Research Topics
Species | Eugenia GurevichSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
G protein-coupled receptor kinases: more than just kinases and not only for GPCRsEugenia V Gurevich
Department of Pharmacology, Vanderbilt University, 2200 Pierce Avenue, Preston Research Building, Rm 454, Nashville, TN 37232, United States
Pharmacol Ther 133:40-69. 2012..Targeted modulation of expression and/or of activity of several GRK isoforms for therapeutic purposes was recently validated in cardiac disorders and Parkinson's disease...
Arrestin2 expression selectively increases during neural differentiationEugenia V Gurevich
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Neurochem 91:1404-16. 2004..The data demonstrate selective increases in the expression of arrestin2 associated with neural development and suggest specific yet unappreciated roles for arrestin2 in neural differentiation...- Each rhodopsin molecule binds its own arrestinSusan M Hanson
Department of Pharmacology, Vanderbilt University, 2200 Pierce Avenue, PRB, Room 418, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 104:3125-8. 2007..Thus, a single Rh molecule is necessary and sufficient to bind Arr. Remarkable structural conservation among receptors and Arrs strongly suggests that all Arr subtypes bind individual molecules of their cognate receptors... - GPCR monomers and oligomers: it takes all kindsVsevolod V Gurevich
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Trends Neurosci 31:74-81. 2008..Different GPCR subtypes, and even the same receptor at different stages of its life cycle, most likely exist in different oligomerization states, from monomers to dimers and possibly higher-order oligomers... - How and why do GPCRs dimerize?Vsevolod V Gurevich
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Trends Pharmacol Sci 29:234-40. 2008..Thus, to figure out the biological role of receptor self-association we must focus on other functions of GPCRs at different stages of their functional cycle... - Rich tapestry of G protein-coupled receptor signaling and regulatory mechanismsVsevolod V Gurevich
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
Mol Pharmacol 74:312-6. 2008..In this issue of Molecular Pharmacology, Luo et al. (p. 338) describe a complex pattern of the regulation of M3 muscarinic receptor signaling... - The structural basis of arrestin-mediated regulation of G-protein-coupled receptorsVsevolod V Gurevich
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Pharmacol Ther 110:465-502. 2006.... - Custom-designed proteins as novel therapeutic tools? The case of arrestinsVsevolod V Gurevich
Vanderbilt University, Nashville, TN 37232, USA
Expert Rev Mol Med 12:e13. 2010..Although this approach is still in its infancy, targeted redesign of individual functions of many proteins offers a promise of a completely new therapeutic toolbox with huge potential... - The molecular acrobatics of arrestin activationVsevolod V Gurevich
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Trends Pharmacol Sci 25:105-11. 2004..In this article, we discuss the molecular mechanisms that underlie the sequential multi-site binding that ensures arrestin selectivity for the active phosphoreceptor and high fidelity of signal regulation by arrestin proteins... - The new face of active receptor bound arrestin attracts new partnersVsevolod V Gurevich
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Structure 11:1037-42. 2003..Conformational change in arrestin induced by receptor binding promotes its interaction with the majority of recently identified nonreceptor binding partners... - Cone arrestin binding to JNK3 and Mdm2: conformational preference and localization of interaction sitesXiufeng Song
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
J Neurochem 103:1053-62. 2007..N-domain of rod arrestin binds Mdm2, which localizes its main interaction site to this region. Comparable binding of JNK3 and Mdm2 to four arrestin subtypes allowed us to identify conserved residues likely involved in these interactions... - Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylationXiufeng Song
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Curr Biol 19:700-5. 2009..Successful modification of protein-protein interactions by appropriate mutations paves the way to targeted redesign of signaling pathways to achieve desired functional outcomes... - Dopamine depletion and subsequent treatment with L-DOPA, but not the long-lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatumEvgeny Bychkov
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Neurochem 102:699-711. 2007..The results support the hypothesis that the Akt pathway is involved in long-term actions of l-DOPA and may be linked to l-DOPA-induced dyskinesia... 
Arrestins: ubiquitous regulators of cellular signaling pathwaysEugenia V Gurevich
Department of Pharmacology, Vanderbilt University, 2200 Pierce Avenue, Preston Research Building, Nashville, TN 37232, USA
Genome Biol 7:236. 2006..Arrestins thus serve as ubiquitous signaling regulators in the cytoplasm and nucleus...- The nature of the arrestin x receptor complex determines the ultimate fate of the internalized receptorLing Pan
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Biol Chem 278:11623-32. 2003..Thus, targeted manipulation of the characteristics of an arrestin protein that binds to a G protein-coupled receptors can dramatically change receptor trafficking and its ultimate fate in a cell... - Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activationMohamed Rafiuddin Ahmed
Department of Pharmacology, Vanderbilt University Medical Center, Preston Research Building, Room 422, Nashville, TN 37232, USA
J Pharmacol Exp Ther 325:276-83. 2008..The data demonstrate that haloperidol and clozapine differentially affect the expression of arrestins and GRKs and ERK activity, which may play a role in determining their clinical profile... - Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatmentM Rafiuddin Ahmed
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Neurochem 104:1622-36. 2008..The data suggest that alterations in the expression and subcellular distribution of arrestins and GRKs contribute to pathophysiology of Parkinson's disease. Thus, these proteins may be targets for antiparkinsonian therapy... - Visual and both non-visual arrestins in their "inactive" conformation bind JNK3 and Mdm2 and relocalize them from the nucleus to the cytoplasmXiufeng Song
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
J Biol Chem 281:21491-9. 2006.... - Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's diseaseMohamed R Ahmed
Department of Pharmacology, Vanderbilt University, 2200 Pierce Avenue, PRB422, Nashville, TN 37232, USA
Sci Transl Med 2:28ra28. 2010.... - Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactionsK Saidas Nair
Department of Molecular and Cellular Pharmacology and Neuroscience Program, University of Miami, Miami, Florida 33136, USA
Neuron 46:555-67. 2005..These results indicate that the distribution of arrestin in rods is controlled by its dynamic interactions with rhodopsin in the OS and microtubules in the IS and that its movement occurs by simple diffusion... - Levodopa-induced dyskinesia in MPTP-treated macaques is not dependent on the extent and pattern of nigrostrial lesioningCeline Guigoni
Laboratoire de Physiologie et Physiopathologie de la Signalization Cellulaire, CNRS UMR 5543, Universite Victor Segalen Bordeaux, 33076 Bordeaux Cedex, France
Eur J Neurosci 22:283-7. 2005..These data indicate that neither the extent nor the pattern of nigrostriatal lesioning are sufficient to explain the occurrence of levodopa-induced dyskinesia...
Research Grants
- Signaling regulation in the striatum in Parkinson's diseaseEugenia V Gurevich; Fiscal Year: 2010..This project is designed to explore whether the proteins called arrestins and G protein-coupled receptor kinases play a role in complications of the levodopa therapy. ..
- ANTIPSYCHOTICS AND RECEPTOR DESENSITIZATION MACHINERYEugenia Gurevich; Fiscal Year: 2002..We expect that the information gained by examining the response of the key components of the receptor trafficking machinery to antipsychotics will be helpful for targeted design of drugs with improved clinical profile. ..
- Dopamine Receptor Trafficking in Parkinson's DiseaseEugenia Gurevich; Fiscal Year: 2007..Drugs targeting the receptor desensitization machinery may prove particularly useful for prevention or alleviating of L-DOPA-induced motor complications. ..
- Signaling regulation in the striatum in Parkinson's diseaseEugenia Gurevich; Fiscal Year: 2009..This project is designed to explore whether the proteins called arrestins and G protein-coupled receptor kinases play a role in complications of the levodopa therapy. ..