Todd L Edwards

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Genome-wide association study identifies possible genetic risk factors for colorectal adenomas
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN 37203, USA
    Cancer Epidemiol Biomarkers Prev 22:1219-26. 2013
  2. pmc A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Cancer Prev Res (Phila) 5:855-63. 2012
  3. pmc HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes
    Todd L Edwards
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    Am J Epidemiol 175:11-21. 2012
  4. pmc A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 5:e9363. 2010
  5. pmc Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study
    Digna R Velez Edwards
    Center for Human Genetics Research, Vanderbilt Epidemiology Center Institute of Medicine and Public Health, Vanderbilt University, 2525 West End Avenue, Suite 600 6th fl, Nashville, TN 37203, USA
    Hum Genet 132:323-36. 2013
  6. pmc Variants in BET1L and TNRC6B associate with increasing fibroid volume and fibroid type among European Americans
    Todd L Edwards
    Vanderbilt Epidemiology Center, Vanderbilt University, 2525 West End Ave, Suite 600 6th Floor, Nashville, TN, 37203, USA
    Hum Genet 132:1361-9. 2013
  7. pmc Optimized selection of unrelated subjects for whole-genome sequencing studies of rare high-penetrance alleles
    Todd L Edwards
    Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN 37212 0700, USA
    Genet Epidemiol 36:472-9. 2012
  8. pmc Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Hum Hered 67:183-92. 2009
  9. pmc Pleiotropy between genetic markers of obesity and risk of prostate cancer
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37203, USA
    Cancer Epidemiol Biomarkers Prev 22:1538-46. 2013
  10. pmc Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Schizophr Res 106:208-17. 2008

Collaborators

Detail Information

Publications25

  1. pmc Genome-wide association study identifies possible genetic risk factors for colorectal adenomas
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN 37203, USA
    Cancer Epidemiol Biomarkers Prev 22:1219-26. 2013
    ..Removal of polyps reduces mortality from colorectal cancer. Colorectal adenomas are known to aggregate in families; however, the genetic determinants for risk of polyps are largely unknown...
  2. pmc A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Cancer Prev Res (Phila) 5:855-63. 2012
    ..We also observed effect modification of the HPGD signal by NSAID exposure...
  3. pmc HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes
    Todd L Edwards
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    Am J Epidemiol 175:11-21. 2012
    ..A SNP in CYP19A1 interacted with dietary energy intake in African Americans, and another SNP in CYP191A had an independent association with BMI in Caucasians...
  4. pmc A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 5:e9363. 2010
    ....
  5. pmc Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study
    Digna R Velez Edwards
    Center for Human Genetics Research, Vanderbilt Epidemiology Center Institute of Medicine and Public Health, Vanderbilt University, 2525 West End Avenue, Suite 600 6th fl, Nashville, TN 37203, USA
    Hum Genet 132:323-36. 2013
    ..04, P = 2.17 × 10(-7)). No results exceeded the Bonferroni-corrected statistical significance threshold...
  6. pmc Variants in BET1L and TNRC6B associate with increasing fibroid volume and fibroid type among European Americans
    Todd L Edwards
    Vanderbilt Epidemiology Center, Vanderbilt University, 2525 West End Ave, Suite 600 6th Floor, Nashville, TN, 37203, USA
    Hum Genet 132:1361-9. 2013
    ..This study is the first to evaluate these SNPs for association with UF characteristics and suggests these genes associate with increasing UF volume and protection from intramural UF in EAs...
  7. pmc Optimized selection of unrelated subjects for whole-genome sequencing studies of rare high-penetrance alleles
    Todd L Edwards
    Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN 37212 0700, USA
    Genet Epidemiol 36:472-9. 2012
    ....
  8. pmc Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Hum Hered 67:183-92. 2009
    ..Previously unknown aspects of MDR performance were the power to detect interactive effects given large numbers of non-model loci or varying degrees of heterogeneity among multiple epistatic disease models...
  9. pmc Pleiotropy between genetic markers of obesity and risk of prostate cancer
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37203, USA
    Cancer Epidemiol Biomarkers Prev 22:1538-46. 2013
    ..To address inconsistent findings of obesity and prostate cancer risk, we analyzed the association between prostate cancer and genetic markers of obesity and metabolism...
  10. pmc Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Schizophr Res 106:208-17. 2008
    ..We also observed a significant main effect in DTNBP1, which survived correction for multiple comparisons, and numerous nominally significant effects in several genes...
  11. pmc Race-specific impact of atrial fibrillation risk factors in blacks and whites in the southern community cohort study
    Loren Lipworth
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Cardiol 110:1637-42. 2012
    ..In conclusion, these findings confirm the lower prevalence of AF among blacks than whites and suggest that traditional risk factors for AF apply similarly to the 2 groups and thus do not appear to explain the AF paradox in blacks...
  12. pmc Enriching targeted sequencing experiments for rare disease alleles
    Todd L Edwards
    Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN 37203, USA
    Bioinformatics 27:2112-8. 2011
    ..This approach is reasonable, but may be inefficient for rare alleles if samples are not carefully selected for the resequencing experiment...
  13. pmc BET1L and TNRC6B associate with uterine fibroid risk among European Americans
    Todd L Edwards
    Vanderbilt Epidemiology Center, Vanderbilt University, 2525 West End Ave, Suite 600 6th Floor, Nashville, TN 37203, USA
    Hum Genet 132:943-53. 2013
    ..These data suggest common variants increase risk for UF in both EA and Japanese populations. However, further research is needed to assess the role of these genes across other racial groups...
  14. doi request reprint Smoking, sex, risk factors and abdominal aortic aneurysms: a prospective study of 18 782 persons aged above 65 years in the Southern Community Cohort Study
    Eiman Jahangir
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA John Ochsner Heart and Vascular Institute, Ochsner Clinical School The University of Queensland School of Medicine, New Orleans, Louisiana, USA
    J Epidemiol Community Health 69:481-8. 2015
    ..Abdominal aortic aneurysm (AAA) is a leading cause of death in the USA. We evaluated the incidence and predictors of AAA in a prospectively followed cohort...
  15. pmc Calcium intake and ion transporter genetic polymorphisms interact in human colorectal neoplasia risk in a 2-phase study
    Xiangzhu Zhu
    Division of Epidemiology, Vanderbilt Ingram Cancer Center, and Department of Veterans Affairs, Tennessee Valley Healthcare System, Geriatric, Research, Education and Clinical Center, Nashville, TN
    J Nutr 144:1734-41. 2014
    ....
  16. pmc Admixture mapping identifies a locus at 15q21.2-22.3 associated with keloid formation in African Americans
    Digna R Velez Edwards
    Vanderbilt Epidemiology Center, 2525 West End Ave, Suite 600 6th Floor, Nashville, TN, 37203, USA
    Hum Genet 133:1513-23. 2014
    ..Our findings support the admixture mapping approach for the study of keloid risk, and indicate potentially common genetic elements on chr15q21.2-22.3 in causation of keloids in AAs, Japanese, and Chinese populations...
  17. pmc Enhancing uterine fibroid research through utilization of biorepositories linked to electronic medical record data
    Lani Feingold-Link
    1 Department of Medicine, Vanderbilt University, Nashville, TN
    J Womens Health (Larchmt) 23:1027-32. 2014
    ..Our objective was to evaluate the performance and accuracy of a fibroid phenotyping algorithm constructed from electronic medical record (EMR) data, limiting to subjects with pelvic imaging...
  18. pmc Subclinical hypothyroidism and risk for incident ischemic stroke among postmenopausal women
    Ayush Giri
    1 Institute for Medicine and Public Health, Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee
    Thyroid 24:1210-7. 2014
    ..Subclinical hypothyroidism (SCH) is postulated to increase stroke risk via atherogenic changes associated with abnormal thyroid function. However, the direct relationship of SCH with subsequent stroke is poorly studied...
  19. pmc An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3
    Todd L Edwards
    Department of Molecular Physiology and Biophysics and Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee 37232, USA
    Am J Med Genet B Neuropsychiatr Genet 150:721-35. 2009
    ....
  20. pmc Addressing population-specific multiple testing burdens in genetic association studies
    Rafal S Sobota
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire
    Ann Hum Genet 79:136-47. 2015
    ..We conclude that the conventional genome-wide significance threshold generates an excess of Type 2 errors, particularly in GWAS performed on more recently founded populations. ..
  21. pmc A genome-wide association study to identify genomic modulators of rate control therapy in patients with atrial fibrillation
    Matthew J Kolek
    Department of Medicine, Vanderbilt University, Nashville, Tennessee
    Am J Cardiol 114:593-600. 2014
    ..However, these failed to reach genome-wide significance. ..
  22. pmc Subclinical hypothyroidism and risk for incident myocardial infarction among postmenopausal women
    Vicky A LeGrys
    Division of Clinical Laboratory Science, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Endocrinol Metab 98:2308-17. 2013
    ..However, few studies have specifically examined the association between SCH and myocardial infarction (MI), and the relationship is poorly understood...
  23. pmc Incidence and predictors of end stage renal disease among low-income blacks and whites
    Loren Lipworth
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA
    PLoS ONE 7:e48407. 2012
    ..Further research characterizing biomedical factors, including CKD progression, in ESRD occurrence in these two racial groups is needed...
  24. doi request reprint Patterns of cytokine profiles differ with pregnancy outcome and ethnicity
    Digna R Velez
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN, USA
    Hum Reprod 23:1902-9. 2008
    ..Preterm birth (PTB) is hypothesized to be an inflammatory response disease. However, no single factor alone is likely to explain PTB risk. It is more probable that coordinated networks of cytokines affect risk...
  25. pmc Exploring epistasis in candidate genes for rheumatoid arthritis
    Marylyn D Ritchie
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University Medical Center, 21st Avenue South and Garland Avenue, Nashville, Tennessee 37232, USA
    BMC Proc 1:S70. 2007
    ..This comparison should be extended in future studies with both simulated and real data...