M K Hahn

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint The functional impact of SLC6 transporter genetic variation
    Maureen K Hahn
    Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Annu Rev Pharmacol Toxicol 47:401-41. 2007
  2. pmc Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression
    M K Hahn
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Genes Brain Behav 7:487-95. 2008
  3. pmc Novel and functional norepinephrine transporter protein variants identified in attention-deficit hyperactivity disorder
    Maureen K Hahn
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neuropharmacology 57:694-701. 2009
  4. ncbi request reprint Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders
    M K Hahn
    Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University, Nashville, TN 37232 6420, USA
    Pharmacogenomics J 2:217-35. 2002
  5. ncbi request reprint A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters
    Maureen K Hahn
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8548, USA
    J Neurosci 23:4470-8. 2003
  6. ncbi request reprint Single nucleotide polymorphisms in the human norepinephrine transporter gene affect expression, trafficking, antidepressant interaction, and protein kinase C regulation
    Maureen K Hahn
    Center for Molecular Neuroscience, 6133 Medical Research Building III, Suite 7140, Vanderbilt School of Medicine, Nashville, TN 37232 8548, USA
    Mol Pharmacol 68:457-66. 2005
  7. ncbi request reprint A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6-hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking
    Richard Nass
    Department of Anesthesiology, Vanderbilt School of Medicine, Nashville, Tennessee 37232 8548, USA
    J Neurochem 94:774-85. 2005
  8. pmc A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder
    Chun Hyung Kim
    Molecular Neurobiology, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 103:19164-9. 2006

Collaborators

Detail Information

Publications8

  1. ncbi request reprint The functional impact of SLC6 transporter genetic variation
    Maureen K Hahn
    Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Annu Rev Pharmacol Toxicol 47:401-41. 2007
    ..Refining phenotypes, through assessment of endophenotypes, specific behavioral tasks, medication response, and brain network properties has also improved detection of the impact of genetic variation on complex behavior and disease...
  2. pmc Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression
    M K Hahn
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Genes Brain Behav 7:487-95. 2008
    ..74 (1.05-7.18)]}. These relationships illustrate an approach to the elucidation of gene influences on trait components of MDD and with replication, may help identify MDD subpopulations that can benefit from more targeted pharmacotherapy...
  3. pmc Novel and functional norepinephrine transporter protein variants identified in attention-deficit hyperactivity disorder
    Maureen K Hahn
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neuropharmacology 57:694-701. 2009
    ..Identification of polymorphic sites within NET, specifically those that produce functional consequences, is one critical step in elucidating the genetic variation contributing to the heritable component of diseases such as ADHD...
  4. ncbi request reprint Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders
    M K Hahn
    Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University, Nashville, TN 37232 6420, USA
    Pharmacogenomics J 2:217-35. 2002
    ....
  5. ncbi request reprint A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters
    Maureen K Hahn
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8548, USA
    J Neurosci 23:4470-8. 2003
    ..These results elucidate a molecular mechanism for the disrupted NE homeostasis and cardiovascular function evident in OI patients with the hNET-A457P mutation...
  6. ncbi request reprint Single nucleotide polymorphisms in the human norepinephrine transporter gene affect expression, trafficking, antidepressant interaction, and protein kinase C regulation
    Maureen K Hahn
    Center for Molecular Neuroscience, 6133 Medical Research Building III, Suite 7140, Vanderbilt School of Medicine, Nashville, TN 37232 8548, USA
    Mol Pharmacol 68:457-66. 2005
    ..These findings reveal functional deficits that are likely to compromise NE signaling in SNP carriers in the population and identify key regions of NET contributing to transporter biosynthesis, activity, and regulation...
  7. ncbi request reprint A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6-hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking
    Richard Nass
    Department of Anesthesiology, Vanderbilt School of Medicine, Nashville, Tennessee 37232 8548, USA
    J Neurochem 94:774-85. 2005
    ....
  8. pmc A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder
    Chun Hyung Kim
    Molecular Neurobiology, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 103:19164-9. 2006
    ....

Research Grants3

  1. GENETIC POLYMORPHISMS HUMAN NOREPINEPHRINE TRANSPORTER
    MAUREEN HAHN; Fiscal Year: 2002
    ..abstract_text> ..
  2. Neurobehavioral Analysis of Norepinephrine Transporter Variants
    MAUREEN HAHN; Fiscal Year: 2007
    ..Understanding the function of NET variants will contribute to our understanding of how genetic variation within NET contributes to human complex traits and disease ..