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Species | Timothy D GirardSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Associations of markers of inflammation and coagulation with delirium during critical illnessTimothy D Girard
Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
Intensive Care Med 38:1965-73. 2012..To assess the associations between a priori-selected markers of inflammation and coagulation and delirium during critical illness...
Brain dysfunction in patients with chronic critical illnessTimothy D Girard
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
Respir Care 57:947-55; discussion 955-7. 2012....
Insights into severe sepsis in older patients: from epidemiology to evidence-based managementTimothy D Girard
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Clin Infect Dis 40:719-27. 2005..Clinicians must be aware of the level of evidence in support of various interventions and must keenly screen older survivors for ongoing deficits that will limit their functional recovery...- Delirium in the intensive care unitTimothy D Girard
Department of Medicine Division of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University School of Medicine 1161 21st Avenue South, Nashville, TN 37232 2650, USA
Crit Care 12:S3. 2008..Strategies for the prevention and treatment of ICU delirium are the subjects of multiple ongoing investigations... - Protocol-driven ventilator weaning: reviewing the evidenceTimothy D Girard
Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, 6 th Floor MCE, 6110, Nashville, TN 37232 8300, USA
Clin Chest Med 29:241-52, v. 2008..This article reviews the rationale for and against the routine use of weaning protocols and highlights informative details of many clinical trials that have evaluated such protocols... - Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trialTimothy D Girard
Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
Lancet 371:126-34. 2008..Our aim was to assess a protocol that paired spontaneous awakening trials (SATs)-ie, daily interruption of sedatives-with spontaneous breathing trials (SBTs)... - Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trialTimothy D Girard
Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 38:428-37. 2010..To demonstrate the feasibility of a placebo-controlled trial of antipsychotics for delirium in the intensive care unit and to test the hypothesis that antipsychotics would improve days alive without delirium or coma... - Delirium as a predictor of long-term cognitive impairment in survivors of critical illnessTimothy D Girard
Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, and Department of Medicine, Saint Thomas Hospital, Nashville, TN, USA
Crit Care Med 38:1513-20. 2010..To test the hypothesis that duration of delirium in the intensive care unit is an independent predictor of long-term cognitive impairment after critical illness requiring mechanical ventilation... - Mechanical ventilation in ARDS: a state-of-the-art reviewTimothy D Girard
Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
Chest 131:921-9. 2007.... - Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort studyTimothy D Girard
Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Crit Care 11:R28. 2007..We sought to identify factors associated with PTSD symptoms in patients following critical illness requiring mechanical ventilation... - Bacteremia and sepsis in older adultsTimothy D Girard
Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, 6th Floor Medical Center East, Suite 6100, Nashville, TN 37232 8300, USA
Clin Geriatr Med 23:633-47, viii. 2007.... - Ultrasound guidance during central venous catheterization: a survey of use by house staff physiciansTimothy D Girard
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
J Crit Care 20:224-9. 2005..The objective of this study is to explore the attitudes, knowledge, and behavior of house staff physicians regarding the use of ultrasound guidance (UG) during central venous catheter placement (CP)... - Long-term cognitive and psychological outcomes in the awakening and breathing controlled trialJames C Jackson
Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
Am J Respir Crit Care Med 182:183-91. 2010..Little is known, however, of how such strategies affect long-term cognitive, psychological, and functional outcomes... - The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study*Alessandro Morandi
Center for Quality of Aging, Vanderbilt University Medical Center, Department of Medicine, Division of Allergy, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Crit Care Med 40:2182-9. 2012..Relationships between 1) delirium duration and brain white matter integrity, and 2) white matter integrity and long-term cognitive impairment are poorly understood and could be explored using magnetic resonance imaging... - Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trialPratik P Pandharipande
Anesthesiology Service, VA TN Valley Health Care System, Nashville, TN 37212 2637, USA
Crit Care 14:R38. 2010.... - The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: the VISIONS cohort magnetic resonance imaging study*Max L Gunther
Department of Psychiatry, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232 8300, USA
Crit Care Med 40:2022-32. 2012.... - Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trialPratik P Pandharipande
Department of Anesthesiology Division of Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
JAMA 298:2644-53. 2007..Dexmedetomidine induces sedation via different central nervous system receptors than the benzodiazepine drugs and may lower the risk of acute brain dysfunction... - Association between endothelial dysfunction and acute brain dysfunction during critical illnessChristopher G Hughes
Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, 1211 21st Ave South, 526 MAB, Nashville, Tennessee 37212, USA
Anesthesiology 118:631-9. 2013..This study sought to determine whether systemic endothelial dysfunction is associated with acute brain dysfunction during critical illness... - A combined early cognitive and physical rehabilitation program for people who are critically Ill: the activity and cognitive therapy in the intensive care unit (ACT-ICU) trialNathan E Brummel
Division of Allergy, Pulmonary, and Critical Care Medicine and Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Phys Ther 92:1580-92. 2012..The feasibility of early cognitive therapy in people who are critically ill remains unknown... - Delirium and sedation recognition using validated instruments: reliability of bedside intensive care unit nursing assessments from 2007 to 2010Eduard E Vasilevskis
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee, USA
J Am Geriatr Soc 59:S249-55. 2011..To describe the reliability and sustainability of delirium and sedation measurements of bedside intensive care unit (ICU) nurses... - Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patientsStuart McGrane
Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, 526 MAB, 1211 21st Ave South, Nashville, TN 37212, USA
Crit Care 15:R78. 2011..This study sought to investigate the relationship between two inflammatory biomarkers, procalcitonin and C-reactive protein (CRP), and duration of acute brain dysfunction in ventilated patients... - Future directions of delirium research and managementChristopher G Hughes
Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, Nashville, TN, USA
Best Pract Res Clin Anaesthesiol 26:395-405. 2012..Physical and cognitive rehabilitation measures need to be further examined as additional means of improving outcomes from delirium in the hospital setting... - Immortal time bias in critical care research: application of time-varying Cox regression for observational cohort studiesAyumi K Shintani
Department of Biostatistics, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 37:2939-45. 2009..To examine the bias introduced by using time-fixed methodology to analyze the effects of a time-varying exposure incurred in the intensive care unit... - Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patientsE Wesley Ely
Department of Medicine, Saint Thomas Hospital, and Vanderbilt University Medical Center, Nashville, TN 37232, USA
Crit Care Med 35:112-7. 2007..To test for an association between apolipoprotein E (APOE) genotypes and duration of intensive care unit delirium... - Post-traumatic stress disorder and post-traumatic stress symptoms following critical illness in medical intensive care unit patients: assessing the magnitude of the problemJames C Jackson
Clinical Research Center of Excellence, VA Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, TN 37212, USA
Crit Care 11:R27. 2007..Recently, investigators have reported that the experience of critical illness can also lead to PTSD, although details of the association between critical illness and PTSD remain unclear... - Markers of inflammation and coagulation may be modulated by enteral feeding strategyJulie A Bastarache
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
JPEN J Parenter Enteral Nutr 36:732-40. 2012..Although enteral nutrition (EN) is provided to most mechanically ventilated patients, the effect of specific feeding strategies on circulating markers of coagulation and inflammation is unknown... - Medical and economic implications of cognitive and psychiatric disability of survivorshipRamona O Hopkins
Department of Medicine, Pulmonary and Critical Care Division, Intermountain Medical Center, Murray, UT 84107, USA
Semin Respir Crit Care Med 33:348-56. 2012.... - The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*Jessica R Adams Wilson
Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 40:835-41. 2012.... - Statins and brain dysfunction: a hypothesis to reduce the burden of cognitive impairment in patients who are critically illAlessandro Morandi
Center for Quality of Aging, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Chest 140:580-5. 2011.... - Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionalsRina P Patel
School of Medicine RPP, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 37:825-32. 2009..Our objective was to assess beliefs and practices regarding ICU delirium and sedation management... - Sedation and weaning from mechanical ventilation: linking spontaneous awakening trials and spontaneous breathing trials to improve patient outcomesMichael H Hooper
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
Crit Care Clin 25:515-25, viii. 2009..Implementation of these strategies in a wake-up-and-breathe protocol has demonstrated benefit over the use of spontaneous breathing trials alone... - Neuroimaging in delirious intensive care unit patients: a preliminary case series reportAlessandro Morandi
Center for Health Services Research Center, Vanderbilt Center for Quality of Aging, Nashville, Tennesee, USA
Psychiatry (Edgmont) 7:28-33. 2010..e. white matter hyperintensities) and short- and long-term neurological outcomes... - A screening, prevention, and restoration model for saving the injured brain in intensive care unit survivorsEduard E Vasilevskis
Center for Health Services Research, Department of Medicine, Vanderbilt School of Medicine, Nashville, TN, USA
Crit Care Med 38:S683-91. 2010..This practical system applying many evidence-based concepts incorporates personalized medicine, systems-based practice, and continuing research and development toward improving acute and chronic cognitive outcomes... - The complex interplay between delirium, sedation, and early mobility during critical illness: applications in the trauma unitArna Banerjee
Department of Anesthesiology, Division of Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Curr Opin Anaesthesiol 24:195-201. 2011..This review will focus on the epidemiology of these two disease processes and discuss strategies aimed at reducing these devastating complications of critical illness... - Communication in critical care: family rounds in the intensive care unitNatalie L Jacobowski
Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8300, USA
Am J Crit Care 19:421-30. 2010..Communication with family members of patients in intensive care units is challenging and fraught with dissatisfaction... - Are we sedating more than just the brain?Nathan E Brummel
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, 1215, 21st Avenue South, Medical Center East, 6th Floor, Suite 6000, Nashville, TN 37232 8300, USA
Crit Care 15:163. 2011..This hypothesis-generating study warns that sedation may harm organs other than the brain during critical illness, a possibility that warrants careful study in the future... - Preventing delirium in the intensive care unitNathan E Brummel
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Crit Care Clin 29:51-65. 2013..The ABCDE approach to critical care is a bundled approach that clinicians can implement for many patients treated in their ICUs to prevent the adverse outcomes associated with delirium and critical illness... - Sedation and weaning from mechanical ventilation: linking spontaneous awakening trials and spontaneous breathing trials to improve patient outcomesMichael H Hooper
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, 6th Floor MCE, 6100, Nashville, TN 37232 8300, USA
Anesthesiol Clin 29:651-61. 2011..Implementation of these strategies in a wake-up-and-breathe protocol has demonstrated benefit over the use of spontaneous breathing trials alone... - Re: Increased levels of serum S100B protein in critically ill patients without brain injuryBryan A Cotton
Shock 30:222; author reply 222-3. 2008 - Increased levels of serum S100B protein in critically ill patients without brain injury: Shock 26(1):20-24, 2006Bryan A Cotton
Shock 27:338; author reply 339. 2007 - Clinical sedation scores as indicators of sedative and analgesic drug exposure in intensive care unit patientsAndrew L Masica
Baylor Institute for Health Care Research and Improvement, Baylor Health Care System, Dallas, Texas, USA
Am J Geriatr Pharmacother 5:218-31. 2007..These issues are of particular concern in elderly patients (aged > or =65 years), who account for at least half of all ICU admissions and nearly two thirds of ICU days... - Comment on "Validity and reliability of the DDS for severity of delirium in the ICU"Timothy D Girard
Neurocrit Care 4:190-1; author reply 192-3. 2006 - Biomarkers of cardiac injury in acute respiratory distress syndrome: getting to the heart of the matterTimothy D Girard
Crit Care Med 35:2638-9. 2007 - The immunopathogenesis of sepsis in elderly patientsSteven M Opal
Infectious Disease Division, Brown University School of Medicine, Providence, Rhode Island, USA
Clin Infect Dis 41:S504-12. 2005..This immune dysregulation is accompanied by a more pronounced procoagulant state in older patients. These molecular events function in concert to render elderly patients at excess risk for mortality from severe sepsis and septic shock... - Comment on "Incidence, risk factors and consequences of ICU delirium" by Ouimet et alTimothy D Girard
Intensive Care Med 33:1479-80; author reply 1481-2. 2007