B S Graham
Affiliation: Vanderbilt University
- Immunological determinants of disease caused by respiratory syncytial virusB S Graham
Dept of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
Trends Microbiol 4:290-3. 1996..Vaccination can influence the types of cytokine produced by selectively activating T cell subpopulations and inducing an immune response that clears the virus with minimal immunopathology...
- Analysis of intercurrent human immunodeficiency virus type 1 infections in phase I and II trials of candidate AIDS vaccines. AIDS Vaccine Evaluation Group, and the Correlates of HIV Immune Protection GroupB S Graham
Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2582, USA
J Infect Dis 177:310-9. 1998..Laboratory analysis suggested that vaccine-induced immune responses did not significantly affect the genotypic or phenotypic characteristics of transmitted virus or the early clinical course of HIV-1 infection...
- Priming with secreted glycoprotein G of respiratory syncytial virus (RSV) augments interleukin-5 production and tissue eosinophilia after RSV challengeT R Johnson
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2582, USA
J Virol 72:2871-80. 1998..The ability of RSV to secrete G protein may therefore represent a viral strategy for immunomodulation and be a key determinant of disease pathogenesis...
- Respiratory syncytial virus (RSV)-induced airway hyperresponsiveness in allergically sensitized mice is inhibited by live RSV and exacerbated by formalin-inactivated RSVR S Peebles
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2582, USA
J Infect Dis 182:671-7. 2000..This study suggests that immune modulation with RSV vaccination can have profound effects on RSV-induced airway disease and that prevention of airway hyperresponsiveness is an important end point in vaccine development...
- Interleukin-4 diminishes CD8(+) respiratory syncytial virus-specific cytotoxic T-lymphocyte activity in vivoS Aung
Department of Microbiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Virol 73:8944-9. 1999..These results demonstrate that local expression of IL-4, at the time of antigen presentation, diminishes the cytolytic activity of primary and memory CD8(+) RSV-specific CTL responses in vivo...
- Immune-mediated disease pathogenesis in respiratory syncytial virus infectionB S Graham
Department of Medicine, A 4103 MCN, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232 2582, USA
Immunopharmacology 48:237-47. 2000..This model suggests strategies for the development of new vaccine and immunotherapeutic interventions, and creates a framework for asking additional questions about the immunopathogenesis of RSV...
- Pertussis toxin sensitization alters the pathogenesis of subsequent respiratory syncytial virus infectionJ E Fischer
Department of Microbiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2582, USA
J Infect Dis 182:1029-38. 2000..These data confirm that the preexisting immune environment can change virus-specific immunity and provide both a model for study of RSV disease and evidence that noninfectious immunomodulators may impact pathogen-specific immunity...
- Respiratory syncytial virus infection does not increase allergen-induced type 2 cytokine production, yet increases airway hyperresponsiveness in miceR S Peebles
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2582, USA
J Med Virol 63:178-88. 2001....