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Genomes and Genes | William M GradySummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Genomic instability and colon cancerWilliam M Grady
Vanderbilt University Medical Center, 1161 21st Ave South, C2104 MCN, Nashville, TN 37232 2279, USA
Cancer Metastasis Rev 23:11-27. 2004..Hopefully, discovery of the cause and specific role of genomic instability in colon cancer will yield more effective chemotherapy strategies that take advantage of this unique characteristic of cancer cells...- Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutationNina M Munoz
Department of Cancer Biology, Vanderbilt University Medical School, Nashville, Tennessee, USA
Cancer Res 66:9837-44. 2006.... - Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cellsSwati Biswas
Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
Genes Chromosomes Cancer 47:95-106. 2008..Through the use of defined cell line systems, we show that both genomic instability and clonal selection of TGFB resistant cells contribute to the high frequency of TGFBR2 mutations in MSI colon cancer... - Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomasChuanzhong Ye
Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA
Oncol Rep 16:429-35. 2006..The methylation status of these genes in rectal mucosa biopsies detected by MSP assays may not distinguish between patients with and without adenomas in the colon... 
The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancerAndres Rojas
Department of Cancer Biology, Vanderbilt University Medical School, Nashville, TN, USA
Int J Cancer 123:14-21. 2008..Our results demonstrate that the aberrant methylation of TSP1 has biological consequences and provide evidence that the aberrant methylation of TSP1 is a novel epigenetic mechanism for suppressing TGF-beta signaling in colorectal cancer...- Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomyJudith Romero-Gallo
Department of Medicine, Vanderbilt University, Nashville, TN, USA
Oncogene 24:3028-41. 2005.... - Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polypsZsolt Petko
Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
Clin Cancer Res 11:1203-9. 2005..Notably, improvements in the specificity and sensitivity of the fecal DNA-based assays will be needed to make them clinically useful diagnostic tests for polyps... - TGF-beta has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell linesNina M Munoz
Department of Cancer Biology, Vanderbilt University Graduate School, Nashville, TN, USA
Growth Factors 26:254-62. 2008.... - Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancerSwati Biswas
Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
Cancer Res 64:4687-92. 2004.... - Diagnosis and management of hereditary non-polyposis colon cancerJohn DeFrancisco
Department of Medicine/Division of Gastroenterology, Vanderbilt University Medical School, Nashville, Tennessee 37232-2279, USA
Gastrointest Endosc 58:390-408. 2003 - Genetic testing for high-risk colon cancer patientsWilliam M Grady
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2279, USA
Gastroenterology 124:1574-94. 2003..In this review, an overview of the colon cancer high-risk syndromes, with a focus on the availability and indications for genetic testing, is presented... - Genetic and epigenetic alterations in colon cancerWilliam M Grady
Vanderbilt University Medical Center, Nashville, Tennessee 37232 2279, USA
Annu Rev Genomics Hum Genet 3:101-28. 2002.... - Do adverse histopathologic findings in colorectal cancer patients explain disparate outcomes?Keith D Gray
Departments of Surgery, Meharry Medica College, Nashville, TN, USA
J Natl Med Assoc 98:348-51. 2006..Histopathologic findings did not explain the apparent disparity in survival. The differences in number of nodes harvested may suggest inadequate resection or insufficient recovery of nodes by the pathologist... - Hereditary colon cancer genesWilliam M Grady
Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, TN, USA
Methods Mol Biol 222:59-83. 2003 - Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryoAnna L Means
Department of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2733, USA
Genesis 42:23-7. 2005.... - CIMP and colon cancer gets more complicatedWilliam M Grady
Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N. D4-100, Seattle, WA 98109, USA
Gut 56:1498-500. 2007 - Hereditary diffuse gastric cancer: more answers or more questions?William M Grady
Gastroenterology 122:830-1; discussion 831-2. 2002 - Consortium approach to identifying genes for Barrett's esophagus and esophageal adenocarcinomaHeather M Ochs Balcom
Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Transl Res 150:3-17. 2007.... - Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreasKamel Izeradjene
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Cell 11:229-43. 2007..Our findings suggest that the sequence, as well as the context, in which these critical mutations are acquired helps determine the ensuing pathology... - DNA alkylation and DNA methylation: cooperating mechanisms driving the formation of colorectal adenomas and adenocarcinomas?William M Grady
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Gut 56:318-20. 2007 - Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomasAndrew Kaz
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Int J Cancer 120:1922-9. 2007..MLH1 methylation in the Lynch syndrome adenomas suggests gene methylation might have a role in the initiation of these neoplasms... - Familiality in Barrett's esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junctionAmitabh Chak
University Hospitals of Cleveland, Case School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA
Cancer Epidemiol Biomarkers Prev 15:1668-73. 2006..The aim of this study was to determine the proportion of patients with these diseases who have familial Barrett's esophagus... - CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancerYoung-Ho Kim
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Genes Chromosomes Cancer 45:781-9. 2006.... - Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutationsWilliam M Grady
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Int J Cancer 118:600-8. 2006.... - Genomic and epigenetic instability in colorectal cancer pathogenesisWilliam M Grady
Department of Medicine, University of Washington Medical School, Seattle, Washington, USA
Gastroenterology 135:1079-99. 2008..Determining the causes and roles of genomic and epigenomic instability in colon tumor formation has the potential to yield more effective prevention strategies and therapeutics for patients with colorectal cancer...