Steven Hanks

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility
    Steven K Hanks
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Front Biosci 8:d982-96. 2003
  2. pmc P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration
    Leslie M Meenderink
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 5:e13412. 2010
  3. pmc Genomic analysis of the eukaryotic protein kinase superfamily: a perspective
    Steven K Hanks
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Genome Biol 4:111. 2003
  4. pmc Dynamics and mechanism of p130Cas localization to focal adhesions
    Dominique M Donato
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Biol Chem 285:20769-79. 2010
  5. ncbi request reprint Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells
    Jan Brabek
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Mol Cancer Res 3:307-15. 2005
  6. ncbi request reprint Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration
    Nah Young Shin
    Department of Cell and Developmental Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 279:38331-7. 2004
  7. ncbi request reprint Regulation and localization of CAS substrate domain tyrosine phosphorylation
    Priscila M Fonseca
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, U 4200 MCN Learned Laboratories, Nashville, TN 37232, USA
    Cell Signal 16:621-9. 2004
  8. ncbi request reprint FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation
    Shyamali Roy
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Cell Biochem 84:377-88. 2002
  9. ncbi request reprint The signaling and biological implications of FAK overexpression in cancer
    Priscila M F Siesser
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    Clin Cancer Res 12:3233-7. 2006
  10. ncbi request reprint Assaying protein kinase activity
    Jan Brabek
    Department of Cell and Developmental Biology, Vanderbuilt University School of Medicine, Nashville, TN, USA
    Methods Mol Biol 284:79-90. 2004

Research Grants

  1. PATHOGENESIS OF FAMILIAL JUVENILE NEPHRONOPHTHISIS
    Steven Hanks; Fiscal Year: 2003
  2. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2003
  3. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2004
  4. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2005
  5. FAK/Src/CAS Signaling in Cell Motility and Invasion
    Steven Hanks; Fiscal Year: 2007
  6. FAK/Src/CAS Signaling in Cell Motility and Invasion
    Steven Hanks; Fiscal Year: 2009
  7. FAK/Src/CAS Signaling in Cell Motility and Invasion
    Steven K Hanks; Fiscal Year: 2010
  8. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2002
  9. PATHOGENESIS OF FAMILIAL JUVENILE NEPHRONOPHTHISIS
    Steven Hanks; Fiscal Year: 2002
  10. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 1999

Collaborators

  • Ambra Pozzi
  • Irina Kaverina
  • Yu li Wang
  • William G Cance
  • Nah Young Shin
  • Jan Brabek
  • Dominique M Donato
  • Leslie M Meenderink
  • Larisa M Ryzhova
  • Wook Kim
  • Priscila M F Siesser
  • Margo T Frey
  • Mariarita Bianchi
  • Songmin Cai
  • Timothy P Hecker
  • Elena Kurenova
  • Sabata S Constancio
  • Priscila M Fonseca
  • Guochun Li
  • Adriana S Torsoni
  • Shyamali Roy
  • Daniel F Gochberg
  • Woo Keun Song
  • Jin Soo Kim
  • Yong Seok Kang
  • Thomas P Russell
  • Irene Y Tsai
  • Priscila Fonseca Siesser
  • Oriano Marin
  • David L Turner
  • Dong Chen
  • Priscila M Fonseca-Siesser
  • Nada Bulus
  • Stefania De Lucchini
  • Roy Zent
  • Emma Villa-Moruzzi
  • Qiang Ding
  • XiHui Yang
  • Dawn M Kilkenny
  • Candece L Gladson
  • Jiong Wu
  • Marylyn D Ritchie
  • Larisa Ryzhova
  • Tanya A Rege
  • Li hui Xu
  • Rebecca S Dise
  • Albert S Baldwin
  • Zheng Gang Liu
  • Jens Schneider-Mergener
  • Rolf J Craven
  • Kleber G Franchini
  • Randall S Johnson
  • Ronald M Wisdom
  • Katie Nason
  • Jeffrey M Arbeit
  • Wilson Nadruz
  • Cindy Gustafson-Brown
  • Kit Pogliano
  • Paul J Ruest

Detail Information

Publications18

  1. ncbi request reprint Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility
    Steven K Hanks
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Front Biosci 8:d982-96. 2003
    ..This article reviews these and other aspects of FAK signaling and function...
  2. pmc P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration
    Leslie M Meenderink
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 5:e13412. 2010
    ....
  3. pmc Genomic analysis of the eukaryotic protein kinase superfamily: a perspective
    Steven K Hanks
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Genome Biol 4:111. 2003
    ..Efforts to identify and classify all the members of the eukaryotic protein kinase superfamily have recently culminated in the mining of essentially complete human genome data...
  4. pmc Dynamics and mechanism of p130Cas localization to focal adhesions
    Dominique M Donato
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Biol Chem 285:20769-79. 2010
    ....
  5. ncbi request reprint Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells
    Jan Brabek
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Mol Cancer Res 3:307-15. 2005
    ..Thus multiple CAS-mediated signaling events are implicated in promoting invasive and metastatic properties of Src-transformed cells...
  6. ncbi request reprint Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration
    Nah Young Shin
    Department of Cell and Developmental Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 279:38331-7. 2004
    ..Effective wound healing was achieved by CAS variants containing as few as four of the major sites, indicating sufficiency of partial SD signaling function in this cell migration response...
  7. ncbi request reprint Regulation and localization of CAS substrate domain tyrosine phosphorylation
    Priscila M Fonseca
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, U 4200 MCN Learned Laboratories, Nashville, TN 37232, USA
    Cell Signal 16:621-9. 2004
    ....
  8. ncbi request reprint FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation
    Shyamali Roy
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Cell Biochem 84:377-88. 2002
    ..Nor is FAK strictly required to achieve the altered morphological and growth characteristics of v-Src transformed cells...
  9. ncbi request reprint The signaling and biological implications of FAK overexpression in cancer
    Priscila M F Siesser
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    Clin Cancer Res 12:3233-7. 2006
  10. ncbi request reprint Assaying protein kinase activity
    Jan Brabek
    Department of Cell and Developmental Biology, Vanderbuilt University School of Medicine, Nashville, TN, USA
    Methods Mol Biol 284:79-90. 2004
    ....
  11. ncbi request reprint CD98 modulates integrin beta1 function in polarized epithelial cells
    Songmin Cai
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA
    J Cell Sci 118:889-99. 2005
    ....
  12. pmc Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration
    Mariarita Bianchi
    Department of Experimental Pathology, University of Pisa, 56126 Pisa, Italy
    Biochem J 391:359-70. 2005
    ..These results indicate an additional mechanism for regulation of FAK activity during cell spreading and migration, involving Ser-722 phosphorylation modulated through the competing actions of GSK3beta and PP1...
  13. ncbi request reprint Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes
    Adriana S Torsoni
    Department of Internal Medicine, School of Medicine, State University of Campinas, SP, Brazil
    Circ Res 93:140-7. 2003
    ....
  14. pmc Cellular responses to substrate topography: role of myosin II and focal adhesion kinase
    Margo T Frey
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Biophys J 90:3774-82. 2006
    ..We propose that increased surface contact provided by topographic features guides cell migration by regulating the strength of local adhesions and contractions, through a FAK- and myosin II-dependent mechanism...
  15. pmc Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein
    Elena Kurenova
    Department of Surgery, University of Florida, Gainesville, Florida 32610, USA
    Mol Cell Biol 24:4361-71. 2004
    ..We thus propose that FAK overexpression in human tumors provides a survival signal function by binding to RIP and inhibiting its interaction with the death receptor complex...
  16. pmc The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling
    Wook Kim
    Cell Dynamics Research Center and Bioimaging Research Center, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Mol Biol Cell 19:2135-46. 2008
    ..Thus, p130Cas-mediated control of TGF-beta/Smad signaling may provide an additional clue to the mechanism underlying resistance to TGF-beta-induced growth inhibition...
  17. ncbi request reprint c-Jun is essential for organization of the epidermal leading edge
    Guochun Li
    Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 4:865-77. 2003
    ..Lack of c-Jun prevents EGF-induced expression of HB-EGF, indicating that c-jun controls formation of the epidermal leading edge through its control of an EGF receptor autocrine loop...
  18. ncbi request reprint Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells
    Timothy P Hecker
    Department of Pathology, Division of Neuropathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Oncogene 23:3962-71. 2004
    ....

Research Grants20

  1. PATHOGENESIS OF FAMILIAL JUVENILE NEPHRONOPHTHISIS
    Steven Hanks; Fiscal Year: 2003
    ..abstract_text> ..
  2. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2003
    ..This work will help define the biological changes that underlie cancer spread and may lead to new preventive or treatment interventions. ..
  3. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2004
    ..This work will help define the biological changes that underlie cancer spread and may lead to new preventive or treatment interventions. ..
  4. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2005
    ..This work will help define the biological changes that underlie cancer spread and may lead to new preventive or treatment interventions. ..
  5. FAK/Src/CAS Signaling in Cell Motility and Invasion
    Steven Hanks; Fiscal Year: 2007
    ..The work has potential to reveal new therapeutic targets and prognostic indicators for diseases that arise from aberrant motility and invasion. ..
  6. FAK/Src/CAS Signaling in Cell Motility and Invasion
    Steven Hanks; Fiscal Year: 2009
    ..The work has potential to reveal new therapeutic targets and prognostic indicators for diseases that arise from aberrant motility and invasion. ..
  7. FAK/Src/CAS Signaling in Cell Motility and Invasion
    Steven K Hanks; Fiscal Year: 2010
    ..The work has potential to reveal new therapeutic targets and prognostic indicators for diseases that arise from aberrant motility and invasion. ..
  8. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2002
    ..This work will help define the biological changes that underlie cancer spread and may lead to new preventive or treatment interventions. ..
  9. PATHOGENESIS OF FAMILIAL JUVENILE NEPHRONOPHTHISIS
    Steven Hanks; Fiscal Year: 2002
    ..abstract_text> ..
  10. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 1999
    ....
  11. PATHOGENESIS OF FAMILIAL JUVENILE NEPHRONOPHTHISIS
    Steven Hanks; Fiscal Year: 2000
    ..abstract_text> ..
  12. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2000
    ....
  13. FUNCTIONAL STUDIES OF FOCAL ADHESION KINASE
    Steven Hanks; Fiscal Year: 2001
    ....
  14. PATHOGENESIS OF FAMILIAL JUVENILE NEPHRONOPHTHISIS
    Steven Hanks; Fiscal Year: 2001
    ..abstract_text> ..
  15. FAK/Src/CAS Signaling in Cell Motility and Invasion
    Steven Hanks; Fiscal Year: 2009
    ..The work has potential to reveal new therapeutic targets and prognostic indicators for diseases that arise from aberrant motility and invasion. ..