Research Topics
| Wonder P DrakeSummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
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Detail Information
Publications
Molecular analysis of sarcoidosis tissues for mycobacterium species DNAWonder Puryear Drake
Vanderbilt University School of Medicine and Veteran Affairs Medical Center, Nashville, Tennessee 37232, USA
Emerg Infect Dis 8:1334-41. 2002..tuberculosis were negative for IS6110. We provide evidence that one of a variety of Mycobacterium species, especially organisms resembling M. tuberculosis, is found in most patients with sarcoidosis...- Multiple mycobacterial antigens are targets of the adaptive immune response in pulmonary sarcoidosisKyra A Oswald-Richter
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
Respir Res 11:161. 2010..To identify other microbial targets of the adaptive immune response, we tested the ability of CD4+ and CD8+ T cells to recognize multiple mycobacterial antigens... - Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101Kyra Oswald-Richter
Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
J Clin Immunol 30:157-66. 2010..We previously reported immune recognition of Mycobacterium peptides from peripheral cells of 26 sarcoidosis subjects, 24 PPD- healthy volunteers, and eight with latent tuberculosis infection... 
Mycobacterial antigens may be important in sarcoidosis pathogenesisWonder Puryear Drake
Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Curr Opin Pulm Med 12:359-63. 2006..To describe the most recent epidemiologic, molecular and immunologic literature related to the role of infectious antigens in sarcoidosis pathogenesis, with a focus upon Mycobacterium and Proprionibacterium species...- Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosisWonder P Drake
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, 1161 21st Avenue, AA2200 MCN, Nashville, TN 37232, USA
Infect Immun 75:527-30. 2007..0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis... - Cellular responses to mycobacterial antigens are present in bronchoalveolar lavage fluid used in the diagnosis of sarcoidosisKyra A Oswald-Richter
Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 2363, USA
Infect Immun 77:3740-8. 2009..Inhibition of immune recognition with monoclonal antibody against Toll-like receptor 2 suggests that induction of innate immunity by mycobacteria contributes to the polarized Th1 immune response... - Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responsesShannon S Allen
Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
Respir Res 9:36. 2008..The purpose of this study is to investigate if target antigens of the sarcoidosis immune response can be identified by molecular analysis of sarcoidosis granulomas... - Dual analysis for mycobacteria and propionibacteria in sarcoidosis BALKyra A Oswald-Richter
Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
J Clin Immunol 32:1129-40. 2012.... 
The etiologic role of infectious antigens in sarcoidosis pathogenesisKyra A Oswald-Richter
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
Semin Respir Crit Care Med 31:375-9. 2010..These studies lay a strong foundation toward identifying therapeutic targets...- Vitamin D, innate immunity, and sarcoidosis granulomatous inflammation: insights from mycobacterial researchBradley W Richmond
Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 2363, USA
Curr Opin Pulm Med 16:461-4. 2010..Here, we briefly review evidence that mycobacterial antigens are involved in sarcoidosis pathogenesis, and explore how defects in innate immunity might contribute to the disease... - Mycobacterium tuberculosis Antigen 85A induces Th-1 immune responses in systemic sarcoidosisRana Hajizadeh
Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, 1161 21st Avenue, AA2200 MCN, Nashville, TN 37232, USA
J Clin Immunol 27:445-54. 2007....
Research Grants
- Role of mycobacteria in sarcoidosis immunopathogenesisWonder Drake; Fiscal Year: 2007..These findings, which will assess in an independent and complementary fashion the role of mycobacteria in sarcoidosis immunopathogenesis, may have an impact on future therapeutic modalities for sarcoidosis. ..
- Investigation of the role of bacteria in the sarcoidosis trimolecular complexWonder Drake; Fiscal Year: 2007....
- Investigation of the role of bacteria in the sarcoidosis trimolecular complexWonder Drake; Fiscal Year: 2009..abstract_text> ..
- Role of mycobacteria in sarcoidosis immunopathogenesisWonder Drake; Fiscal Year: 2009..These findings, which will assess in an independent and complementary fashion the role of mycobacteria in sarcoidosis immunopathogenesis, may have an impact on future therapeutic modalities for sarcoidosis. ..