Affiliation: Vanderbilt University
Shaffer C, Good J, Kumar S, Krishnan K, Gaddy J, Loh J, et al
. Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens. MBio. 2016;7:e00221-16 pubmed publisher
..tumefaciens to target cells. Thus, these compounds are versatile molecular tools that can be used to study and disarm these important bacterial machines. ..
Floyd K, Mitchell C, Eberly A, Colling S, Zhang E, Depas W, et al
. The UbiI (VisC) Aerobic Ubiquinone Synthase Is Required for Expression of Type 1 Pili, Biofilm Formation, and Pathogenesis in Uropathogenic Escherichia coli. J Bacteriol. 2016;198:2662-72 pubmed publisher
Steiner B, Eberly A, Hurst M, Zhang E, Green H, Behr S, et al
. Evidence of Cross-Regulation in Two Closely Related Pyruvate-Sensing Systems in Uropathogenic Escherichia coli. J Membr Biol. 2018;251:65-74 pubmed publisher
Shaffer C, Zhang E, Dudley A, Dixon B, Guckes K, Breland E, et al
. Purine Biosynthesis Metabolically Constrains Intracellular Survival of Uropathogenic Escherichia coli. Infect Immun. 2017;85: pubmed publisher
..These findings indicate that UPEC is deprived of purine nucleotides within the intracellular niche and relies on de novo purine synthesis to meet this metabolic requirement. ..
Breland E, Zhang E, Bermudez T, Martinez C, Hadjifrangiskou M. The Histidine Residue of QseC Is Required for Canonical Signaling between QseB and PmrB in Uropathogenic Escherichia coli. J Bacteriol. 2017;199: pubmed publisher
..Understanding the important role of the sensor kinase QseC will provide insight into additional ways to therapeutically target uropathogens that harbor these signaling systems. ..
Eberly A, Floyd K, Beebout C, Colling S, Fitzgerald M, Stratton C, et al
. Biofilm Formation by Uropathogenic Escherichia coli Is Favored under Oxygen Conditions That Mimic the Bladder Environment. Int J Mol Sci. 2017;18: pubmed publisher
..Biofilm production was reduced under all tested sub-atmospheric levels of oxygen, with the notable exception of 4% oxygen, the reported concentration of oxygen within the bladder. ..
Guckes K, Breland E, Zhang E, Hanks S, Gill N, Algood H, et al
. Signaling by two-component system noncognate partners promotes intrinsic tolerance to polymyxin B in uropathogenic Escherichia coli. Sci Signal. 2017;10: pubmed publisher
..This study defines physiologically relevant cross talk between TCSs in a bacterial pathogen and provides a potential mechanism for antibiotic resistance of some strains of UPEC. ..