William M Grady

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Genomic instability and colon cancer
    William M Grady
    Vanderbilt University Medical Center, 1161 21st Ave South, C2104 MCN, Nashville, TN 37232 2279, USA
    Cancer Metastasis Rev 23:11-27. 2004
  2. ncbi request reprint Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation
    Nina M Munoz
    Department of Cancer Biology, Vanderbilt University Medical School, Nashville, Tennessee, USA
    Cancer Res 66:9837-44. 2006
  3. ncbi request reprint Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells
    Swati Biswas
    Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Genes Chromosomes Cancer 47:95-106. 2008
  4. ncbi request reprint Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas
    Chuanzhong Ye
    Department of Medicine, Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
    Oncol Rep 16:429-35. 2006
  5. pmc The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer
    Andres Rojas
    Department of Cancer Biology, Vanderbilt University Medical School, Nashville, TN, USA
    Int J Cancer 123:14-21. 2008
  6. ncbi request reprint Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy
    Judith Romero-Gallo
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Oncogene 24:3028-41. 2005
  7. ncbi request reprint Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps
    Zsolt Petko
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Clin Cancer Res 11:1203-9. 2005
  8. pmc TGF-beta has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines
    Nina M Munoz
    Department of Cancer Biology, Vanderbilt University Graduate School, Nashville, TN, USA
    Growth Factors 26:254-62. 2008
  9. ncbi request reprint Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer
    Swati Biswas
    Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Cancer Res 64:4687-92. 2004
  10. ncbi request reprint Diagnosis and management of hereditary non-polyposis colon cancer
    John DeFrancisco
    Department of Medicine Division of Gastroenterology, Vanderbilt University Medical School, Nashville, Tennessee 37232 2279, USA
    Gastrointest Endosc 58:390-408. 2003

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Genomic instability and colon cancer
    William M Grady
    Vanderbilt University Medical Center, 1161 21st Ave South, C2104 MCN, Nashville, TN 37232 2279, USA
    Cancer Metastasis Rev 23:11-27. 2004
    ..Hopefully, discovery of the cause and specific role of genomic instability in colon cancer will yield more effective chemotherapy strategies that take advantage of this unique characteristic of cancer cells...
  2. ncbi request reprint Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation
    Nina M Munoz
    Department of Cancer Biology, Vanderbilt University Medical School, Nashville, Tennessee, USA
    Cancer Res 66:9837-44. 2006
    ....
  3. ncbi request reprint Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells
    Swati Biswas
    Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Genes Chromosomes Cancer 47:95-106. 2008
    ..Through the use of defined cell line systems, we show that both genomic instability and clonal selection of TGFB resistant cells contribute to the high frequency of TGFBR2 mutations in MSI colon cancer...
  4. ncbi request reprint Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas
    Chuanzhong Ye
    Department of Medicine, Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
    Oncol Rep 16:429-35. 2006
    ..The methylation status of these genes in rectal mucosa biopsies detected by MSP assays may not distinguish between patients with and without adenomas in the colon...
  5. pmc The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer
    Andres Rojas
    Department of Cancer Biology, Vanderbilt University Medical School, Nashville, TN, USA
    Int J Cancer 123:14-21. 2008
    ..Our results demonstrate that the aberrant methylation of TSP1 has biological consequences and provide evidence that the aberrant methylation of TSP1 is a novel epigenetic mechanism for suppressing TGF-beta signaling in colorectal cancer...
  6. ncbi request reprint Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy
    Judith Romero-Gallo
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Oncogene 24:3028-41. 2005
    ....
  7. ncbi request reprint Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps
    Zsolt Petko
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Clin Cancer Res 11:1203-9. 2005
    ..Notably, improvements in the specificity and sensitivity of the fecal DNA-based assays will be needed to make them clinically useful diagnostic tests for polyps...
  8. pmc TGF-beta has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines
    Nina M Munoz
    Department of Cancer Biology, Vanderbilt University Graduate School, Nashville, TN, USA
    Growth Factors 26:254-62. 2008
    ....
  9. ncbi request reprint Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer
    Swati Biswas
    Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Cancer Res 64:4687-92. 2004
    ....
  10. ncbi request reprint Diagnosis and management of hereditary non-polyposis colon cancer
    John DeFrancisco
    Department of Medicine Division of Gastroenterology, Vanderbilt University Medical School, Nashville, Tennessee 37232 2279, USA
    Gastrointest Endosc 58:390-408. 2003
  11. ncbi request reprint Genetic testing for high-risk colon cancer patients
    William M Grady
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2279, USA
    Gastroenterology 124:1574-94. 2003
    ..In this review, an overview of the colon cancer high-risk syndromes, with a focus on the availability and indications for genetic testing, is presented...
  12. ncbi request reprint Genetic and epigenetic alterations in colon cancer
    William M Grady
    Vanderbilt University Medical Center, Nashville, Tennessee 37232 2279, USA
    Annu Rev Genomics Hum Genet 3:101-28. 2002
    ....
  13. pmc Do adverse histopathologic findings in colorectal cancer patients explain disparate outcomes?
    Keith D Gray
    Departments of Surgery, Meharry Medica College, Nashville, TN, USA
    J Natl Med Assoc 98:348-51. 2006
    ..Histopathologic findings did not explain the apparent disparity in survival. The differences in number of nodes harvested may suggest inadequate resection or insufficient recovery of nodes by the pathologist...
  14. ncbi request reprint Hereditary colon cancer genes
    William M Grady
    Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, TN, USA
    Methods Mol Biol 222:59-83. 2003
  15. ncbi request reprint Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo
    Anna L Means
    Department of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2733, USA
    Genesis 42:23-7. 2005
    ....
  16. pmc CIMP and colon cancer gets more complicated
    William M Grady
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N D4 100, Seattle, WA 98109, USA
    Gut 56:1498-500. 2007
  17. ncbi request reprint Hereditary diffuse gastric cancer: more answers or more questions?
    William M Grady
    Gastroenterology 122:830-1; discussion 831-2. 2002
  18. ncbi request reprint Consortium approach to identifying genes for Barrett's esophagus and esophageal adenocarcinoma
    Heather M Ochs-Balcom
    Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Transl Res 150:3-17. 2007
    ....
  19. ncbi request reprint Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
    Kamel Izeradjene
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Cell 11:229-43. 2007
    ..Our findings suggest that the sequence, as well as the context, in which these critical mutations are acquired helps determine the ensuing pathology...
  20. pmc DNA alkylation and DNA methylation: cooperating mechanisms driving the formation of colorectal adenomas and adenocarcinomas?
    William M Grady
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Gut 56:318-20. 2007
  21. ncbi request reprint Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas
    Andrew Kaz
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Int J Cancer 120:1922-9. 2007
    ..MLH1 methylation in the Lynch syndrome adenomas suggests gene methylation might have a role in the initiation of these neoplasms...
  22. ncbi request reprint Familiality in Barrett's esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junction
    Amitabh Chak
    University Hospitals of Cleveland, Case School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Cancer Epidemiol Biomarkers Prev 15:1668-73. 2006
    ..The aim of this study was to determine the proportion of patients with these diseases who have familial Barrett's esophagus...
  23. ncbi request reprint CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer
    Young Ho Kim
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genes Chromosomes Cancer 45:781-9. 2006
    ....
  24. ncbi request reprint Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations
    William M Grady
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Int J Cancer 118:600-8. 2006
    ....
  25. pmc Genomic and epigenetic instability in colorectal cancer pathogenesis
    William M Grady
    Department of Medicine, University of Washington Medical School, Seattle, Washington, USA
    Gastroenterology 135:1079-99. 2008
    ..Determining the causes and roles of genomic and epigenomic instability in colon tumor formation has the potential to yield more effective prevention strategies and therapeutics for patients with colorectal cancer...