E Ely

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients
    Stuart McGrane
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, 526 MAB, 1211 21st Ave South, Nashville, TN 37212, USA
    Crit Care 15:R78. 2011
  2. pmc Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN Nashville, TN 37221, USA
    Crit Care 15:R86. 2011
  3. pmc Liberation and animation for ventilated ICU patients: the ABCDE bundle for the back-end of critical care
    Pratik Pandharipande
    Anesthesiology Service, VA TN Valley Health Care System, 1310 24th Ave South, Nashville 37212, USA
    Crit Care 14:157. 2010
  4. pmc Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients
    Jason W W Thomason
    Division of Allergy Pulmonary Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care 9:R375-81. 2005
  5. pmc Bench-to-bedside review: delirium in ICU patients - importance of sleep deprivation
    Gerald L Weinhouse
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Crit Care 13:234. 2009
  6. pmc Post-traumatic stress disorder and post-traumatic stress symptoms following critical illness in medical intensive care unit patients: assessing the magnitude of the problem
    James C Jackson
    Clinical Research Center of Excellence, VA Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, TN 37212, USA
    Crit Care 11:R27. 2007
  7. pmc A research algorithm to improve detection of delirium in the intensive care unit
    Margaret A Pisani
    Department of Internal Medicine, Pulmonary and Critical Care Section, and the Program on Aging, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    Crit Care 10:R121. 2006
  8. pmc Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial
    Pratik P Pandharipande
    Anesthesiology Service, VA TN Valley Health Care System, Nashville, TN 37212 2637, USA
    Crit Care 14:R38. 2010
  9. pmc Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Crit Care 11:R28. 2007
  10. ncbi request reprint Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS)
    E Wesley Ely
    Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Tennessee Valley Veteran s Affairs Healthcare System, Geriatric Research Education and Clinical Center, Nashville 37232, USA
    JAMA 289:2983-91. 2003

Research Grants

  1. Cognitive Impairment in the ICU: Evaluation and Outcomes
    E Ely; Fiscal Year: 2005
  2. CORE--PATIENT SUPPORT
    E Ely; Fiscal Year: 2007
  3. The MIND ICU Study
    E Ely; Fiscal Year: 2006
  4. The MIND ICU Study
    E Ely; Fiscal Year: 2007
  5. The MIND ICU Study
    E Ely; Fiscal Year: 2009
  6. The MIND ICU Study
    E Wesley Ely; Fiscal Year: 2010
  7. The MIND ICU Study
    E Wesley Ely; Fiscal Year: 2010

Detail Information

Publications89

  1. pmc Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients
    Stuart McGrane
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, 526 MAB, 1211 21st Ave South, Nashville, TN 37212, USA
    Crit Care 15:R78. 2011
    ..This study sought to investigate the relationship between two inflammatory biomarkers, procalcitonin and C-reactive protein (CRP), and duration of acute brain dysfunction in ventilated patients...
  2. pmc Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN Nashville, TN 37221, USA
    Crit Care 15:R86. 2011
    ..The VPW was studied in ALI patients to determine the correlation between VPW and intravascular pressure measurements and whether VPW could predict fluid status...
  3. pmc Liberation and animation for ventilated ICU patients: the ABCDE bundle for the back-end of critical care
    Pratik Pandharipande
    Anesthesiology Service, VA TN Valley Health Care System, 1310 24th Ave South, Nashville 37212, USA
    Crit Care 14:157. 2010
    ....
  4. pmc Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients
    Jason W W Thomason
    Division of Allergy Pulmonary Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care 9:R375-81. 2005
    ..The study objective was to determine the relationship between delirium and outcomes among non-ventilated ICU patients...
  5. pmc Bench-to-bedside review: delirium in ICU patients - importance of sleep deprivation
    Gerald L Weinhouse
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Crit Care 13:234. 2009
    ..Sleep deprivation may prove to be a modifiable risk factor for the development of delirium with important implications for the acute and long-term outcome of critically ill patients...
  6. pmc Post-traumatic stress disorder and post-traumatic stress symptoms following critical illness in medical intensive care unit patients: assessing the magnitude of the problem
    James C Jackson
    Clinical Research Center of Excellence, VA Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, TN 37212, USA
    Crit Care 11:R27. 2007
    ..Recently, investigators have reported that the experience of critical illness can also lead to PTSD, although details of the association between critical illness and PTSD remain unclear...
  7. pmc A research algorithm to improve detection of delirium in the intensive care unit
    Margaret A Pisani
    Department of Internal Medicine, Pulmonary and Critical Care Section, and the Program on Aging, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    Crit Care 10:R121. 2006
    ..The purpose of this study was to develop a research algorithm to enhance detection of delirium in critically ill ICU patients using chart review to complement a validated clinical delirium instrument...
  8. pmc Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial
    Pratik P Pandharipande
    Anesthesiology Service, VA TN Valley Health Care System, Nashville, TN 37212 2637, USA
    Crit Care 14:R38. 2010
    ....
  9. pmc Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Crit Care 11:R28. 2007
    ..We sought to identify factors associated with PTSD symptoms in patients following critical illness requiring mechanical ventilation...
  10. ncbi request reprint Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS)
    E Wesley Ely
    Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Tennessee Valley Veteran s Affairs Healthcare System, Geriatric Research Education and Clinical Center, Nashville 37232, USA
    JAMA 289:2983-91. 2003
    ....
  11. ncbi request reprint Consciousness monitoring in ventilated patients: bispectral EEG monitors arousal not delirium
    E Wesley Ely
    Tennessee Valley Veteran s Affairs Healthcare System, Geriatric Research, Education and Clinical Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Intensive Care Med 30:1537-43. 2004
    ..e., arousal vs. content of consciousness) the BIS measures. This study compared BIS levels to well-validated clinical measures of arousal and the presence or absence of delirium...
  12. ncbi request reprint Current opinions regarding the importance, diagnosis, and management of delirium in the intensive care unit: a survey of 912 healthcare professionals
    E Wesley Ely
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 32:106-12. 2004
    ..The aim of this survey was to assess the medical community's beliefs and practices regarding delirium in the intensive care unit...
  13. ncbi request reprint Drotrecogin alfa (activated) treatment of older patients with severe sepsis
    E Wesley Ely
    Division of Allergy, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Clin Infect Dis 37:187-95. 2003
    ..97). In conclusion, older patients with severe sepsis have higher short- and long-term survival rates when treated with DAA than when treated with placebo but an increased risk of serious bleeding that is not aged related...
  14. ncbi request reprint Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients
    E Wesley Ely
    Department of Medicine, Saint Thomas Hospital, and Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Crit Care Med 35:112-7. 2007
    ..To test for an association between apolipoprotein E (APOE) genotypes and duration of intensive care unit delirium...
  15. ncbi request reprint Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis
    E Wesley Ely
    Division of Allergy, Pulmonary and Critical Care Medicine, Tennessee Valley Veteran s Affairs Geriatric Research Education and Clinical Center, Vanderbilt University School of Medicine, Nashville 37232 8300, USA
    Crit Care Med 31:12-9. 2003
    ....
  16. ncbi request reprint Brain dysfunction: another burden for the chronically critically ill
    Judith E Nelson
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Intern Med 166:1993-9. 2006
    ..To our knowledge, no previous research has addressed brain dysfunction in the chronically critically ill, although this topic is important for medical decision making...
  17. ncbi request reprint Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome
    E Wesley Ely
    Division of Allergy, Center for Health Services Research, 6th Floor, 6109 Medical Center East, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Ann Intern Med 136:25-36. 2002
    ..The incidence of acute respiratory failure requiring mechanical ventilation increases 10-fold from the ages of 55 to 85 years, yet the rate of recovery and outcomes in older persons who develop acute lung injury are poorly defined...
  18. ncbi request reprint Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit
    E Wesley Ely
    Department of Medicine, Division of General Internal Medicine and Center for Health Services Research and the Veterans Affairs Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, Tenn, USA
    JAMA 291:1753-62. 2004
    ..In the intensive care unit (ICU), delirium is a common yet underdiagnosed form of organ dysfunction, and its contribution to patient outcomes is unclear...
  19. ncbi request reprint Six-month neuropsychological outcome of medical intensive care unit patients
    James C Jackson
    Department of Internal Medicine, Division of General Internal Medicine and Center for Health Services Research and the Geriatric Research Education and Clinical Center of the Veterans Administration Tennessee Valley Healthcare System, Nashville, TN, USA
    Crit Care Med 31:1226-34. 2003
    ..To examine neuropsychological function, depression, and quality of life 6 months after discharge in patients who received mechanical ventilation in the intensive care unit...
  20. ncbi request reprint The cognitive consequences of critical illness: practical recommendations for screening and assessment
    Max L Gunther
    VA Tennessee Valley Geriatric Research, Education and Clinical Center GRECC 1310 24th Ave S, Nashville, TN 37212 2637, USA
    Crit Care Clin 23:491-506. 2007
    ....
  21. ncbi request reprint Advances in sedation for critically ill patients
    A Morandi
    Center for Health Services Research, Vanderbilt Medical Center, Nashville, TN 37232 8300, USA
    Minerva Anestesiol 75:385-91. 2009
    ..New choices for sedation, such as alpha-2 agonists and ultra short narcotics, are also being actively investigated, which may lead to complementary improvements in the future management of these critically ill, vulnerable patients...
  22. pmc Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients
    Pratik Pandharipande
    Department of Anesthesia Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Trauma 65:34-41. 2008
    ..The purpose of this study was to analyze the prevalence of and risk factors for delirium in surgical and trauma ICU patients...
  23. ncbi request reprint Protocol-driven ventilator weaning: reviewing the evidence
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, 6 th Floor MCE, 6110, Nashville, TN 37232 8300, USA
    Clin Chest Med 29:241-52, v. 2008
    ..This article reviews the rationale for and against the routine use of weaning protocols and highlights informative details of many clinical trials that have evaluated such protocols...
  24. pmc Delirium in the intensive care unit
    Timothy D Girard
    Department of Medicine Division of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University School of Medicine 1161 21st Avenue South, Nashville, TN 37232 2650, USA
    Crit Care 12:S3. 2008
    ..Strategies for the prevention and treatment of ICU delirium are the subjects of multiple ongoing investigations...
  25. doi request reprint Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Lancet 371:126-34. 2008
    ..Our aim was to assess a protocol that paired spontaneous awakening trials (SATs)-ie, daily interruption of sedatives-with spontaneous breathing trials (SBTs)...
  26. ncbi request reprint Loss of IQ in the ICU brain injury without the insult
    Max L Gunther
    Vanderbilt University, Center for Health Services Research, 6100 Medical Center East, Nashville, TN 37232 8300, United States
    Med Hypotheses 69:1179-82. 2007
    ..Over time this has the potential to result in apoptosis and long-term cognitive impairment. Delirium appears to be a good candidate for the causal mechanism of ICU related cognitive decline and may be a critical point of intervention...
  27. ncbi request reprint The importance of diagnosing and managing ICU delirium
    Brenda T Pun
    RN, MSN, Center for Health Services Research, Vanderbilt Medical Center, Nashville, TN 37232 8300, USA
    Chest 132:624-36. 2007
    ....
  28. ncbi request reprint Bacteremia and sepsis in older adults
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, 6th Floor Medical Center East, Suite 6100, Nashville, TN 37232 8300, USA
    Clin Geriatr Med 23:633-47, viii. 2007
    ....
  29. pmc Presence of electroencephalogram burst suppression in sedated, critically ill patients is associated with increased mortality
    Paula L Watson
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA
    Crit Care Med 36:3171-7. 2008
    ..Burst suppression has never been studied as a potential risk factor for death in patients without a known neurologic disorder or injury...
  30. doi request reprint Delirium in older emergency department patients: recognition, risk factors, and psychomotor subtypes
    Jin H Han
    Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Acad Emerg Med 16:193-200. 2009
    ....
  31. pmc Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit
    Heidi A B Smith
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA
    Crit Care Med 39:150-7. 2011
    ..To validate a diagnostic instrument for pediatric delirium in critically ill children, both ventilated and nonventilated, that uses standardized, developmentally appropriate measurements...
  32. pmc Communication in critical care: family rounds in the intensive care unit
    Natalie L Jacobowski
    Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8300, USA
    Am J Crit Care 19:421-30. 2010
    ..Communication with family members of patients in intensive care units is challenging and fraught with dissatisfaction...
  33. pmc Brain autopsy findings in intensive care unit patients previously suffering from delirium: a pilot study
    David R Janz
    Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    J Crit Care 25:538.e7-12. 2010
    ....
  34. pmc Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, and Department of Medicine, Saint Thomas Hospital, Nashville, TN, USA
    Crit Care Med 38:1513-20. 2010
    ..To test the hypothesis that duration of delirium in the intensive care unit is an independent predictor of long-term cognitive impairment after critical illness requiring mechanical ventilation...
  35. pmc Delirium in the emergency department: an independent predictor of death within 6 months
    Jin H Han
    Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 4700, USA
    Ann Emerg Med 56:244-252.e1. 2010
    ..As a result, we seek to determine whether delirium in the ED is independently associated with 6-month mortality in older patients and whether this relationship is modified by nursing home status...
  36. pmc Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 38:428-37. 2010
    ..To demonstrate the feasibility of a placebo-controlled trial of antipsychotics for delirium in the intensive care unit and to test the hypothesis that antipsychotics would improve days alive without delirium or coma...
  37. pmc Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case study
    James C Jackson
    Center for Health Services Research, Vanderbilt University, 6100 Medical Center East, Nashville, TN 37232 8300, USA
    South Med J 102:1150-7. 2009
    ....
  38. pmc Immortal time bias in critical care research: application of time-varying Cox regression for observational cohort studies
    Ayumi K Shintani
    Department of Biostatistics, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 37:2939-45. 2009
    ..To examine the bias introduced by using time-fixed methodology to analyze the effects of a time-varying exposure incurred in the intensive care unit...
  39. pmc Delirium in the older emergency department patient: a quiet epidemic
    Jin H Han
    Department of Emergency Medicine, Vanderbilt University Medical Center, 703 Oxford House, 1313 21st Avenue South, Nashville, TN 37232 4700, USA
    Emerg Med Clin North Am 28:611-31. 2010
    ..Once delirium is diagnosed, the ED evaluation should focus on searching for the underlying cause. Infection is one of the most common precipitants of delirium, but multiple causes may exist concurrently...
  40. pmc Delirium: an emerging frontier in the management of critically ill children
    Heidi A B Smith
    Pediatrics and Anesthesiology Division of Critical Care, Department of Pediatrics, 5121 Doctor s Office Tower, 2200 Children s Way, Nashville, TN 37232 9075, USA
    Crit Care Clin 25:593-614, x. 2009
    ....
  41. doi request reprint Documentation and management of words associated with delirium among elderly patients in postacute care: a pilot investigation
    Alessandro Morandi
    Center for Health Services Research, Vanderbilt Medical Center, 1215 21st Avenue South Nashville, Nashville, TN 37205, USA
    J Am Med Dir Assoc 10:330-4. 2009
    ..To describe in a pilot investigation the frequency that keywords associated with delirium were documented by providers and to study the effect of reporting such observations on physician orders...
  42. doi request reprint Acute eosinophilic pneumonia: A case report and review of the literature
    David R Janz
    Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Crit Care Med 37:1470-4. 2009
    ..This review uses a patient with AEP to emphasize certain aspects of this illness and discusses the current literature regarding its features, diagnosis, and treatment...
  43. pmc Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment score
    Pratik P Pandharipande
    Department of Anesthesiology, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 37:1317-21. 2009
    ....
  44. pmc Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients
    P P Pandharipande
    Division of Critical Care Medicine, Department of Anesthesiology, Vanderbilt Medical Center, 526 MAB, Nashville, TN, 37212, USA
    Intensive Care Med 35:1886-92. 2009
    ..This pilot study investigated whether alterations of tryptophan (Trp), phenylalanine (Phe), and tyrosine (Tyr) plasma levels were associated with a higher risk of transitioning to delirium in critically ill patients...
  45. doi request reprint Sedation, delirium and mechanical ventilation: the 'ABCDE' approach
    Alessandro Morandi
    Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Curr Opin Crit Care 17:43-9. 2011
    ..We review recent findings on the management of mechanically ventilated patients focusing on strategies that may improve neurologic and functional outcomes in critically ill patients...
  46. ncbi request reprint Sedative and analgesic medications: risk factors for delirium and sleep disturbances in the critically ill
    Pratik Pandharipande
    Division of Critical Care, Department of Anesthesiology, Vanderbilt University School of Medicine, 324 MAB, 1313 21st Avenue South, Nashville, TN 37232, USA
    Crit Care Clin 22:313-27, vii. 2006
    ....
  47. ncbi request reprint The association between delirium and cognitive decline: a review of the empirical literature
    James C Jackson
    Division of Allergy Pulmonary Critical Care Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Neuropsychol Rev 14:87-98. 2004
    ..Additional research on delirium-related effects on long-term cognitive outcome is needed...
  48. ncbi request reprint Insights into severe sepsis in older patients: from epidemiology to evidence-based management
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Infect Dis 40:719-27. 2005
    ..Clinicians must be aware of the level of evidence in support of various interventions and must keenly screen older survivors for ongoing deficits that will limit their functional recovery...
  49. ncbi request reprint Monitoring delirium in critically ill patients. Using the confusion assessment method for the intensive care unit
    Brenda Truman
    Vanderbilt University Medical Center, Nashville, Tenn, USA
    Crit Care Nurse 23:25-36; quiz 37-8. 2003
  50. pmc Narcotic-based sedation regimens for critically ill mechanically ventilated patients
    Pratik Pandharipande
    Division of Critical Care, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Crit Care 9:247-8. 2005
    ..Modifying sedation paradigms utilizing either narcotic-based regimens with remifentanil or fentanyl, or by using alpha2 agonists such as dexmedetomidine may help in improving these outcomes in critically ill patients...
  51. ncbi request reprint Extended evaluation of recombinant human activated protein C United States Trial (ENHANCE US): a single-arm, phase 3B, multicenter study of drotrecogin alfa (activated) in severe sepsis
    Gordon R Bernard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Chest 125:2206-16. 2004
    ..To gather additional 28-day all-cause mortality and safety data among adult patients with severe sepsis who were treated with drotrecogin alfa (activated)...
  52. ncbi request reprint Delirium and cognitive dysfunction in the intensive care unit
    Russell R Miller
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, 6th Floor Medical Center East 6100, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Curr Psychiatry Rep 9:26-34. 2007
    ..This article reviews prevention and treatment options, and current pharmacologic and nonpharmacologic approaches to delirium, acknowledging limited but improving quality of evidence to date...
  53. ncbi request reprint Delirium and its motoric subtypes: a study of 614 critically ill patients
    Josh F Peterson
    Division of General Internal Medicine, Center for Health Services Research, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Am Geriatr Soc 54:479-84. 2006
    ..To describe the motoric subtypes of delirium in critically ill patients and compare patients aged 65 and older with a younger cohort...
  54. ncbi request reprint Using the chest radiograph to determine intravascular volume status: the role of vascular pedicle width
    E Wesley Ely
    Department of Medicine the Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Chest 121:942-50. 2002
    ..Lastly, the measurement of the VPW should be incorporated into the training of chest clinicians and radiologists...
  55. pmc Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial
    James C Jackson
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Am J Respir Crit Care Med 182:183-91. 2010
    ..Little is known, however, of how such strategies affect long-term cognitive, psychological, and functional outcomes...
  56. ncbi request reprint Long-term cognitive, emotional, and functional outcomes in trauma intensive care unit survivors without intracranial hemorrhage
    James C Jackson
    Division of Allergy Pulmonary Critical Care Medicine, Center for Health Services Research, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville TN, USA
    J Trauma 62:80-8. 2007
    ....
  57. ncbi request reprint Radiographic measures of intravascular volume status: the role of vascular pedicle width
    Russell R Miller
    Department of Medicine, Division of Allergy Pulmonary Critical Care Medicine of the Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Curr Opin Crit Care 12:255-62. 2006
    ..A valid, low-cost, high-yield instrument to assess intravascular volume status in critically ill patients does not exist. The portable chest X-ray is a common part of any intensivist's or chest clinician's daily rounds...
  58. ncbi request reprint Delirium and cognitive dysfunction in the intensive care unit
    Russell R Miller
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Semin Respir Crit Care Med 27:210-20. 2006
    ..Furthermore, consideration of a continuum may better elucidate the true magnitude of acute brain dysfunction in the ICU...
  59. ncbi request reprint Large-scale implementation of sedation and delirium monitoring in the intensive care unit: a report from two medical centers
    Brenda Truman Pun
    Department of Medicine, Division of Allergy Pulmonary Critical Care Medicine, and Center for Health Services Research, Vanderbilt University School of Medicine, Vanderbilt University School of Nursing, Nashville, TN 37232, USA
    Crit Care Med 33:1199-205. 2005
    ....
  60. ncbi request reprint Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial
    Pratik P Pandharipande
    Department of Anesthesiology Division of Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 298:2644-53. 2007
    ..Dexmedetomidine induces sedation via different central nervous system receptors than the benzodiazepine drugs and may lower the risk of acute brain dysfunction...
  61. ncbi request reprint Research issues in the evaluation of cognitive impairment in intensive care unit survivors
    James C Jackson
    Division of Allergy, Pulmonary and Critical Care Medicine, T 1218 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Intensive Care Med 30:2009-16. 2004
    ....
  62. doi request reprint Reducing iatrogenic risks: ICU-acquired delirium and weakness--crossing the quality chasm
    Eduard E Vasilevskis
    Division of Pulmonary Sciences and Critical Care Medicine, Veterans Affairs, Tennessee Valley Healthcare System, Vanderbilt University Medical Center, 1215 21st Ave, S, 6006 Medical Center East, NT, Nashville, TN 37232 8300, USA
    Chest 138:1224-33. 2010
    ..This evidence-based bundle of practices will build a bridge across the current quality chasm from the "front end" to the "back end" of critical care and toward improved cognitive and functional outcomes for ICU survivors...
  63. ncbi request reprint Delirium: acute cognitive dysfunction in the critically ill
    Pratik Pandharipande
    Department of Anesthesiology Division of Critical Care, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Opin Crit Care 11:360-8. 2005
    ..Hence, critical care physicians and nurses should routinely assess their patients for delirium and develop strategies for its prevention and treatment...
  64. ncbi request reprint Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients
    Pratik Pandharipande
    Department of Anesthesia Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Anesthesiology 104:21-6. 2006
    ..Sedative and analgesic medications relieve anxiety and pain but may contribute to patients' transitioning into delirium...
  65. ncbi request reprint Clinical identification of cognitive impairment in ICU survivors: insights for intensivists
    Sharon M Gordon
    Center for Health Services Research, Vanderbilt University, 6100 Medical Center East, Nashville, TN 37232, USA
    Intensive Care Med 30:1997-2008. 2004
    ..A growing body of research has demonstrated the presence of ongoing cognitive impairment in large numbers of ICU survivors...
  66. pmc Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals
    Rina P Patel
    School of Medicine RPP, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 37:825-32. 2009
    ..Our objective was to assess beliefs and practices regarding ICU delirium and sedation management...
  67. ncbi request reprint Outcome of older patients receiving mechanical ventilation
    Andres Esteban
    Servicio de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo km 12500, 28905 Madrid, Spain
    Intensive Care Med 30:639-46. 2004
    ..To determine the threshold of age that best discriminates the survival of mechanically ventilated patients and to estimate the outcome of mechanically ventilated older patients...
  68. ncbi request reprint Costs associated with delirium in mechanically ventilated patients
    Eric B Milbrandt
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 32:955-62. 2004
    ..To determine the costs associated with delirium in mechanically ventilated medical intensive care unit patients...
  69. ncbi request reprint Delirium in the intensive care unit: occurrence and clinical course in older patients
    Lynn McNicoll
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Am Geriatr Soc 51:591-8. 2003
    ..To describe the occurrence of delirium in a cohort of older medical intensive care unit (ICU) patients and its short-term duration in the hospital and to determine the association between preexisting dementia and the occurrence of delirium...
  70. ncbi request reprint Underrecognition of preexisting cognitive impairment by physicians in older ICU patients
    Margaret A Pisani
    Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, PO Box 208057, New Haven, CT 06520 8057, USA
    Chest 124:2267-74. 2003
    ..Little is known, however, about physician recognition of preexisting cognitive impairment in the ICU and which patient factors may play a role in physician recognition...
  71. ncbi request reprint Advances in the understanding of clinical manifestations and therapy of severe sepsis: an update for critical care nurses
    E Wesley Ely
    Department of Medicine, Division of Allergy, Tennessee Valley Veterans Affairs Geriatric Research Education and Clinical Center, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    Am J Crit Care 12:120-33; quiz 134-5. 2003
    ..This review provides an overview of severe sepsis, highlighting recent advances in treatment of the disease and the role of critical care nurses...
  72. ncbi request reprint Activated protein C for severe sepsis
    E Wesley Ely
    N Engl J Med 347:1035-6. 2002
  73. ncbi request reprint Findings on the portable chest radiograph correlate with fluid balance in critically ill patients
    Greg S Martin
    Division of Pulmonary and Critical Care Medicine, Emory University School of Medicine, 69 Jesse Hill Jr Drive SE, Room 2D 004, Atlanta, GA 30335, USA
    Chest 122:2087-95. 2002
    ..Chest radiographs (CXRs) quantify pulmonary edema in acute lung injury (ALI) and total blood volume in normal subjects. We hypothesized that CXRs would reflect temporal changes in fluid balance in critically ill patients...
  74. ncbi request reprint Protocols to improve the care of critically ill pediatric and adult patients
    Maureen O Meade
    JAMA 288:2601-3. 2002
  75. ncbi request reprint Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis
    Derek C Angus
    Department of Critical Care Medicine, Clinical Research, Investigation and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, PA 15213, USA
    Crit Care Med 31:1-11. 2003
    ..To assess the cost-effectiveness of drotrecogin alfa (activated) therapy, which was recently shown to reduce mortality in severe sepsis...
  76. doi request reprint Nurse practitioners and physician assistants in the intensive care unit: an evidence-based review
    Ruth M Kleinpell
    Rush University Medical Center and Rush University College of Nursing, Chicago, IL, USA
    Crit Care Med 36:2888-97. 2008
    ..However, the impact of nurse practitioners and physician assistants in the intensive care unit setting is not well known...
  77. ncbi request reprint Increased levels of serum S100B protein in critically ill patients without brain injury: Shock 26(1):20-24, 2006
    Bryan A Cotton
    Shock 27:338; author reply 339. 2007
  78. ncbi request reprint The role of future longitudinal studies in ICU survivors: understanding determinants and pathophysiology of brain dysfunction
    Ramona O Hopkins
    Psychology Department and Neuroscience Center, Brigham Young University, Provo, USA
    Curr Opin Crit Care 13:497-502. 2007
    ..In this paper, we examine important areas of investigation heretofore unaddressed and propose directions for clinically oriented outcomes research...
  79. ncbi request reprint Comment on "Validity and reliability of the DDS for severity of delirium in the ICU"
    Timothy D Girard
    Neurocrit Care 4:190-1; author reply 192-3. 2006
  80. ncbi request reprint Clinical sedation scores as indicators of sedative and analgesic drug exposure in intensive care unit patients
    Andrew L Masica
    Baylor Institute for Health Care Research and Improvement, Baylor Health Care System, Dallas, Texas, USA
    Am J Geriatr Pharmacother 5:218-31. 2007
    ..These issues are of particular concern in elderly patients (aged > or =65 years), who account for at least half of all ICU admissions and nearly two thirds of ICU days...
  81. ncbi request reprint Comment on "Inter-rater reliability of delirium rating scales"
    E Wesley Ely
    Neuroepidemiology 25:213-4; author reply 214. 2005
  82. doi request reprint Re: Increased levels of serum S100B protein in critically ill patients without brain injury
    Bryan A Cotton
    Shock 30:222; author reply 222-3. 2008
  83. ncbi request reprint Evidence-based algorithms for diagnosing and treating ventilator-associated pneumonia
    Richard J Wall
    Pulmonary, Critical Care and Sleep Disorders Medicine, Southlake Clinic, Valley Medical Center, Renton, Washington 98055, USA
    J Hosp Med 3:409-22. 2008
    ..Given the complexity of caring for heterogeneous populations in the intensive care unit (ICU), however, there is still uncertainty regarding how to diagnose and manage VAP...
  84. ncbi request reprint Short-term outcomes in older intensive care unit patients with dementia
    Margaret A Pisani
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    Crit Care Med 33:1371-6. 2005
    ..To determine the impact of dementia on the outcomes of intensive care unit (ICU) care and use of ICU interventions among older patients...
  85. ncbi request reprint Quality of dying and death in two medical ICUs: perceptions of family and clinicians
    Cari R Levy
    Division of Healthcare Policy and Research, University of Colorado Health Sciences Center, Aurora, CO 80011, USA
    Chest 127:1775-83. 2005
    ..The aim was to obtain a surrogate assessment of the quality of the dying process and examine differences in the perceptions of different types of raters...
  86. ncbi request reprint Detection of delirium in the intensive care unit: comparison of confusion assessment method for the intensive care unit with confusion assessment method ratings
    Lynn McNicoll
    Department of Internal Medicine, School of Medicine, Brown University, Providence, Rhode Island, USA
    J Am Geriatr Soc 53:495-500. 2005
    ..To compare the Confusion Assessment Method (CAM) and CAM for the Intensive Care Unit (CAM-ICU) methods for detecting delirium in alert, nonintubated older ICU patients...
  87. ncbi request reprint Delirium in the intensive care unit is bad: what is the confusion?
    Jason W W Thomason
    Crit Care Med 32:2352-4. 2004
  88. ncbi request reprint The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis
    Derek C Angus
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 32:2199-206. 2004
    ..To determine long-term survival for subjects with severe sepsis enrolled in the previous multiple-center trial (PROWESS) of drotrecogin alfa (activated) (DrotAA) vs. placebo...
  89. ncbi request reprint Motoric subtypes of delirium in mechanically ventilated surgical and trauma intensive care unit patients
    Pratik Pandharipande
    Vanderbilt University School of Medicine corrected Department of Anesthesia Critical Care Medicine, 1121 21st Ave So, Nashville MAB 526, TN corrected 37212, USA
    Intensive Care Med 33:1726-31. 2007
    ..Their use, however, has not been reported in surgical and trauma patients. The objective of this study was to identify the prevalence of the motoric subtypes of delirium in surgical and trauma ICU patients...

Research Grants8

  1. Cognitive Impairment in the ICU: Evaluation and Outcomes
    E Ely; Fiscal Year: 2005
    ..Along with the candidate's record of publications and achievement, he will have rich academic surroundings, excellent mentors and strong institutional commitment to ensure that he achieve these goals. ..
  2. CORE--PATIENT SUPPORT
    E Ely; Fiscal Year: 2007
    ..Christopher's Hospital will coordinate and supervise these activities with the Clinical Cores at Thomas Jefferson University Hospital and at the Kosair Children's Hospital (University of Louisville). ..
  3. The MIND ICU Study
    E Ely; Fiscal Year: 2006
    ....
  4. The MIND ICU Study
    E Ely; Fiscal Year: 2007
    ....
  5. The MIND ICU Study
    E Ely; Fiscal Year: 2009
    ....
  6. The MIND ICU Study
    E Wesley Ely; Fiscal Year: 2010
    ....
  7. The MIND ICU Study
    E Wesley Ely; Fiscal Year: 2010
    ....