Joshua C Denny

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Chapter 13: Mining electronic health records in the genomics era
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS Comput Biol 8:e1002823. 2012
  2. doi request reprint Tracking medical students' clinical experiences using natural language processing
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University Medical Center, Eskind Biomedical Library, Room 442, 2209 Garland Ave, Nashville, TN 37232, USA
    J Biomed Inform 42:781-9. 2009
  3. pmc PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA
    Bioinformatics 26:1205-10. 2010
  4. pmc Evaluation of a method to identify and categorize section headers in clinical documents
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt UniversitySchool of Medicine, Eskind Biomedical Library, Room 442, 2209 Garland Ave, Nashville TN 37232, USA
    J Am Med Inform Assoc 16:806-15. 2009
  5. pmc Identifying QT prolongation from ECG impressions using a general-purpose Natural Language Processor
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
    Int J Med Inform 78:S34-42. 2009
  6. ncbi request reprint Identifying QT prolongation from ECG impressions using natural language processing and negation detection
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Stud Health Technol Inform 129:1283-8. 2007
  7. pmc Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN 37232, USA
    Am J Hum Genet 89:529-42. 2011
  8. pmc Extracting timing and status descriptors for colonoscopy testing from electronic medical records
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, USA
    J Am Med Inform Assoc 17:383-8. 2010
  9. pmc Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record
    Marylyn D Ritchie
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Am J Hum Genet 86:560-72. 2010
  10. pmc Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records
    Logan Dumitrescu
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA
    Genet Med 12:648-50. 2010

Collaborators

Detail Information

Publications55

  1. pmc Chapter 13: Mining electronic health records in the genomics era
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS Comput Biol 8:e1002823. 2012
    ..This chapter reviews several examples of phenotype extraction and their application to genetic research, demonstrating a viable future for genomic discovery using EHR-linked data...
  2. doi request reprint Tracking medical students' clinical experiences using natural language processing
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University Medical Center, Eskind Biomedical Library, Room 442, 2209 Garland Ave, Nashville, TN 37232, USA
    J Biomed Inform 42:781-9. 2009
    ..The coupling of section header identification and concept identification holds promise for other natural language processing tasks, such as clinical research or phenotype identification...
  3. pmc PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA
    Bioinformatics 26:1205-10. 2010
    ..The primary outcome of this study was replication of seven previously known SNP-disease associations for these SNPs...
  4. pmc Evaluation of a method to identify and categorize section headers in clinical documents
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt UniversitySchool of Medicine, Eskind Biomedical Library, Room 442, 2209 Garland Ave, Nashville TN 37232, USA
    J Am Med Inform Assoc 16:806-15. 2009
    ..The authors designed and evaluated an algorithm ("SecTag") to identify both labeled and unlabeled (implied) note section headers in "history and physical examination" documents ("H&P notes")...
  5. pmc Identifying QT prolongation from ECG impressions using a general-purpose Natural Language Processor
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
    Int J Med Inform 78:S34-42. 2009
    ..We investigated the accuracy of natural language processing (NLP) for identifying QT prolongation from cardiologist-generated, free-text ECG impressions compared to corrected QT (QTc) thresholds reported by ECG machines...
  6. ncbi request reprint Identifying QT prolongation from ECG impressions using natural language processing and negation detection
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Stud Health Technol Inform 129:1283-8. 2007
    ..We conclude that a natural language processing system can effectively identify QT prolongation and other cardiac diagnoses from ECG impressions for potential decision support and clinical research...
  7. pmc Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN 37232, USA
    Am J Hum Genet 89:529-42. 2011
    ..Our findings indicate that EMR-linked genomic data could allow discovery of genes associated with many diseases without additional genotyping cost...
  8. pmc Extracting timing and status descriptors for colonoscopy testing from electronic medical records
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, USA
    J Am Med Inform Assoc 17:383-8. 2010
    ..Further investigations must validate extension of NLP approaches for other types of CRC screening applications...
  9. pmc Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record
    Marylyn D Ritchie
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Am J Hum Genet 86:560-72. 2010
    ....
  10. pmc Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records
    Logan Dumitrescu
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA
    Genet Med 12:648-50. 2010
    ....
  11. pmc Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science
    Joshua C Denny
    Office of Personalized Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 0575, USA
    Circulation 122:2016-21. 2010
    ..The extent to which this can be demonstrated in cohorts derived from electronic medical records is unknown...
  12. pmc Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records
    Matthew T Oetjens
    Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University, 2215 Garland Avenue, 519 Light Hall, Nashville, TN 37232 0700, USA
    Pharmacogenomics 14:735-44. 2013
    ..The ADME Core Panel assays 184 variants across 34 pharmacogenes, many of which are difficult to accurately genotype with standard multiplexing methods...
  13. pmc Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record
    Andrea H Ramirez
    Department of Medicine, Vanderbilt University in Nashville, TN 37232, USA
    Pharmacogenomics 13:407-18. 2012
    ..Electronic health record (EHR) systems linked to biobanks may allow for pharmacogenomic analysis, but they have not yet been used for this purpose...
  14. pmc Development of a natural language processing system to identify timing and status of colonoscopy testing in electronic medical records
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA
    AMIA Annu Symp Proc 2009:141. 2009
    ..The system detected completed colonoscopies with recall and precision of 0.93 and 0.92. The system was superior to a query of colonoscopy billing codes to determine screening status...
  15. pmc Applying active learning to high-throughput phenotyping algorithms for electronic health records data
    Yukun Chen
    Department of Biomedical Informatics, Vanderbilt University, School of Medicine, Nashville, Tennessee, USA
    J Am Med Inform Assoc 20:e253-9. 2013
    ..However, they often require large numbers of annotated samples, which are costly and time-consuming to review. We investigated the use of active learning (AL) in ML-based phenotyping algorithms...
  16. pmc Development and evaluation of an ensemble resource linking medications to their indications
    Wei Qi Wei
    Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, USA
    J Am Med Inform Assoc 20:954-61. 2013
    ..To create a computable MEDication Indication resource (MEDI) to support primary and secondary use of electronic medical records (EMRs)...
  17. pmc Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk
    Marylyn D Ritchie
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA
    Circulation 127:1377-85. 2013
    ..ECG QRS duration, a measure of cardiac intraventricular conduction, varies ≈2-fold in individuals without cardiac disease. Slow conduction may promote re-entrant arrhythmias...
  18. pmc Detecting abbreviations in discharge summaries using machine learning methods
    Yonghui Wu
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA
    AMIA Annu Symp Proc 2011:1541-9. 2011
    ..8% (precision 98.8% and recall of 91.2%). When a voting scheme was used to combine output from various ML classifiers, the system achieved the highest F-measure of 95.7%...
  19. ncbi request reprint A common variant on chromosome 4q25 is associated with prolonged PR interval in subjects with and without atrial fibrillation
    Matthew J Kolek
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
    Am J Cardiol 113:309-13. 2014
    ....
  20. pmc A comparative study of current Clinical Natural Language Processing systems on handling abbreviations in discharge summaries
    Yonghui Wu
    Department of Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, TN, USA
    AMIA Annu Symp Proc 2012:997-1003. 2012
    ..This study suggested that accurate identification of clinical abbreviations is a challenging task and that more advanced abbreviation recognition modules might improve existing clinical NLP systems...
  21. pmc Modeling drug exposure data in electronic medical records: an application to warfarin
    Mei Liu
    Department of Biomedical Informatics, Vanderbilt University, School of Medicine, Nashville, TN, USA
    AMIA Annu Symp Proc 2011:815-23. 2011
    ..We applied the framework to determine patient warfarin exposure at hospital admissions and achieved 87% precision, 79% recall, and an area under the receiver-operator characteristic curve of 0.93...
  22. doi request reprint Natural language processing improves identification of colorectal cancer testing in the electronic medical record
    Joshua C Denny
    Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8300, USA
    Med Decis Making 32:188-97. 2012
    ..Difficulty identifying patients in need of colorectal cancer (CRC) screening contributes to low screening rates...
  23. pmc Analyses of longitudinal, hospital clinical laboratory data with application to blood glucose concentrations
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Stat Med 30:3208-20. 2011
    ..To illustrate these points, we present a detailed analysis of the relationship between blood glucose levels and insulin doses on the basis of data from an intensive care unit...
  24. pmc Modulators of normal electrocardiographic intervals identified in a large electronic medical record
    Andrea H Ramirez
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Heart Rhythm 8:271-7. 2011
    ..Traditional electrocardiographic (ECG) reference ranges were derived from studies in communities or clinical trial populations. The distribution of ECG parameters in a large population presenting to a healthcare system has not been studied...
  25. pmc An analytical approach to characterize morbidity profile dissimilarity between distinct cohorts using electronic medical records
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2156, USA
    J Biomed Inform 43:914-23. 2010
    ..The phenotypes studied include type II diabetes and type II diabetes controls, peripheral arterial disease and peripheral arterial disease controls, normal cardiac conduction as measured by electrocardiography, and senile cataracts...
  26. ncbi request reprint Validation and enhancement of a computable medication indication resource (MEDI) using a large practice-based dataset
    Wei Qi Wei
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN
    AMIA Annu Symp Proc 2013:1448-56. 2013
    ..We believe MEDI will be useful for both clinical informatics and to aid in recognition of phenotypes for electronic medical record-based research. ..
  27. pmc Integrating existing natural language processing tools for medication extraction from discharge summaries
    Son Doan
    Department of Biomedical Informatics, Vanderbilt University, School of Medicine, Nashville, TN, USA
    J Am Med Inform Assoc 17:528-31. 2010
    ..This task required accurate recognition of medication name, dosage, mode, frequency, duration, and reason for drug administration...
  28. pmc Automated extraction of clinical traits of multiple sclerosis in electronic medical records
    Mary F Davis
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Am Med Inform Assoc 20:e334-40. 2013
    ..We evaluated natural language processing techniques applied to electronic medical records (EMR) to identify MS patients and the key clinical traits of their disease course...
  29. ncbi request reprint Analyzing differences between chinese and english clinical text: a cross-institution comparison of discharge summaries in two languages
    Yonghui Wu
    School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TN, USA
    Stud Health Technol Inform 192:662-6. 2013
    ..Our study also provided valuable insights for developing natural language processing tools for Chinese clinical text. ..
  30. pmc Portability of an algorithm to identify rheumatoid arthritis in electronic health records
    Robert J Carroll
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Am Med Inform Assoc 19:e162-9. 2012
    ..This study evaluated the portability of a published phenotype algorithm to identify rheumatoid arthritis (RA) patients from EHR records at three institutions with different EHR systems...
  31. pmc A study of transportability of an existing smoking status detection module across institutions
    Mei Liu
    Department of Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, TN, USA
    AMIA Annu Symp Proc 2012:577-86. 2012
    ..Our results showed that the customized module achieved significantly higher F-measures at all levels of classification (i.e., sentence, document, patient) compared to the direct application of the cTAKES module to the Vanderbilt data...
  32. pmc PASTE: patient-centered SMS text tagging in a medication management system
    Shane P Stenner
    Department of Biomedical Informatics, Vanderbilt University, School of Medicine, Nashville, Tennessee, USA
    J Am Med Inform Assoc 19:368-74. 2012
    ..To evaluate the performance of a system that extracts medication information and administration-related actions from patient short message service (SMS) messages...
  33. pmc A study of machine-learning-based approaches to extract clinical entities and their assertions from discharge summaries
    Min Jiang
    Department of Biomedical Informatics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, USA
    J Am Med Inform Assoc 18:601-6. 2011
    ..This project was part of the 2010 Center of Informatics for Integrating Biology and the Bedside/Veterans Affairs (VA) natural-language-processing challenge...
  34. pmc Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin
    Hua Xu
    Department of Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Am Med Inform Assoc 18:387-91. 2011
    ..This study sought to develop natural-language-processing algorithms to extract drug-dose information from clinical text, and to assess the capabilities of such tools to automate the data-extraction process for pharmacogenetic studies...
  35. pmc Data from clinical notes: a perspective on the tension between structure and flexible documentation
    S Trent Rosenbloom
    Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Am Med Inform Assoc 18:181-6. 2011
    ..When reusable data are needed from notes, providers can use structured documentation or rely on post-hoc text processing to produce structured data, as appropriate...
  36. ncbi request reprint Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans
    Janina M Jeff
    Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 9:e86931. 2014
    ..We identified 13 independent associations between TCIRG1, CHKA, and ALDH3B1 genes on chromosome 11 and T2D. Our results suggest a novel region on chromosome 11 identified by admixture mapping is associated with T2D in African Americans...
  37. ncbi request reprint Biobanks and electronic medical records: enabling cost-effective research
    Erica Bowton
    Institute for Clinical and Translational Research, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Sci Transl Med 6:234cm3. 2014
    ..Here, we present a model that highlights potential advantages for genomic discovery and describe the operational infrastructure that facilitated multiple simultaneous discovery efforts. ..
  38. pmc Mapping the incidentalome: estimating incidental findings generated through clinical pharmacogenomics testing
    Matthew J Westbrook
    Center for Biomedical Ethics and Society, Vanderbilt University, Nashville, Tennessee, USA
    Genet Med 15:325-31. 2013
    ..Of particular importance are disparities in findings relevant to different ancestry groups...
  39. pmc The effect of reducing maximum shift lengths to 16 hours on internal medicine interns' educational opportunities
    Cecelia N Theobald
    Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee 37212, USA
    Acad Med 88:512-8. 2013
    ..To evaluate educational experiences of internal medicine interns before and after maximum shift lengths were decreased from 30 hours to 16 hours...
  40. pmc Applying semantic-based probabilistic context-free grammar to medical language processing--a preliminary study on parsing medication sentences
    Hua Xu
    Department of Biomedical Informatics, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA
    J Biomed Inform 44:1068-75. 2011
    ..Our evaluation using a 10-fold cross validation showed that the PCFG parser dramatically improved parsing performance when compared to the CFG parser...
  41. pmc Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks
    Stephen D Turner
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 6:e19586. 2011
    ..These results demonstrate that gene-gene interactions modulate complex human traits, including HDL cholesterol...
  42. doi request reprint Teaching evidence-based medicine: Impact on students' literature use and inpatient clinical documentation
    Elizabeth Ann Sastre
    Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Med Teach 33:e306-12. 2011
    ..Effective teaching of evidence-based medicine (EBM) to medical students is important for lifelong self-directed learning...
  43. doi request reprint Development of inpatient risk stratification models of acute kidney injury for use in electronic health records
    Michael E Matheny
    Geriatric Research Education Clinical Center, Tennessee Valley Health System, Veterans Health Administration, Nashville, TN, USA
    Med Decis Making 30:639-50. 2010
    ....
  44. pmc The disclosure of diagnosis codes can breach research participants' privacy
    Grigorios Loukides
    Department of Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, Tennessee 37203, USA
    J Am Med Inform Assoc 17:322-7. 2010
    ....
  45. ncbi request reprint Using systems approaches to address challenges for clinical implementation of pharmacogenomics
    Jason H Karnes
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Wiley Interdiscip Rev Syst Biol Med 6:125-35. 2014
    ....
  46. pmc Enabling genomic-phenomic association discovery without sacrificing anonymity
    Raymond D Heatherly
    Department of Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, TN, USA
    PLoS ONE 8:e53875. 2013
    ..We demonstrate this strategy with a dataset of over one million medical records and show that 192 genotype-phenotype associations can be discovered with fidelity equivalent to non-anonymized clinical data...
  47. doi request reprint Detecting temporal expressions in medical narratives
    Ruth M Reeves
    Geriatric Research Education and Clinical Center, Tennessee Valley Healthcare System, Department of Veterans Affairs, Nashville, TN, USA
    Int J Med Inform 82:118-27. 2013
    ..TTK was developed on newspaper articles. We extended TTK to support medical notes using veterans' affairs (VA) clinical notes and compared it to TTK...
  48. pmc MedEx: a medication information extraction system for clinical narratives
    Hua Xu
    Department of Biomedical Informatics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, USA
    J Am Med Inform Assoc 17:19-24. 2010
    ..5%, 93.9%, and 96.0% respectively. We then applied MedEx unchanged to outpatient clinic visit notes. It performed similarly with F-measures over 90% on a set of 25 clinic visit notes...
  49. pmc Comparing content coverage in medical curriculum to trainee-authored clinical notes
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN
    AMIA Annu Symp Proc 2010:157-61. 2010
    ..Such methods may prove useful for future curriculum evaluations and revisions...
  50. pmc "Where do we teach what?" Finding broad concepts in the medical school curriculum
    Joshua C Denny
    Department of Medicine, Vanderbilt School of Medicine, Nashville, TN 37232, USA
    J Gen Intern Med 20:943-6. 2005
    ..Often, medical educators and students do not know where important concepts are taught and learned in medical school. Manual efforts to identify and track concepts covered across the curriculum are inaccurate and resource intensive...
  51. pmc "Understanding" medical school curriculum content using KnowledgeMap
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    J Am Med Inform Assoc 10:351-62. 2003
    ..The long-term goal of the KnowledgeMap (KM) project is to provide faculty and students with an improved ability to develop, review, and integrate components of the medical school curriculum...
  52. pmc Computational phenotype discovery using unsupervised feature learning over noisy, sparse, and irregular clinical data
    Thomas A Lasko
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS ONE 8:e66341. 2013
    ..We expect such data-driven phenotypes to expose unknown disease variants and subtypes and to provide rich targets for genetic association studies. ..
  53. pmc Naïve Electronic Health Record phenotype identification for Rheumatoid arthritis
    Robert J Carroll
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA
    AMIA Annu Symp Proc 2011:189-96. 2011
    ..We show that with an expert defined feature set as few as 50-100 training samples are required. This study demonstrates that SVMs operating on non-curated sets of attributes can accurately identify cases from an EHR...
  54. pmc Automatic capture of student notes to augment mentor feedback and student performance on patient write-ups
    Anderson Spickard
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    J Gen Intern Med 23:979-84. 2008
    ..To determine whether the integration of an automated electronic clinical portfolio into clinical clerkships can improve the quality of feedback given to students on their patient write-ups and the quality of students' write-ups...
  55. ncbi request reprint Portal venous hyperinsulinemia does not stimulate gut glucose absorption in the conscious dog
    Raul C Camacho
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashille, TN 37232, USA
    Metabolism 53:1290-5. 2004
    ..This study shows that under physiological conditions, a portal vein insulin infusion that results in circulating hyperinsulinemia does not increase either transporter-mediated or passive absorption of an intraduodenal glucose load...