. ncbi Regulation and localization of CAS substrate domain tyrosine phosphorylation
    Priscila M Fonseca
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, U-4200 MCN Learned Laboratories, Nashville, TN 37232, USA
    Cell Signal 16:621-9. 2004
  6. ncbi Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration
    Nah Young Shin
    Department of Cell and Developmental Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 279:38331-7. 2004
  7. ncbi The signaling and biological implications of FAK overexpression in cancer
    Priscila M F Siesser
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2175, USA
    Clin Cancer Res 12:3233-7. 2006
  8. ncbi CD98 modulates integrin beta1 function in polarized epithelial cells
    Songmin Cai
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA
    J Cell Sci 118:889-99. 2005
  9. ncbi Assaying protein kinase activity
    Jan Brabek
    Department of Cell and Developmental Biology, Vanderbuilt University School of Medicine, Nashville, TN, USA
    Methods Mol Biol 284:79-90. 2004
  10. ncbi FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation
    Shyamali Roy
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Cell Biochem 84:377-88. 2002

Research Grants

  1. PATHOGENESIS OF FAMILIAL JUVENILE NEPHRONOPHTHISIS
    Steven Hanks; Fiscal Year: 2003
  2. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2005
  3. FAK/Src/CAS Signaling in Cell Motility and Invasion
    Steven K Hanks; Fiscal Year: 2010
  4. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2001
  5. FAK/Src/CAS Signaling in Cell Motility and Invasion
    Steven Hanks; Fiscal Year: 2009

Collaborators

  • Ambra Pozzi
  • Yu li Wang
  • William G Cance
  • Nah Young Shin
  • Nah-Young Shin
  • Jan Brabek
  • Dominique M Donato
  • Wook Kim
  • Margo T Frey
  • Priscila M F Siesser
  • Mariarita Bianchi
  • Songmin Cai
  • Sabata S Constancio
  • Priscila M Fonseca
  • Timothy P Hecker
  • Elena Kurenova
  • Guochun Li
  • Adriana S Torsoni
  • Shyamali Roy
  • Larisa M Ryzhova
  • Irina Kaverina
  • Leslie M Meenderink
  • Woo Keun Song
  • Jin Soo Kim
  • Yong Seok Kang
  • Thomas P Russell
  • Irene Y Tsai
  • Priscila Fonseca Siesser
  • Oriano Marin
  • David L Turner
  • Emma Villa-Moruzzi
  • Nada Bulus
  • Roy Zent
  • Dong Chen
  • Stefania De Lucchini
  • Priscila M Fonseca-Siesser
  • XiHui Yang
  • Tanya A Rege
  • Larisa Ryzhova
  • Albert S Baldwin
  • Marylyn D Ritchie
  • Rebecca S Dise
  • Zheng Gang Liu
  • Li-Hui Xu
  • Jens Schneider-Mergener
  • Dawn M Kilkenny
  • Qiang Ding
  • Jiong Wu
  • Rolf J Craven
  • Zheng-Gang Liu
  • Li hui Xu
  • Candece L Gladson
  • Ronald M Wisdom
  • Randall S Johnson
  • Wilson Nadruz
  • Kit Pogliano
  • Katie Nason
  • Kleber G Franchini
  • Cindy Gustafson-Brown
  • Jeffrey M Arbeit
  • Paul J Ruest

Detail Information

Publications17

  1. ncbi Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility
    Steven K Hanks
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Front Biosci 8:d982-96. 2003
    ..This article reviews these and other aspects of FAK signaling and function...
  2. ncbi Genomic analysis of the eukaryotic protein kinase superfamily: a perspective
    Steven K Hanks
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Genome Biol 4:111. 2003
    ..Efforts to identify and classify all the members of the eukaryotic protein kinase superfamily have recently culminated in the mining of essentially complete human genome data...
  3. ncbi Dynamics and mechanism of p130Cas localization to focal adhesions
    Dominique M Donato
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Biol Chem 285:20769-79. 2010
    ....
  4. ncbi Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells
    Jan Brabek
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Mol Cancer Res 3:307-15. 2005
    ..Thus multiple CAS-mediated signaling events are implicated in promoting invasive and metastatic properties of Src-transformed cells...
  5. ncbi Regulation and localization of CAS substrate domain tyrosine phosphorylation
    Priscila M Fonseca
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, U-4200 MCN Learned Laboratories, Nashville, TN 37232, USA
    Cell Signal 16:621-9. 2004
    ....
  6. ncbi Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration
    Nah Young Shin
    Department of Cell and Developmental Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 279:38331-7. 2004
    ..Effective wound healing was achieved by CAS variants containing as few as four of the major sites, indicating sufficiency of partial SD signaling function in this cell migration response...
  7. ncbi The signaling and biological implications of FAK overexpression in cancer
    Priscila M F Siesser
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2175, USA
    Clin Cancer Res 12:3233-7. 2006
  8. ncbi CD98 modulates integrin beta1 function in polarized epithelial cells
    Songmin Cai
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA
    J Cell Sci 118:889-99. 2005
    ....
  9. ncbi Assaying protein kinase activity
    Jan Brabek
    Department of Cell and Developmental Biology, Vanderbuilt University School of Medicine, Nashville, TN, USA
    Methods Mol Biol 284:79-90. 2004
    ....
  10. ncbi FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation
    Shyamali Roy
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Cell Biochem 84:377-88. 2002
    ..Nor is FAK strictly required to achieve the altered morphological and growth characteristics of v-Src transformed cells...
  11. ncbi Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration
    Mariarita Bianchi
    Department of Experimental Pathology, University of Pisa, 56126 Pisa, Italy
    Biochem J 391:359-70. 2005
    ..These results indicate an additional mechanism for regulation of FAK activity during cell spreading and migration, involving Ser-722 phosphorylation modulated through the competing actions of GSK3beta and PP1...
  12. ncbi Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein
    Elena Kurenova
    Department of Surgery, University of Florida, Gainesville, Florida 32610, USA
    Mol Cell Biol 24:4361-71. 2004
    ..We thus propose that FAK overexpression in human tumors provides a survival signal function by binding to RIP and inhibiting its interaction with the death receptor complex...
  13. ncbi Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells
    Timothy P Hecker
    Department of Pathology, Division of Neuropathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Oncogene 23:3962-71. 2004
    ....
  14. ncbi Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes
    Adriana S Torsoni
    Department of Internal Medicine, School of Medicine, State University of Campinas, SP, Brazil
    Circ Res 93:140-7. 2003
    ....
  15. ncbi Cellular responses to substrate topography: role of myosin II and focal adhesion kinase
    Margo T Frey
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Biophys J 90:3774-82. 2006
    ..We propose that increased surface contact provided by topographic features guides cell migration by regulating the strength of local adhesions and contractions, through a FAK- and myosin II-dependent mechanism...
  16. ncbi c-Jun is essential for organization of the epidermal leading edge
    Guochun Li
    Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 4:865-77. 2003
    ..Lack of c-Jun prevents EGF-induced expression of HB-EGF, indicating that c-jun controls formation of the epidermal leading edge through its control of an EGF receptor autocrine loop...
  17. ncbi The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling
    Wook Kim
    Cell Dynamics Research Center and Bioimaging Research Center, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Mol Biol Cell 19:2135-46. 2008
    ..Thus, p130Cas-mediated control of TGF-beta/Smad signaling may provide an additional clue to the mechanism underlying resistance to TGF-beta-induced growth inhibition...

Research Grants20

  1. PATHOGENESIS OF FAMILIAL JUVENILE NEPHRONOPHTHISIS
    Steven Hanks; Fiscal Year: 2003
    ..abstract_text> ..
  2. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2005
    ..This work will help define the biological changes that underlie cancer spread and may lead to new preventive or treatment interventions. ..
  3. FAK/Src/CAS Signaling in Cell Motility and Invasion
    Steven K Hanks; Fiscal Year: 2010
    ..The work has potential to reveal new therapeutic targets and prognostic indicators for diseases that arise from aberrant motility and invasion. ..
  4. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2001
    ....
  5. FAK/Src/CAS Signaling in Cell Motility and Invasion
    Steven Hanks; Fiscal Year: 2009
    ..The work has potential to reveal new therapeutic targets and prognostic indicators for diseases that arise from aberrant motility and invasion. ..