MICHAEL E ENGEL
Affiliation: Vanderbilt University
- Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemiaMICHAEL E ENGEL
Department of Pediatrics, Monroe Carell Jr Children s Hospital, Nashville, TN, USA
Cancer Treat Res 145:127-47. 2010..Here we present an overview of the structural features of RUNX1/CBFbeta and their derivatives, their roles in transcriptional control, and their contributions to normal and malignant hematopoiesis...
- Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specificationMICHAEL E ENGEL
Department of Pediatrics, Division of Pediatric Hematology Oncology, Vanderbilt Univesity School of Medicine, 397 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232 6310, USA
Mol Cell Biol 30:1852-63. 2010..These data suggest that MTG16 interfaces with critical components of the Notch transcription complex to affect Notch-dependent lineage allocation in hematopoiesis...
- Mtg16/Eto2 contributes to murine T-cell developmentAUBREY HUNT
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Mol Cell Biol 31:2544-51. 2011..Thus, Mtg16 integrates the activities of signaling pathways and nuclear factors in the establishment of T-cell fate specification...
- MTG-16 Regulation by PhosphorylationMichael Engel; Fiscal Year: 2006..Ultimately, the goal is to ascertain the effect of specific phosphorylation events on growth, transformation and development. These data may have future therapeutic implications for diverse cancer types. ..