Sean S Davies

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc F2-isoprostanes as an indicator and risk factor for coronary heart disease
    Sean S Davies
    Division of Clinical Pharmacology and Department of Pharmacology, Vanderbilt University, Nashville, TN 37221, USA
    Free Radic Biol Med 50:559-66. 2011
  2. ncbi request reprint Quantification of dinor, dihydro metabolites of F2-isoprostanes in urine by liquid chromatography/tandem mass spectrometry
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, Nashville, TN 27232, USA
    Anal Biochem 348:185-91. 2006
  3. pmc Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity
    Sean S Davies
    Departments of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biochemistry 45:15756-67. 2006
  4. ncbi request reprint Localization of isoketal adducts in vivo using a single-chain antibody
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    Free Radic Biol Med 36:1163-74. 2004
  5. ncbi request reprint Isoketals: highly reactive gamma-ketoaldehydes formed from the H2-isoprostane pathway
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    Chem Phys Lipids 128:85-99. 2004
  6. pmc Ischemia/reperfusion unveils impaired capacity of older adults to restrain oxidative insult
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 47:1014-8. 2009
  7. pmc Treatment with a γ-ketoaldehyde scavenger prevents working memory deficits in hApoE4 mice
    Sean S Davies
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232 6602, USA
    J Alzheimers Dis 27:49-59. 2011
  8. pmc Identification of novel bioactive aldehyde-modified phosphatidylethanolamines formed by lipid peroxidation
    Lilu Guo
    Division of Clinical Pharmacology Vanderbilt University at Nashville, Nashville, TN 37232, USA
    Free Radic Biol Med 53:1226-38. 2012
  9. ncbi request reprint Potential role of isoketals formed via the isoprostane pathway of lipid peroxidation in ischemic arrhythmias
    Penelope A Boyden
    Department of Pharmacology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Cardiovasc Pharmacol 50:480-6. 2007
  10. ncbi request reprint Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 27232 6602, USA
    Nat Protoc 2:2079-91. 2007

Collaborators

Detail Information

Publications27

  1. pmc F2-isoprostanes as an indicator and risk factor for coronary heart disease
    Sean S Davies
    Division of Clinical Pharmacology and Department of Pharmacology, Vanderbilt University, Nashville, TN 37221, USA
    Free Radic Biol Med 50:559-66. 2011
    ..This review focuses on the evidence that specific PUFA peroxidation products, the F(2)-isoprostanes, are useful biomarkers that could potentially be utilized as indicators of CHD...
  2. ncbi request reprint Quantification of dinor, dihydro metabolites of F2-isoprostanes in urine by liquid chromatography/tandem mass spectrometry
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, Nashville, TN 27232, USA
    Anal Biochem 348:185-91. 2006
    ..77y = 67.2x-0.5). The levels of F2-IsoP-M detected in spot urines from 40 normal subjects were 38.1+/-19.1 ng/mg creatinine (mean+/-SD). This method provides an accurate and rapid assay to assess oxidative status in vivo...
  3. pmc Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity
    Sean S Davies
    Departments of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biochemistry 45:15756-67. 2006
    ....
  4. ncbi request reprint Localization of isoketal adducts in vivo using a single-chain antibody
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    Free Radic Biol Med 36:1163-74. 2004
    ..We conclude that isoketal adducts form in epithelial cells as a result of high oxygen exposure and that this single-chain antibody provides a valuable tool to localize the formation of isoketal adducts in tissues in vivo...
  5. ncbi request reprint Isoketals: highly reactive gamma-ketoaldehydes formed from the H2-isoprostane pathway
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    Chem Phys Lipids 128:85-99. 2004
    ....
  6. pmc Ischemia/reperfusion unveils impaired capacity of older adults to restrain oxidative insult
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 47:1014-8. 2009
    ....
  7. pmc Treatment with a γ-ketoaldehyde scavenger prevents working memory deficits in hApoE4 mice
    Sean S Davies
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232 6602, USA
    J Alzheimers Dis 27:49-59. 2011
    ..These data provide a rational basis for future studies exploring whether γ-ketoaldehyde scavengers may mitigate the development of cognitive dysfunction in patients with AD...
  8. pmc Identification of novel bioactive aldehyde-modified phosphatidylethanolamines formed by lipid peroxidation
    Lilu Guo
    Division of Clinical Pharmacology Vanderbilt University at Nashville, Nashville, TN 37232, USA
    Free Radic Biol Med 53:1226-38. 2012
    ..PEs modified by acrolein or by glucose were only partial agonists for adhesion. These studies indicate that lipid peroxidation generates a large family of al-PEs, many of which have the potential to drive inflammation...
  9. ncbi request reprint Potential role of isoketals formed via the isoprostane pathway of lipid peroxidation in ischemic arrhythmias
    Penelope A Boyden
    Department of Pharmacology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Cardiovasc Pharmacol 50:480-6. 2007
    ..Furthermore, we review what is known about the generation of such in the highly remodeled post myocardial infarction substrate. We suggest prevention of adduction of these highly reactive compounds would be antiarrhythmic...
  10. ncbi request reprint Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 27232 6602, USA
    Nat Protoc 2:2079-91. 2007
    ..IsoK/LG-lysyl-lactam adducts are measured by liquid chromatography tandem mass spectrometry after proteolytic digestion of extracted proteins, solid-phase extraction and preparative HPLC...
  11. doi request reprint Bioactive aldehyde-modified phosphatidylethanolamines
    Lilu Guo
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    Biochimie 95:74-8. 2013
    ..This review summarizes our current understanding of these al-PEs, including formation, detection, structural characterization, physiological relevance and mechanism of action...
  12. ncbi request reprint Oxidant stress modulates murine allergic airway responses
    Megha Talati
    Department of Medicine, T 1217 MCN, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 40:1210-9. 2006
    ..Oxidant stress plays a role in the production of airway responsiveness...
  13. ncbi request reprint Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels
    Koji Fukuda
    Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Circ Res 97:1262-9. 2005
    ..These data suggest Na+ channel dysfunction evoked by lipid peroxidation is a candidate mechanism for ischemia-related conduction abnormalities and arrhythmias...
  14. doi request reprint Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice
    Alexandra Bernardo
    Department of Pharmacology, Vanderbilt University, Nashville, TN, United States
    Neurobiol Aging 30:1777-91. 2009
    ..These results suggest that GD3 synthase may be a novel therapeutic target to combat the cognitive deficits, amyloid plaque formation, and neurodegeneration that afflict Alzheimer's patients...
  15. ncbi request reprint Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation
    Olivier Boutaud
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    J Biol Chem 278:16926-8. 2003
    ..They also demonstrate that a physiological stimulus is sufficient to lead to the lipid modification of proteins through the levuglandin pathway in human platelets...
  16. ncbi request reprint Modification of proteins by isoketal-containing oxidized phospholipids
    Cynthia J Brame
    Departments of Pharmacology and Medicine, Vanderbilt University, Nashville, Tennessee 27232 6602, USA
    J Biol Chem 279:13447-51. 2004
    ....
  17. pmc Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
    Hiroshi Watanabe
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Med 15:380-3. 2009
    ..Flecainide completely prevented CPVT in two human subjects who had remained highly symptomatic on conventional drug therapy, indicating that this currently available drug is a promising mechanism-based therapy for CPVT...
  18. ncbi request reprint Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 27232 6602, USA
    FASEB J 16:715-7. 2002
    ..These findings suggest that IsoKs/NeuroKs/LGs can inhibit proteasome activity and, if overproduced, may have relevance to the pathogenesis of neurodegenerative diseases...
  19. doi request reprint Modulation of protein function by isoketals and levuglandins
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, 506A RRB, 2222 Pierce Ave, Nashville, TN 37232, USA
    Subcell Biochem 49:49-70. 2008
    ....
  20. pmc Isoketals form cytotoxic phosphatidylethanolamine adducts in cells
    C Blake Sullivan
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University, Nashville, TN, USA
    J Lipid Res 51:999-1009. 2010
    ..2 muM). These results indicate that cellular PE is a significant target of IsoKs, and that formation of PE adducts may mediate some of the biological effects of IsoKs relevant to disease...
  21. pmc A liquid chromatography-tandem mass spectrometry method for measurement of N-modified phosphatidylethanolamines
    Lilu Guo
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Anal Biochem 405:236-45. 2010
    ..Therefore, we developed an accurate assay for NAPEs and gammaKA-PEs using CH(3)NH(2)-mediated deacylation and quantitation of the resulting glycerophospho-N-modified ethanolamines by liquid chromatography-tandem mass spectrometry...
  22. pmc Phosphatidylethanolamines modified by γ-ketoaldehyde (γKA) induce endoplasmic reticulum stress and endothelial activation
    Lilu Guo
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    J Biol Chem 286:18170-80. 2011
    ..Thus, γKA-PE is a potential mediator of the inflammation induced by lipid peroxidation...
  23. ncbi request reprint The biochemistry of the isoprostane, neuroprostane, and isofuran Pathways of lipid peroxidation
    L Jackson Roberts
    Department of Pharmacology, 522 RRB, Vanderbilt University, Nashville, TN 37232 6602, USA
    Brain Pathol 15:143-8. 2005
    ..Oxygen concentration differentially modulates the formation of isoprostanes and isofurans. As oxygen concentrations increase, the formation of isofurans is favored whereas the formation of isoprostanes becomes disfavored...
  24. ncbi request reprint Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro
    Sean S Davies
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Ocul Pharmacol Ther 19:45-54. 2003
    ..Our findings suggest that bimatoprost can act as prodrug for FP receptor activation and questions the concept of a "prostamide receptor" agonist...
  25. pmc Amitriptyline activates cardiac ryanodine channels and causes spontaneous sarcoplasmic reticulum calcium release
    Nagesh Chopra
    Oates Institute for Experimental Therapeutics and Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0575, USA
    Mol Pharmacol 75:183-95. 2009
    ....
  26. ncbi request reprint Covalent binding of isoketals to ethanolamine phospholipids
    Nathalie Bernoud-Hubac
    INSERM U585, Physiopathologie des Lipides et Membranes, INSA Lyon, 69621 Villeurbanne, France
    Free Radic Biol Med 37:1604-11. 2004
    ..These studies identify in vitro novel isoketal adducts. This provides the basis to explore the formation of isoketal-aminophospholipid adducts in vivo and the biological consequences of the formation of these adducts...
  27. pmc Aging, resting metabolic rate, and oxidative damage: results from the Louisiana Healthy Aging Study
    Madlyn I Frisard
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    J Gerontol A Biol Sci Med Sci 62:752-9. 2007
    ..The current study was designed to test whether nonagenarians have a relatively low metabolic rate and whether it is associated with low levels of oxidative stress relative to age...