Michael R Debaun

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure
    Michael R Debaun
    Department of Pediatrics, Division of Hematology Oncology, Vanderbilt University, Nashville, TN, USA
    Blood 119:3684-90. 2012
  2. doi request reprint Transition and sickle cell disease
    Michael R Debaun
    Department of Pediatrics, Vanderbilt University School of Medicine and Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee 37232 9000, USA
    Pediatrics 130:926-35. 2012
  3. pmc Silent cerebral infarcts: a review on a prevalent and progressive cause of neurologic injury in sickle cell anemia
    Michael R Debaun
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Blood 119:4587-96. 2012
  4. doi request reprint Secondary prevention of overt strokes in sickle cell disease: therapeutic strategies and efficacy
    Michael R Debaun
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hematology Am Soc Hematol Educ Program 2011:427-33. 2011
  5. ncbi request reprint Asthma is associated with increased mortality in individuals with sickle cell anemia
    Jessica H Boyd
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    Haematologica 92:1115-8. 2007
  6. pmc Daytime pulse oximeter measurements do not predict incidence of pain and acute chest syndrome episodes in sickle cell anemia
    Elizabeth C Uong
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine and Division of Genetics, Washington University School of Medicine, St Louis, MO 63108, USA
    J Pediatr 149:707-9. 2006
  7. pmc Lower airway obstruction is associated with increased morbidity in children with sickle cell disease
    Jessica H Boyd
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pediatr Pulmonol 44:290-6. 2009
  8. pmc Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease
    Monica L Hulbert
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 117:772-9. 2011
  9. ncbi request reprint Recurrent, severe wheezing is associated with morbidity and mortality in adults with sickle cell disease
    Robyn T Cohen
    Department of Pediatrics, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Am J Hematol 86:756-61. 2011
  10. ncbi request reprint Blood transfusion therapy is feasible in a clinical trial setting in children with sickle cell disease and silent cerebral infarcts
    Allison A King
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri, USA
    Pediatr Blood Cancer 50:599-602. 2008

Collaborators

Detail Information

Publications36

  1. pmc Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure
    Michael R Debaun
    Department of Pediatrics, Division of Hematology Oncology, Vanderbilt University, Nashville, TN, USA
    Blood 119:3684-90. 2012
    ..Hemoglobin concentration and systolic blood pressure are risk factors for SCI in children with SCA and may be therapeutic targets for decreasing the risk of SCI. This study is registered at www.clinicaltrials.gov as #NCT00072761...
  2. doi request reprint Transition and sickle cell disease
    Michael R Debaun
    Department of Pediatrics, Vanderbilt University School of Medicine and Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee 37232 9000, USA
    Pediatrics 130:926-35. 2012
    ..We identify how the primary care physicians in tandem with the pediatric specialist can enhance transition interventions for children and adolescents with SCD...
  3. pmc Silent cerebral infarcts: a review on a prevalent and progressive cause of neurologic injury in sickle cell anemia
    Michael R Debaun
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Blood 119:4587-96. 2012
    ..In this review, we describe the epidemiology, natural history, morbidity, medical management, and potential therapeutic options for SCI in SCA...
  4. doi request reprint Secondary prevention of overt strokes in sickle cell disease: therapeutic strategies and efficacy
    Michael R Debaun
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hematology Am Soc Hematol Educ Program 2011:427-33. 2011
    ....
  5. ncbi request reprint Asthma is associated with increased mortality in individuals with sickle cell anemia
    Jessica H Boyd
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    Haematologica 92:1115-8. 2007
    ..After controlling for established risk factors, individuals with SCA and asthma had a more than two-fold higher risk of mortality (hazard ratio 2.36, 95% CI 1.21 to 4.62, p=0.01). To summarize, asthma is a risk factor for death in SCA...
  6. pmc Daytime pulse oximeter measurements do not predict incidence of pain and acute chest syndrome episodes in sickle cell anemia
    Elizabeth C Uong
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine and Division of Genetics, Washington University School of Medicine, St Louis, MO 63108, USA
    J Pediatr 149:707-9. 2006
    ..The Pearson correlation between SpO2 and pain and ACS episode rates were 0.00 (P = .97) and 0.10 (P = .27), respectively. Daytime SpO2 cannot independently predict the subsequent rate of pain and ACS episodes...
  7. pmc Lower airway obstruction is associated with increased morbidity in children with sickle cell disease
    Jessica H Boyd
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pediatr Pulmonol 44:290-6. 2009
    ..Our objective was to study the relationship between abnormalities in pulmonary function and morbidity as represented by the rate of hospitalizations for pain or acute chest syndrome (ACS) in children with SCD...
  8. pmc Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease
    Monica L Hulbert
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 117:772-9. 2011
    ..Additional therapies are needed for secondary stroke prevention in children with SCD...
  9. ncbi request reprint Recurrent, severe wheezing is associated with morbidity and mortality in adults with sickle cell disease
    Robyn T Cohen
    Department of Pediatrics, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Am J Hematol 86:756-61. 2011
    ..Asthma features were not associated with recurrent, severe wheezing. Our data suggest that wheezing in SCD may occur independently of asthma and is a marker of disease severity...
  10. ncbi request reprint Blood transfusion therapy is feasible in a clinical trial setting in children with sickle cell disease and silent cerebral infarcts
    Allison A King
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri, USA
    Pediatr Blood Cancer 50:599-602. 2008
    ..The overall goals of this study were to determine the feasibility and short-term efficacy of blood transfusion therapy for silent cerebral infarcts...
  11. pmc Multi-modal intervention and prospective implementation of standardized sickle cell pain admission orders reduces 30-day readmission rate
    Melissa J Frei-Jones
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Pediatr Blood Cancer 53:401-5. 2009
    ..Based on previous research identifying risk factors for 30-day readmission in our patient population, we designed and implemented a multi-modal intervention to reduce 30-day readmission rate in children with SCD and pain...
  12. pmc Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking oxygen desaturation
    Mark C Johnson
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Blood 116:16-21. 2010
    ..These data provide evidence that low asleep and waking oxygen saturations are associated with LV abnormalities in children with SCD...
  13. ncbi request reprint Mailing of a sickle cell disease educational packet increases blood donors within an African American community
    Cynthia L Price
    Department of Pediatrics, Division of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Transfusion 46:1388-93. 2006
    ..Low blood donor rates among African American persons are recognized; however, few strategies exist to increase these numbers...
  14. pmc Elevated urinary leukotriene E4 levels are associated with hospitalization for pain in children with sickle cell disease
    Jeanine E Jennings
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hematol 83:640-3. 2008
    ..52 episodes per 100 patient-years, P = 0.038). LTE(4) levels are elevated in children with SCD when compared with controls. LTE(4) levels are associated with an increased rate of hospitalizations for pain...
  15. pmc Asthma is associated with acute chest syndrome and pain in children with sickle cell anemia
    Jessica H Boyd
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine in St Louis, Patient Oriented Research Unit, 4444 Forest Park Blvd, CB 8519, St Louis, MO 63108, USA
    Blood 108:2923-7. 2006
    ..39 vs 0.47 events per patient year, P < .001). In conclusion, in children with SCA, asthma is associated with an increased incidence of sickle cell disease-related morbidity, including ACS and painful episodes...
  16. ncbi request reprint LIT1 and H19 methylation defects in isolated hemihyperplasia
    Rick A Martin
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Med Genet A 134:129-31. 2005
    ..Eight children (29.6%) had a defect in methylation of one or both of these alleles, supporting our hypothesis that these epigenetic changes can result in a phenotype distinct from typical Beckwith-Wiedemann syndrome...
  17. pmc Methacholine challenge in children with sickle cell disease: a case series
    Robert C Strunk
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatr Pulmonol 43:924-9. 2008
    ..No patient developed a pain or ACS episode within at least 1 month after the challenge. Evaluation of AHR with methacholine challenge in patients with SCD appears to be well tolerated and may elucidate a cause of SCD morbidity...
  18. ncbi request reprint The Sickle Cell Sabbath: a community program increases first-time blood donors in the African American faith community
    Cynthia L Price
    Department of Pediatrics, Division of Genetics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Transfusion 49:519-23. 2009
    ..This study tested the hypothesis that when informed at church about the importance of blood donation, African Americans will have a higher than expected rate of first-time blood donation compared to the general population...
  19. pmc Painful episodes in children with sickle cell disease and asthma are temporally associated with respiratory symptoms
    Jeffrey Glassberg
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Pediatr Hematol Oncol 28:481-5. 2006
    ..We tested the hypothesis that respiratory symptoms either immediately precede or occur concomitantly with painful episodes more frequently in children with SCD and asthma when compared with children with SCD without asthma...
  20. pmc Low daytime pulse oximetry reading is associated with nocturnal desaturation and obstructive sleep apnea in children with sickle cell anemia
    John F Spivey
    Department of Pediatrics, Washington University School of Medicine St Louis Children s Hospital, St Louis, Missouri, USA
    Pediatr Blood Cancer 50:359-62. 2008
    ..453; P = 0.045). Our results indicate that in children with SCA, a daytime SpO(2) </=94% is a reasonable threshold to recommend a pulmonary evaluation, including a PSG...
  21. pmc Asthma morbidity and treatment in children with sickle cell disease
    Samuel O Anim
    Division of Pediatric Hematology and Oncology, Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO, USA
    Expert Rev Respir Med 5:635-45. 2011
    ....
  22. ncbi request reprint Racial disparity in the frequency of recurrence of preterm birth
    Zachary A F Kistka
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    Am J Obstet Gynecol 196:131.e1-6. 2007
    ..We examined the hypothesis that black race independent of other factors increases the risk for extreme preterm birth and its frequency of recurrence at a similar gestational age...
  23. pmc Asthma is a distinct comorbid condition in children with sickle cell anemia with elevated total and allergen-specific IgE levels
    Jerlinda G C Ross
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    J Pediatr Hematol Oncol 33:e205-8. 2011
    ..In children with SCA, elevated total and specific immunoglobulin E levels were significantly associated with a diagnosis of asthma (P<0.05), further supporting the concept that asthma is a separate comorbid condition of SCA...
  24. doi request reprint Exploring barriers and facilitators to clinical trial enrollment in the context of sickle cell anemia and hydroxyurea
    Jeffrey D Lebensburger
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatr Blood Cancer 60:1333-7. 2013
    ..To limit the early cessation of a proposed clinical trial due to low accrual rates, we sought to better understand barriers and facilitators to enrolling parents of children with sickle cell anemia (SCD) into clinical trials...
  25. pmc Prospects for primary stroke prevention in children with sickle cell anaemia
    Lori C Jordan
    Department of Neurology, Division of Pediatric Neurology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Br J Haematol 157:14-25. 2012
    ....
  26. pmc Enuresis associated with sleep disordered breathing in children with sickle cell anemia
    Gloria C Lehmann
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    J Urol 188:1572-6. 2012
    ..Enuresis and sleep disordered breathing are common among children with sickle cell anemia. We evaluated whether enuresis is associated with sleep disordered breathing in children with sickle cell anemia...
  27. ncbi request reprint Reversible posterior leukoencephalopathy syndrome and silent cerebral infarcts are associated with severe acute chest syndrome in children with sickle cell disease
    Jessica N Henderson
    Department of Pediatrics, Division of Pediatric Hematology Oncology, Mallinkrodt Institute of Radiology, Neuroradiology, Washington University School of Medicine, St Louis, MO, USA
    Blood 101:415-9. 2003
    ..Children with severe ACS should have a magnetic resonance image of the brain, neurologic examination by a neurologist, and cognitive testing to detect the presence of neurologic morbidity...
  28. ncbi request reprint Etiology of strokes in children with sickle cell anemia
    Michael R Debaun
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Ment Retard Dev Disabil Res Rev 12:192-9. 2006
    ..This review focuses on the relationship between these factors in order to provide a foundation for further study of the etiology of strokes in this high-risk population...
  29. pmc Risk factors for hospital readmission within 30 days: a new quality measure for children with sickle cell disease
    Melissa J Frei-Jones
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pediatr Blood Cancer 52:481-5. 2009
    ..Among children with SCD, limited data exists to identify risk factors for readmission and whether they are modifiable...
  30. ncbi request reprint Primary hemorrhagic stroke in children with sickle cell disease is associated with recent transfusion and use of corticosteroids
    John J Strouse
    Division of Pediatric Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pediatrics 118:1916-24. 2006
    ..We performed a retrospective case-control study to evaluate risk and prognostic factors for primary hemorrhagic stroke among children with sickle cell disease...
  31. ncbi request reprint Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease
    Charles H Pegelow
    Department of Pediatrics, University of Miami, Miami, FL 33101, USA
    Blood 99:3014-8. 2002
    ..Until safe and effective preventive strategies against infarct recurrence are discovered, MRI studies are best reserved for children with neurologic symptoms, neuropsychometric deficits, or elevated cerebral artery velocities...
  32. pmc Inadequate community knowledge about sickle cell disease among African-American women
    Jessica H Boyd
    Department of Pediatrics, Division of Genetics, Washington University School of Medicine, St Louis, MO 63108, USA
    J Natl Med Assoc 97:62-7. 2005
    ..Few assessments have examined the impact of these programs. The aim of this study is to assess existing knowledge about SCD among African-American women in St. Louis, MO...
  33. ncbi request reprint Wheezing in children with sickle cell disease
    Jeffrey A Glassberg
    aEmergency Medicine, Hematology and Medical Oncology, Mount Sinai School of Medicine, New York bWashington University School of Medicine in St Louis, St Louis, Missouri cVanderbilt Meharry Center of Excellence in Sickle Cell Disease, Monroe Carell Jr Children s Hospital, Vanderbilt, Nashville, Tennessee, USA
    Curr Opin Pediatr 26:9-18. 2014
    ....
  34. pmc Sickle hemoglobin disturbs normal coupling among erythrocyte O2 content, glycolysis, and antioxidant capacity
    Stephen C Rogers
    Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, 1 Children s Pl, St Louis, MO 63110, USA
    Blood 121:1651-62. 2013
    ..Such disturbance of cdB3-based linkage between O2 gradients and RBC metabolism suggests a novel mechanism by which hypoxia may influence the sickle cell anemia phenotype...
  35. pmc Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19
    Michael R Debaun
    Division of Pediatric Hematology Oncology, Department of Pediatrics, Washington University School of Medicine, St Louis, USA
    Am J Hum Genet 72:156-60. 2003
    ..We discuss the implications of our finding that ART is associated with human overgrowth, similar to the large offspring syndrome reported in ruminants...
  36. ncbi request reprint Asthma and acute chest in sickle-cell disease
    Jessica H Boyd
    Division of Hematology Oncology, Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Pediatr Pulmonol 38:229-32. 2004
    ....