E W Ely

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi The prognostic significance of passing a daily screen of weaning parameters
    E W Ely
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Intensive Care Med 25:581-7. 1999
  2. ncbi Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)
    E W Ely
    Division of Allergy Pulmonary Critical Care Medicine, Center for Health Services Research, 6th Floor Medical Center East 6109, Vanderbilt University Medical Center, Nashville, TN 37323 8300, USA
    JAMA 286:2703-10. 2001
  3. ncbi Protocol-driven care in the intensive care unit: a tool for quality
    R J Wall
    Division of General Internal Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Crit Care 5:283-5. 2001
  4. ncbi The impact of delirium in the intensive care unit on hospital length of stay
    E W Ely
    Departments of Internal Medicine, Divisions of General Internal Medicine and Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Intensive Care Med 27:1892-900. 2001
  5. ncbi Using the chest radiograph to determine intravascular volume status: the role of vascular pedicle width
    E Wesley Ely
    Department of Medicine the Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Chest 121:942-50. 2002
  6. ncbi Radiologic determination of intravascular volume status using portable, digital chest radiography: a prospective investigation in 100 patients
    E W Ely
    Department of Internal Medicine, Division of Allergy Pulmonary Critical Care Medicine, Vanderbilt University Medical Center, 6th Floor Medical Center East, Nashville, TN 37232 8300, USA
    Crit Care Med 29:1502-12. 2001
  7. ncbi Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
    E W Ely
    Department of Internal Medicine, Divisions of General Internal Medicine and Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 29:1370-9. 2001
  8. ncbi Mechanical ventilator weaning protocols driven by nonphysician health-care professionals: evidence-based clinical practice guidelines
    E W Ely
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Chest 120:454S-63S. 2001
  9. ncbi The utility of weaning protocols to expedite liberation from mechanical ventilation
    E W Ely
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, The Vanderbilt University Medical Center, Nashville, Tennessee 37232 4760, USA
    Respir Care Clin N Am 6:303-19,vi. 2000
  10. ncbi The distribution of costs of care in mechanically ventilated patients with chronic obstructive pulmonary disease
    E W Ely
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Crit Care Med 28:408-13. 2000

Detail Information

Publications83

  1. ncbi The prognostic significance of passing a daily screen of weaning parameters
    E W Ely
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Intensive Care Med 25:581-7. 1999
    ..We evaluated whether passing weaning parameters was associated with survival...
  2. ncbi Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)
    E W Ely
    Division of Allergy Pulmonary Critical Care Medicine, Center for Health Services Research, 6th Floor Medical Center East 6109, Vanderbilt University Medical Center, Nashville, TN 37323 8300, USA
    JAMA 286:2703-10. 2001
    ..Delirium is a common problem in the intensive care unit (ICU). Accurate diagnosis is limited by the difficulty of communicating with mechanically ventilated patients and by lack of a validated delirium instrument for use in the ICU...
  3. ncbi Protocol-driven care in the intensive care unit: a tool for quality
    R J Wall
    Division of General Internal Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Crit Care 5:283-5. 2001
    ..As ICU physicians increasingly assume leadership roles in the pursuit of higher quality ICU care, their knowledge and skills in the discipline of quality improvement will become essential...
  4. ncbi The impact of delirium in the intensive care unit on hospital length of stay
    E W Ely
    Departments of Internal Medicine, Divisions of General Internal Medicine and Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Intensive Care Med 27:1892-900. 2001
    ..To determine the relationship between delirium in the intensive care unit (ICU) and outcomes including length of stay in the hospital...
  5. ncbi Using the chest radiograph to determine intravascular volume status: the role of vascular pedicle width
    E Wesley Ely
    Department of Medicine the Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Chest 121:942-50. 2002
    ..Lastly, the measurement of the VPW should be incorporated into the training of chest clinicians and radiologists...
  6. ncbi Radiologic determination of intravascular volume status using portable, digital chest radiography: a prospective investigation in 100 patients
    E W Ely
    Department of Internal Medicine, Division of Allergy Pulmonary Critical Care Medicine, Vanderbilt University Medical Center, 6th Floor Medical Center East, Nashville, TN 37232 8300, USA
    Crit Care Med 29:1502-12. 2001
    ..To answer the following questions: Can the digital chest roentgenogram (CXR) be used to differentiate patients' volume status? Do clinical data alter radiologists' accuracy in interpreting the digital CXR?..
  7. ncbi Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
    E W Ely
    Department of Internal Medicine, Divisions of General Internal Medicine and Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 29:1370-9. 2001
    ..To develop and validate an instrument for use in the intensive care unit to accurately diagnose delirium in critically ill patients who are often nonverbal because of mechanical ventilation...
  8. ncbi Mechanical ventilator weaning protocols driven by nonphysician health-care professionals: evidence-based clinical practice guidelines
    E W Ely
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Chest 120:454S-63S. 2001
    ..Moreover, the protocols may evolve over time as clinical and institutional experience with them increases. Useful protocols aim to safely and efficiently liberate patients from MV, reducing unnecessary or harmful variations in approach...
  9. ncbi The utility of weaning protocols to expedite liberation from mechanical ventilation
    E W Ely
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, The Vanderbilt University Medical Center, Nashville, Tennessee 37232 4760, USA
    Respir Care Clin N Am 6:303-19,vi. 2000
    ..The author also presents techniques to faciliate the implementation of weaning protocols based on the published experience of one hospital...
  10. ncbi The distribution of costs of care in mechanically ventilated patients with chronic obstructive pulmonary disease
    E W Ely
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Crit Care Med 28:408-13. 2000
    ..To delineate the costs of care of patients with Chronic Obstructive Pulmonary Disease (COPD) and respiratory failure and to compare them with those of other mechanically ventilated patients...
  11. ncbi Venous air embolism from central venous catheterization: a need for increased physician awareness
    E W Ely
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Crit Care Med 27:2113-7. 1999
    ....
  12. ncbi Efficacy and safety of recombinant human activated protein C for severe sepsis
    G R Bernard
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    N Engl J Med 344:699-709. 2001
    ..In this phase 3 trial, we assessed whether treatment with drotrecogin alfa activated reduced the rate of death from any cause among patients with severe sepsis...
  13. ncbi Insulin-like growth factor-1 and delirium in critically ill mechanically ventilated patients: a preliminary investigation
    A Morandi
    Center for Quality of Aging, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Int Psychogeriatr 23:1175-81. 2011
    ..We sought to test the hypothesis that low IGF-1 concentrations are associated with delirium during critical illness...
  14. ncbi Using real time process measurements to reduce catheter related bloodstream infections in the intensive care unit
    R J Wall
    Veterans Affairs National Quality Scholars Program, Tennessee Valley Healthcare System, Nashville, TN, USA
    Qual Saf Health Care 14:295-302. 2005
    ..Our inability to measure the process of central venous catheter (CVC) care in real time prevented CQI efforts aimed at reducing catheter related bloodstream infections (CR-BSIs) from these devices...
  15. ncbi Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis
    G R Bernard
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Crit Care Med 29:2051-9. 2001
    ..To assess the safety and effect on coagulopathy of a range of doses of recombinant human activated protein C (rhAPC). To determine an effective dose and duration of rhAPC for use in future clinical trials...
  16. ncbi Alpha-2 agonists: can they modify the outcomes in the Postanesthesia Care Unit?
    P Pandharipande
    Department of Anesthesiology, Division of Critical Care Medicine, Vanderbilt University School of Medicine, 324 MAB, 21st Ave South, Nashville, TN 37232, USA
    Curr Drug Targets 6:749-54. 2005
    ....
  17. ncbi Lung allocation in the United States, 1995-1997: an analysis of equity and utility
    R N Pierson
    Cardiac and Thoracic Surgery, Vanderbilt University, Nashville, Tennessee, USA
    J Heart Lung Transplant 19:846-51. 2000
    ....
  18. ncbi Understanding terminology of delirium and long-term cognitive impairment in critically ill patients
    A Morandi
    Department of Rehabilitation and Aged Care Unit Hospital Ancelle, Cremona, Italy
    Best Pract Res Clin Anaesthesiol 26:267-76. 2012
    ..Future research is needed to interpret the trajectories of LTCI-CI, to differentiate it from neurodegenerative diseases and to provide a formal disease classification...
  19. ncbi A research algorithm to improve detection of delirium in the intensive care unit
    Margaret A Pisani
    Department of Internal Medicine, Pulmonary and Critical Care Section, and the Program on Aging, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    Crit Care 10:R121. 2006
    ..The purpose of this study was to develop a research algorithm to enhance detection of delirium in critically ill ICU patients using chart review to complement a validated clinical delirium instrument...
  20. ncbi Organisational culture: variation across hospitals and connection to patient safety climate
    T Speroff
    Department of Medicine, Center for Health Services Research, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Qual Saf Health Care 19:592-6. 2010
    ..Bureaucratic organisational culture is less favourable to quality improvement, whereas organisations with group (teamwork) culture are better aligned for quality improvement...
  21. ncbi New ways to reduce unnecessary variation and improve outcomes in the intensive care unit
    B W Holcomb
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-8300, USA
    Curr Opin Crit Care 7:304-11. 2001
    ..In this article, we discuss examples of these trials investigating four major areas of modern ICU medicine: ventilator management, ventilator weaning, sedation and analgesia, and blood transfusions...
  22. ncbi Cryptococcal pneumonia complicating pregnancy
    E W Ely
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Medicine (Baltimore) 77:153-67. 1998
    ..In conclusion, cryptococcosis during pregnancy presents a special challenge to the clinician. A balanced therapeutic approach holds great promise for successful maternal and fetal outcomes...
  23. ncbi Post-traumatic stress disorder and post-traumatic stress symptoms following critical illness in medical intensive care unit patients: assessing the magnitude of the problem
    James C Jackson
    Clinical Research Center of Excellence, VA Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, TN 37212, USA
    Crit Care 11:R27. 2007
    ..Recently, investigators have reported that the experience of critical illness can also lead to PTSD, although details of the association between critical illness and PTSD remain unclear...
  24. ncbi Long-term cognitive, emotional, and functional outcomes in trauma intensive care unit survivors without intracranial hemorrhage
    James C Jackson
    Division of Allergy Pulmonary Critical Care Medicine, Center for Health Services Research, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville TN, USA
    J Trauma 62:80-8. 2007
    ....
  25. ncbi Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients
    E Wesley Ely
    Department of Medicine, Saint Thomas Hospital, and Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Crit Care Med 35:112-7. 2007
    ..To test for an association between apolipoprotein E (APOE) genotypes and duration of intensive care unit delirium...
  26. ncbi Brain dysfunction: another burden for the chronically critically ill
    Judith E Nelson
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Intern Med 166:1993-9. 2006
    ..To our knowledge, no previous research has addressed brain dysfunction in the chronically critically ill, although this topic is important for medical decision making...
  27. ncbi Delirium and cognitive dysfunction in the intensive care unit
    Russell R Miller
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Semin Respir Crit Care Med 27:210-20. 2006
    ..Furthermore, consideration of a continuum may better elucidate the true magnitude of acute brain dysfunction in the ICU...
  28. ncbi Sedative and analgesic medications: risk factors for delirium and sleep disturbances in the critically ill
    Pratik Pandharipande
    Division of Critical Care, Department of Anesthesiology, Vanderbilt University School of Medicine, 324 MAB, 1313 21st Avenue South, Nashville, TN 37232, USA
    Crit Care Clin 22:313-27, vii. 2006
    ....
  29. ncbi Radiographic measures of intravascular volume status: the role of vascular pedicle width
    Russell R Miller
    Department of Medicine, Division of Allergy Pulmonary Critical Care Medicine of the Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Curr Opin Crit Care 12:255-62. 2006
    ..A valid, low-cost, high-yield instrument to assess intravascular volume status in critically ill patients does not exist. The portable chest X-ray is a common part of any intensivist's or chest clinician's daily rounds...
  30. ncbi Comment on "Validity and reliability of the DDS for severity of delirium in the ICU"
    Timothy D Girard
    Neurocrit Care 4:190-1; author reply 192-3. 2006
  31. ncbi Delirium and its motoric subtypes: a study of 614 critically ill patients
    Josh F Peterson
    Division of General Internal Medicine, Center for Health Services Research, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Am Geriatr Soc 54:479-84. 2006
    ..To describe the motoric subtypes of delirium in critically ill patients and compare patients aged 65 and older with a younger cohort...
  32. ncbi Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients
    Pratik Pandharipande
    Department of Anesthesia Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Anesthesiology 104:21-6. 2006
    ..Sedative and analgesic medications relieve anxiety and pain but may contribute to patients' transitioning into delirium...
  33. ncbi Delirium and cognitive dysfunction in the intensive care unit
    Russell R Miller
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, 6th Floor Medical Center East 6100, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Curr Psychiatry Rep 9:26-34. 2007
    ..This article reviews prevention and treatment options, and current pharmacologic and nonpharmacologic approaches to delirium, acknowledging limited but improving quality of evidence to date...
  34. ncbi Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Crit Care 11:R28. 2007
    ..We sought to identify factors associated with PTSD symptoms in patients following critical illness requiring mechanical ventilation...
  35. ncbi Motoric subtypes of delirium in mechanically ventilated surgical and trauma intensive care unit patients
    Pratik Pandharipande
    Vanderbilt University School of Medicine corrected Department of Anesthesia Critical Care Medicine, 1121 21st Ave So, Nashville MAB 526, TN corrected 37212, USA
    Intensive Care Med 33:1726-31. 2007
    ..Their use, however, has not been reported in surgical and trauma patients. The objective of this study was to identify the prevalence of the motoric subtypes of delirium in surgical and trauma ICU patients...
  36. ncbi Evidence-based algorithms for diagnosing and treating ventilator-associated pneumonia
    Richard J Wall
    Pulmonary, Critical Care and Sleep Disorders Medicine, Southlake Clinic, Valley Medical Center, Renton, Washington 98055, USA
    J Hosp Med 3:409-22. 2008
    ..Given the complexity of caring for heterogeneous populations in the intensive care unit (ICU), however, there is still uncertainty regarding how to diagnose and manage VAP...
  37. ncbi Nurse practitioners and physician assistants in the intensive care unit: an evidence-based review
    Ruth M Kleinpell
    Rush University Medical Center and Rush University College of Nursing, Chicago, IL, USA
    Crit Care Med 36:2888-97. 2008
    ..However, the impact of nurse practitioners and physician assistants in the intensive care unit setting is not well known...
  38. ncbi Re: Increased levels of serum S100B protein in critically ill patients without brain injury
    Bryan A Cotton
    Shock 30:222; author reply 222-3. 2008
  39. ncbi Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients
    Pratik Pandharipande
    Department of Anesthesia Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Trauma 65:34-41. 2008
    ..The purpose of this study was to analyze the prevalence of and risk factors for delirium in surgical and trauma ICU patients...
  40. ncbi Delirium in the intensive care unit
    Timothy D Girard
    Department of Medicine Division of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University School of Medicine 1161 21st Avenue South, Nashville, TN 37232 2650, USA
    Crit Care 12:S3. 2008
    ..Strategies for the prevention and treatment of ICU delirium are the subjects of multiple ongoing investigations...
  41. ncbi Protocol-driven ventilator weaning: reviewing the evidence
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, 6 th Floor MCE, 6110, Nashville, TN 37232 8300, USA
    Clin Chest Med 29:241-52, v. 2008
    ..This article reviews the rationale for and against the routine use of weaning protocols and highlights informative details of many clinical trials that have evaluated such protocols...
  42. ncbi Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Lancet 371:126-34. 2008
    ..Our aim was to assess a protocol that paired spontaneous awakening trials (SATs)-ie, daily interruption of sedatives-with spontaneous breathing trials (SBTs)...
  43. ncbi Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial
    Pratik P Pandharipande
    Department of Anesthesiology Division of Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 298:2644-53. 2007
    ..Dexmedetomidine induces sedation via different central nervous system receptors than the benzodiazepine drugs and may lower the risk of acute brain dysfunction...
  44. ncbi Clinical sedation scores as indicators of sedative and analgesic drug exposure in intensive care unit patients
    Andrew L Masica
    Baylor Institute for Health Care Research and Improvement, Baylor Health Care System, Dallas, Texas, USA
    Am J Geriatr Pharmacother 5:218-31. 2007
    ..These issues are of particular concern in elderly patients (aged > or =65 years), who account for at least half of all ICU admissions and nearly two thirds of ICU days...
  45. ncbi The cognitive consequences of critical illness: practical recommendations for screening and assessment
    Max L Gunther
    VA Tennessee Valley Geriatric Research, Education and Clinical Center GRECC 1310 24th Ave S, Nashville, TN 37212 2637, USA
    Crit Care Clin 23:491-506. 2007
    ....
  46. ncbi The role of future longitudinal studies in ICU survivors: understanding determinants and pathophysiology of brain dysfunction
    Ramona O Hopkins
    Psychology Department and Neuroscience Center, Brigham Young University, Provo, USA
    Curr Opin Crit Care 13:497-502. 2007
    ..In this paper, we examine important areas of investigation heretofore unaddressed and propose directions for clinically oriented outcomes research...
  47. ncbi The importance of diagnosing and managing ICU delirium
    Brenda T Pun
    RN, MSN, Center for Health Services Research, Vanderbilt Medical Center, Nashville, TN 37232 8300, USA
    Chest 132:624-36. 2007
    ....
  48. ncbi Bacteremia and sepsis in older adults
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, 6th Floor Medical Center East, Suite 6100, Nashville, TN 37232 8300, USA
    Clin Geriatr Med 23:633-47, viii. 2007
    ....
  49. ncbi Loss of IQ in the ICU brain injury without the insult
    Max L Gunther
    Vanderbilt University, Center for Health Services Research, 6100 Medical Center East, Nashville, TN 37232 8300, United States
    Med Hypotheses 69:1179-82. 2007
    ..Over time this has the potential to result in apoptosis and long-term cognitive impairment. Delirium appears to be a good candidate for the causal mechanism of ICU related cognitive decline and may be a critical point of intervention...
  50. ncbi Increased levels of serum S100B protein in critically ill patients without brain injury: Shock 26(1):20-24, 2006
    Bryan A Cotton
    Shock 27:338; author reply 339. 2007
  51. ncbi Comment on "Inter-rater reliability of delirium rating scales"
    E Wesley Ely
    Neuroepidemiology 25:213-4; author reply 214. 2005
  52. ncbi Outcome of older patients receiving mechanical ventilation
    Andres Esteban
    Servicio de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo km 12500, 28905 Madrid, Spain
    Intensive Care Med 30:639-46. 2004
    ..To determine the threshold of age that best discriminates the survival of mechanically ventilated patients and to estimate the outcome of mechanically ventilated older patients...
  53. ncbi Current opinions regarding the importance, diagnosis, and management of delirium in the intensive care unit: a survey of 912 healthcare professionals
    E Wesley Ely
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 32:106-12. 2004
    ..The aim of this survey was to assess the medical community's beliefs and practices regarding delirium in the intensive care unit...
  54. ncbi Underrecognition of preexisting cognitive impairment by physicians in older ICU patients
    Margaret A Pisani
    Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, PO Box 208057, New Haven, CT 06520 8057, USA
    Chest 124:2267-74. 2003
    ..Little is known, however, about physician recognition of preexisting cognitive impairment in the ICU and which patient factors may play a role in physician recognition...
  55. ncbi Drotrecogin alfa (activated) treatment of older patients with severe sepsis
    E Wesley Ely
    Division of Allergy, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Clin Infect Dis 37:187-95. 2003
    ..97). In conclusion, older patients with severe sepsis have higher short- and long-term survival rates when treated with DAA than when treated with placebo but an increased risk of serious bleeding that is not aged related...
  56. ncbi Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS)
    E Wesley Ely
    Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Tennessee Valley Veteran s Affairs Healthcare System, Geriatric Research Education and Clinical Center, Nashville 37232, USA
    JAMA 289:2983-91. 2003
    ....
  57. ncbi Delirium in the intensive care unit: occurrence and clinical course in older patients
    Lynn McNicoll
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Am Geriatr Soc 51:591-8. 2003
    ..To describe the occurrence of delirium in a cohort of older medical intensive care unit (ICU) patients and its short-term duration in the hospital and to determine the association between preexisting dementia and the occurrence of delirium...
  58. ncbi Monitoring delirium in critically ill patients. Using the confusion assessment method for the intensive care unit
    Brenda Truman
    Vanderbilt University Medical Center, Nashville, Tenn, USA
    Crit Care Nurse 23:25-36; quiz 37-8. 2003
  59. ncbi Six-month neuropsychological outcome of medical intensive care unit patients
    James C Jackson
    Department of Internal Medicine, Division of General Internal Medicine and Center for Health Services Research and the Geriatric Research Education and Clinical Center of the Veterans Administration Tennessee Valley Healthcare System, Nashville, TN, USA
    Crit Care Med 31:1226-34. 2003
    ..Future investigations are warranted to elucidate the nature of the association between critical illness, neuropsychological impairment, depression, and decreased quality of life...
  60. ncbi Advances in the understanding of clinical manifestations and therapy of severe sepsis: an update for critical care nurses
    E Wesley Ely
    Department of Medicine, Division of Allergy, Tennessee Valley Veterans Affairs Geriatric Research Education and Clinical Center, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    Am J Crit Care 12:120-33; quiz 134-5. 2003
    ..This review provides an overview of severe sepsis, highlighting recent advances in treatment of the disease and the role of critical care nurses...
  61. ncbi Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis
    E Wesley Ely
    Division of Allergy, Pulmonary and Critical Care Medicine, Tennessee Valley Veteran s Affairs Geriatric Research Education and Clinical Center, Vanderbilt University School of Medicine, Nashville 37232 8300, USA
    Crit Care Med 31:12-9. 2003
    ....
  62. ncbi Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis
    Derek C Angus
    Department of Critical Care Medicine, Clinical Research, Investigation and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, PA 15213, USA
    Crit Care Med 31:1-11. 2003
    ..To assess the cost-effectiveness of drotrecogin alfa (activated) therapy, which was recently shown to reduce mortality in severe sepsis...
  63. ncbi Findings on the portable chest radiograph correlate with fluid balance in critically ill patients
    Greg S Martin
    Division of Pulmonary and Critical Care Medicine, Emory University School of Medicine, 69 Jesse Hill Jr Drive SE, Room 2D 004, Atlanta, GA 30335, USA
    Chest 122:2087-95. 2002
    ..Chest radiographs (CXRs) quantify pulmonary edema in acute lung injury (ALI) and total blood volume in normal subjects. We hypothesized that CXRs would reflect temporal changes in fluid balance in critically ill patients...
  64. ncbi Protocols to improve the care of critically ill pediatric and adult patients
    Maureen O Meade
    JAMA 288:2601-3. 2002
  65. ncbi Activated protein C for severe sepsis
    E Wesley Ely
    N Engl J Med 347:1035-6. 2002
  66. ncbi Costs associated with delirium in mechanically ventilated patients
    Eric B Milbrandt
    CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 32:955-62. 2004
    ..Future efforts to prevent or treat intensive care unit delirium have the potential to improve patient outcomes and reduce costs of care...
  67. ncbi Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit
    E Wesley Ely
    Department of Medicine, Division of General Internal Medicine and Center for Health Services Research and the Veterans Affairs Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, Tenn, USA
    JAMA 291:1753-62. 2004
    ..CONCLUSION: Delirium was an independent predictor of higher 6-month mortality and longer hospital stay even after adjusting for relevant covariates including coma, sedatives, and analgesics in patients receiving mechanical ventilation...
  68. ncbi Consciousness monitoring in ventilated patients: bispectral EEG monitors arousal not delirium
    E Wesley Ely
    Tennessee Valley Veteran s Affairs Healthcare System, Geriatric Research, Education and Clinical Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Intensive Care Med 30:1537-43. 2004
    ..e., arousal vs. content of consciousness) the BIS measures. This study compared BIS levels to well-validated clinical measures of arousal and the presence or absence of delirium...
  69. ncbi Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients
    Jason W W Thomason
    Division of Allergy/Pulmonary/Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care 9:R375-81. 2005
    ..55-2.98, p = 0.58). CONCLUSION: Delirium occurred in nearly half of the non-ventilated ICU patients in this cohort. Even after adjustment for relevant covariates, delirium was found to be an independent predictor of longer hospital stay...
  70. ncbi Delirium: acute cognitive dysfunction in the critically ill
    Pratik Pandharipande
    Department of Anesthesiology Division of Critical Care, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Opin Crit Care 11:360-8. 2005
    ..Hence, critical care physicians and nurses should routinely assess their patients for delirium and develop strategies for its prevention and treatment...
  71. ncbi Narcotic-based sedation regimens for critically ill mechanically ventilated patients
    Pratik Pandharipande
    Division of Critical Care, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Crit Care 9:247-8. 2005
    ..Modifying sedation paradigms utilizing either narcotic-based regimens with remifentanil or fentanyl, or by using alpha2 agonists such as dexmedetomidine may help in improving these outcomes in critically ill patients...
  72. ncbi Short-term outcomes in older intensive care unit patients with dementia
    Margaret A Pisani
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    Crit Care Med 33:1371-6. 2005
    ..To determine the impact of dementia on the outcomes of intensive care unit (ICU) care and use of ICU interventions among older patients...
  73. ncbi Large-scale implementation of sedation and delirium monitoring in the intensive care unit: a report from two medical centers
    Brenda Truman Pun
    Department of Medicine, Division of Allergy Pulmonary Critical Care Medicine, and Center for Health Services Research, Vanderbilt University School of Medicine, Vanderbilt University School of Nursing, Nashville, TN 37232, USA
    Crit Care Med 33:1199-205. 2005
    ....
  74. ncbi Quality of dying and death in two medical ICUs: perceptions of family and clinicians
    Cari R Levy
    Division of Healthcare Policy and Research, University of Colorado Health Sciences Center, Aurora, CO 80011, USA
    Chest 127:1775-83. 2005
    ..The aim was to obtain a surrogate assessment of the quality of the dying process and examine differences in the perceptions of different types of raters...
  75. ncbi Detection of delirium in the intensive care unit: comparison of confusion assessment method for the intensive care unit with confusion assessment method ratings
    Lynn McNicoll
    Department of Internal Medicine, School of Medicine, Brown University, Providence, Rhode Island, USA
    J Am Geriatr Soc 53:495-500. 2005
    ..To compare the Confusion Assessment Method (CAM) and CAM for the Intensive Care Unit (CAM-ICU) methods for detecting delirium in alert, nonintubated older ICU patients...
  76. ncbi Insights into severe sepsis in older patients: from epidemiology to evidence-based management
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Infect Dis 40:719-27. 2005
    ..Clinicians must be aware of the level of evidence in support of various interventions and must keenly screen older survivors for ongoing deficits that will limit their functional recovery...
  77. ncbi Delirium in the intensive care unit is bad: what is the confusion?
    Jason W W Thomason
    Crit Care Med 32:2352-4. 2004
  78. ncbi The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis
    Derek C Angus
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 32:2199-206. 2004
    ..Post hoc analysis suggests the effect of DrotAA varies by APACHE II score with improved long-term survival in subjects with APACHE II scores >/=25 but no benefit in those with lower scores...
  79. ncbi Clinical identification of cognitive impairment in ICU survivors: insights for intensivists
    Sharon M Gordon
    Center for Health Services Research, Vanderbilt University, 6100 Medical Center East, Nashville, TN 37232, USA
    Intensive Care Med 30:1997-2008. 2004
    ..However, it can be identified by objective (test scores) or subjective evidence (clinical judgment, patient observation, family interaction)...
  80. ncbi Research issues in the evaluation of cognitive impairment in intensive care unit survivors
    James C Jackson
    Division of Allergy, Pulmonary and Critical Care Medicine, T 1218 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Intensive Care Med 30:2009-16. 2004
    ....
  81. ncbi The association between delirium and cognitive decline: a review of the empirical literature
    James C Jackson
    Division of Allergy Pulmonary Critical Care Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Neuropsychol Rev 14:87-98. 2004
    ..Additional research on delirium-related effects on long-term cognitive outcome is needed...
  82. ncbi Extended evaluation of recombinant human activated protein C United States Trial (ENHANCE US): a single-arm, phase 3B, multicenter study of drotrecogin alfa (activated) in severe sepsis
    Gordon R Bernard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Chest 125:2206-16. 2004
    ..To gather additional 28-day all-cause mortality and safety data among adult patients with severe sepsis who were treated with drotrecogin alfa (activated)...
  83. ncbi Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome
    E Wesley Ely
    Division of Allergy, Center for Health Services Research, 6th Floor, 6109 Medical Center East, Vanderbilt University Medical Center, Nashville, TN 37232-8300, USA
    Ann Intern Med 136:25-36. 2002
    ....