Wonder P Drake

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Molecular analysis of sarcoidosis tissues for mycobacterium species DNA
    Wonder Puryear Drake
    Vanderbilt University School of Medicine and Veteran Affairs Medical Center, Nashville, Tennessee 37232, USA
    Emerg Infect Dis 8:1334-41. 2002
  2. pmc Effects of broad-spectrum antimycobacterial therapy on chronic pulmonary sarcoidosis
    Wonder Drake
    Division of Infectious Diseases Department of Medicine, Vanderbilt University Medical School, Nashville, TN 37232 2363 Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363
    Sarcoidosis Vasc Diffuse Lung Dis 30:201-11. 2013
  3. pmc Multiple mycobacterial antigens are targets of the adaptive immune response in pulmonary sarcoidosis
    Kyra A Oswald-Richter
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    Respir Res 11:161. 2010
  4. pmc Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101
    Kyra Oswald-Richter
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Clin Immunol 30:157-66. 2010
  5. ncbi request reprint Mycobacterial antigens may be important in sarcoidosis pathogenesis
    Wonder Puryear Drake
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Opin Pulm Med 12:359-63. 2006
  6. pmc Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis
    Wonder P Drake
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, 1161 21st Avenue, AA2200 MCN, Nashville, TN 37232, USA
    Infect Immun 75:527-30. 2007
  7. pmc Dual analysis for mycobacteria and propionibacteria in sarcoidosis BAL
    Kyra A Oswald-Richter
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    J Clin Immunol 32:1129-40. 2012
  8. pmc Cellular responses to mycobacterial antigens are present in bronchoalveolar lavage fluid used in the diagnosis of sarcoidosis
    Kyra A Oswald-Richter
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 2363, USA
    Infect Immun 77:3740-8. 2009
  9. pmc Reversal of global CD4+ subset dysfunction is associated with spontaneous clinical resolution of pulmonary sarcoidosis
    Kyra A Oswald-Richter
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:5446-53. 2013
  10. pmc Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses
    Shannon S Allen
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
    Respir Res 9:36. 2008

Detail Information

Publications15

  1. pmc Molecular analysis of sarcoidosis tissues for mycobacterium species DNA
    Wonder Puryear Drake
    Vanderbilt University School of Medicine and Veteran Affairs Medical Center, Nashville, Tennessee 37232, USA
    Emerg Infect Dis 8:1334-41. 2002
    ..tuberculosis were negative for IS6110. We provide evidence that one of a variety of Mycobacterium species, especially organisms resembling M. tuberculosis, is found in most patients with sarcoidosis...
  2. pmc Effects of broad-spectrum antimycobacterial therapy on chronic pulmonary sarcoidosis
    Wonder Drake
    Division of Infectious Diseases Department of Medicine, Vanderbilt University Medical School, Nashville, TN 37232 2363 Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363
    Sarcoidosis Vasc Diffuse Lung Dis 30:201-11. 2013
    ..Larger, randomized, controlled trials are needed to confirm these findings and to identify patients most likely to benefit from therapy. ClinicalTrials.gov number NCT01169038. ..
  3. pmc Multiple mycobacterial antigens are targets of the adaptive immune response in pulmonary sarcoidosis
    Kyra A Oswald-Richter
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    Respir Res 11:161. 2010
    ..To identify other microbial targets of the adaptive immune response, we tested the ability of CD4+ and CD8+ T cells to recognize multiple mycobacterial antigens...
  4. pmc Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101
    Kyra Oswald-Richter
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Clin Immunol 30:157-66. 2010
    ..We previously reported immune recognition of Mycobacterium peptides from peripheral cells of 26 sarcoidosis subjects, 24 PPD- healthy volunteers, and eight with latent tuberculosis infection...
  5. ncbi request reprint Mycobacterial antigens may be important in sarcoidosis pathogenesis
    Wonder Puryear Drake
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Opin Pulm Med 12:359-63. 2006
    ..To describe the most recent epidemiologic, molecular and immunologic literature related to the role of infectious antigens in sarcoidosis pathogenesis, with a focus upon Mycobacterium and Proprionibacterium species...
  6. pmc Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis
    Wonder P Drake
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, 1161 21st Avenue, AA2200 MCN, Nashville, TN 37232, USA
    Infect Immun 75:527-30. 2007
    ..0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis...
  7. pmc Dual analysis for mycobacteria and propionibacteria in sarcoidosis BAL
    Kyra A Oswald-Richter
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    J Clin Immunol 32:1129-40. 2012
    ....
  8. pmc Cellular responses to mycobacterial antigens are present in bronchoalveolar lavage fluid used in the diagnosis of sarcoidosis
    Kyra A Oswald-Richter
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 2363, USA
    Infect Immun 77:3740-8. 2009
    ..Inhibition of immune recognition with monoclonal antibody against Toll-like receptor 2 suggests that induction of innate immunity by mycobacteria contributes to the polarized Th1 immune response...
  9. pmc Reversal of global CD4+ subset dysfunction is associated with spontaneous clinical resolution of pulmonary sarcoidosis
    Kyra A Oswald-Richter
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:5446-53. 2013
    ..These findings implicate normalized CD4(+) T cell function as a potential therapeutic target for sarcoidosis resolution...
  10. pmc Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses
    Shannon S Allen
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
    Respir Res 9:36. 2008
    ..The purpose of this study is to investigate if target antigens of the sarcoidosis immune response can be identified by molecular analysis of sarcoidosis granulomas...
  11. pmc Oral antimycobacterial therapy in chronic cutaneous sarcoidosis: a randomized, single-masked, placebo-controlled study
    Wonder P Drake
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee2Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee
    JAMA Dermatol 149:1040-9. 2013
    ..This is the first randomized, placebo-controlled study to demonstrate that antimycobacterial therapy reduces lesion diameter and disease severity among patients with chronic cutaneous sarcoidosis...
  12. pmc Sarcoidosis Th17 cells are ESAT-6 antigen specific but demonstrate reduced IFN-╬│ expression
    Bradley W Richmond
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical School, Nashville, TN 37232 2363, USA
    J Clin Immunol 33:446-55. 2013
    ..It is unclear whether Th-17 cells in sarcoidosis are specific for mycobacterial antigens, or whether they have similar functionality to control Th-17 cells...
  13. ncbi request reprint The etiologic role of infectious antigens in sarcoidosis pathogenesis
    Kyra A Oswald-Richter
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    Semin Respir Crit Care Med 31:375-9. 2010
    ..These studies lay a strong foundation toward identifying therapeutic targets...
  14. ncbi request reprint Vitamin D, innate immunity, and sarcoidosis granulomatous inflammation: insights from mycobacterial research
    Bradley W Richmond
    Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 2363, USA
    Curr Opin Pulm Med 16:461-4. 2010
    ..Here, we briefly review evidence that mycobacterial antigens are involved in sarcoidosis pathogenesis, and explore how defects in innate immunity might contribute to the disease...
  15. pmc Mycobacterium tuberculosis Antigen 85A induces Th-1 immune responses in systemic sarcoidosis
    Rana Hajizadeh
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, 1161 21st Avenue, AA2200 MCN, Nashville, TN 37232, USA
    J Clin Immunol 27:445-54. 2007
    ....

Research Grants13

  1. Role of mycobacteria in sarcoidosis immunopathogenesis
    Wonder Drake; Fiscal Year: 2007
    ..These findings, which will assess in an independent and complementary fashion the role of mycobacteria in sarcoidosis immunopathogenesis, may have an impact on future therapeutic modalities for sarcoidosis. ..
  2. Investigation of the role of bacteria in the sarcoidosis trimolecular complex
    Wonder Drake; Fiscal Year: 2007
    ....
  3. Investigation of the role of bacteria in the sarcoidosis trimolecular complex
    Wonder Drake; Fiscal Year: 2006
    ....
  4. Role of mycobacteria in sarcoidosis immunopathogenesis
    Wonder Drake; Fiscal Year: 2009
    ..These findings, which will assess in an independent and complementary fashion the role of mycobacteria in sarcoidosis immunopathogenesis, may have an impact on future therapeutic modalities for sarcoidosis. ..
  5. Investigation of the role of bacteria in the sarcoidosis trimolecular complex
    Wonder Drake; Fiscal Year: 2009
    ..abstract_text> ..
  6. Investigation of the role of bacteria in the sarcoidosis trimolecular complex
    Wonder Drake; Fiscal Year: 2006
    ....
  7. Investigation of the role of bacteria in the sarcoidosis trimolecular complex
    Wonder Drake; Fiscal Year: 2006
    ....
  8. Role of mycobacteria in sarcoidosis immunopathogenesis
    Wonder Drake; Fiscal Year: 2006
    ..These findings, which will assess in an independent and complementary fashion the role of mycobacteria in sarcoidosis immunopathogenesis, may have an impact on future therapeutic modalities for sarcoidosis. ..
  9. Role of mycobacteria in sarcoidosis immunopathogenesis
    Wonder Drake; Fiscal Year: 2009
    ..These findings, which will assess in an independent and complementary fashion the role of mycobacteria in sarcoidosis immunopathogenesis, may have an impact on future therapeutic modalities for sarcoidosis. ..