Volker Haase

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. doi request reprint Mechanisms of hypoxia responses in renal tissue
    Volker H Haase
    Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, C 3119A, MCN, 1161 21st Avenue, Nashville, TN 37232, USA
    J Am Soc Nephrol 24:537-41. 2013
  2. pmc Regulation of erythropoiesis by hypoxia-inducible factors
    Volker H Haase
    Department of Medicine, Vanderbilt School of Medicine, Nashville, TN, USA
    Blood Rev 27:41-53. 2013
  3. pmc Renal cancer: oxygen meets metabolism
    Volker H Haase
    Department of Medicine, Vanderbilt School of Medicine, Nashville, TN 37232, USA
    Exp Cell Res 318:1057-67. 2012
  4. pmc Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury
    Pinelopi P Kapitsinou
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Physiol Renal Physiol 302:F1172-9. 2012
  5. pmc Hypoxic regulation of erythropoiesis and iron metabolism
    Volker H Haase
    Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 299:F1-13. 2010
  6. pmc The sweet side of HIF
    Volker H Haase
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    Kidney Int 78:10-3. 2010
  7. pmc Angiotensin II: breathtaking in the renal medulla
    Volker H Haase
    Division of Nephrology and Hypertension, Departments of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    Kidney Int 79:269-71. 2011
  8. doi request reprint Pathophysiological Consequences of HIF Activation: HIF as a modulator of fibrosis
    Volker H Haase
    Departments of Medicine, Vanderbilt School of Medicine, Nashville, TN37232, USA
    Ann N Y Acad Sci 1177:57-65. 2009
  9. pmc The VHL tumor suppressor: master regulator of HIF
    Volker H Haase
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Curr Pharm Des 15:3895-903. 2009
  10. pmc Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease
    Volker H Haase
    Department of Medicine, Vanderbilt University Medical Center, C 3119A, MCN, 1161 21stAvenue, Nashville, TN 37232, USA
    Kidney Int 76:492-9. 2009

Research Grants

  1. Hypoxia VHL nad HIF in Renal Tumor Development
    Volker Haase; Fiscal Year: 2007
  2. MOLECULAR MECHANISMS OF RENAL INJURY
    Volker H Haase; Fiscal Year: 2010
  3. Hypoxia-Inducible Factors in Liver Metabolism
    Volker H Haase; Fiscal Year: 2010
  4. MOLECULAR MECHANISMS OF RENAL INJURY
    Volker Haase; Fiscal Year: 2009

Collaborators

  • Kai Uwe Eckardt
  • Liping Huang
  • Anton Wutz
  • Wanja M Bernhardt
  • M Kretzler
  • MARK OKUSA
  • T B Drueke
  • Marcus J Moeller
  • Masayuki Iwano
  • M Simon
  • Chuan Ming Hao
  • Jonathan Epstein
  • Bernd Hohenstein
  • Debra F Higgins
  • Pinelopi P Kapitsinou
  • Randall S Johnson
  • Erinn B Rankin
  • Mangatt P Biju
  • Connie L Erickson-Miller
  • Bernhard Bielesz
  • Amandeep Bajwa
  • James J Lee
  • Brian Keith
  • Jennifer Rha
  • Qingdu Liu
  • Travis L Unger
  • Kuniko Kimura
  • Kirsten Brukamp
  • Yasuhiro Akai
  • Mark Michael
  • Jonathan Jaffe
  • Christina E Swan
  • Kevin J Duffy
  • Shinya Ohashi
  • Yasemin Sirin
  • James Pullman
  • Manfred Gessler
  • Mitsuteru Natsuizaka
  • Sang Kyung Jo
  • Krishna R Dondeti
  • Daniela Budo
  • Kevin R Lynch
  • Hideki Kato
  • Gabrielle S Wong
  • Sheri L Moores
  • Hong Ye
  • Seonho Ahn
  • Munenori Takaoka
  • Yasuhiro Shirakawa
  • Carmen Z Michaylira
  • John W Tobias
  • Timothy L Macdonald
  • Michiyuki Kanai
  • Diane L Rosin
  • Katalin Susztak
  • Han Si
  • Andres J P Klein-Szanto
  • Thiruvur Niranjan
  • Olena Davidoff
  • Hiroshi Nakagawa
  • Yoshio Naomoto
  • Antje Gruenwald
  • Clemens D Cohen
  • Nikita Shrimanker
  • Yoshihiko Saito
  • Belinda Jim
  • Jacqueline A Walisser
  • Christopher A Bradfield
  • Aaron K Neumann
  • Laurence A Turka
  • Steven J Bensinger

Detail Information

Publications25

  1. doi request reprint Mechanisms of hypoxia responses in renal tissue
    Volker H Haase
    Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, C 3119A, MCN, 1161 21st Avenue, Nashville, TN 37232, USA
    J Am Soc Nephrol 24:537-41. 2013
    ..This review provides an integrative perspective on the role of molecular hypoxia responses in normal kidney physiology and pathophysiology, and discusses their therapeutic potential for the treatment of renal diseases...
  2. pmc Regulation of erythropoiesis by hypoxia-inducible factors
    Volker H Haase
    Department of Medicine, Vanderbilt School of Medicine, Nashville, TN, USA
    Blood Rev 27:41-53. 2013
    ..The therapeutic potential of pharmacologic HIF activation for the treatment of anemia is discussed...
  3. pmc Renal cancer: oxygen meets metabolism
    Volker H Haase
    Department of Medicine, Vanderbilt School of Medicine, Nashville, TN 37232, USA
    Exp Cell Res 318:1057-67. 2012
    ..This review's focus is on the von Hippel-Lindau (VHL)/hypoxia-inducible factor (HIF) oxygen-sensing pathway and its role in physiology, energy metabolism and tumorigenesis...
  4. pmc Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury
    Pinelopi P Kapitsinou
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Physiol Renal Physiol 302:F1172-9. 2012
    ..Therefore, preischemic targeting of the PHD/HIF pathway represents an effective therapeutic strategy for the prevention of CKD resulting from AKI, and it warrants further investigation in clinical trials...
  5. pmc Hypoxic regulation of erythropoiesis and iron metabolism
    Volker H Haase
    Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 299:F1-13. 2010
    ....
  6. pmc The sweet side of HIF
    Volker H Haase
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    Kidney Int 78:10-3. 2010
    ....
  7. pmc Angiotensin II: breathtaking in the renal medulla
    Volker H Haase
    Division of Nephrology and Hypertension, Departments of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    Kidney Int 79:269-71. 2011
    ....
  8. doi request reprint Pathophysiological Consequences of HIF Activation: HIF as a modulator of fibrosis
    Volker H Haase
    Departments of Medicine, Vanderbilt School of Medicine, Nashville, TN37232, USA
    Ann N Y Acad Sci 1177:57-65. 2009
    ..Under certain conditions, these responses may lead to further tissue destruction by promoting fibrogenesis...
  9. pmc The VHL tumor suppressor: master regulator of HIF
    Volker H Haase
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Curr Pharm Des 15:3895-903. 2009
    ..Here we focus on the contribution of individual HIF transcription factors to the development of VHL phenotypes and discuss how the pVHL/HIF axis could be exploited pharmacologically...
  10. pmc Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease
    Volker H Haase
    Department of Medicine, Vanderbilt University Medical Center, C 3119A, MCN, 1161 21stAvenue, Nashville, TN 37232, USA
    Kidney Int 76:492-9. 2009
    ..Recent insights into potential molecular mechanisms underlying oxygen-dependent regulation of this process and their relevance to disease are discussed...
  11. pmc Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia
    Pinelopi P Kapitsinou
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    Blood 116:3039-48. 2010
    ..Furthermore, we provide evidence that hepatocyte-derived Hif-2 is involved in the regulation of iron metabolism genes, supporting a role for HIF-2 in the coordination of EPO synthesis with iron homeostasis...
  12. pmc Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
    Debra F Higgins
    Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 117:3810-20. 2007
    ....
  13. pmc Hypoxia-inducible factor signaling in the development of tissue fibrosis
    Debra F Higgins
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Cell Cycle 7:1128-32. 2008
    ..Here we discuss the role of HIF signaling in the pathogenesis and progression of chronic kidney disease...
  14. ncbi request reprint Hypoxia-inducible factors in the kidney
    Volker H Haase
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6144, USA
    Am J Physiol Renal Physiol 291:F271-81. 2006
    ..This review summarizes some of the most recent advances in the HIF field and discusses their relevance to renal development, normal kidney function and disease...
  15. doi request reprint Sirtuins and their relevance to the kidney
    Chuan Ming Hao
    Division of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Am Soc Nephrol 21:1620-7. 2010
    ..Here, we review sirtuin biology and discuss how CR-triggered sirtuin-dependent pathways affect renal physiology and the pathogenesis of kidney diseases and related disorders...
  16. pmc Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans
    Bernhard Bielesz
    Department of Medicine, Division of Nephrology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 120:4040-54. 2010
    ..In summary, our experiments establish that epithelial injury and Notch signaling play key roles in fibrosis development and indicate that Notch blockade may be a therapeutic strategy to reduce fibrosis and ESRD development...
  17. pmc Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice
    Erinn B Rankin
    Department of Medicine, 700 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104 6144, USA
    Mol Cell Biol 25:3163-72. 2005
    ..Furthermore, we provide evidence that individual HIF transcription factors may play distinct roles in the development of specific VHL disease manifestations...
  18. pmc Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury
    Amandeep Bajwa
    Department of Medicine, Division of Nephrology, Box 800133, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Am Soc Nephrol 21:955-65. 2010
    ..Selective agonists of S1P1Rs may hold therapeutic potential for the prevention and treatment of acute kidney injury...
  19. pmc Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis
    James J Lee
    Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Carcinogenesis 31:427-34. 2010
    ..Thus, PTGES is a novel HIF-1alpha target gene, involved in prostaglandin E biosynthesis in the esophageal tumor hypoxic microenvironment, and this has implications in diverse tumors types, especially of squamous origin...
  20. pmc Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo
    Erinn B Rankin
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6144, USA
    J Clin Invest 117:1068-77. 2007
    ....
  21. pmc Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes
    Mangatt P Biju
    Department of Medicine, 700 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 6144, USA
    Mol Cell Biol 24:9038-47. 2004
    ..Our data suggest that tight regulation of Hif-1 via pVhl is required for normal thymocyte development and viability and that an increase in Hif-1 transcriptional activity enhances caspase 8-mediated apoptosis in thymocytes...
  22. ncbi request reprint Hypoxic induction of Ctgf is directly mediated by Hif-1
    Debra F Higgins
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6144, USA
    Am J Physiol Renal Physiol 287:F1223-32. 2004
    ..Our findings have important implications for a number of fibrotic disorders in which hypoxia, CTGF, and TGF-beta(1) are involved, including renal, dermal, hepatic, and pulmonary fibrosis...
  23. ncbi request reprint Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease
    Kirsten Brukamp
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, USA
    Am J Physiol Renal Physiol 293:F1397-407. 2007
    ....
  24. pmc The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting
    Volker H Haase
    Department of Medicine, University of Pennsylvania School of Medicine, 700 CRB, 415 Curie Boulevard, Philadelphia, PA 19104 6144, USA
    Semin Cell Dev Biol 16:564-74. 2005
    ..Mouse knock out studies have provided novel mechanistic insights into VHL associated tumorigenesis and established a central role for HIF in the development of the VHL phenotype...

Research Grants12

  1. Hypoxia VHL nad HIF in Renal Tumor Development
    Volker Haase; Fiscal Year: 2007
    ..Ultimately they have the potential to create a murine model of VHL associated renal tumors. ..
  2. MOLECULAR MECHANISMS OF RENAL INJURY
    Volker H Haase; Fiscal Year: 2010
    ..Identification and characterization of molecular pathways that are activated by hypoxia has the potential to provide the basis for new therapeutic approaches to halt the progression of renal scarring. ..
  3. Hypoxia-Inducible Factors in Liver Metabolism
    Volker H Haase; Fiscal Year: 2010
    ..The proposal has relevance for all patients with non-alcoholic fatty liver disease, obesity, diabetes and those that suffer from cardio-pulmonary conditions resulting in chronically low blood oxygen levels. ..
  4. MOLECULAR MECHANISMS OF RENAL INJURY
    Volker Haase; Fiscal Year: 2009
    ..Identification and characterization of molecular pathways that are activated by hypoxia has the potential to provide the basis for new therapeutic approaches to halt the progression of renal scarring. ..