Todd L Edwards

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Cancer Prev Res (Phila) 5:855-63. 2012
  2. ncbi HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes
    Todd L Edwards
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    Am J Epidemiol 175:11-21. 2012
  3. ncbi A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 5:e9363. 2010
  4. ncbi Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study
    Digna R Velez Edwards
    Center for Human Genetics Research, Vanderbilt Epidemiology Center Institute of Medicine and Public Health, Vanderbilt University, 2525 West End Avenue, Suite 600 6th fl, Nashville, TN 37203, USA
    Hum Genet 132:323-36. 2013
  5. ncbi Optimized selection of unrelated subjects for whole-genome sequencing studies of rare high-penetrance alleles
    Todd L Edwards
    Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN 37212 0700, USA
    Genet Epidemiol 36:472-9. 2012
  6. ncbi Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Hum Hered 67:183-92. 2009
  7. ncbi Enriching targeted sequencing experiments for rare disease alleles
    Todd L Edwards
    Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN 37203, USA
    Bioinformatics 27:2112-8. 2011
  8. ncbi Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Schizophr Res 106:208-17. 2008
  9. ncbi Race-specific impact of atrial fibrillation risk factors in blacks and whites in the southern community cohort study
    Loren Lipworth
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Cardiol 110:1637-42. 2012
  10. ncbi An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3
    Todd L Edwards
    Department of Molecular Physiology and Biophysics and Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee 37232, USA
    Am J Med Genet B Neuropsychiatr Genet 150:721-35. 2009

Detail Information

Publications12

  1. ncbi A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Cancer Prev Res (Phila) 5:855-63. 2012
    ..We also observed effect modification of the HPGD signal by NSAID exposure...
  2. ncbi HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes
    Todd L Edwards
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    Am J Epidemiol 175:11-21. 2012
    ..A SNP in CYP19A1 interacted with dietary energy intake in African Americans, and another SNP in CYP191A had an independent association with BMI in Caucasians...
  3. ncbi A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT
    Todd L Edwards
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 5:e9363. 2010
    ....
  4. ncbi Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study
    Digna R Velez Edwards
    Center for Human Genetics Research, Vanderbilt Epidemiology Center Institute of Medicine and Public Health, Vanderbilt University, 2525 West End Avenue, Suite 600 6th fl, Nashville, TN 37203, USA
    Hum Genet 132:323-36. 2013
    ..04, P = 2.17 × 10(-7)). No results exceeded the Bonferroni-corrected statistical significance threshold...
  5. ncbi Optimized selection of unrelated subjects for whole-genome sequencing studies of rare high-penetrance alleles
    Todd L Edwards
    Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN 37212 0700, USA
    Genet Epidemiol 36:472-9. 2012
    ....
  6. ncbi Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Hum Hered 67:183-92. 2009
    ..Previously unknown aspects of MDR performance were the power to detect interactive effects given large numbers of non-model loci or varying degrees of heterogeneity among multiple epistatic disease models...
  7. ncbi Enriching targeted sequencing experiments for rare disease alleles
    Todd L Edwards
    Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN 37203, USA
    Bioinformatics 27:2112-8. 2011
    ..SampleSeq also can be used to calculate the sample size needed for the resequencing to increase the chance of successful capture of rare alleles of desired frequencies. SOFTWARE: http://biostat.mc.vanderbilt.edu/SampleSeq..
  8. ncbi Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Schizophr Res 106:208-17. 2008
    ..We also observed a significant main effect in DTNBP1, which survived correction for multiple comparisons, and numerous nominally significant effects in several genes...
  9. ncbi Race-specific impact of atrial fibrillation risk factors in blacks and whites in the southern community cohort study
    Loren Lipworth
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Cardiol 110:1637-42. 2012
    ..In conclusion, these findings confirm the lower prevalence of AF among blacks than whites and suggest that traditional risk factors for AF apply similarly to the 2 groups and thus do not appear to explain the AF paradox in blacks...
  10. ncbi An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3
    Todd L Edwards
    Department of Molecular Physiology and Biophysics and Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee 37232, USA
    Am J Med Genet B Neuropsychiatr Genet 150:721-35. 2009
    ....
  11. ncbi Patterns of cytokine profiles differ with pregnancy outcome and ethnicity
    Digna R Velez
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN, USA
    Hum Reprod 23:1902-9. 2008
    ..Preterm birth (PTB) is hypothesized to be an inflammatory response disease. However, no single factor alone is likely to explain PTB risk. It is more probable that coordinated networks of cytokines affect risk...
  12. ncbi Exploring epistasis in candidate genes for rheumatoid arthritis
    Marylyn D Ritchie
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University Medical Center, 21st Avenue South and Garland Avenue, Nashville, Tennessee 37232, USA
    BMC Proc 1:S70. 2007
    ..This comparison should be extended in future studies with both simulated and real data...