Research Topics
| K FujimotoSummaryAffiliation: Vanderbilt University Country: USA Publications
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Detail Information
Publications
Inhibition of pRb phosphorylation and cell cycle progression by an antennapedia-p16(INK4A) fusion peptide in pancreatic cancer cellsK Fujimoto
Department of Surgery and Surgical Basic Science, Kyoto University, Kyoto, Japan
Cancer Lett 159:151-8. 2000..Restoration of p16/pRb tumor-suppressive pathway by re-expression of p16(INK4A) may play a therapeutic role in the treatment of pancreatic cancer...- Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cellsK Fujimoto
Department of Surgery and Surgical Basic Science, Kyoto University, Japan
Int J Cancer 81:637-44. 1999..TAC-101 may therefore be a useful agent for new therapeutic strategies focusing on inhibition of pancreatic-cancer-cell proliferation... - An exogenous cdk inhibitor, butyrolactone-I, induces apoptosis with increased Bax/Bcl-2 ratio in p53-mutated pancreatic cancer cellsM Wada
Department of Surgery and Surgical Basic Science, Kyoto University, Japan
Anticancer Res 18:2559-66. 1998..These data, suggest that dynamic changes of the Bax/Bcl-2 ratio might be important in determining point of apoptosis induction in pancreatic cancer cells with p53 mutation... - Immunohistochemical analysis of cyclooxygenase-2 expression in pancreatic tumorsT Koshiba
Department of Surgery and Surgical Basic Science, Kyoto University, Japan
Int J Pancreatol 26:69-76. 1999..In this study, we investigated Cox-2 expression by means of both immunohistochemical analysis and immunoblot analysis in pancreatic tumors... - Antiproliferative activity induced by the somatostatin analogue, TT-232, in human pancreatic cancer cellsJ-U Lee
Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto, University, 54 Shogoin-Kawaracho, Sakyo, 606-8507, Kyoto, Japan
Eur J Cancer 38:1526-34. 2002..Our results indicate that TT-232 could be a potentially useful therapeutic agent if these data are translated into clinical practice... - Immunohistochemical analysis of apoptosis-related proteins in human embryonic and fetal pancreatic tissuesH Kobayash
Department of Surgery and Surgical Basic Science, Kyoto University, Sakyo, Japan
Int J Pancreatol 27:113-22. 2000..Therefore, in the current study we investigated the expression of apoptosis-related proteins in fetal pancreatic tissues... - SDS-digested freeze-fracture replica labeling electron microscopy to study the two-dimensional distribution of integral membrane proteins and phospholipids in biomembranes: practical procedure, interpretation and applicationK Fujimoto
Department of Anatomy, Faculty of Medicine, Kyoto University, Japan
Histochem Cell Biol 107:87-96. 1997..In this review, we describe the practical procedure for SDS-FRL in detail, present its application to labeling of various membrane components, and briefly discuss the possibility of a combination of SDS-FRL with atomic force microscopy... - A novel synthetic Arg-Gly-Asp-containing peptide cyclo(-RGDf==V-) is the potent inhibitor of angiogenesisM Kawaguchi
Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8507, Japan
Biochem Biophys Res Commun 288:711-7. 2001..These results suggest the potential usefulness of the cyclo(-RGDf==V-) as an antiangiogenic agent for clinical use in the future... - Hand-assisted laparoscopic resection of serous cystadenoma of the pancreasR Doi
Department of Surgery and Surgical Basic Sciences, Kyoto University, 54 Shogoinkawaracho, Sakyo, Kyoto 606 8507, Japan
Surg Endosc 17:2028-31. 2003..Hand-assisted, spleen-preserving laparoscopic distal pancreatectomy with preservation of the splenic artery and vein is a feasible procedure for the treatment of benign or borderline-malignant cystic lesions of the distal pancreas... - Dynamics of connexins, E-cadherin and alpha-catenin on cell membranes during gap junction formationK Fujimoto
Department of Anatomy, Faculty of Medicine, Kyoto University, Japan
J Cell Sci 110:311-22. 1997..In addition, connexin-immunoreactivity was also observed along tight junctional strands, suggesting that the gap junction may also form along the tight junctions... - A simple and reliable quick-freezing/freeze-fracturing procedureK Fujimoto
Department of Anatomy, Faculty of Medicine, Kyoto University, Japan
Histochem Cell Biol 107:81-4. 1997..Replicas were processed for conventional electron microscopic observation or cytochemical labeling. This method allows the ultrastructural and cytochemical examination of large areas of fractured membrane without chemical fixation... 
A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblastsM Furuse
Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
J Cell Biol 143:391-401. 1998..These findings suggested that claudin-1 and -2 are mainly responsible for TJ strand formation, and that occludin is an accessory protein in some function of TJ strands...- Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretionT Tomita
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, 606 8507, Japan
Diabetologia 49:962-8. 2006..The aim of this study, therefore, was to examine GPR40 expression and its clinical implications in humans...