ANTHONY FORSTER

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Towards synthesis of a minimal cell
    Anthony C Forster
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mol Syst Biol 2:45. 2006
  2. ncbi request reprint Synthetic biology projects in vitro
    Anthony C Forster
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Genome Res 17:1-6. 2007
  3. pmc Low modularity of aminoacyl-tRNA substrates in polymerization by the ribosome
    Anthony C Forster
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, 2222 Pierce Ave, Nashville, TN 37232, USA
    Nucleic Acids Res 37:3747-55. 2009
  4. pmc Chemical models of peptide formation in translation
    R Edward Watts
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, 2222 Pierce Avenue, Nashville, Tennessee 37232, USA
    Biochemistry 49:2177-85. 2010
  5. pmc Changeability of individual domains of an aminoacyl-tRNA in polymerization by the ribosome
    Rong Gao
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    FEBS Lett 584:99-105. 2010
  6. pmc Specificity of translation for N-alkyl amino acids
    Baolin Zhang
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, 2222 Pierce Avenue, Nashville, Tennessee 37232, USA
    J Am Chem Soc 129:11316-7. 2007
  7. pmc Engineering multigene expression in vitro and in vivo with small terminators for T7 RNA polymerase
    Liping Du
    Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biotechnol Bioeng 104:1189-96. 2009
  8. ncbi request reprint Pure translation display
    Anthony C Forster
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Anal Biochem 333:358-64. 2004
  9. ncbi request reprint De novo genetic codes and pure translation display
    Zhongping Tan
    Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA
    Methods 36:279-90. 2005

Research Grants

  1. Directed evolution of inhibitors of anthrax toxin
    ANTHONY CARLYLE FORSTER; Fiscal Year: 2010
  2. Directed evolution of inhibitors of anthrax toxin
    ANTHONY FORSTER; Fiscal Year: 2009

Collaborators

  • Rong Gao
  • Zhongping Tan
  • R Edward Watts
  • Liping Du
  • Baolin Zhang
  • Virginia W Cornish
  • Madhavi N L Nalam
  • Lucas Gartenmann Dickson
  • Stephen C Blacklow

Detail Information

Publications9

  1. pmc Towards synthesis of a minimal cell
    Anthony C Forster
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mol Syst Biol 2:45. 2006
    ..Our proposed minimal genome is 113 kbp long and contains 151 genes. We detail building blocks already in place and major hurdles to overcome for completion...
  2. ncbi request reprint Synthetic biology projects in vitro
    Anthony C Forster
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Genome Res 17:1-6. 2007
    ..Known functions are being integrated and debugged with the aim of synthesizing life-like systems. The goals are knowledge, tools, smart materials, and therapies...
  3. pmc Low modularity of aminoacyl-tRNA substrates in polymerization by the ribosome
    Anthony C Forster
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, 2222 Pierce Ave, Nashville, TN 37232, USA
    Nucleic Acids Res 37:3747-55. 2009
    ..Data indicate that the degree of interchangeability of the modules of aminoacyl-tRNAs is low...
  4. pmc Chemical models of peptide formation in translation
    R Edward Watts
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, 2222 Pierce Avenue, Nashville, Tennessee 37232, USA
    Biochemistry 49:2177-85. 2010
    ..The effects of N-substitution sterics, side chain sterics, induction, and pK(a) were evaluated in the chemical model. The dominant factor affecting relative rates was found to be N-substitution sterics...
  5. pmc Changeability of individual domains of an aminoacyl-tRNA in polymerization by the ribosome
    Rong Gao
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    FEBS Lett 584:99-105. 2010
    ..Surprisingly, changing the terminal CCA to CdCA was sometimes inhibitory and non-cognate AAs were sometimes compensatory. Results have implications for translational fidelity and engineering...
  6. pmc Specificity of translation for N-alkyl amino acids
    Baolin Zhang
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, 2222 Pierce Avenue, Nashville, Tennessee 37232, USA
    J Am Chem Soc 129:11316-7. 2007
  7. pmc Engineering multigene expression in vitro and in vivo with small terminators for T7 RNA polymerase
    Liping Du
    Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biotechnol Bioeng 104:1189-96. 2009
    ..Our modular, flexible, rational method should further empower synthetic biologists wishing to overexpress multiple proteins simultaneously...
  8. ncbi request reprint Pure translation display
    Anthony C Forster
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Anal Biochem 333:358-64. 2004
    ..Pure translation display should enable the directed evolution of peptide analogs with desirable catalytic or pharmacological properties...
  9. ncbi request reprint De novo genetic codes and pure translation display
    Zhongping Tan
    Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA
    Methods 36:279-90. 2005
    ..Toward this goal, we have demonstrated the display of polypeptides on their mRNAs in a purified translation system, termed "pure translation display."..

Research Grants4

  1. Directed evolution of inhibitors of anthrax toxin
    ANTHONY CARLYLE FORSTER; Fiscal Year: 2010
    ..Furthermore, the technology developed will have potential utility in diagnosis, target validation and treatment of any disease. ..
  2. Directed evolution of inhibitors of anthrax toxin
    ANTHONY FORSTER; Fiscal Year: 2009
    ..Furthermore, the technology developed will have potential utility in diagnosis, target validation and treatment of any disease. ..