Martin J Gallagher

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc The GABAA receptor alpha1 subunit epilepsy mutation A322D inhibits transmembrane helix formation and causes proteasomal degradation
    Martin J Gallagher
    Department of Neurology, Vanderbilt University, Nashville, TN 37232 8552, USA
    Proc Natl Acad Sci U S A 104:12999-3004. 2007
  2. pmc GABA(A) receptor alpha1 subunit mutation A322D associated with autosomal dominant juvenile myoclonic epilepsy reduces the expression and alters the composition of wild type GABA(A) receptors
    Li Ding
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:26390-405. 2010
  3. pmc Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome
    Chengwen Zhou
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 288:21458-72. 2013
  4. pmc Slow degradation and aggregation in vitro of mutant GABAA receptor gamma2(Q351X) subunits associated with epilepsy
    Jing Qiong Kang
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212 8552, USA
    J Neurosci 30:13895-905. 2010
  5. pmc Mutations in GABAA receptor subunits associated with genetic epilepsies
    Robert L Macdonald
    Department of Neurology, Vanderbilt University, 6140 Medical Research Building III, 465 21st Avenue, Nashville, TN 37232 8552, USA
    J Physiol 588:1861-9. 2010
  6. ncbi request reprint Endoplasmic reticulum retention and associated degradation of a GABAA receptor epilepsy mutation that inserts an aspartate in the M3 transmembrane segment of the alpha1 subunit
    Martin J Gallagher
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 280:37995-8004. 2005
  7. pmc Alteration of GABAergic neurotransmission by pulsed infrared laser stimulation
    Hua Jun Feng
    Department of Neurology, Vanderbilt University Medical Center, 6140 MRB III, 465 21st Ave South, Nashville, TN 37232 8552, United States
    J Neurosci Methods 192:110-4. 2010
  8. ncbi request reprint GABA(A) receptor epilepsy mutations
    Robert L Macdonald
    Department of Neurology, Vanderbilt University, 6140 Medical Research Building III, 465 21st Ave Nashville, TN 37232 8552, USA
    Biochem Pharmacol 68:1497-506. 2004
  9. ncbi request reprint The juvenile myoclonic epilepsy GABA(A) receptor alpha1 subunit mutation A322D produces asymmetrical, subunit position-dependent reduction of heterozygous receptor currents and alpha1 subunit protein expression
    Martin J Gallagher
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37212, USA
    J Neurosci 24:5570-8. 2004
  10. pmc Decreased viability and absence-like epilepsy in mice lacking or deficient in the GABAA receptor α1 subunit
    Fazal M Arain
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232 8552, USA
    Epilepsia 53:e161-5. 2012

Collaborators

Detail Information

Publications12

  1. pmc The GABAA receptor alpha1 subunit epilepsy mutation A322D inhibits transmembrane helix formation and causes proteasomal degradation
    Martin J Gallagher
    Department of Neurology, Vanderbilt University, Nashville, TN 37232 8552, USA
    Proc Natl Acad Sci U S A 104:12999-3004. 2007
    ....
  2. pmc GABA(A) receptor alpha1 subunit mutation A322D associated with autosomal dominant juvenile myoclonic epilepsy reduces the expression and alters the composition of wild type GABA(A) receptors
    Li Ding
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:26390-405. 2010
    ..These findings demonstrated that, in addition to causing a heterozygous loss of function of alpha1(AD) subunits, this epilepsy mutation also elicited a modest dominant negative effect that likely shapes the epilepsy phenotype...
  3. pmc Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome
    Chengwen Zhou
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 288:21458-72. 2013
    ....
  4. pmc Slow degradation and aggregation in vitro of mutant GABAA receptor gamma2(Q351X) subunits associated with epilepsy
    Jing Qiong Kang
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212 8552, USA
    J Neurosci 30:13895-905. 2010
    ....
  5. pmc Mutations in GABAA receptor subunits associated with genetic epilepsies
    Robert L Macdonald
    Department of Neurology, Vanderbilt University, 6140 Medical Research Building III, 465 21st Avenue, Nashville, TN 37232 8552, USA
    J Physiol 588:1861-9. 2010
    ....
  6. ncbi request reprint Endoplasmic reticulum retention and associated degradation of a GABAA receptor epilepsy mutation that inserts an aspartate in the M3 transmembrane segment of the alpha1 subunit
    Martin J Gallagher
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 280:37995-8004. 2005
    ....
  7. pmc Alteration of GABAergic neurotransmission by pulsed infrared laser stimulation
    Hua Jun Feng
    Department of Neurology, Vanderbilt University Medical Center, 6140 MRB III, 465 21st Ave South, Nashville, TN 37232 8552, United States
    J Neurosci Methods 192:110-4. 2010
    ..These data show that optical stimulation using transient infrared laser light can alter GABAergic neurotransmission and demonstrate that it may be an alternative approach to electrical stimulation in studying GABAergic function...
  8. ncbi request reprint GABA(A) receptor epilepsy mutations
    Robert L Macdonald
    Department of Neurology, Vanderbilt University, 6140 Medical Research Building III, 465 21st Ave Nashville, TN 37232 8552, USA
    Biochem Pharmacol 68:1497-506. 2004
    ....
  9. ncbi request reprint The juvenile myoclonic epilepsy GABA(A) receptor alpha1 subunit mutation A322D produces asymmetrical, subunit position-dependent reduction of heterozygous receptor currents and alpha1 subunit protein expression
    Martin J Gallagher
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37212, USA
    J Neurosci 24:5570-8. 2004
    ....
  10. pmc Decreased viability and absence-like epilepsy in mice lacking or deficient in the GABAA receptor α1 subunit
    Fazal M Arain
    Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232 8552, USA
    Epilepsia 53:e161-5. 2012
    ..These findings suggest that α1 subunit haploinsufficiency can produce epilepsy and may be a major mechanism by which the S326fs328X and A322D mutations cause these epilepsy syndromes...
  11. ncbi request reprint Clinical features of epilepsy in patients with cerebellar structural abnormalities in a referral center
    Maria V Recio
    Department of Neurology, Vanderbilt University, 2311 Pierce Avenue, Nashville, TN 37232, USA
    Epilepsy Res 76:1-5. 2007
    ..The objective of this study was to describe epilepsy localization, clinical features and surgery outcome in patients with epilepsy and cerebellar structural abnormalities...
  12. ncbi request reprint Structural determinants of benzodiazepine allosteric regulation of GABA(A) receptor currents
    Dorothy M Jones-Davis
    Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan 48104 1687, USA
    J Neurosci 25:8056-65. 2005
    ..Benzodiazepine transduction involves a group of residues that connects the N terminus and M1, and another group of residues that may facilitate an interaction between the N terminus and the M2 and M2-M3 loop domains...

Research Grants4

  1. Physiologic Analysis of Two GABAR Gamma2-Subunit Domains
    Martin Gallagher; Fiscal Year: 2006
    ..Such an environment maximizes the probability that the principal investigator will establish a scientific niche and embark upon a successful independent academic career. ..
  2. GABA-A Receptor Alpha 1 Subunit Degradation and Its Association with Epilepsy
    Martin Gallagher; Fiscal Year: 2007
    ....
  3. GABA-A Receptor Alpha 1 Subunit Mutations and Epilepsy
    Martin J Gallagher; Fiscal Year: 2010
    ..The experiments in this proposal will determine the effects of mutations an epilepsy gene and will thus provide crucial information for the development of novel epilepsy therapies. ..