Research Topics
Genomes and GenesSpecies | Kathleen M EganSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Early life factors in relation to breast cancer risk in postmenopausal womenLinda Titus-Ernstoff
Norris Cotton Cancer Center and the Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Cancer Epidemiol Biomarkers Prev 11:207-10. 2002..Overall, our results are consistent with previous studies and suggest that these early life factors have a modest influence on breast cancer risk in postmenopausal women...- MnSOD polymorphism and breast cancer in a population-based case-control studyKathleen M Egan
Department of Medicine, Vanderbilt University Medical Center, Suite 6000 Medical Center East, Nashville, TN 37232 8300, USA
Cancer Lett 199:27-33. 2003..91-1.77) or two (RR: 1.18; 95% CI: 0.81-1.73) Ala alleles compared to those homozygous for the wild-type Val genotype. Results do not support any overall association of the Ala-9Val MnSOD polymorphism to the development of breast cancer... - Commentary: sunlight, vitamin D, and the cancer connection revisitedKathleen M Egan
Vanderbilt-Ingram Cancer Center, Health Services Research, Vanderbilt University, 6000 Medical Center East, Nashville, TN 37235, USA
Int J Epidemiol 35:227-30. 2006 - STK15 polymorphism and breast cancer risk in a population-based studyKathleen M Egan
Vanderbilt University Medical Center, Suite 6000, MCE, Nashville, TN 37232 8300, USA
Carcinogenesis 25:2149-53. 2004..79). No interaction was detected between STK15 variants and estrogenic risk factors, although the power of these analyses was limited. These results suggest that STK15 may represent a low penetrance type breast cancer susceptibility gene... - Genetic polymorphisms in GSTM1, GSTP1, and GSTT1 and the risk for breast cancer: results from the Shanghai Breast Cancer Study and meta-analysisKathleen M Egan
Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 27232 8300, USA
Cancer Epidemiol Biomarkers Prev 13:197-204. 2004.... 
Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese womenHui Cai
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
Pharmacogenet Genomics 18:657-64. 2008..We investigated the associations of genetic polymorphisms in CYP19A1, a critical gene involved in estrogen synthesis, with plasma levels of sex hormones among postmenopausal Chinese women...- Alcohol consumption and ovarian cancer risk in a population-based case-control studyNeeraja B Peterson
Center for Health Services Research, Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
Int J Cancer 119:2423-7. 2006..30), though results for other subtypes were based on sparse data and results were imprecise. In this study, neither total alcohol consumption as a young adult nor recently was associated with an increase in the risk of ovarian cancer... - Population-based case-control study of AhR (aryl hydrocarbon receptor) and CYP1A2 polymorphisms and breast cancer riskJi Rong Long
Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
Pharmacogenet Genomics 16:237-43. 2006.... - Association of COMT haplotypes and breast cancer risk in caucasian womenNeeraja B Peterson
Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Suite 6108 Medical Center East, North Tower, Nashville, TN 37232 8300, USA
Anticancer Res 30:217-20. 2010..These results suggest that genetic variation in COMT has no significant association with breast cancer risk among Caucasian women... - Obesity, gynecological factors, and abnormal mammography follow-up in minority and medically underserved womenAlecia Malin Fair
Department of Surgery, Meharry Medical College, Nashville, Tennessee 37208, USA
J Womens Health (Larchmt) 18:1033-9. 2009.... - Childbearing recency and modifiers of premenopausal breast cancer riskNeeraja B Peterson
Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Suite 6108, Medical Center East, North Tower, Nashville, TN 37232 8300, USA
Cancer Epidemiol Biomarkers Prev 17:3284-7. 2008..90-2.04), adjusting for age and known breast cancer risk factors (Ptrend = 0.14). We did not find a significant interaction with breast-feeding (Pinteraction = 0.30) or pregnancy weight gain (Pinteraction = 0.09)... 
A multistage genetic association study identifies breast cancer risk loci at 10q25 and 16q24Kathryn S Higginbotham
Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Cancer Epidemiol Biomarkers Prev 21:1565-73. 2012..We conducted a multistage genetic association study in a series of independent epidemiologic breast cancer study populations to identify novel breast cancer risk variants...- Whole-genome amplification of oral rinse self-collected DNA in a population-based case-control study of breast cancerXueying Liang
Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Cancer Epidemiol Biomarkers Prev 16:1610-4. 2007..Whole-genome amplification may introduce substantial allele amplification bias in gDNA collected using a common protocol in population-based epidemiologic studies... - Psychosocial determinants of mammography follow-up after receipt of abnormal mammography results in medically underserved womenAlecia Malin Fair
Department of Surgery, Meharry Medical College, Nashville, TN 37208, USA
J Health Care Poor Underserved 21:71-94. 2010..0 vs. 5.3) (p-value<.01). These constructs have implications for understanding mammography follow-up among minority and medically underserved women. Further comprehensive study of these concepts is warranted... - Replication and functional genomic analyses of the breast cancer susceptibility locus at 6q25.1 generalize its importance in women of chinese, Japanese, and European ancestryQiuyin Cai
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Cancer Res 71:1344-55. 2011..This association may be explained in part by a putatively functional variant (rs6913578) identified in the region... - Prospective study of cigarette smoking and the risk of primary open-angle glaucomaJae H Kang
Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
Arch Ophthalmol 121:1762-8. 2003..To examine the association between cigarette smoking and incident primary open-angle glaucoma (POAG)... - The "Got D'ViBE?" study: an inter-institutional project assessing vitamin D and mammographic breast densityToni J Lewis
Department of Surgery, Meharry Medical College, Nashville, TN 37208, USA
J Health Care Poor Underserved 21:17-25. 2010..This effort resulted in techniques to measure vitamin D levels, breast density, and sunlight exposure. Outcomes from this collaboration may provide insight to researchers conducting similar investigations... - Relation of anthropometric measurements to ovarian cancer risk in a population-based case-control study (United States)Neeraja B Peterson
Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt University School of Medicine, Medical Center East, Suite 6000, Nashville, TN 37232 8300, USA
Cancer Causes Control 17:459-67. 2006..To examine the relationship between anthropometric measures and ovarian cancer by menopausal status... - Association of NAT2 and smoking in relation to breast cancer incidence in a population-based case-control study (United States)Kathleen M Egan
Division of General Internal Medicine and the Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, 37232, USA
Cancer Causes Control 14:43-51. 2003..To evaluate the potential interaction between N-acetyltransferase 2 (NAT2) and smoking in breast cancer incidence... - Timing is everything: methodologic issues locating and recruiting medically underserved women for abnormal mammography follow-up researchAlecia Malin Fair
Department of Surgery, Meharry Medical College, 1005 Dr D B Todd Boulevard, Nashville, TN 37208, USA
Contemp Clin Trials 29:537-46. 2008..We present our experience attempting to locate and recruit minority and medically underserved women identified in a Nashville, Tennessee public hospital for a mammography follow-up study... - A multistage association study identifies a breast cancer genetic locus at NCOA7Kathryn S P Higginbotham
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Cancer Res 71:3881-8. 2011..These observations provide consistent evidence that genetic variants at the NCOA7 locus may confer a reduced risk of breast cancer... - Vitamin D insufficiency among African-Americans in the southeastern United States: implications for cancer disparities (United States)Kathleen M Egan
Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA
Cancer Causes Control 19:527-35. 2008..To determine the prevalence and predictors of vitamin D insufficiency among black and white adult residents of the southern US... - Antioxidant intake and primary open-angle glaucoma: a prospective studyJae H Kang
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Epidemiol 158:337-46. 2003..97 (95% CI: 0.62, 1.52) for vitamin E, and 1.11 (95% CI: 0.82, 1.51) for vitamin A. In conclusion, the authors did not observe any strong associations between antioxidant consumption and the risk of primary open-angle glaucoma... - Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancerYawei Zhang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
Cancer Epidemiol Biomarkers Prev 15:353-8. 2006..6; 95% CI, 1.1-2.4; P = 0.02). In conclusion, our results do not support that the polymorphisms evaluated in six BER pathway genes play a major role in breast carcinogenesis, particularly in Caucasian populations... - Cigarette smoking and risk of breast carcinoma in situAmy Trentham-Dietz
University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, Wisconsin 53726, USA
Epidemiology 18:629-38. 2007..Although the associations with cigarette smoking have been explored extensively for invasive breast cancer, the relation to in situ cancer has not previously been examined in depth... - Statin use and risk of breast cancerGaia Pocobelli
Department of Epidemiology, University of Washington, Seattle, Washington, USA
Cancer 112:27-33. 2008..We analyzed data from a population-based case-control study to evaluate the association between the use of statins and breast cancer risk... - Prediagnostic use of hormone therapy and mortality after breast cancerPolly A Newcomb
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 17:864-71. 2008..Due to the high prevalence of past and current hormone use, it is important to investigate whether these preparations are related to breast cancer mortality... - Early life risk factors in cancer: the relation of birth weight to adult obesityNicole M Leong
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Int J Cancer 103:789-91. 2003..76). These data suggest that both low and high birth weights are associated with higher adult BMI and support the hypothesis that fetal experience may influence adult obesity with potential consequences for risk of several major cancers... - Proportion of invasive breast cancer attributable to risk factors modifiable after menopauseBrian L Sprague
Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI 53726, USA
Am J Epidemiol 168:404-11. 2008..3%. These findings suggest that a substantial fraction of postmenopausal breast cancer may be avoided by purposeful changes in lifestyle later in life... - Genetic variation in TP53 and risk of breast cancer in a population-based case control studyBrian L Sprague
Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI 53726, USA
Carcinogenesis 28:1680-6. 2007..03). These results indicate that common variation in the TP53 gene could modify the risk of invasive breast cancer... - Occupational exposure to electromagnetic field and breast cancer risk in a large, population-based, case-control study in the United StatesJane A McElroy
University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, WI 53726, USA
J Occup Environ Med 49:266-74. 2007..Our objective was to evaluate women who were occupationally exposed to electromagnetic fields (EMF) and breast cancer risk... - Postmenopausal estrogen and progestin use in relation to breast cancer riskPolly A Newcomb
University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53706, USA
Cancer Epidemiol Biomarkers Prev 11:593-600. 2002..09; 95% CI, 1.07-4.07 for ever use versus nonuse). Estrogen-progestin use, both sequential and continuous, appears to be more strongly associated with risk of breast cancer than use of estrogen alone... - Dietary fat consumption and primary open-angle glaucomaJae H Kang
Department of Epidemiology, Harvard School of Public Health, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Clin Nutr 79:755-64. 2004..Prostaglandin F(2alpha) analogues are effective intraocular-pressure-lowering drugs. Dietary fatty acids affect endogenous prostaglandin F(2alpha) concentrations and may thus influence intraocular pressure... - Sunlight and reduced risk of cancer: is the real story vitamin D?Kathleen M Egan
J Natl Cancer Inst 97:161-3. 2005 - Recreational physical activity and ovarian cancer in a population-based case-control studyElizabeth R Bertone
Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003 9304, USA
Int J Cancer 99:431-6. 2002..70; 95% CI = 0.36-1.35; p for trend = 0.41). Overall, our results provide only limited support for an inverse association between recreational physical activity and risk of ovarian cancer... - Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analysesMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 7076, Rockville, MD 20952 7234, USA
Hum Genet 119:376-88. 2006..Evaluation of potential underlying gene-gene interactions or associations in population subgroups will require even larger sample sizes... - Vitamin D receptor polymorphism and breast cancer riskPolly A Newcomb
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Epidemiol Biomarkers Prev 11:1503-4. 2002 - Duration of sleep and breast cancer risk in a large population-based case-control studyJane A McElroy
University of Wisconsin Comprehensive Cancer Center, Madison, 53726, USA
J Sleep Res 15:241-9. 2006..In contrast, short duration of sleep (<7 h/night) is not substantially associated with increased risk. Further research in this area is warranted... - Familial relative risk estimates for use in epidemiologic analysesYutaka Yasui
Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
Am J Epidemiol 164:697-705. 2006.... - From menarche to menopause: trends among US Women born from 1912 to 1969Hazel B Nichols
University of Wisconsin Comprehensive Cancer Center, Madison, WI 53726, USA
Am J Epidemiol 164:1003-11. 2006..1 years among women born between 1915 and 1919 to 37.7 years among the 1935-1939 cohort (p = 0.0001). These findings have implications for women's lifetime exposure to circulating endogenous hormones... - Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer riskMia M Gaudet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Hum Genet 121:483-90. 2007..Additional studies are required to replicate these findings and to determine whether rs361525 is a causative SNP or is a marker of a causative SNP... - Lifetime recreational and occupational physical activity and risk of in situ and invasive breast cancerBrian L Sprague
University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Department of Population Health Sciences, University of Wisconsin Madison, Madison, Wisconsin 53726, USA
Cancer Epidemiol Biomarkers Prev 16:236-43. 2007..Lifetime strenuous occupational activity was not associated with invasive breast cancer risk. These results provide further evidence that, for most women, physical activity may reduce the risk of invasive breast cancer... - Active and passive smoking in breast cancer: prospective results from the Nurses' Health StudyKathleen M Egan
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Epidemiology 13:138-45. 2002..The role of active and passive smoking in breast cancer remains controversial... - Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skinTeresa T Fung
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
Int J Cancer 103:110-5. 2003..No evidence was found that vitamins A, C and E; folate; or carotenoids play an important protective role against incident SCC... - Conservation treatment of the eye: Conformal proton reirradiation for recurrent uveal melanomaLaura Marucci
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 64:1018-22. 2006..Although most patients lost vision, the majority were able to retain the reirradiated eye. Further evaluation is needed to assess metastasis-free survival of additional proton irradiation vs. enucleation after local recurrence... - Dairy food and ovarian cancer riskPolly A Newcomb
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Lancet 367:797-9. 2006 - Oral contraceptive use and risk of breast carcinoma in situHazel B Nichols
University of Wisconsin Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53726, USA
Cancer Epidemiol Biomarkers Prev 16:2262-8. 2007..16; 95% CI, 1.01-1.32 for ever versus never use). Consistent with invasive breast cancer, these results suggest that oral contraceptive use is at most a minor contributor to BCIS risk... - Physical activity and survival after diagnosis of invasive breast cancerCrystal N Holick
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Cancer Epidemiol Biomarkers Prev 17:379-86. 2008..This study provides support for reduced overall mortality and mortality from breast cancer among women who engage in physical activity after breast cancer diagnosis...