Research Topics
| C G GrijalvaSummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
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Detail Information
Publications
Reduction of frequent otitis media and pressure-equalizing tube insertions in children after introduction of pneumococcal conjugate vaccineKatherine A Poehling
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Pediatrics 119:707-15. 2007..In this study we estimated the effect of routine childhood immunization with heptavalent pneumococcal conjugate vaccine on frequent otitis media (3 episodes in 6 months or 4 episodes in 1 year) and pressure-equalizing tube insertions...
CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination surveyAdriana M Hung
Veterans Administration Tennessee Valley Healthcare System Nashville, TN, USA
BMC Med Genet 12:65. 2011..We recently reported an association between the gene variant rs2808630 and CKD progression in African Americans with hypertensive kidney disease. This association has not been studied in other ethnic groups...
Initiation of tumor necrosis factor-α antagonists and the risk of hospitalization for infection in patients with autoimmune diseasesCarlos G Grijalva
Division of Pharmacoepidemiology, Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Ave S, Ste 2600, The Village at Vanderbilt, Nashville, TN 37212, USA
JAMA 306:2331-9. 2011..Although tumor necrosis factor (TNF)-α antagonists are increasingly used in place of nonbiologic comparator medications, their safety profile remains incomplete...
Evidence of effectiveness from a large county-wide school-based influenza immunization campaignCarlos G Grijalva
Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Avenue Suite 2600, The Village at Vanderbilt, Nashville, TN 37232 2637, United States
Vaccine 27:2633-6. 2009..79; 95% CI, 0.59-1.05) and 27% (RR, 0.73; 95% CI, 0.60-0.87) during the first and second campaign season, respectively. These findings suggest a direct beneficial effect of the immunization campaign...
Recognising pneumonia burden through preventionCarlos G Grijalva
Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Vaccine 27:C6-8. 2009..In this age group, there was a 39% and 65% reduction in rates of all-cause and pneumococcal pneumonia hospitalisations, respectively, indicating a direct effect of routine immunisation with PCV7...
Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settingsCarlos G Grijalva
Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Ave, Ste 2600, The Village at Vanderbilt, Nashville, TN 37232 2637, USA
JAMA 302:758-66. 2009..During the 1990s, antibiotic prescriptions for acute respiratory tract infection (ARTI) decreased in the United States. The sustainability of those changes is unknown...
Initiation of rheumatoid arthritis treatments and the risk of serious infectionsCarlos G Grijalva
Department of Preventive Medicine, Center for Education and Research on Therapeutics, Vanderbilt University School of Medicine, 1500 21st Avenue Suite 2600, The Village at Vanderbilt, Nashville, TN 37232 2637, USA
Rheumatology (Oxford) 49:82-90. 2010..Our objective was to compare serious infections following initiation of different RA regimens. Prior comparative studies of DMARD initiation have yielded conflicting results...
Increasing incidence of empyema complicating childhood community-acquired pneumonia in the United StatesCarlos G Grijalva
Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
Clin Infect Dis 50:805-13. 2010..We assessed whether early decreases in pneumonia hospitalization rates were sustained and trends in such hospitalizations complicated by empyema in United States children aged <5 years...
Adherence to disease-modifying antirheumatic drugs and the effects of exposure misclassification on the risk of hospital admissionCarlos G Grijalva
Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2637, USA
Arthritis Care Res (Hoboken) 62:730-4. 2010..To describe the effect of different exposure classification strategies for disease-modifying antirheumatic drugs (DMARDs) on drug-outcome associations...
Establishing the baseline burden of influenza in preparation for the evaluation of a countywide school-based influenza vaccination campaignCarlos G Grijalva
Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States
Vaccine 29:123-9. 2010..Assessment of campaign effects requires identification of appropriate control populations. We hypothesized that contiguous counties would share similar pre-campaign patterns of influenza activity...
The population impact of a large school-based influenza vaccination campaignCarlos G Grijalva
Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
PLoS ONE 5:e15097. 2010..We sought to determine the population impact of this campaign...
Emergence of parapneumonic empyema in the USACarlos G Grijalva
Department of Preventive Medicine, Vanderbilt University School of Medicine 1500 21st Avenue Suite 2600, The Village at Vanderbilt, Nashville, TN 37232 2637, USA
Thorax 66:663-8. 2011..National trends in the incidence of parapneumonic empyema hospitalisations and changes in empyema by associated pathogens were examined...
Computerized definitions showed high positive predictive values for identifying hospitalizations for congestive heart failure and selected infections in Medicaid enrollees with rheumatoid arthritisCarlos G Grijalva
Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Pharmacoepidemiol Drug Saf 17:890-5. 2008..However, information on their accuracy is limited. We evaluated the ability of computerized definitions to identify these conditions as the reason for admission among patients diagnosed with rheumatoid arthritis (RA)...
Changing patterns of medication use in patients with rheumatoid arthritis in a Medicaid populationC G Grijalva
Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Avenue, 2600 VAV, Nashville, TN 37212, USA
Rheumatology (Oxford) 47:1061-4. 2008..To examine changes in patterns of medication utilization in patients with RA...
Population-based impact of routine infant immunization with pneumococcal conjugate vaccine in the USACarlos G Grijalva
Division of Pharmacoepidemiology, Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Ave S The Village at Vanderbilt Suite 2650, Nashville, TN 37212, USA
Expert Rev Vaccines 7:83-95. 2008..This article aims to summarize current evidence on the population-based impact of this infant immunization program in the USA...
Assessment of adherence to and persistence on disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritisCarlos G Grijalva
Department of Preventive Medicine, Division of Pharmacoepidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Med Care 45:S66-76. 2007..However, measurements of relative effectiveness, including treatment adherence and persistence, are lacking. We evaluated adherence and persistence during new episodes of use of traditional and biologic DMARDs...
Trends in antibiotic prescribing for adults in the United States--1995 to 2002Christianne L Roumie
VA Tennessee Valley Healthcare System, Tennessee Valley Geriatric Research Education Clinical Center, Nashville, TN, USA
J Gen Intern Med 20:697-702. 2005..The impact of national efforts to limit antibiotic prescribing has not been fully evaluated...
The effect of incident antidiabetic regimens on lipid profiles in veterans with type 2 diabetes: a retrospective cohortChristianne L Roumie
VA Tennessee Valley Geriatric Research Education Clinical Center, HSR and D Targeted Research Enhancement Program for Patient Healthcare Behavior, Clinical Research Center of Excellence, Nashville, TN, USA
Pharmacoepidemiol Drug Saf 20:36-44. 2011..Effects of oral antidiabetic drugs (OADs) on lipids may influence cardiovascular outcomes. Our aim was to compare time to initiation of lipid lowering medication (LLM) and 12-month lipid profiles among new OAD users...
National impact of universal childhood immunization with pneumococcal conjugate vaccine on outpatient medical care visits in the United StatesCarlos G Grijalva
Department of Preventive Medicine, Division of Pharmacoepidemiology, Vanderbilt University School of Medicine, Nashville, TN 37232-2637, USA
Pediatrics 118:865-73. 2006..Persistence of this trend will produce a significant reduction of the otitis media burden and further enhance the cost-effectiveness of heptavalent pneumococcal conjugate vaccine...
Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysisCarlos G Grijalva
Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Lancet 369:1179-86. 2007..We therefore assessed the effect of the programme on rates of all-cause and pneumococcal pneumonia admissions...
Changing epidemiology of pneumococcal meningitis after the introduction of pneumococcal conjugate vaccine in the United StatesChiaojung Jillian Tsai
Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
Clin Infect Dis 46:1664-72. 2008....
The underrecognized burden of influenza in young childrenKatherine A Poehling
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, USA
N Engl J Med 355:31-40. 2006..CONCLUSIONS: Among young children, outpatient visits associated with influenza were 10 to 250 times as common as hospitalizations. Few influenza infections were recognized clinically...
Comparisons of persistence and durability among three oral antidiabetic therapies using electronic prescription-fill data: the impact of adherence requirements and stockpilingR A Greevy
VA Tennessee Valley Geriatric Research Education Clinical Center, Nashville, Tennessee, USA
Clin Pharmacol Ther 90:813-9. 2011..05, P = 0.046). All the drug comparisons showed statistically significant effects in both directions, the risk of nonpersistence increasing or decreasing depending on the design parameters...
Accuracy and interpretation of rapid influenza tests in childrenCarlos G Grijalva
Preventive Medicine Department, Vanderbilt University Medical Center, Nashville, TN 37232 2637, USA
Pediatrics 119:e6-11. 2007..Although the interpretation of test results depends on test characteristics and influenza prevalence, this information is limited in routine clinical practice...
Orthostatic hypotension-related hospitalizations in the United StatesCyndya Shibao
Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tenn 37212, USA
Am J Med 120:975-80. 2007..Nevertheless, the precise burden of this condition in the US is currently unknown...
Promises and challenges of pneumococcal conjugate vaccines for the developing worldCarlos G Grijalva
Clin Infect Dis 43:680-2. 2006
Estimating influenza hospitalizations among childrenCarlos G Grijalva
Vanderbilt University School of Medicine; Nashville, Tennessee 37232-2637, USA
Emerg Infect Dis 12:103-9. 2006....
Research Grants
- The impact of the pneumococcal conjugate vaccine on pneumonia hospitalizationsCARLOS GRIJALVA; Fiscal Year: 2007..The potential of large databases for research is commonly underappreciated. We propose the use of NIS and SID for the evaluation of the pneumococcal conjugate vaccination program, using an innovative approach. ..
