S Fazio

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages
    S Fazio
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 94:4647-52. 1997
  2. ncbi Recycling of apolipoprotein E in mouse liver
    S Fazio
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 274:8247-53. 1999
  3. ncbi The inflamed plaque: cytokine production and cellular cholesterol balance in the vessel wall
    S Fazio
    Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6300, USA
    Am J Cardiol 88:12E-15E. 2001
  4. ncbi Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages
    S Fazio
    Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 315 Medical Research Building, Nashville, Tennessee 37232 6300, USA
    J Clin Invest 107:163-71. 2001
  5. ncbi Mouse models of hyperlipidemia and atherosclerosis
    S Fazio
    Vanderbilt University School of Medicine, Division of Cardiovascular Medicine, Department of Medicine, 315 Medical Research Building II, Nashville, TN 37232, USA
    Front Biosci 6:D515-25. 2001
  6. ncbi Isoform-specific effects of apolipoprotein E on atherogenesis: gene transduction studies in mice
    H Yoshida
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Circulation 104:2820-5. 2001
  7. ncbi Increased cholesterol efflux in apolipoprotein AI (ApoAI)-producing macrophages as a mechanism for reduced atherosclerosis in ApoAI((-/-)) mice
    A S Major
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Arterioscler Thromb Vasc Biol 21:1790-5. 2001
  8. ncbi Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor
    M F Linton
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 101:1726-36. 1998
  9. ncbi Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice
    V R Babaev
    Departments of Medicine, Pathology, and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 275:26293-9. 2000
  10. ncbi Determination of the lower threshold of apolipoprotein E resulting in remnant lipoprotein clearance
    A H Hasty
    Departments of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232 6303, USA
    J Lipid Res 40:1529-38. 1999

Detail Information

Publications83

  1. ncbi Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages
    S Fazio
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 94:4647-52. 1997
    ..Thus, lack of apoE expression by the macrophage promotes foam cell formation. These data support a protective role for apoE expression by the macrophage in early atherogenesis...
  2. ncbi Recycling of apolipoprotein E in mouse liver
    S Fazio
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 274:8247-53. 1999
    ..These studies show that apoE recycling is a physiologic phenomenon in vivo and establish the presence of a unique pathway of intracellular processing of apoE-containing remnant lipoproteins...
  3. ncbi The inflamed plaque: cytokine production and cellular cholesterol balance in the vessel wall
    S Fazio
    Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6300, USA
    Am J Cardiol 88:12E-15E. 2001
    ..In this brief review, we discuss some of the convergence points between inflammation and cholesterol balance, and we highlight the additional therapeutic targets suggested by these new developments in vascular biology...
  4. ncbi Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages
    S Fazio
    Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 315 Medical Research Building, Nashville, Tennessee 37232 6300, USA
    J Clin Invest 107:163-71. 2001
    ....
  5. ncbi Mouse models of hyperlipidemia and atherosclerosis
    S Fazio
    Vanderbilt University School of Medicine, Division of Cardiovascular Medicine, Department of Medicine, 315 Medical Research Building II, Nashville, TN 37232, USA
    Front Biosci 6:D515-25. 2001
    ..This paper presents an overview of the most utilized mouse models and a summary of the results obtained with the technique of bone marrow transplantation, an approach to study macrophages in atherosclerosis...
  6. ncbi Isoform-specific effects of apolipoprotein E on atherogenesis: gene transduction studies in mice
    H Yoshida
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Circulation 104:2820-5. 2001
    ..CONCLUSIONS: These data provide in vivo evidence suggesting that macrophage-derived apoE delays development of atherosclerosis through a receptor-dependent pathway...
  7. ncbi Increased cholesterol efflux in apolipoprotein AI (ApoAI)-producing macrophages as a mechanism for reduced atherosclerosis in ApoAI((-/-)) mice
    A S Major
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Arterioscler Thromb Vasc Biol 21:1790-5. 2001
    ..This protection is likely mediated by increased cholesterol efflux and decreased foam cell formation in vivo...
  8. ncbi Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor
    M F Linton
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 101:1726-36. 1998
    ..These data demonstrate in vivo the physiologic relevance of the apo E secretion-capture mechanism in the liver...
  9. ncbi Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice
    V R Babaev
    Departments of Medicine, Pathology, and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 275:26293-9. 2000
    ..5% and 5.9 +/- 0.8%, respectively). Taken together, these data indicate that macrophage LPL expression in the artery wall promotes atherogenesis during foam cell lesion formation, but this impact may be limited to macrophage-rich lesions...
  10. ncbi Determination of the lower threshold of apolipoprotein E resulting in remnant lipoprotein clearance
    A H Hasty
    Departments of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232 6303, USA
    J Lipid Res 40:1529-38. 1999
    ..04 mg/dl, and indicate that apoE below this level affects lipoprotein size distribution possibly by accelerating the clearance of smaller remnants...
  11. ncbi A direct role for the macrophage low density lipoprotein receptor in atherosclerotic lesion formation
    M F Linton
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 274:19204-10. 1999
    ..We conclude that the macrophage LDLR is responsible for a significant portion of lipid accumulation in foam cells under conditions of dietary stress...
  12. ncbi Retrovirus-mediated expression of apolipoprotein A-I in the macrophage protects against atherosclerosis in vivo
    H Ishiguro
    Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6300, USA
    J Biol Chem 276:36742-8. 2001
    ..These data demonstrate that expression of apoA-I from macrophages protects against atherogenesis without affecting plasma apoA-I and high density lipoprotein cholesterol levels...
  13. ncbi Leukocyte low density lipoprotein receptor (LDL-R) does not contribute to LDL clearance in vivo: bone marrow transplantation studies in the mouse
    S Fazio
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    J Lipid Res 38:391-400. 1997
    ..Thus, despite their large number and wide distribution, bone marrow-derived cells do not significantly influence receptor-mediated clearance of plasma LDL...
  14. ncbi Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo
    V R Babaev
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37323, USA
    J Clin Invest 103:1697-705. 1999
    ..These data demonstrate in vivo that LPL expression by macrophages in the artery wall promotes foam cell formation and atherosclerosis. off..
  15. ncbi Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies
    M F Linton
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Curr Opin Lipidol 10:97-105. 1999
    ..This article describes recent insights into the role of macrophage expression of apolipoprotein E and the LDL receptor gained from bone marrow transplantation studies in the mouse...
  16. ncbi Purine-rich foods, protein intake, and the prevalence of hyperuricemia: the Shanghai Men's Health Study
    R Villegas
    Vanderbilt University Medical Center, Nashville, TN 37206, USA
    Nutr Metab Cardiovasc Dis 22:409-16. 2012
    ....
  17. ncbi Class A scavenger receptors, macrophages, and atherosclerosis
    M F Linton
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Curr Opin Lipidol 12:489-95. 2001
    ....
  18. ncbi A recycling pathway for resecretion of internalized apolipoprotein E in liver cells
    L L Swift
    Departments of Pathology, Medicine, and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 276:22965-70. 2001
    ..These studies provide definitive evidence for the sparing of apoE and its routing through the secretory pathway and demonstrate that internalized apoE can be resecreted in a quantitatively significant fashion...
  19. ncbi Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice
    T J Montine
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Exp Neurol 158:234-41. 1999
    ....
  20. ncbi Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats
    L J Ma
    Department of Pathology and Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2561, USA
    Kidney Int 59:1899-910. 2001
    ..PPAR gamma beneficial effects are independent of insulin/glucose effects and are associated with regulation of glomerular cell proliferation, hypertrophy, and decreased PAI-1 and TGF-beta expression...
  21. ncbi Free fatty acids are associated with metabolic syndrome and insulin resistance but not inflammation in systemic lupus erythematosus
    M J Ormseth
    Division of Rheumatology, Department of Medicine, Vanderbilt University, Nashville, TN 37232 2681, USA
    Lupus 22:26-33. 2013
    ..FFAs in patients with SLE are not associated with markers of generalized inflammation but are associated with insulin resistance and markers of endothelial activation...
  22. ncbi Lifestyle determinants of C-reactive protein in middle-aged, urban Chinese men
    R Villegas
    Vanderbilt University Medical Center, Nashville, TN 37206, USA
    Nutr Metab Cardiovasc Dis 22:223-30. 2012
    ..The aim of this study was to investigate associations between lifestyle factors and high CRP among middle-aged men living in Shanghai, China...
  23. ncbi Current perspectives on statins
    D J Maron
    Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, School of Medicine, Nashville, TN 37232 6300, USA
    Circulation 101:207-13. 2000
    ..Mechanisms independent of LDL lowering may play an important role in the clinical benefits conferred by these drugs and may ultimately broaden their indication from lipid-lowering to antiatherogenic agents...
  24. ncbi Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse
    Cheryl D Overton
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Circ Res 100:670-7. 2007
    ..Our data support the hypothesis that macrophage LRP modulates atherogenesis through regulation of inflammatory responses...
  25. ncbi Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI
    Patricia G Yancey
    Atherosclerosis Research Unit, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    J Lipid Res 48:1140-9. 2007
    ..Both factors are likely to contribute to the accelerated atherosclerosis in DKO mice...
  26. ncbi Metabolic syndrome and the risk of cardiovascular disease in older adults
    Javed Butler
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Am Coll Cardiol 47:1595-602. 2006
    ..The purpose of this study was to assess whether metabolic syndrome (MetSyn) predicts a higher risk for cardiovascular events in older adults...
  27. ncbi Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis
    Julia Baumgartl
    Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne, D 50931 Cologne, Germany
    Cell Metab 3:247-56. 2006
    ....
  28. ncbi Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells
    Nicole A Braun
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Lipid Res 47:1176-86. 2006
    ..Our data suggest that apoE recycling in CHO cells is linked to cellular cholesterol removal via the ERC and phospholipid-containing acceptors in a pathway alternative to the ABCA1-apoA-I axis...
  29. ncbi Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice
    Vladimir R Babaev
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Circulation 113:108-17. 2006
    ..Here, we examined the impact of COX-1 deficiency in bone marrow-derived cells on early atherogenesis in the mouse...
  30. ncbi Antiatherogenic effects of angiotensin receptor antagonism in mild renal dysfunction
    Eisuke Suganuma
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Am Soc Nephrol 17:433-41. 2006
    ....
  31. ncbi Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout mice
    Hong Yu
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Arterioscler Thromb Vasc Biol 26:150-6. 2006
    ..The current study examines the ability of macrophage apoE to improve the dyslipidemia, reduce atherosclerosis, and rescue the lethal phenotype of DKO mice...
  32. ncbi Physiological relevance of apolipoprotein E recycling: studies in primary mouse hepatocytes
    Mei-Ying Zhu
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232-2561, USA
    Metabolism 54:1309-15. 2005
    ..Rather, recycling may provide a mechanism for modulating general cellular effects such as intracellular cholesterol transport or cholesterol efflux...
  33. ncbi ACAT1 deficiency increases cholesterol synthesis in mouse peritoneal macrophages
    Dwayne E Dove
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Atherosclerosis 186:267-74. 2006
    ..This change in cholesterol homeostasis may contribute to the atherogenic potential of ACAT1(-/-) macrophages...
  34. ncbi Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice
    Michael E Burleigh
    Department of Pharmacology, 383 Preston Research Building, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    J Mol Cell Cardiol 39:443-52. 2005
    ..These results are compatible with COX-2 expression by macrophages having a proatherogenic role, and support the potential of anti-inflammatory therapeutic approaches for atherosclerosis...
  35. ncbi Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice
    Nobuhiko Ayabe
    Department of Pediatrics, MCN C4204, Vanderbilt University Medical Center, Nashville, TN 37232-2584, USA
    Atherosclerosis 184:312-21. 2006
    ..By contrast, transient AngII-exposure causes prompt aneurysm formation that does not parallel atherosclerosis and disappears even in the face of progressively greater atherosclerotic lesions...
  36. ncbi A pathway-dependent on apoE, ApoAI, and ABCA1 determines formation of buoyant high-density lipoprotein by macrophage foam cells
    Patricia G Yancey
    Atherosclerosis Research Unit, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn 37232 6300, USA
    Arterioscler Thromb Vasc Biol 27:1123-31. 2007
    ..ABCA1-dependent and ABCA1-independent pathways may operate in high-density lipoprotein formation by macrophages secreting apolipoprotein (apo) E. We examined the impact of ABCA1 on apoE-mediated efflux from cholesterol-enriched macrophages...
  37. ncbi Impaired secretion of apolipoprotein E2 from macrophages
    Daping Fan
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6300, USA
    J Biol Chem 282:13746-53. 2007
    ..Given the role of locally produced apoE in regulating cholesterol efflux, modulating inflammation, and controlling oxidative stress, this unique property of apoE2 may have important impacts on atherogenesis...
  38. ncbi Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
    Masato Furuhashi
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 447:959-65. 2007
    ..Our findings demonstrate that targeting aP2 with small-molecule inhibitors is possible and can lead to a new class of powerful therapeutic agents to prevent and treat metabolic diseases such as type 2 diabetes and atherosclerosis...
  39. ncbi Correlates of high serum C-reactive protein levels in a socioeconomically disadvantaged population
    Xianglan Zhang
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA
    Dis Markers 24:351-9. 2008
    ..Moreover, inflammatory response to obesity differed by race and sex, which may contribute to CVD disparities...
  40. ncbi Evidence of metabolic syndrome in lean children with premature pubarche at diagnosis
    Revi P Mathew
    Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA
    Metabolism 57:733-40. 2008
    ..028) compared with matched controls. When corrected for height, TNF-alpha was higher in the total (P = .037) and normal-BMI (P = .043) PP children. Premature pubarche can be linked to markers of the metabolic syndrome in lean children...
  41. ncbi Lentiviral transduction of apoAI into hematopoietic progenitor cells and macrophages: applications to cell therapy of atherosclerosis
    Yan Ru Su
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville TN 37232 6300, USA
    Arterioscler Thromb Vasc Biol 28:1439-46. 2008
    ..We used genetically engineered mouse hematopoietic progenitor cells (HPCs) to investigate the therapeutic effects of human apoAI on atherosclerosis in apoE(-/-) mice...
  42. ncbi Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor
    Alban Gaultier
    Department of Pathology, University of California San Diego School of Medicine, La Jolla, CA 92093 0612, USA
    Blood 111:5316-25. 2008
    ..We propose that LRP-1 suppresses expression of inflammatory mediators indirectly, by regulating TNFR1-dependent cell signaling through the I kappaB kinase-NF-kappaB pathway...
  43. ncbi Targeting cardiovascular risk in patients with diabetes: management of dyslipidemia
    Yasmine S Ali
    Atherosclerosis Research Unit, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6300, USA
    Curr Opin Endocrinol Diabetes Obes 15:142-6. 2008
    ..This article will review the characteristics of dyslipidemia in diabetes, and discuss guidelines and strategies for treatment to reduce cardiovascular disease risk...
  44. ncbi Intra-individual variation of plasma adipokine levels and utility of single measurement of these biomarkers in population-based studies
    Sang Ah Lee
    Vanderbilt Epidemiology Center, Nashville, Tennessee 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 16:2464-70. 2007
    ..This study suggests that adipokine levels in a single blood sample may be useful biomarkers of inflammation in population-based studies of obesity-related disease...
  45. ncbi The relationship between dose of vitamin E and suppression of oxidative stress in humans
    L Jackson Roberts
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 43:1388-93. 2007
    ..This study provides information on the dosage of vitamin E that decreases systemic oxidant stress in vivo in humans and informs the planning and evaluation of clinical studies that assess the efficacy of vitamin E to mitigate disease...
  46. ncbi Retention of low-density lipoprotein in atherosclerotic lesions of the mouse: evidence for a role of lipoprotein lipase
    Maria Gustafsson
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Goteborg University, Sweden
    Circ Res 101:777-83. 2007
    ..Thus, retention of LDL in the artery wall is initiated by direct LDL-proteoglycan binding but shifts to indirect binding with bridging molecules such as LPL...
  47. ncbi Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice
    Vladimir R Babaev
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Circulation 116:1404-12. 2007
    ..PPARalpha ligands have been shown to reduce cardiovascular events in high-risk subjects. PPARalpha expression by arterial cells, including macrophages, may exert local antiatherogenic effects independent of plasma lipid changes...
  48. ncbi Inflammatory mechanisms affecting the lipid profile in patients with systemic lupus erythematosus
    Cecilia P Chung
    Departments of Medicine, Molecular Physiology and Biophysics, Biostatistics, Pathology, and Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
    J Rheumatol 34:1849-54. 2007
    ..We examined the relationships between lipid concentrations, cytokines, and inflammatory markers in patients with SLE...
  49. ncbi Angiotensin inhibition decreases progression of advanced atherosclerosis and stabilizes established atherosclerotic plaques
    Eisuke Suganuma
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2584, USA
    J Am Soc Nephrol 18:2311-9. 2007
    ....
  50. ncbi A new age of discovery for plasma lipoproteins
    Sergio Fazio
    Curr Opin Lipidol 18:387-8. 2007
  51. ncbi Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus
    Aleksandar K Stanic
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6300, USA
    Proc Natl Acad Sci U S A 103:7018-23. 2006
    ..Collectively, these studies demonstrate that the lupus-susceptible immune system enhances atherogenesis and modulates plaque composition...
  52. ncbi Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages
    Natalie E Freeman
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0581, USA
    J Lipid Res 46:1933-43. 2005
    ..These results suggest that 7KC not only initiates the apoptosis pathway by activating cPLA2, as we have reported previously, but also participates in the downstream signaling pathway when esterified by ACAT to form 7KC-arachidonate...
  53. ncbi Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I
    Marnie L Gruen
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Lipid Res 46:2007-14. 2005
    ..Moreover, the presence of large HDLs without apoA-I provides evidence for an apoA-I-independent pathway of cholesterol efflux, possibly sustained by apoE...
  54. ncbi Macrophages, inflammation, and atherosclerosis
    Macrae F Linton
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Int J Obes Relat Metab Disord 27:S35-40. 2003
    ..Through its distinct actions in adipocytes and macrophages, aP2 links features of the metabolic syndrome including insulin resistance, obesity, inflammation, and atherosclerosis...
  55. ncbi Premature coronary-artery atherosclerosis in systemic lupus erythematosus
    Yu Asanuma
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, USA
    N Engl J Med 349:2407-15. 2003
    ..Early detection of atherosclerosis may provide an opportunity for therapeutic intervention...
  56. ncbi Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice
    Wenwu Zhang
    Atherosclerosis Research Unit, Division of Cardiovascular Medicine, Departments of Medicine, Vanderbilt University Medical Center, Nashville, Tenn 37232 6300, USA
    Circulation 108:2258-63. 2003
    ..In this study, we examined the in vivo role of macrophage SR-BI in atherosclerotic lesion development in the apolipoprotein (apo) E-deficient mouse model...
  57. ncbi Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-deficient mice and up-regulates ABC transporters
    Yan Ru Su
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6300, USA
    Mol Ther 8:576-83. 2003
    ....
  58. ncbi A practical approach to risk assessment to prevent coronary artery disease and its complications
    Macrae F Linton
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6300, USA
    Am J Cardiol 92:19i-26i. 2003
    ..The emerging risk factors may be useful for further stratifying risk in individuals with intermediate risk and the presence of risk factors not included in the Framingham calculation...
  59. ncbi The recycling of apolipoprotein E in primary cultures of mouse hepatocytes. Evidence for a physiologic connection to high density lipoprotein metabolism
    Monica H Farkas
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 278:9412-7. 2003
    ....
  60. ncbi Absence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis
    Masashi Nishida
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
    J Clin Invest 110:1859-68. 2002
    ..Thus, during urinary tract obstruction, the Agtr1 on bone marrow-derived macrophages functions to preserve the renal parenchymal architecture, and this function depends in part on its modulatory effect on phagocytosis...
  61. ncbi B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice
    Amy S Major
    Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tenn 37232 6300, USA
    Arterioscler Thromb Vasc Biol 22:1892-8. 2002
    ..We investigated the role of B cells and antibodies in the development of atherosclerosis in low density lipoprotein (LDL) receptor-deficient (LDLR(-/-)) mice...
  62. ncbi Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia
    Jeffrey B Boord
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Arterioscler Thromb Vasc Biol 22:1686-91. 2002
    ..This study was designed to determine whether aP2 deficiency has a similar effect in the setting of advanced atherosclerosis and severe hypercholesterolemia...
  63. ncbi Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice
    Sergio Fazio
    Vanderbilt University Medical Center, Departments of Medicine, Nashville, TN 37232, USA
    J Lipid Res 43:1602-9. 2002
    ..These data show that physiologic levels of macrophage apoE in the vessel wall are anti-atherogenic in conditions of severe hyperlipidemia and can affect later stages of plaque development...
  64. ncbi Cyclooxygenase-2 and atherosclerosis
    Macrae F Linton
    Department of Medicine, Division of Cardiovascular Medicine, Room 383 PRB, Vanderbilt University Medical Center, Nashville, TN 37232 6303, USA
    Curr Opin Lipidol 13:497-504. 2002
    ..These results support the potential of antiinflammatory approaches for the prevention of atherosclerosis and identify cyclooxygenase-2 as a target for intervention...
  65. ncbi Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression
    Kevin L Doggett
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5310, USA
    J Cell Biochem 86:56-66. 2002
    ..These results indicate that MNDA alters expression of a gene essential for normal hematopoiesis...
  66. ncbi Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice
    Michael E Burleigh
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Circulation 105:1816-23. 2002
    ....
  67. ncbi Apolipoprotein AI as therapy for atherosclerosis: does the future of preventive cardiology include weekly injections of the HDL protein?
    Sergio Fazio
    Departments of Medicine, Pathology, Vanderbilt University Medical Center, Nashville, TN USA
    Mol Interv 3:436-40. 2003
    ..What is certain is that attention should be focused on the removal of cholesterol from plaques rather than simply desiring to raise HDL concentrations in patients...
  68. ncbi The role of fibrates in managing hyperlipidemia: mechanisms of action and clinical efficacy
    Sergio Fazio
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 383 PRB, Nashville, TN 37232 6300, USA
    Curr Atheroscler Rep 6:148-57. 2004
    ....
  69. ncbi Cyclooxygenase-2 and inflammation in atherosclerosis
    Macrae F Linton
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Curr Opin Pharmacol 4:116-23. 2004
    ..Prospective randomized evaluation of the effects of selective COX-2 inhibitors on cardiovascular events is warranted...
  70. ncbi Interplay between apolipoprotein E and scavenger receptor class B type I controls coronary atherosclerosis and lifespan in the mouse
    Sergio Fazio
    Circulation 111:3349-51. 2005
  71. ncbi Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice
    Michael E Burleigh
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6300, USA
    Biochem Pharmacol 70:334-42. 2005
    ....
  72. ncbi Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice
    Vladimir R Babaev
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Arterioscler Thromb Vasc Biol 25:1647-53. 2005
    ..Peroxisome proliferator-activated receptor gamma (PPARgamma) is highly expressed in macrophage-derived foam cells of atherosclerotic lesions, and its expression may have a dramatic impact on atherosclerosis...
  73. ncbi Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1
    Yan Ru Su
    Atherosclerosis Research Unit, Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tenn 37232 6300, USA
    Circulation 111:2373-81. 2005
    ..We have studied the effect of macrophage ACAT1 deletion on atherogenesis in apoE-deficient (apoE-/-) mice with or without the restoration of macrophage apoE...
  74. ncbi The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I
    Alyssa H Hasty
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Lipid Res 46:1433-9. 2005
    ..These results suggest that apoE recycling in macrophages may be part of a larger signaling loop activated by HDL and directed at maximizing cholesterol losses from the cell...
  75. ncbi ApoE-mediated cholesterol efflux from macrophages: separation of autocrine and paracrine effects
    Dwayne E Dove
    Department of Pathology, Vanderbilt University Medical Center, 383 Preston Research Bldg, Nashville, TN 37232-6300, USA
    Am J Physiol Cell Physiol 288:C586-92. 2005
    ..Furthermore, autocrine effects of apoE could be critical in the prevention of foam cell formation in vivo. This novel methodology may be applicable to other types of mixed autocrine/paracrine systems, such as signal transduction systems...
  76. ncbi ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages
    Dwayne E Dove
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tenn 37232-6300, USA
    Arterioscler Thromb Vasc Biol 25:128-34. 2005
    ..CONCLUSIONS: Together, these data show that macrophage ACAT1 influences the efflux of both cellular and lipoprotein-derived cholesterol and propose a pathway for the pro-atherogenic transformation of ACAT1(-/-) macrophages...
  77. ncbi Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice
    June Liu
    Department of Biochemistry and Molecular Biology, East Tennessee State University, Johnson City, TN 37614, USA
    Arterioscler Thromb Vasc Biol 25:174-9. 2005
    ..05). CONCLUSIONS: The reduction of apoptotic activity in macrophages stimulates atherosclerosis in LDLR-/- mice, which is consistent with the hypothesis that macrophage apoptosis suppresses the development of atherosclerosis...
  78. ncbi Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice
    Amy S Major
    Department of Medicine, Division of Cardiovascular Medicine, 2220 Pierce Avenue, Room 383 PRB, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Arterioscler Thromb Vasc Biol 24:2351-7. 2004
    ..The capacity of NKT cells to respond to lipid antigens and modulate innate and acquired immunity suggests that they may play a role in atherogenesis...
  79. ncbi Angiotensin II amplifies macrophage-driven atherosclerosis
    Ayabe Nobuhiko
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    Arterioscler Thromb Vasc Biol 24:2143-8. 2004
    ....
  80. ncbi Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice
    Jeffrey B Boord
    Research Department and Geriatric Research, Education, and Clinical Center, VA Tennessee Valley Healthcare System, Nashville, USA
    Circulation 110:1492-8. 2004
    ..We tested the hypothesis that combined aP2 and mal1 deficiency would produce synergistic effects on metabolism and reduce atherosclerosis in apolipoprotein E-deficient (apoE-/-) mice...
  81. ncbi Unique pathway for cholesterol uptake in fat cells
    Sergio Fazio
    Arterioscler Thromb Vasc Biol 24:1538-9. 2004
  82. ncbi Proatherogenic role for NK cells revealed
    Macrae F Linton
    Arterioscler Thromb Vasc Biol 24:992-4. 2004
  83. ncbi Cytoplasmic fatty acid-binding proteins: emerging roles in metabolism and atherosclerosis
    Jeffrey B Boord
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6300, USA
    Curr Opin Lipidol 13:141-7. 2002
    ..The FABPs are promising targets for the treatment of dyslipidemia, insulin resistance, and atherosclerosis in humans...