R Hamid

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. doi request reprint Role of BMPR2 alternative splicing in heritable pulmonary arterial hypertension penetrance
    JOY COGAN
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Circulation 126:1907-16. 2012
  2. pmc BMPR2 expression is suppressed by signaling through the estrogen receptor
    Eric D Austin
    Department of Pediatrics, Vanderbilt University Medical Center, 1161 21st Ave S Suite DD 2205, Nashville, TN 37232 2578, USA
    Biol Sex Differ 3:6. 2012
  3. pmc Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetrance
    Charles Flynn
    Departments of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Respir Cell Mol Biol 47:20-7. 2012
  4. pmc Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension
    Eric D Austin
    Department of Pediatrics, Vanderbilt University, Medical Center, Nashville, TN, USA
    Respir Res 10:87. 2009
  5. pmc Transcripts from a novel BMPR2 termination mutation escape nonsense mediated decay by downstream translation re-initiation: implications for treating pulmonary hypertension
    R Hamid
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA
    Clin Genet 77:280-6. 2010
  6. pmc A molecular basis for variation in clinical severity of isolated growth hormone deficiency type II
    Rizwan Hamid
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2578, USA
    J Clin Endocrinol Metab 94:4728-34. 2009
  7. doi request reprint Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells
    Rizwan Hamid
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, United States
    Mol Oncol 3:451-63. 2009
  8. pmc Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele
    Rizwan Hamid
    Department of Pediatrics, Division of Medical Genetics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Hum Mutat 30:649-54. 2009
  9. doi request reprint Genomic structure, alternative splicing and expression of TG-interacting factor, in human myeloid leukemia blasts and cell lines
    Rizwan Hamid
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biochim Biophys Acta 1779:347-55. 2008
  10. pmc Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females
    E D Austin
    Dept of Pediatrics, Division of Pulmonary, Allergy, and Immunology Medicine, DD 2205 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN, 37232 2578, USA
    Eur Respir J 34:1093-9. 2009

Collaborators

Detail Information

Publications10

  1. doi request reprint Role of BMPR2 alternative splicing in heritable pulmonary arterial hypertension penetrance
    JOY COGAN
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Circulation 126:1907-16. 2012
    ..However, only 20% of mutation carriers get clinical disease. Here, we explored the hypothesis that this reduced penetrance is due in part to an alteration in BMPR2 alternative splicing...
  2. pmc BMPR2 expression is suppressed by signaling through the estrogen receptor
    Eric D Austin
    Department of Pediatrics, Vanderbilt University Medical Center, 1161 21st Ave S Suite DD 2205, Nashville, TN 37232 2578, USA
    Biol Sex Differ 3:6. 2012
    ..abstract:..
  3. pmc Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetrance
    Charles Flynn
    Departments of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Respir Cell Mol Biol 47:20-7. 2012
    ..These results provide the first molecular insights into NMD+ BMPR2 related HPAH penetrance and highlight the potential utility of cMap analyses in pulmonary research...
  4. pmc Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension
    Eric D Austin
    Department of Pediatrics, Vanderbilt University, Medical Center, Nashville, TN, USA
    Respir Res 10:87. 2009
    ..We hypothesized that patients with missense BMPR2 mutations have more severe disease than those with truncating mutations...
  5. pmc Transcripts from a novel BMPR2 termination mutation escape nonsense mediated decay by downstream translation re-initiation: implications for treating pulmonary hypertension
    R Hamid
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA
    Clin Genet 77:280-6. 2010
    ..Our data also suggest the need for a more thorough characterization of mutations prior to labeling them as haploinsufficient or dominant negative based simply on sequencing data...
  6. pmc A molecular basis for variation in clinical severity of isolated growth hormone deficiency type II
    Rizwan Hamid
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2578, USA
    J Clin Endocrinol Metab 94:4728-34. 2009
    ..The basis of the variable expression and progression of IGHD II among relatives who share the same GH1 mutation is poorly understood...
  7. doi request reprint Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells
    Rizwan Hamid
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, United States
    Mol Oncol 3:451-63. 2009
    ..Reduced TGIF expression could tip the balance toward quiescence thus providing progenitor as well as hematopoietic stem cells protection from anti-cycle agents...
  8. pmc Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele
    Rizwan Hamid
    Department of Pediatrics, Division of Medical Genetics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Hum Mutat 30:649-54. 2009
    ..Furthermore, our study illustrates a novel application of lymphoblastoid cell lines in the study of PAH, especially important because the affected site, that is, the lung, is not available for unaffected mutation carriers...
  9. doi request reprint Genomic structure, alternative splicing and expression of TG-interacting factor, in human myeloid leukemia blasts and cell lines
    Rizwan Hamid
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biochim Biophys Acta 1779:347-55. 2008
    ..A detailed characterization of this complex locus is important as it may help to clarify the functions of this gene in brain development and leukemia biology...
  10. pmc Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females
    E D Austin
    Dept of Pediatrics, Division of Pulmonary, Allergy, and Immunology Medicine, DD 2205 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN, 37232 2578, USA
    Eur Respir J 34:1093-9. 2009
    ..Further investigation of the role of oestrogens in this disease with profound sex bias may yield new insights and, perhaps, therapeutic interventions...