Eugenia Gurevich

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc The origin and evolution of G protein-coupled receptor kinases
    Arcady Mushegian
    Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
    PLoS ONE 7:e33806. 2012
  2. pmc Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice
    Lilia Zurkovsky
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dis Model Mech 6:171-83. 2013
  3. pmc Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum
    Evgeny Bychkov
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    PLoS ONE 7:e48912. 2012
  4. doi request reprint Therapeutic potential of small molecules and engineered proteins
    Eugenia V Gurevich
    Department of Pharmacology, Vanderbilt University, 2200 Pierce Avenue, Nashville, TN, 37232, USA
    Handb Exp Pharmacol 219:1-12. 2014
  5. pmc G protein-coupled receptor kinases: more than just kinases and not only for GPCRs
    Eugenia V Gurevich
    Department of Pharmacology, Vanderbilt University, 2200 Pierce Avenue, Preston Research Building, Rm 454, Nashville, TN 37232, United States
    Pharmacol Ther 133:40-69. 2012
  6. ncbi request reprint Arrestin2 expression selectively increases during neural differentiation
    Eugenia V Gurevich
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Neurochem 91:1404-16. 2004
  7. pmc Each rhodopsin molecule binds its own arrestin
    Susan M Hanson
    Department of Pharmacology, Vanderbilt University, 2200 Pierce Avenue, PRB, Room 418, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:3125-8. 2007
  8. pmc GPCR monomers and oligomers: it takes all kinds
    Vsevolod V Gurevich
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Trends Neurosci 31:74-81. 2008
  9. pmc Rich tapestry of G protein-coupled receptor signaling and regulatory mechanisms
    Vsevolod V Gurevich
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Mol Pharmacol 74:312-6. 2008
  10. pmc Cone arrestin binding to JNK3 and Mdm2: conformational preference and localization of interaction sites
    Xiufeng Song
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Neurochem 103:1053-62. 2007

Research Grants

Collaborators

  • VSEVOLOD GUREVICH
  • JEFFREY BENOVIC
  • MARIE BURNS
  • E Bezard
  • B Bloch
  • Vladlen Slepak
  • Evgeny Bychkov
  • Xiufeng Song
  • Mohamed R Ahmed
  • Lilia Zurkovsky
  • Sergey A Vishnivetskiy
  • M Rafiuddin Ahmed
  • Susan M Hanson
  • Arcady Mushegian
  • Mohamed Rafiuddin Ahmed
  • Bernard H Bioulac
  • Sandra Dovero
  • Incarnation Aubert
  • Qin Li
  • Kevin N Dalby
  • Ana Mendez
  • Jeannie Chen
  • Celine Guigoni
  • K Saidas Nair
  • Ling Pan
  • Randy D Blakely
  • Carley Siedlecki
  • Elviche L Tsakem
  • Mika B Garret
  • Evelyne Doudnikoff
  • Gregory Porras
  • Seunghyi Kook
  • Amandine Berthet
  • Yonatan T Carl
  • Owen P Gross
  • Katrina Emelianoff
  • Dayanidhi Raman
  • Matthew J Kennedy
  • Valery I Shestopalov
  • Christian E Gross
  • James B Hurley

Detail Information

Publications25

  1. pmc The origin and evolution of G protein-coupled receptor kinases
    Arcady Mushegian
    Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
    PLoS ONE 7:e33806. 2012
    ..Thus, GRKs apparently emerged before animals and rapidly expanded in true Metazoa, most likely due to the need for rapid signalling adjustments in fast-moving animals...
  2. pmc Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice
    Lilia Zurkovsky
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dis Model Mech 6:171-83. 2013
    ..The results suggest that combined loss of DA and ACh could be sufficient for pathogenesis of specific cognitive deficits in PDD...
  3. pmc Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum
    Evgeny Bychkov
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    PLoS ONE 7:e48912. 2012
    ..These data suggest cell type- and subcellular compartment-dependent differences in GRK/arrestin-mediated desensitization and signaling...
  4. doi request reprint Therapeutic potential of small molecules and engineered proteins
    Eugenia V Gurevich
    Department of Pharmacology, Vanderbilt University, 2200 Pierce Avenue, Nashville, TN, 37232, USA
    Handb Exp Pharmacol 219:1-12. 2014
    ....
  5. pmc G protein-coupled receptor kinases: more than just kinases and not only for GPCRs
    Eugenia V Gurevich
    Department of Pharmacology, Vanderbilt University, 2200 Pierce Avenue, Preston Research Building, Rm 454, Nashville, TN 37232, United States
    Pharmacol Ther 133:40-69. 2012
    ..Targeted modulation of expression and/or of activity of several GRK isoforms for therapeutic purposes was recently validated in cardiac disorders and Parkinson's disease...
  6. ncbi request reprint Arrestin2 expression selectively increases during neural differentiation
    Eugenia V Gurevich
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Neurochem 91:1404-16. 2004
    ..The data demonstrate selective increases in the expression of arrestin2 associated with neural development and suggest specific yet unappreciated roles for arrestin2 in neural differentiation...
  7. pmc Each rhodopsin molecule binds its own arrestin
    Susan M Hanson
    Department of Pharmacology, Vanderbilt University, 2200 Pierce Avenue, PRB, Room 418, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:3125-8. 2007
    ..Thus, a single Rh molecule is necessary and sufficient to bind Arr. Remarkable structural conservation among receptors and Arrs strongly suggests that all Arr subtypes bind individual molecules of their cognate receptors...
  8. pmc GPCR monomers and oligomers: it takes all kinds
    Vsevolod V Gurevich
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Trends Neurosci 31:74-81. 2008
    ..Different GPCR subtypes, and even the same receptor at different stages of its life cycle, most likely exist in different oligomerization states, from monomers to dimers and possibly higher-order oligomers...
  9. pmc Rich tapestry of G protein-coupled receptor signaling and regulatory mechanisms
    Vsevolod V Gurevich
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Mol Pharmacol 74:312-6. 2008
    ..In this issue of Molecular Pharmacology, Luo et al. (p. 338) describe a complex pattern of the regulation of M3 muscarinic receptor signaling...
  10. pmc Cone arrestin binding to JNK3 and Mdm2: conformational preference and localization of interaction sites
    Xiufeng Song
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Neurochem 103:1053-62. 2007
    ..N-domain of rod arrestin binds Mdm2, which localizes its main interaction site to this region. Comparable binding of JNK3 and Mdm2 to four arrestin subtypes allowed us to identify conserved residues likely involved in these interactions...
  11. pmc Custom-designed proteins as novel therapeutic tools? The case of arrestins
    Vsevolod V Gurevich
    Vanderbilt University, Nashville, TN 37232, USA
    Expert Rev Mol Med 12:e13. 2010
    ..Although this approach is still in its infancy, targeted redesign of individual functions of many proteins offers a promise of a completely new therapeutic toolbox with huge potential...
  12. ncbi request reprint The new face of active receptor bound arrestin attracts new partners
    Vsevolod V Gurevich
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Structure 11:1037-42. 2003
    ..Conformational change in arrestin induced by receptor binding promotes its interaction with the majority of recently identified nonreceptor binding partners...
  13. ncbi request reprint The molecular acrobatics of arrestin activation
    Vsevolod V Gurevich
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Trends Pharmacol Sci 25:105-11. 2004
    ..In this article, we discuss the molecular mechanisms that underlie the sequential multi-site binding that ensures arrestin selectivity for the active phosphoreceptor and high fidelity of signal regulation by arrestin proteins...
  14. pmc The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
    Vsevolod V Gurevich
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Pharmacol Ther 110:465-502. 2006
    ....
  15. pmc How and why do GPCRs dimerize?
    Vsevolod V Gurevich
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Trends Pharmacol Sci 29:234-40. 2008
    ..Thus, to figure out the biological role of receptor self-association we must focus on other functions of GPCRs at different stages of their functional cycle...
  16. pmc Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation
    Xiufeng Song
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Curr Biol 19:700-5. 2009
    ..Successful modification of protein-protein interactions by appropriate mutations paves the way to targeted redesign of signaling pathways to achieve desired functional outcomes...
  17. ncbi request reprint The nature of the arrestin x receptor complex determines the ultimate fate of the internalized receptor
    Ling Pan
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 278:11623-32. 2003
    ..Thus, targeted manipulation of the characteristics of an arrestin protein that binds to a G protein-coupled receptors can dramatically change receptor trafficking and its ultimate fate in a cell...
  18. ncbi request reprint Dopamine depletion and subsequent treatment with L-DOPA, but not the long-lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatum
    Evgeny Bychkov
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Neurochem 102:699-711. 2007
    ..The results support the hypothesis that the Akt pathway is involved in long-term actions of l-DOPA and may be linked to l-DOPA-induced dyskinesia...
  19. pmc Arrestins: ubiquitous regulators of cellular signaling pathways
    Eugenia V Gurevich
    Department of Pharmacology, Vanderbilt University, 2200 Pierce Avenue, Preston Research Building, Nashville, TN 37232, USA
    Genome Biol 7:236. 2006
    ..Arrestins thus serve as ubiquitous signaling regulators in the cytoplasm and nucleus...
  20. pmc Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activation
    Mohamed Rafiuddin Ahmed
    Department of Pharmacology, Vanderbilt University Medical Center, Preston Research Building, Room 422, Nashville, TN 37232, USA
    J Pharmacol Exp Ther 325:276-83. 2008
    ..The data demonstrate that haloperidol and clozapine differentially affect the expression of arrestins and GRKs and ERK activity, which may play a role in determining their clinical profile...
  21. pmc Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease
    Mohamed R Ahmed
    Department of Pharmacology, Vanderbilt University, 2200 Pierce Avenue, PRB422, Nashville, TN 37232, USA
    Sci Transl Med 2:28ra28. 2010
    ....
  22. pmc Visual and both non-visual arrestins in their "inactive" conformation bind JNK3 and Mdm2 and relocalize them from the nucleus to the cytoplasm
    Xiufeng Song
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 281:21491-9. 2006
    ....
  23. pmc Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment
    M Rafiuddin Ahmed
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Neurochem 104:1622-36. 2008
    ..The data suggest that alterations in the expression and subcellular distribution of arrestins and GRKs contribute to pathophysiology of Parkinson's disease. Thus, these proteins may be targets for antiparkinsonian therapy...
  24. pmc Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions
    K Saidas Nair
    Department of Molecular and Cellular Pharmacology and Neuroscience Program, University of Miami, Miami, Florida 33136, USA
    Neuron 46:555-67. 2005
    ..These results indicate that the distribution of arrestin in rods is controlled by its dynamic interactions with rhodopsin in the OS and microtubules in the IS and that its movement occurs by simple diffusion...
  25. ncbi request reprint Levodopa-induced dyskinesia in MPTP-treated macaques is not dependent on the extent and pattern of nigrostrial lesioning
    Celine Guigoni
    Laboratoire de Physiologie et Physiopathologie de la Signalization Cellulaire, CNRS UMR 5543, Universite Victor Segalen Bordeaux, 33076 Bordeaux Cedex, France
    Eur J Neurosci 22:283-7. 2005
    ..These data indicate that neither the extent nor the pattern of nigrostriatal lesioning are sufficient to explain the occurrence of levodopa-induced dyskinesia...

Research Grants8

  1. Signaling regulation in the striatum in Parkinson's disease
    Eugenia V Gurevich; Fiscal Year: 2010
    ..This project is designed to explore whether the proteins called arrestins and G protein-coupled receptor kinases play a role in complications of the levodopa therapy. ..
  2. ANTIPSYCHOTICS AND RECEPTOR DESENSITIZATION MACHINERY
    Eugenia Gurevich; Fiscal Year: 2002
    ..We expect that the information gained by examining the response of the key components of the receptor trafficking machinery to antipsychotics will be helpful for targeted design of drugs with improved clinical profile. ..
  3. Dopamine Receptor Trafficking in Parkinson's Disease
    Eugenia Gurevich; Fiscal Year: 2003
    ..Drugs targeting the receptor desensitization machinery may prove particularly useful for prevention or alleviating of L-DOPA-induced motor complications. ..
  4. Dopamine Receptor Trafficking in Parkinson's Disease
    Eugenia Gurevich; Fiscal Year: 2004
    ..Drugs targeting the receptor desensitization machinery may prove particularly useful for prevention or alleviating of L-DOPA-induced motor complications. ..
  5. Dopamine Receptor Trafficking in Parkinson's Disease
    Eugenia Gurevich; Fiscal Year: 2005
    ..Drugs targeting the receptor desensitization machinery may prove particularly useful for prevention or alleviating of L-DOPA-induced motor complications. ..
  6. Dopamine Receptor Trafficking in Parkinson's Disease
    Eugenia Gurevich; Fiscal Year: 2006
    ..Drugs targeting the receptor desensitization machinery may prove particularly useful for prevention or alleviating of L-DOPA-induced motor complications. ..
  7. Dopamine Receptor Trafficking in Parkinson's Disease
    Eugenia Gurevich; Fiscal Year: 2007
    ..Drugs targeting the receptor desensitization machinery may prove particularly useful for prevention or alleviating of L-DOPA-induced motor complications. ..
  8. Signaling regulation in the striatum in Parkinson's disease
    Eugenia Gurevich; Fiscal Year: 2009
    ..This project is designed to explore whether the proteins called arrestins and G protein-coupled receptor kinases play a role in complications of the levodopa therapy. ..