Sudhansu K Dey

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages
    Carol A Rouzer
    Departments of Biochemistry and Chemistry, Vanderbilt Institute for Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 0146
    J Biol Chem 279:34256-68. 2004
  2. ncbi Molecular cues to implantation
    S K Dey
    Department of Pediatrics, Vanderbilt University Medical Center, MCN D4100, Nashville, Tennessee 37232, USA
    Endocr Rev 25:341-73. 2004
  3. ncbi Progesterone receptor requires a co-chaperone for signalling in uterine biology and implantation
    Susanne Tranguch
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2678, USA
    Reprod Biomed Online 13:651-60. 2006
  4. ncbi Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, 2220 Pierce Avenue, Nashville, TN 37232 2279, USA
    Proc Natl Acad Sci U S A 103:19069-74. 2006
  5. ncbi Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Biol Chem 282:37770-82. 2007
  6. ncbi Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
    Susanne Tranguch
    Departments of Pediatrics, Cell and Developmental Biology, Cancer Biology, and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:14326-31. 2005
  7. ncbi Genetic loss of Faah compromises male fertility in mice
    Xiaofei Sun
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biol Reprod 80:235-42. 2009
  8. ncbi Deficiency of immunophilin FKBP52 promotes endometriosis
    Yasushi Hirota
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Pathol 173:1747-57. 2008
  9. ncbi Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer
    Takiko Daikoku
    Department of Pediatrics, Division of Reproductive and Development Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Cancer Res 67:5285-92. 2007
  10. ncbi Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA
    Cancer Cell 6:285-95. 2004

Research Grants

  1. ASPECTS OF BLASTOCYST IMPLANTATION
    SUDHANSU DEY; Fiscal Year: 2007
  2. Endocannabinoid Signaling During Early Pregnancy
    SUDHANSU DEY; Fiscal Year: 2007
  3. Reproductive Biology: Training for the 21st Century
    SUDHANSU DEY; Fiscal Year: 2007

Detail Information

Publications79

  1. ncbi Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages
    Carol A Rouzer
    Departments of Biochemistry and Chemistry, Vanderbilt Institute for Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 0146
    J Biol Chem 279:34256-68. 2004
    ..These results demonstrate autocrine regulation of TNF-alpha secretion by endogenous PGs synthesized primarily by COX-1 in RPM and suggest that COX-1 may play a significant role in the regulation of the early response to endotoxemia...
  2. ncbi Molecular cues to implantation
    S K Dey
    Department of Pediatrics, Vanderbilt University Medical Center, MCN D4100, Nashville, Tennessee 37232, USA
    Endocr Rev 25:341-73. 2004
    ..It is hoped that the forthcoming information will generate new ideas and concepts for a process that is essential for maintaining procreation and solving major reproductive health issues in women...
  3. ncbi Progesterone receptor requires a co-chaperone for signalling in uterine biology and implantation
    Susanne Tranguch
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2678, USA
    Reprod Biomed Online 13:651-60. 2006
    ..Future studies are likely to provide a better understanding of FKBP52-PR signalling in promoting uterine receptivity for implantation and may reveal new targets for improving infertility...
  4. ncbi Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, 2220 Pierce Avenue, Nashville, TN 37232 2279, USA
    Proc Natl Acad Sci U S A 103:19069-74. 2006
    ....
  5. ncbi Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Biol Chem 282:37770-82. 2007
    ..This study is clinically relevant because deferral of on time implantation leads to spontaneous pregnancy loss, and defective trophoblast invasion is one cause of preeclampsia in humans...
  6. ncbi Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
    Susanne Tranguch
    Departments of Pediatrics, Cell and Developmental Biology, Cancer Biology, and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:14326-31. 2005
    ..Collectively, the present investigation provides evidence for an in vivo role for this cochaperone in regulating tissue-specific hormone action and its critical role in uterine receptivity for implantation...
  7. ncbi Genetic loss of Faah compromises male fertility in mice
    Xiaofei Sun
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biol Reprod 80:235-42. 2009
    ..Collectively, the results show that aberrant endocannabinoid signaling via CNR1 impairs normal sperm function. Besides unveiling a new regulatory mechanism of sperm function, this study has clinical significance in male fertility...
  8. ncbi Deficiency of immunophilin FKBP52 promotes endometriosis
    Yasushi Hirota
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Pathol 173:1747-57. 2008
    ..This investigation is highly relevant for clinical application, particularly because P(4) resistance is favorably indicated in endometriosis and other gynecological diseases...
  9. ncbi Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer
    Takiko Daikoku
    Department of Pediatrics, Division of Reproductive and Development Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Cancer Res 67:5285-92. 2007
    ..The ability of aspirin to inhibit EOC growth in vivo is an exciting finding because of its low cost, lack of cardiovascular side effects, and availability...
  10. ncbi Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA
    Cancer Cell 6:285-95. 2004
    ..We demonstrate that PPARdelta is a focal point of crosstalk between the prostaglandin and Wnt signaling pathways which results in a shift from cell death to cell survival, leading to increased tumor growth...
  11. ncbi Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus
    Takiko Daikoku
    Department of Pediatrics and Cancer Biology, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Endocrinol 19:683-97. 2005
    ..Collectively, these results and the female infertility phenotype of FKBP52 suggest that a Hoxa10-FKBP52 signaling axis is critical to uterine receptivity and implantation...
  12. ncbi Cyclin G1 and cyclin G2 are expressed in the periimplantation mouse uterus in a cell-specific and progesterone-dependent manner: evidence for aberrant regulation with Hoxa-10 deficiency
    Limin Yue
    Division of Reproductive and Developmental Biology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Endocrinology 146:2424-33. 2005
    ....
  13. ncbi CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Exp Med 203:941-51. 2006
    ..Collectively, our findings show for the first time that CXCL1 is regulated by PGE2 and indicate that CXCL1 inhibitors should be evaluated further as potential anti-angiogenic agents for treatment of CRC...
  14. ncbi Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenessee 37232, USA
    Cancer Res 68:5619-27. 2008
    ..These mouse models have the added advantage because they mimic several features of human EMC...
  15. ncbi Inactivation of nuclear Wnt-beta-catenin signaling limits blastocyst competency for implantation
    Huirong Xie
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA
    Development 135:717-27. 2008
    ..These findings constitute novel evidence that Wnt signaling is at least one pathway that determines blastocyst competency for implantation...
  16. ncbi N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation
    Yong Guo
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 280:23429-32. 2005
    ..The expression is well correlated with its activity and anandamide levels. This study is clinically relevant, since elevated anandamide levels in peripheral circulation are associated with spontaneous pregnancy failure in women...
  17. ncbi Fatty acid amide hydrolase deficiency limits early pregnancy events
    Haibin Wang
    Department of Pediatrics, Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 116:2122-31. 2006
    ..This study uncovers what we believe to be a novel regulation of preimplantation processes, which could be clinically relevant for fertility regulation in women...
  18. ncbi FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific
    Susanne Tranguch
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2678, USA
    J Clin Invest 117:1824-34. 2007
    ....
  19. ncbi Hoxa-10 deficiency alters region-specific gene expression and perturbs differentiation of natural killer cells during decidualization
    Mohammad A Rahman
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 290:105-17. 2006
    ..Collectively, the results provide evidence that Hoxa-10 influences a host of genes and cell functions necessary for propagating normal decidual development during the post-implantation period...
  20. ncbi Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Prostaglandins Other Lipid Mediat 83:62-74. 2007
    ..The results suggest that aberrant functioning of these pathways impacting uterine anandamide and/or 2-AG levels would compromise pregnancy outcome...
  21. ncbi Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
    Dingzhi Wang
    Departments of Medicine, Vanderbilt University Medical Center, Nashville, Tenessee, USA
    Cancer Res 68:6468-76. 2008
    ..These results indicate that the endogenous cannabinoid system may represent a potential therapeutic target for prevention or treatment of colorectal cancer...
  22. ncbi Rescue of female infertility from the loss of cyclooxygenase-2 by compensatory up-regulation of cyclooxygenase-1 is a function of genetic makeup
    Haibin Wang
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 279:10649-58. 2004
    ..In light of this finding, the therapeutic use and efficacy of COX-2-specific inhibitors among human populations without regard for genetic and ethnic diversities should be revisited...
  23. ncbi Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus
    Xi Huang
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 136:2535-43. 2009
    ....
  24. ncbi Conditional gene recombination by adenovirus-driven Cre in the mouse uterus
    Haibin Wang
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2678, USA
    Genesis 44:51-6. 2006
    ..These findings demonstrate the feasibility of achieving conditional expression or deletion of specific genes in uterine cells at desired times and physiological states...
  25. ncbi Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2
    Carol A Rouzer
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Biochem J 399:91-9. 2006
    ..They also indicate that the 2-AG and AA used for PG-G and PG synthesis respectively are derived from independent pathways...
  26. ncbi Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer
    Michael G Backlund
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Cancer Res 68:9331-7. 2008
    ..These results also provide a cyclooxygenase-2-independent mechanism to explain increased PGE(2) levels that contribute to progression of CRC...
  27. ncbi Loss of cannabinoid receptor CB1 induces preterm birth
    Haibin Wang
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    PLoS ONE 3:e3320. 2008
    ..Since our previous studies demonstrated that loss of CB1 defers the normal implantation window in mice, we surmised that CB1 deficiency would influence parturition events...
  28. ncbi Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Cancer Res 65:3735-44. 2005
    ..The growth inhibitory effects of SC-560 result from reduced cell proliferation and/or accelerated apoptosis. Our results imply COX-1 as a target for the prevention and/or treatment of EOC...
  29. ncbi Maternal pentraxin 3 deficiency compromises implantation in mice
    Susanne Tranguch
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biol Reprod 77:425-32. 2007
    ..This study has clinical implications, since PTX3 is expressed in the receptive endometrium, and trophoblast cells influence decidual Ptx3 expression in humans...
  30. ncbi Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity
    Jiyoung Hong
    Pediatrics, Cell and Developmental Biology, Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Reproduction 133:395-403. 2007
    ..This study is clinically relevant because unraveling the role of immunophilin signaling in male fertility will help identify new targets for male contraceptives and/or alleviate male infertility...
  31. ncbi Cyclooxygenase-2-derived prostaglandin E(2) directs oocyte maturation by differentially influencing multiple signaling pathways
    Toshifumi Takahashi
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 281:37117-29. 2006
    ....
  32. ncbi Lipid signaling in embryo implantation
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Prostaglandins Other Lipid Mediat 77:84-102. 2005
    ..A better understanding of these molecular signaling pathways is hoped to generate new strategies to correct implantation failure and improve pregnancy rates in women...
  33. ncbi Uterine Msx-1 and Wnt4 signaling becomes aberrant in mice with the loss of leukemia inhibitory factor or Hoxa-10: evidence for a novel cytokine-homeobox-Wnt signaling in implantation
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Mol Endocrinol 18:1238-50. 2004
    ..Collectively, the present results provide evidence for a novel cytokine-homeotic-Wnt signaling network in implantation...
  34. ncbi Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer
    Rajnish A Gupta
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 63:906-11. 2003
    ....
  35. ncbi MicroRNA regulation of cyclooxygenase-2 during embryo implantation
    Anindita Chakrabarty
    Department of Pediatrics, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:15144-9. 2007
    ..Thus, elucidating the physiological roles of uterine miRNAs will help us better understand the genetic control of implantation, the gateway to a successful pregnancy...
  36. ncbi Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression
    Jason R Mann
    Departments of Cell and Developmental Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 2300 Pierce Avenue, Nashville, TN 37232, USA
    Cancer Res 66:6649-56. 2006
    ..These data indicate that PGDH may serve a tumor suppressor function in colorectal cancer and provide a possible COX-2-independent way to target PGE(2) to inhibit cancer progression...
  37. ncbi Aberrant cannabinoid signaling impairs oviductal transport of embryos
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Nat Med 10:1074-80. 2004
    ..Besides uncovering a new regulatory mechanism, this study could be clinically relevant to ectopic pregnancy...
  38. ncbi Maternal heparin-binding-EGF deficiency limits pregnancy success in mice
    Huirong Xie
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:18315-20. 2007
    ..Our study provides genetic evidence that HB-EGF is critical for normal implantation. This finding has high clinical relevance, because HB-EGF signaling is known to be important for human implantation...
  39. ncbi Endocannabinoid signaling directs periimplantation events
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232-2678, USA
    AAPS J 8:E425-32. 2006
    ..It is hoped that a deeper understanding will lead to potential clinical applications of the endocannabinoid system as a target for regulating female fertility...
  40. ncbi Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation
    Wen-Ge Ma
    Division of Reproductive and Developmental Biology and Department of Pediatric, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 100:2963-8. 2003
    ..These results suggest that careful regulation of estrogen levels is one of the important factors for improvement of female fertility in IVFET programs...
  41. ncbi Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:9960-5. 2005
    ....
  42. ncbi Canonical Wnt signaling is critical to estrogen-mediated uterine growth
    Xiaonan Hou
    Department of Pediatrics, D-4105 Medical Center North, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232-2678, USA
    Mol Endocrinol 18:3035-49. 2004
    ..Our present results provide evidence for a novel role of estrogen that targets early Wnt/beta-catenin signaling in an ER-independent manner to regulate the late uterine growth response that is ER dependent...
  43. ncbi Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice
    Vladimir R Babaev
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Circulation 113:108-17. 2006
    ..Here, we examined the impact of COX-1 deficiency in bone marrow-derived cells on early atherogenesis in the mouse...
  44. ncbi Roadmap to embryo implantation: clues from mouse models
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Nat Rev Genet 7:185-99. 2006
    ..A better understanding of periimplantation biology could alleviate female infertility and help to develop novel contraceptives...
  45. ncbi Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Cancer Res 66:2527-31. 2006
    ..The results provide further evidence that Cox-1 overexpression is common in various models of EOC. Thus, Cox-1 serves as a potential marker of EOC and is a possible target for the prevention and/or treatment of this deadly disease...
  46. ncbi Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation
    Kristin E Burnum
    Departments of Biochemistry, Mass Spectrometry Research Center, Nashville, TN 37232, USA
    J Lipid Res 50:2290-8. 2009
    ..Overall, molecular images revealed the dynamic complexity of lipid distributions in early pregnancy, signifying the importance of complex interplay of lipid molecules in uterine biology and implantation...
  47. ncbi Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation
    Haibin Wang
    Department of Pediatric, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 100:14914-9. 2003
    ....
  48. ncbi alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila
    Jessica R Von Stetina
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 135:3697-706. 2008
    ....
  49. ncbi Jekyll and hyde: two faces of cannabinoid signaling in male and female fertility
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Endocr Rev 27:427-48. 2006
    ..It is hoped that a deeper insight would lead to potential clinical applications of the endocannabinoid signaling as a target for correcting infertility and improving reproductive health in humans...
  50. ncbi Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth
    Rajnish A Gupta
    Department of Medicine, The Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6838, USA
    Nat Med 10:245-7. 2004
    ..The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-delta in the regulation of intestinal adenoma growth...
  51. ncbi Expression of hypoxia-inducible factors in the peri-implantation mouse uterus is regulated in a cell-specific and ovarian steroid hormone-dependent manner. Evidence for differential function of HIFs during early pregnancy
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2678, USA
    J Biol Chem 278:7683-91. 2003
    ..Using pharmacological, molecular, and genetic approaches, we also observed that although progesterone primarily up-regulates uterine HIF-1alpha expression, estrogen transiently stimulates that of HIF-2alpha...
  52. ncbi Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase
    Ling Gao
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 278:28479-89. 2003
    ..These findings strongly support the contention that a second pathway exists for the formation of bioactive PGs in vivo that is independent of COX...
  53. ncbi Implantation: molecular basis of embryo-uterine dialogue
    B C Paria
    Department of Pediatrics, Ralph L. Smith Research Center, University of Kansas Medical Center, Kansas City 66160, USA
    Int J Dev Biol 45:597-605. 2001
    ....
  54. ncbi Endocannabinoid signaling in synchronizing embryo development and uterine receptivity for implantation
    B C Paria
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2678, USA
    Chem Phys Lipids 121:201-10. 2002
    ....
  55. ncbi Deciphering the cross-talk of implantation: advances and challenges
    B C Paria
    Department of Pediatrics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160-7336, USA
    Science 296:2185-8. 2002
    ..Recent advances have identified numerous molecules involved in implantation (1-4), yet new discoveries have not yielded a unifying scheme for the mechanisms of implantation...
  56. ncbi Aspects of endocannabinoid signaling in periimplantation biology
    Xiaofei Sun
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mol Cell Endocrinol 286:S3-11. 2008
    ..The information generated from studies in mice is likely to shed deeper insight into fertility regulation in women...
  57. ncbi Expression of neu differentiation factor during the periimplantation period in the mouse uterus
    J Reese
    Department of Pediatrics, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338, USA
    Biol Reprod 58:719-27. 1998
    ....
  58. ncbi Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors
    B C Paria
    Department of Pediatrics, University of Kansas Medical Center, Ralph L Smith Research Center, Kansas City, KS 66160 7338, USA
    Proc Natl Acad Sci U S A 98:1047-52. 2001
    ..Significantly, beads containing BMP-2 do not themselves elicit an implantation response but affect the spacing of implantation sites induced by blastocysts cotransferred with the beads...
  59. ncbi Progesterone receptor requires a co-chaperone for signalling in uterine biology and implantation
    Susanne Tranguch
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2678, USA
    Reprod Biomed Online 14:39-48. 2007
    ..Future studies are likely to provide a better understanding of FKBP52-PR signalling in promoting uterine receptivity for implantation and may reveal new targets for improving infertility...
  60. ncbi Imaging mass spectrometry reveals unique protein profiles during embryo implantation
    Kristin E Burnum
    Department of Chemistry and Biochemistry, Mass Spectrometry Research Center, Vanderbilt University Medical Center, MCN D4100, 1161 21st Avenue South, Nashville, TN 37232, USA
    Endocrinology 149:3274-8. 2008
    ..More interestingly, the use of this approach has provided new insights regarding uterine biology of cytosolic phospholipase A(2alpha) null females that show implantation defects...
  61. ncbi Molecular complexity in establishing uterine receptivity and implantation
    S Tranguch
    Department of Pediatrics, Vanderbilt University Medical Center, MCN-D4100, Nashville, Tennessee, 37232, USA
    Cell Mol Life Sci 62:1964-73. 2005
    ..Unraveling the nature of these signals and discovering additional molecular cascades may lead to strategies to correct implantation failure and improve pregnancy rates in women...
  62. ncbi Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation
    J Reese
    Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 276:44137-45. 2001
    ..The identification of unique genetic markers for the onset of implantation signifies that genome-wide analysis coupled with functional assays is a promising approach to resolve the molecular pathways required for successful implantation...
  63. ncbi Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR
    J Reese
    Department of Pediatrics, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338, USA
    Endocrinology 141:1872-81. 2000
    ..The function of uterine PRLR remains unclear. However, the eventual loss of pregnancy in P4-treated PRLR-/- mice suggests that uterine PRLR may be essential for the support of late gestation...
  64. ncbi Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation
    B C Paria
    Department of Pediatrics, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160 7338, USA
    J Biol Chem 276:20523-8. 2001
    ..The present study is clinically important because of the widely debated medicinal use of cannabinoids and their reported adverse effects on pregnancy...
  65. ncbi Comparative analysis of pharmacologic and/or genetic disruption of cyclooxygenase-1 and cyclooxygenase-2 function in female reproduction in mice
    J Reese
    Department of Pediatrics, University of Kansas Medical Center, Ralph L Smith Research Center, Kansas City, Kansas 66160 7338, USA
    Endocrinology 142:3198-206. 2001
    ..This investigation raises caution regarding the indiscriminate use of COX inhibitors and shows for the first time the distinct and overlapping pathways of the cyclooxygenase systems in female reproduction...
  66. ncbi Coordinated regulation of fetal and maternal prostaglandins directs successful birth and postnatal adaptation in the mouse
    J Reese
    Department of Pediatrics, University of Kansas Medical Center, Kansas City 66160 7338, USA
    Proc Natl Acad Sci U S A 97:9759-64. 2000
    ..Collectively, these findings demonstrate the coordinated regulation of fetal and maternal PGs at the time of birth but raise concern regarding the use of selective COX inhibitors for the management of preterm labor...
  67. ncbi COX-2 compensation in the uterus of COX-1 deficient mice during the pre-implantation period
    J Reese
    Department of Pediatrics, University of Kansas Medical Center, Kansas City 66160 7338, USA
    Mol Cell Endocrinol 150:23-31. 1999
    ..These data indicate that COX-1-derived PGs are important during uterine preparation for implantation, and that COX-2 compensation occurs in the absence of COX-1...
  68. ncbi Preimplantation mouse blastocysts fail to express CYP genes required for estrogen biosynthesis
    M Stromstedt
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Mol Reprod Dev 43:428-36. 1996
    ..Maternal estrogen synthesis is essential for implantation of the mouse blastocyst...
  69. ncbi Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2
    Ruxana T Sadikot
    Department of Veterans Affairs, Jesse Brown VA Hospital, Chicago, IL 60612, USA
    Eur J Immunol 37:1001-9. 2007
    ..Thus it is possible that inhibition of COX-2 or EP2 receptors could be an effective adjunctive treatment for severe or resistant P. aeruginosa pneumonia...
  70. ncbi Focus on implantation
    Sudhansu K Dey
    Reproduction 128:655-6. 2004
  71. ncbi A novel pathway of prostacyclin signaling-hanging out with nuclear receptors
    Hyunjung Lim
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Endocrinology 143:3207-10. 2002
    ..This review attempts to cover recent developments in nuclear actions of PGI(2) in diverse biological functions...
  72. ncbi Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development
    Haengseok Song
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160 7336, USA
    Development 129:2879-89. 2002
    ....
  73. ncbi Cyclooxygenase-2 differentially directs uterine angiogenesis during implantation in mice
    Hiromichi Matsumoto
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160 7336, USA
    J Biol Chem 277:29260-7. 2002
    ..The attenuation of uterine angiogenesis in these mice is primarily due to defective VEGF signaling and not due to the defective angiopoietin system...
  74. ncbi Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors
    Peter B Anning
    Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Blood 108:4059-62. 2006
    ..These data indicate that NO suppresses vascular side effects of NSAIDs, suggesting that risk will be greatest in patients with impaired vascular function associated with decreased NO bioavailability...
  75. ncbi Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage
    Daekee Lee
    Department of Genetics, CB 7264, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell Biol 24:8907-16. 2004
    ..However, Ereg null mice are highly susceptible to cancer-predisposing intestinal damage caused by oral administration of dextran sulfate sodium...
  76. ncbi Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha
    Taisuke Otani
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Physiol Gastrointest Liver Physiol 290:G361-8. 2006
    ..The decrease in amounts of 15-PGDH in inflamed mucosa can be explained at least, in part, by TNF-alpha-mediated suppression of 15-PGDH transcription...
  77. ncbi Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade
    Dingzhi Wang
    Departments of Medicine, Pediatrics, Cancer Biology, and Cell and Developmental and Biology, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee
    Cancer Res 65:1822-9. 2005
    ..One intriguing finding is that COX-2-derived PGE2 mimics the effects of constitutively active Ras through a self-amplifying loop that allows for a distinct growth advantage...
  78. ncbi Evidence for coordinated interaction of cyclin D3 with p21 and cdk6 in directing the development of uterine stromal cell decidualization and polyploidy during implantation
    Jian Tan
    Department of Obstetrics and Gynecology, MRRC 37 3004, Ralph L Smith Research Center, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7338, USA
    Mech Dev 111:99-113. 2002
    ....
  79. ncbi Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation
    Toshio Hamatani
    Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:10326-31. 2004
    ....

Research Grants5

  1. ASPECTS OF BLASTOCYST IMPLANTATION
    SUDHANSU DEY; Fiscal Year: 2007
    ..Basic research to better understand these events will help alleviate problems of infertility, and aid in the development of new and improved contraceptive methods. ..
  2. Endocannabinoid Signaling During Early Pregnancy
    SUDHANSU DEY; Fiscal Year: 2007
    ..abstract_text> ..
  3. Reproductive Biology: Training for the 21st Century
    SUDHANSU DEY; Fiscal Year: 2007
    ..These areas of research training require the infusion and active participation of preceptors who are experts in developmental biology, signal transductions, genomics and proteomics (Lee, Caprioli, and Sealy). ..